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1. 发明申请

US20080150531A1 3D MR IMAGING WITH FAT SUPPRESSION 失效
标题翻译：具有FAT抑制的3D MR成像
公开(公告)号：US20080150531A1
公开(公告)日：2008-06-26
申请号：US11962792
申请日：2007-12-21
申请人： Timothy Hughes , Bernd Kuehn
发明人： Timothy Hughes , Bernd Kuehn
IPC分类号： G01R33/56
CPC分类号： G01R33/561 , G01R33/4824 , G01R33/4828 , G01R33/5602 , G01R33/5607
摘要： In a method for image generation by magnetic resonance with suppression of a spectral component of the magnetic resonance signal during the signal acquisition, k-space is sampled in sub-sections, an excitation pulse for excitation of the spectral component to be suppressed is radiated at a point in time TI before acquisition of each sub-section of k-space, and different TI values are selected for the respective sub-sections.
摘要翻译：在信号采集期间通过抑制磁共振信号的频谱分量的磁共振成像的方法中，在子部分中对k空间进行采样，将要抑制的频谱分量的激励用激励脉冲放射在在获取k空间的每个子部分之前的时间点TI，并且为各个子部分选择不同的TI值。

2. 发明授权

US07639009B2 3D MR imaging with fat suppression 失效
标题翻译：具有脂肪抑制的3D MR成像
公开(公告)号：US07639009B2
公开(公告)日：2009-12-29
申请号：US11962792
申请日：2007-12-21
申请人： Timothy Hughes , Bernd Kuehn
发明人： Timothy Hughes , Bernd Kuehn
IPC分类号： G01V3/00
CPC分类号： G01R33/561 , G01R33/4824 , G01R33/4828 , G01R33/5602 , G01R33/5607
摘要： In a method for image generation by magnetic resonance with suppression of a spectral component of the magnetic resonance signal during the signal acquisition, k-space is sampled in sub-sections, an excitation pulse for excitation of the spectral component to be suppressed is radiated at a point in time TI before acquisition of each sub-section of k-space, and different TI values are selected for the respective sub-sections.
摘要翻译：在信号采集期间通过抑制磁共振信号的频谱分量的磁共振成像的方法中，在子部分中对k空间进行采样，将要抑制的频谱分量的激励用激励脉冲放射在在获取k空间的每个子部分之前的时间点TI，并且为各个子部分选择不同的TI值。

3. 发明授权

US09825434B2 Spark gap comprising a capacitive energy store 有权
公开(公告)号：US09825434B2
公开(公告)日：2017-11-21
申请号：US14412703
申请日：2012-07-11
申请人： Oliver Heid , Timothy Hughes , Jennifer Sirtl
发明人： Oliver Heid , Timothy Hughes , Jennifer Sirtl
IPC分类号： H01J35/22 , H01T15/00 , H01T1/20 , H01T2/00 , H05G1/24 , H01G4/02
CPC分类号： H01T15/00 , H01G4/02 , H01J35/22 , H01J2235/166 , H01T1/20 , H01T2/00 , H05G1/24
摘要： A spark gap including a capacitive energy store is provided. The spark gap is fed via a multiplicity of capacitors arranged in a form of a ring, wherein the capacitors are electrically connected to the anode and the cathode via ring-shaped and conical or funnel-shaped conductors. As a result, sudden changes in impedance can be avoided. At the same time, it is possible to realize as large a cross-sectional area of the conductor as possible within a very small space. Therefore, the spark gap has a switching response with a high rate of rise of the voltage pulse as soon as the spark gaps flash over. This results in an easily predictable switching response of the spark gap. The spark gap can be used, for example, to generate pulses of monochromatic X-ray radiation.

4. 发明授权

US09520262B2 X-ray source, method for producing X-rays and use of an X-ray source emitting monochromatic X-rays 有权
标题翻译： X射线源，X射线的制造方法以及使用发射单色X射线的X射线源
公开(公告)号：US09520262B2
公开(公告)日：2016-12-13
申请号：US14406301
申请日：2012-06-14
申请人： Oliver Heid , Timothy Hughes , Jennifer Sirtl
发明人： Oliver Heid , Timothy Hughes , Jennifer Sirtl
IPC分类号： H01J35/10 , H01J35/08 , H01J35/24 , A61B6/00
CPC分类号： H01J35/108 , A61B6/484 , H01J35/08 , H01J35/24 , H01J2235/081 , H01J2235/084 , H01J2235/1006
摘要： X-ray sources and production of X-rays, in particular, producing monochromatic x-rays is provided. More specifically, a method for producing X-rays and the use of the X-ray source for x-raying bodies (for example human bodies). An aerogel, for example in the form of a rod, may be provided in a housing as a target. Said target may be bombarded with an electron beam, the aerogel being vaporized due to the extreme low density and the high energy. As a result, the target is guided by means of a roller such that an unused target for producing, in particular, the monochromatic X-rays, is always available.
摘要翻译：提供X射线源和X射线的生产，特别是生产单色X射线。更具体地说，一种X射线的制造方法和X射线源（例如人体）的X射线源的使用。可以将例如以棒的形式形成的气凝胶作为目标设置在壳体中。所述靶可以用电子束轰击，由于极低的密度和高的能量，气凝胶被蒸发。结果，目标是通过一个辊来引导的，使得用于产生特别是单色X射线的未使用的目标总是可用的。

5. 发明申请

US20150170868A1 X-RAY SOURCE AND THE USE THEREOF AND METHOD FOR PRODUCING X-RAYS 有权
标题翻译： X射线源及其用途以及生产X射线的方法
公开(公告)号：US20150170868A1
公开(公告)日：2015-06-18
申请号：US14407504
申请日：2012-06-15
申请人： Oliver Heid , Timothy Hughes , Jennifer Sirtl
发明人： Oliver Heid , Timothy Hughes , Jennifer Sirtl
IPC分类号： H01J35/08 , H01J35/18
CPC分类号： H01J35/08 , H01J35/18 , H01J2235/082 , H01J2235/18 , H05G2/005
摘要： An x-ray source comprising a housing, in which a target in the form of an ionized cloud based on metal vapour is provided. The ionized cloud can be excited by means of an electron beam for emitting monochromatic x-rays. The low atom density advantageously produces only a little braking radiation. The robustness of the plasma with respect to the inevitable thermal energy input is also advantageous with respect to the solid target materials. The cloud can be filled at any time with target material which can be vaporised by means of an electric arc. A method for producing x-rays with the above-mentioned x-ray source is also provided. The use of an x-ray source for emitting monochromatic x-rays for x-raying a body is further provided.
摘要翻译：一种x射线源，包括壳体，其中提供了基于金属蒸汽的电离云形式的靶。可以通过用于发射单色x射线的电子束激发电离云。低原子密度有利地仅产生一些制动辐射。相对于不可避免的热能输入，等离子体的鲁棒性对于固体靶材料也是有利的。可以随时使用可通过电弧蒸发的目标材料填充云。还提供了一种用上述x射线源产生X射线的方法。还提供了使用x射线源发射单色X射线以进行身体X射线照射。

6. 发明申请

US20140015385A1 HF GENERATOR 有权
标题翻译： HF发电机
公开(公告)号：US20140015385A1
公开(公告)日：2014-01-16
申请号：US14008090
申请日：2011-10-13
申请人： Oliver Heid , Timothy Hughes
发明人： Oliver Heid , Timothy Hughes
IPC分类号： H02K29/00
CPC分类号： H02K29/00 , H01P5/026 , H01R24/46 , H01R2107/00
摘要： An HF generator has first and second solid-state switches. Each of the solid-state switches has first and second output connectors and is designed to switch a high-frequency electrical current between the first and second output connectors. Furthermore, the HF generator has a coaxial cable with first and second conductors. The first conductor successively has a first section and a second section in the longitudinal direction of the coaxial cable which are separated from one another by a first break point. The first output connector of the first solid-state switch is conductively connected to the second conductor, and the second output connector of the first solid-state switch is conductively connected to the first section. In addition, the first output connector of the second solid-state switch is conductively connected to the first section, and the second output connector of the second solid-state switch is conductively connected to the second section.
摘要翻译： HF发生器具有第一和第二固态开关。每个固态开关具有第一和第二输出连接器，并且被设计成在第一和第二输出连接器之间切换高频电流。此外，HF发生器具有与第一和第二导体的同轴电缆。第一导体依次具有沿着同轴电缆的纵向的第一部分和第二部分，它们通过第一断点彼此分离。第一固态开关的第一输出连接器导电地连接到第二导体，并且第一固态开关的第二输出连接器导电地连接到第一部分。此外，第二固态开关的第一输出连接器导电地连接到第一部分，并且第二固态开关的第二输出连接器导电地连接到第二部分。

7. 发明申请

US20120314828A1 METHOD AND DEVICE FOR PRODUCING 99mTc 有权
标题翻译：用于生产99mTc的方法和装置
公开(公告)号：US20120314828A1
公开(公告)日：2012-12-13
申请号：US13576475
申请日：2011-01-20
申请人： Arnd Baurichter , Olivier Heid , Timothy Hughes
发明人： Arnd Baurichter , Olivier Heid , Timothy Hughes
IPC分类号： G21G1/10
CPC分类号： G21G1/10 , A61K51/025 , C01G99/003 , G21G1/001 , G21G2001/0042
摘要： A method for producing 99mTc may include: providing a solution comprising 100Mo-molybdate-ions; providing a proton beam having an energy suitable for inducing a 100Mo (p, 2n) 99mTc-nuclear reaction when exposing 100Mo-molybdate-ions; exposing the solution to the proton beams and inducing a 100Mo (p, 2n) 99mTc-nuclear reaction; and applying an extraction method for extracting the 99mTc from the solution. Further, a device for producing 99mTc may include: a solution with 100Mo-molybdate-ions; an accelerator for providing a proton beam with energy which is suitable for inducing a 100Mo (p, 2n) 99mTc-nuclear reaction when exposing 100Mo-molybdate-ions, for exposing the solution and for inducing a 100Mo (p, 2n) 99mTc-nuclear reaction; and an extraction step for extracting 99mTc from the solution.
摘要翻译：制备99mTc的方法可以包括：提供包含100M钼酸盐离子的溶液; 提供具有适于在暴露100M钼酸盐离子时诱导100Mo（p，2n）99mTc-核反应的能量的质子束; 将溶液暴露于质子束并诱导100Mo（p，2n）99m Tc核反应; 并从溶液中提取提取99mTc的提取方法。此外，用于制备99mTc的装置可以包括：具有100M钼酸根离子的溶液; 用于提供质子束具有能量的加速器，其适于在暴露100M钼酸盐离子时诱导100Mo（p，2n）99mTc-核反应，用于暴露溶液和诱导100Mo（p，2n）99mTc-核反应; 以及从溶液中提取99mTc的提取步骤。

8. 发明申请

US20120301814A1 ELECTRICALLY DRIVEN AIRCRAFT 审中-公开
标题翻译：电动驾驶飞机
公开(公告)号：US20120301814A1
公开(公告)日：2012-11-29
申请号：US13576108
申请日：2011-01-28
申请人： Paul Beasley , Oliver Heid , Timothy Hughes
发明人： Paul Beasley , Oliver Heid , Timothy Hughes
IPC分类号： B64D27/24 , H01M8/22
CPC分类号： B64D27/24 , B64D2041/005 , H01M8/0687 , H01M8/222 , H01M2250/20 , Y02T50/62 , Y02T90/32 , Y02T90/36
摘要： An electrically driven aircraft may include a tank for NH3 in order to provide NH3, an energy source, which generates electric energy using and converting NH3, an electrically driven propulsion system that ensures the propulsion of the aircraft, and an energy distribution system that supplies the generated electric energy to the propulsion system.
摘要翻译：电动飞机可以包括用于NH 3的罐，以提供NH 3，其是使用和转化NH 3的能量源，NH3是确保飞机推进的电驱动推进系统，以及提供飞行器的能量分配系统向推进系统产生电能。

9. 发明申请

US20100217110A1 MAGNETIC RESONANCE METHOD AND APPARATUS FOR AUTOMATED ANALYSIS OF JOINT INFLAMMATION, JOINT PROTEOGLYCAN PROPORTION, AND JOINT OSTEOARTHRITIS 有权
标题翻译：磁共振方法和装置自动分析联合爆炸，联合保护成分和联合作战技术
公开(公告)号：US20100217110A1
公开(公告)日：2010-08-26
申请号：US12710869
申请日：2010-02-23
申请人： Timothy Hughes , Tallal Charles Mamisch
发明人： Timothy Hughes , Tallal Charles Mamisch
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/4514 , A61B5/4528 , A61K49/06 , G01R33/20 , G01R33/5601
摘要： In a magnetic resonance method and apparatus for generating an analysis of an inflammation of a joint, for determining a proteoglycan proportion of a joint, and for generating an analysis of osteoarthritis of a joint, for a predetermined region within a body of a patient, a three-dimensional MR image data set is generated with a magnetic resonance imaging scanner. At least, a portion of a joint is located within the region. For each of several different automatically determined layers, a two-dimensional MR image is calculated from the three-dimensional MR image data set. For each layer, the thickness of a predetermined tissue, which is represented in the two-dimensional MR image corresponding to the layer, is determined, by means of which an analysis of a joint inflammation is automatically determined depending on the respective thicknesses. A further layer in the region is also automatically determined and, after injecting a contrast medium, a two-dimensional T1-weighted MR image is generated for this layer, from which a proteoglycan proportion is automatically determined. From the analysis of the joint inflammation and the proteoglycan proportion, it is then possible to perform a reproducible analysis of osteoarthritis of the joint.
摘要翻译：在用于产生关节炎症分析的磁共振方法和装置中，用于确定关节的蛋白聚糖比例，并且用于产生关节骨关节炎的分析，对于患者体内的预定区域，利用磁共振成像扫描器生成三维MR图像数据集。至少，关节的一部分位于该区域内。对于几个不同的自动确定的层中的每一个，从三维MR图像数据集计算二维MR图像。对于每个层，确定在与层相对应的二维MR图像中表示的预定组织的厚度，借助于此，根据各自的厚度自动确定关节炎症的分析。还自动地确定该区域中的另一层，并且在注射造影剂之后，为该层生成二维T1加权MR图像，从其自动确定蛋白多糖比例。从关节炎和蛋白多糖比例的分析可以对关节骨关节炎进行可重复的分析。

10. 发明申请

US20100021920A1 MUTATED ABL KINASE DOMAINS 审中-公开
公开(公告)号：US20100021920A1
公开(公告)日：2010-01-28
申请号：US12545113
申请日：2009-08-21
申请人： Christophe Barthe , Susan Branford , Amie Corbin , Brian Jay Druker , Justus Duyster , Andreas Hochhaus , Timothy Hughes , Sebastian Kreil , Thlbaut Leguay , Francois-Xavier Mahon , Gèrald Marit , Martin Müller , Christian Peschel , Claude Preudhomme , Catherine Roche Lestienne , Zbigniew Rudzki
发明人： Christophe Barthe , Susan Branford , Amie Corbin , Brian Jay Druker , Justus Duyster , Andreas Hochhaus , Timothy Hughes , Sebastian Kreil , Thlbaut Leguay , Francois-Xavier Mahon , Gèrald Marit , Martin Müller , Christian Peschel , Claude Preudhomme , Catherine Roche Lestienne , Zbigniew Rudzki
IPC分类号： C12Q1/68 , C12N9/12 , C07H21/00 , C12N15/63 , C12N1/00
CPC分类号： C12N9/1205
摘要： The present invention relates to isolated polypeptides which comprise a functional kinase domain comprising the amino acid sequence of the native human Abl kinase domain or an essentially similar sequence thereof in which at least one amino acid selected from Met244, Leu248, Gly250, Glu252, Tyr253, Val256, Glu258, Phe311, Ile313, Phe317, Met318, Met351, Glu355, Glu359, Ile360, His361, Leu370, Asp381, Phe382, His396, Ser417, Glu459 and Phe486 is replaced by another amino acid, said mutated functional kinase domain being resistant to inhibition of its tyrosine kinase activity by N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-4-(4-methyl-piperazin-1-ylmethyl)-benzamide or a salt thereof, to the use of such polypeptides to screen for compounds which inhibit the tyrosine kinase activity of such polypeptides, to nucleic acid molecules encoding such polypeptides, to recombinant vectors and host cells comprising such nucleic acid molecules and to the use of such nucleic acid molecules in the production of such polypeptides for use in screening for compounds which inhibit the tyrosine kinase activity of such polypeptides.

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