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1. 发明授权

US07675624B2 Portable and cartridge-based surface plasmon resonance sensing systems 有权
标题翻译：便携式和基于盒式的表面等离子体共振传感系统
公开(公告)号：US07675624B2
公开(公告)日：2010-03-09
申请号：US11398964
申请日：2006-04-05
申请人： Timothy M. Chinowsky , Scott D. Soelberg , Peter C. Kauffman , Clement E. Furlong , Jared Tritz , Michael S. Grow , Alexei N. Naimushin , Sinclair S. Yee
发明人： Timothy M. Chinowsky , Scott D. Soelberg , Peter C. Kauffman , Clement E. Furlong , Jared Tritz , Michael S. Grow , Alexei N. Naimushin , Sinclair S. Yee
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01N2201/04
摘要： This specification discloses various improvements in the field of SPR sensing systems. One improvement relates to a portable SPR sensing system, e.g., a system contained within a suitcase that can be hand-carried to a monitoring site. Another improvement relates to a portable, cartridge-based SPR sensing system. In this system, selected portions of the system's electrical and fluidics systems are allocated between a base unit and a removable/disposable cartridge. Other improvements relate to methods or protocols for operating an SPR sensing system. Such methods provide for the elimination of false positives and increased sensitivity, e.g., by using secondary antibodies with specificity for different target epitopes and by sensor element redundancy. In addition, protocols are provided for the detection of small molecules. Such protocols may employ a competition type assay where the presence of the analyte inhibits the binding of antibodies to surface immobilized analyte, or a displacement assay, where antibodies bound to the analyte on the sensor surface are displaced by free analyte.
摘要翻译：本说明书公开了SPR传感系统领域的各种改进。一个改进涉及便携式SPR感测系统，例如，可以手提携带到监控地点的手提箱内的系统。另一项改进涉及一种便携式，基于盒式SPR感测系统。在该系统中，系统的电和流体系统的选定部分被分配在基本单元和可移动/一次性盒之间。其他改进涉及用于操作SPR感测系统的方法或协议。这样的方法提供消除假阳性和提高灵敏度，例如通过使用对不同靶标表位具有特异性的二级抗体以及通过传感器元件冗余。此外，提供了用于检测小分子的方案。这样的方案可以采用竞争型测定法，其中分析物的存在抑制抗体与表面固定化分析物的结合，或位移测定法，其中与传感器表面上的分析物结合的抗体被游离分析物置换。

2. 发明授权

US08174700B2 Portable and cartridge-based surface plasmon resonance sensing systems 有权
标题翻译：便携式和基于盒式的表面等离子体共振传感系统
公开(公告)号：US08174700B2
公开(公告)日：2012-05-08
申请号：US13016788
申请日：2011-01-28
申请人： Timothy M. Chinowsky , Scott D. Soelberg , Peter C. Kauffman , Clement E. Furlong , Jared Tritz , Michael S. Grow , Alexei N. Naimushin , Sinclair S. Yee
发明人： Timothy M. Chinowsky , Scott D. Soelberg , Peter C. Kauffman , Clement E. Furlong , Jared Tritz , Michael S. Grow , Alexei N. Naimushin , Sinclair S. Yee
IPC分类号： G01N21/00
CPC分类号： G01N21/553 , G01N2201/04
摘要： This specification discloses various improvements in the field of SPR sensing systems. One improvement relates to a portable SPR sensing system, e.g., a system contained within a suitcase that can be hand-carried to a monitoring site. Another improvement relates to a portable, cartridge-based SPR sensing system. In this system, selected portions of the system's electrical and fluidics systems are allocated between a base unit and a removable/disposable cartridge. Other improvements relate to methods or protocols for operating an SPR sensing system. Such methods provide for the elimination of false positives and increased sensitivity, e.g., by using secondary antibodies with specificity for different target epitopes and by sensor element redundancy. In addition, protocols are provided for the detection of small molecules. Such protocols may employ a competition type assay where the presence of the analyte inhibits the binding of antibodies to surface immobilized analyte, or a displacement assay, where antibodies bound to the analyte on the sensor surface are displaced by free analyte.
摘要翻译：本说明书公开了SPR传感系统领域的各种改进。一个改进涉及便携式SPR感测系统，例如，可以手提携带到监控地点的手提箱内的系统。另一项改进涉及一种便携式，基于盒式SPR感测系统。在该系统中，系统的电和流体系统的选定部分被分配在基本单元和可移动/一次性盒之间。其他改进涉及用于操作SPR感测系统的方法或协议。这样的方法提供消除假阳性和提高灵敏度，例如通过使用对不同靶标表位具有特异性的二级抗体以及通过传感器元件冗余。此外，提供了用于检测小分子的方案。这样的方案可以采用竞争型测定法，其中分析物的存在抑制抗体与表面固定化分析物的结合，或位移测定法，其中与传感器表面上的分析物结合的抗体被游离分析物置换。

3. 发明申请

US20110128548A1 Portable and Cartridge-Based Surface Plasmon Resonance Sensing Systems 有权
标题翻译：便携式和基于盒式的表面等离子体共振传感系统
公开(公告)号：US20110128548A1
公开(公告)日：2011-06-02
申请号：US13016788
申请日：2011-01-28
申请人： Timothy M. Chinowsky , Scott D. Soelberg , Peter C. Kauffman , Clement E. Furlong , Jared Tritz , Michael S. Grow , Alexei N. Naimushin , Sinclair S. Yee
发明人： Timothy M. Chinowsky , Scott D. Soelberg , Peter C. Kauffman , Clement E. Furlong , Jared Tritz , Michael S. Grow , Alexei N. Naimushin , Sinclair S. Yee
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01N2201/04
摘要： This specification discloses various improvements in the field of SPR sensing systems. One improvement relates to a portable SPR sensing system, e.g., a system contained within a suitcase that can be hand-carried to a monitoring site. Another improvement relates to a portable, cartridge-based SPR sensing system. In this system, selected portions of the system's electrical and fluidics systems are allocated between a base unit and a removable/disposable cartridge. Other improvements relate to methods or protocols for operating an SPR sensing system. Such methods provide for the elimination of false positives and increased sensitivity, e.g., by using secondary antibodies with specificity for different target epitopes and by sensor element redundancy. In addition, protocols are provided for the detection of small molecules. Such protocols may employ a competition type assay where the presence of the analyte inhibits the binding of antibodies to surface immobilized analyte, or a displacement assay, where antibodies bound to the analyte on the sensor surface are displaced by free analyte.
摘要翻译：本说明书公开了SPR传感系统领域的各种改进。一个改进涉及便携式SPR感测系统，例如，可以手提携带到监控地点的手提箱内的系统。另一项改进涉及一种便携式，基于盒式SPR感测系统。在该系统中，系统的电和流体系统的选定部分被分配在基本单元和可移动/一次性盒之间。其他改进涉及用于操作SPR感测系统的方法或协议。这样的方法提供消除假阳性和提高灵敏度，例如通过使用对不同靶标表位具有特异性的二级抗体以及通过传感器元件冗余。此外，提供了用于检测小分子的方案。这样的方案可以采用竞争型测定法，其中分析物的存在抑制抗体与表面固定化分析物的结合，或位移测定法，其中与传感器表面上的分析物结合的抗体被游离分析物置换。

4. 发明申请

US20100284012A1 Portable and Cartridge-Based Surface Plasmon Resonance Sensing Systems 审中-公开
标题翻译：便携式和基于盒式的表面等离子体共振传感系统
公开(公告)号：US20100284012A1
公开(公告)日：2010-11-11
申请号：US12699377
申请日：2010-02-03
申请人： Timothy M. Chinowsky , Scott D. Soelberg , Peter C. Kauffman , Clement E. Furlong , Jared Tritz , Michael S. Grow , Alexei N. Naimushin , Sinclair S. Yee
发明人： Timothy M. Chinowsky , Scott D. Soelberg , Peter C. Kauffman , Clement E. Furlong , Jared Tritz , Michael S. Grow , Alexei N. Naimushin , Sinclair S. Yee
IPC分类号： G01N21/55
CPC分类号： G01N21/553 , G01N2201/04
摘要： This specification discloses various improvements in the field of SPR sensing systems. One improvement relates to a portable SPR sensing system, e.g., a system contained within a suitcase that can be hand-carried to a monitoring site. Another improvement relates to a portable, cartridge-based SPR sensing system. In this system, selected portions of the system's electrical and fluidics systems are allocated between a base unit and a removable/disposable cartridge. Other improvements relate to methods or protocols for operating an SPR sensing system. Such methods provide for the elimination of false positives and increased sensitivity, e.g., by using secondary antibodies with specificity for different target epitopes and by sensor element redundancy. In addition, protocols are provided for the detection of small molecules. Such protocols may employ a competition type assay where the presence of the analyte inhibits the binding of antibodies to surface immobilized analyte, or a displacement assay, where antibodies bound to the analyte on the sensor surface are displaced by free analyte.
摘要翻译：本说明书公开了SPR传感系统领域的各种改进。一个改进涉及便携式SPR感测系统，例如，可以手提携带到监控地点的手提箱内的系统。另一项改进涉及一种便携式，基于盒式SPR感测系统。在该系统中，系统的电和流体系统的选定部分被分配在基本单元和可移动/一次性盒之间。其他改进涉及用于操作SPR感测系统的方法或协议。这样的方法提供消除假阳性和提高灵敏度，例如通过使用对不同靶标表位具有特异性的二级抗体以及通过传感器元件冗余。此外，提供了用于检测小分子的方案。这样的方案可以采用竞争型测定法，其中分析物的存在抑制抗体与表面固定化分析物的结合，或位移测定法，其中与传感器表面上的分析物结合的抗体被游离分析物置换。

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