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1. 发明授权

US08792960B2 Magnetic resonance method and apparatus for automated analysis of joint inflammation, joint proteoglycan proportion, and joint osteoarthritis 有权
标题翻译：用于自发分析关节炎症，关节蛋白聚糖比例和关节骨关节炎的磁共振方法和装置
公开(公告)号：US08792960B2
公开(公告)日：2014-07-29
申请号：US12710869
申请日：2010-02-23
申请人： Timothy Hughes , Tallal Charles Mamisch
发明人： Timothy Hughes , Tallal Charles Mamisch
IPC分类号： A61B5/055 , A61K49/06 , G01R33/56 , G01R33/20
CPC分类号： A61B5/055 , A61B5/4514 , A61B5/4528 , A61K49/06 , G01R33/20 , G01R33/5601
摘要： In a magnetic resonance method and apparatus for generating an analysis of an inflammation of a joint, for determining a proteoglycan proportion of a joint, and for generating an analysis of osteoarthritis of a joint, for a predetermined region within a body of a patient, a three-dimensional MR image data set is generated with a magnetic resonance imaging scanner. At least, a portion of a joint is located within the region. For each of several different automatically determined layers, a two-dimensional MR image is calculated from the three-dimensional MR image data set. For each layer, the thickness of a predetermined tissue, which is represented in the two-dimensional MR image corresponding to the layer, is determined, by means of which an analysis of a joint inflammation is automatically determined depending on the respective thicknesses. A further layer in the region is also automatically determined and, after injecting a contrast medium, a two-dimensional T1-weighted MR image is generated for this layer, from which a proteoglycan proportion is automatically determined. From the analysis of the joint inflammation and the proteoglycan proportion, it is then possible to perform a reproducible analysis of osteoarthritis of the joint.
摘要翻译：在用于产生关节炎症分析的磁共振方法和装置中，用于确定关节的蛋白聚糖比例，并且用于产生关节骨关节炎的分析，对于患者体内的预定区域，利用磁共振成像扫描器生成三维MR图像数据集。至少，关节的一部分位于该区域内。对于几个不同的自动确定的层中的每一个，从三维MR图像数据集计算二维MR图像。对于每个层，确定在与层相对应的二维MR图像中表示的预定组织的厚度，借助于此，根据各自的厚度自动确定关节炎症的分析。还自动地确定该区域中的另一层，并且在注射造影剂之后，为该层生成二维T1加权MR图像，从其自动确定蛋白多糖比例。从关节炎和蛋白多糖比例的分析可以对关节骨关节炎进行可重复的分析。

2. 发明申请

US20100217110A1 MAGNETIC RESONANCE METHOD AND APPARATUS FOR AUTOMATED ANALYSIS OF JOINT INFLAMMATION, JOINT PROTEOGLYCAN PROPORTION, AND JOINT OSTEOARTHRITIS 有权
标题翻译：磁共振方法和装置自动分析联合爆炸，联合保护成分和联合作战技术
公开(公告)号：US20100217110A1
公开(公告)日：2010-08-26
申请号：US12710869
申请日：2010-02-23
申请人： Timothy Hughes , Tallal Charles Mamisch
发明人： Timothy Hughes , Tallal Charles Mamisch
IPC分类号： A61B5/055
CPC分类号： A61B5/055 , A61B5/4514 , A61B5/4528 , A61K49/06 , G01R33/20 , G01R33/5601
摘要： In a magnetic resonance method and apparatus for generating an analysis of an inflammation of a joint, for determining a proteoglycan proportion of a joint, and for generating an analysis of osteoarthritis of a joint, for a predetermined region within a body of a patient, a three-dimensional MR image data set is generated with a magnetic resonance imaging scanner. At least, a portion of a joint is located within the region. For each of several different automatically determined layers, a two-dimensional MR image is calculated from the three-dimensional MR image data set. For each layer, the thickness of a predetermined tissue, which is represented in the two-dimensional MR image corresponding to the layer, is determined, by means of which an analysis of a joint inflammation is automatically determined depending on the respective thicknesses. A further layer in the region is also automatically determined and, after injecting a contrast medium, a two-dimensional T1-weighted MR image is generated for this layer, from which a proteoglycan proportion is automatically determined. From the analysis of the joint inflammation and the proteoglycan proportion, it is then possible to perform a reproducible analysis of osteoarthritis of the joint.
摘要翻译：在用于产生关节炎症分析的磁共振方法和装置中，用于确定关节的蛋白聚糖比例，并且用于产生关节骨关节炎的分析，对于患者体内的预定区域，利用磁共振成像扫描器生成三维MR图像数据集。至少，关节的一部分位于该区域内。对于几个不同的自动确定的层中的每一个，从三维MR图像数据集计算二维MR图像。对于每个层，确定在与层相对应的二维MR图像中表示的预定组织的厚度，借助于此，根据各自的厚度自动确定关节炎症的分析。还自动地确定该区域中的另一层，并且在注射造影剂之后，为该层生成二维T1加权MR图像，从其自动确定蛋白多糖比例。从关节炎和蛋白多糖比例的分析可以对关节骨关节炎进行可重复的分析。

3. 发明授权

US08314616B2 Magnetic resonance method and apparatus for determining the magnetization transfer constant in spin echo imaging sequences 有权
标题翻译：用于确定自旋回波成像序列中的磁化传递常数的磁共振方法和装置
公开(公告)号：US08314616B2
公开(公告)日：2012-11-20
申请号：US12704693
申请日：2010-02-12
申请人： Timothy Hughes , Tallal Charles Mamisch
发明人： Timothy Hughes , Tallal Charles Mamisch
IPC分类号： G01V3/00
CPC分类号： G01R33/5617 , G01R33/5605
摘要： In a magnetic resonance method and apparatus for determining a magnetization transfer constant a first MR signal sequence is acquired from an object being examined using a spin echo based imaging sequence, a second MR signal sequence is acquired from the object being examined using a spin echo based imaging sequence having basically identical imaging parameters to the first MR signal sequence, with the exception that the energy level of the RF pulses for exciting the magnetization in the first MR signal sequence and the energy level of the RF pulses for exciting the magnetization in the second MR signal sequence are different. The magnetization transfer constant is determined based on the signal differences between the first and second MR signal sequences.
摘要翻译：在用于确定磁化传递常数的磁共振方法和装置中，使用基于自旋回波的成像序列从被检查的对象获取第一MR信号序列，使用基于自旋回波的被检查对象获取第二MR信号序列成像序列具有与第一MR信号序列基本相同的成像参数，除了用于激发第一MR信号序列中的磁化的RF脉冲的能级和用于激发第二MR信号中的磁化的RF脉冲的能级 MR信号序列不同。基于第一和第二MR信号序列之间的信号差来确定磁化传递常数。

4. 发明申请

US20100207628A1 MAGNETIC RESONANCE METHOD AND APPARATUS FOR DETERMINING THE MAGNETIZATION TRANSFER CONSTANT IN SPIN ECHO IMAGING SEQUENCES 有权
标题翻译：用于确定旋转成像序列中的磁化传递常数的磁共振方法和装置
公开(公告)号：US20100207628A1
公开(公告)日：2010-08-19
申请号：US12704693
申请日：2010-02-12
申请人： Timothy Hughes , Tallal Charles Mamisch
发明人： Timothy Hughes , Tallal Charles Mamisch
IPC分类号： G01R33/48
CPC分类号： G01R33/5617 , G01R33/5605
摘要： In a magnetic resonance method and apparatus for determining a magnetization transfer constant a first MR signal sequence is acquired from an object being examined using a spin echo based imaging sequence, a second MR signal sequence is acquired from the object being examined using a spin echo based imaging sequence having basically identical imaging parameters to the first MR signal sequence, with the exception that the energy level of the RF pulses for exciting the magnetization in the first MR signal sequence and the energy level of the RF pulses for exciting the magnetization in the second MR signal sequence are different. The magnetization transfer constant is determined based on the signal differences between the first and second MR signal sequences.
摘要翻译：在用于确定磁化传递常数的磁共振方法和装置中，使用基于自旋回波的成像序列从被检查的对象获取第一MR信号序列，使用基于自旋回波的被检查对象获取第二MR信号序列成像序列具有与第一MR信号序列基本相同的成像参数，除了用于激发第一MR信号序列中的磁化的RF脉冲的能级和用于激发第二MR信号中的磁化的RF脉冲的能级 MR信号序列不同。基于第一和第二MR信号序列之间的信号差来确定磁化传递常数。

5. 发明授权

US08461839B2 Magnetic resonance control system, method and apparatus for producing a 2D MR image 有权
标题翻译：磁共振控制系统，用于生成2D MR图像的方法和装置
公开(公告)号：US08461839B2
公开(公告)日：2013-06-11
申请号：US12704688
申请日：2010-02-12
申请人： Timothy Hughes , Tallal Charles Mamisch
发明人： Timothy Hughes , Tallal Charles Mamisch
IPC分类号： G01V3/00
CPC分类号： G01R33/5614 , G01R33/4833 , G01R33/543 , G01R33/546
摘要： In a method and control system for producing two-dimensional diagnostic MR images using a magnetic resonance imaging scanner, a first three-dimensional MR image data set of a predetermined region within a body is produced using the magnetic resonance imaging scanner with an initial resolution. A second three-dimensional MR image data set of the predetermined region with a second resolution is then produced using the magnetic resonance imaging scanner, the second resolution being higher than the first resolution. Using the first three-dimensional MR image data set, layers are determined for the diagnostic two-dimensional MR images to be produced. The two-dimensional MR images are then computed from the second MR image data set for these layers automatically.
摘要翻译：在使用磁共振成像扫描仪产生二维诊断MR图像的方法和控制系统中，使用具有初始分辨率的磁共振成像扫描器产生体内预定区域的第一三维MR图像数据集。然后使用磁共振成像扫描仪产生具有第二分辨率的预定区域的第二三维MR图像数据集，第二分辨率高于第一分辨率。使用第一三维MR图像数据集，确定要产生的诊断二维MR图像的层。然后从这些层的第二MR图像数据集自动计算二维MR图像。

6. 发明申请

US20100207627A1 MAGNETIC RESONANCE CONTROL SYSTEM, METHOD AND APPARATUS FOR PRODUCING A 2D MR IMAGE 有权
标题翻译：用于生成2D MR图像的磁共振控制系统，方法和装置
公开(公告)号：US20100207627A1
公开(公告)日：2010-08-19
申请号：US12704688
申请日：2010-02-12
申请人： Timothy Hughes , Tallal Charles Mamisch
发明人： Timothy Hughes , Tallal Charles Mamisch
IPC分类号： G01R33/48
CPC分类号： G01R33/5614 , G01R33/4833 , G01R33/543 , G01R33/546
摘要： In a method and control system for producing two-dimensional diagnostic MR images using a magnetic resonance imaging scanner, a first three-dimensional MR image data set of a predetermined region within a body is produced using the magnetic resonance imaging scanner with an initial resolution. A second three-dimensional MR image data set of the predetermined region with a second resolution is then produced using the magnetic resonance imaging scanner, the second resolution being higher than the first resolution. Using the first three-dimensional MR image data set, layers are determined for the diagnostic two-dimensional MR images to be produced. The two-dimensional MR images are then computed from the second MR image data set for these layers automatically.
摘要翻译：在使用磁共振成像扫描仪产生二维诊断MR图像的方法和控制系统中，使用具有初始分辨率的磁共振成像扫描器产生体内预定区域的第一三维MR图像数据集。然后使用磁共振成像扫描仪产生具有第二分辨率的预定区域的第二三维MR图像数据集，第二分辨率高于第一分辨率。使用第一三维MR图像数据集，确定要产生的诊断二维MR图像的层。然后从这些层的第二MR图像数据集自动计算二维MR图像。

7. 发明授权

US09662036B2 Method and apparatus for generating a tomographic image 有权
公开(公告)号：US09662036B2
公开(公告)日：2017-05-30
申请号：US12704684
申请日：2010-02-12
申请人： Timothy Hughes , Tallal Charles Mamisch
发明人： Timothy Hughes , Tallal Charles Mamisch
IPC分类号： G06K9/00 , A61B5/055 , A61B5/00 , A61B6/03 , A61B6/00
CPC分类号： A61B5/055 , A61B5/4514 , A61B6/032 , A61B6/5235
摘要： In a method for generating a tomographic image, at a first point in time, a first tomographic image is acquired of a layer of a patient and the region of cartilaginous tissue is determined in the first tomographic image. At a later second point in time a second tomographic image is acquired of the layer of the patient and the region of the cartilaginous tissue is determined in the second tomographic image. The tomographic image is generated from the first tomographic image and the second tomographic image, in which every pixel of the tomographic image is assigned a difference value between a corresponding pixel of the first tomographic image and a corresponding pixel of the second tomographic image. The validation number is determined by adding all the pixels in the region of the cartilaginous tissue in the tomographic image.

8. 发明申请

US20100208966A1 METHOD AND APPARATUS FOR GENERATING A TOMOGRAPHIC IMAGE 有权
标题翻译：用于产生TOMOGRAPHIC图像的方法和装置
公开(公告)号：US20100208966A1
公开(公告)日：2010-08-19
申请号：US12704684
申请日：2010-02-12
申请人： Timothy Hughes , Tallal Charles Mamisch
发明人： Timothy Hughes , Tallal Charles Mamisch
IPC分类号： G06K9/00
CPC分类号： A61B5/055 , A61B5/4514 , A61B6/032 , A61B6/5235
摘要： In a method for generating a tomographic image, at a first point in time, a first tomographic image is acquired of a layer of a patient and the region of cartilaginous tissue is determined in the first tomographic image. At a later second point in time a second tomographic image is acquired of the layer of the patient and the region of the cartilaginous tissue is determined in the second tomographic image. The tomographic image is generated from the first tomographic image and the second tomographic image, in which every pixel of the tomographic image is assigned a difference value between a corresponding pixel of the first tomographic image and a corresponding pixel of the second tomographic image. The validation number is determined by adding all the pixels in the region of the cartilaginous tissue in the tomographic image.
摘要翻译：在用于生成断层图像的方法中，在第一时间点，获取患者的层的第一断层图像，并且在第一断层图像中确定软骨组织区域。在稍后的第二时间点，获取患者的层的第二断层图像，并且在第二断层图像中确定软骨组织的区域。从第一断层图像和第二断层图像生成断层图像，其中断层图像的每个像素被分配在第一断层图像的对应像素和第二断层图像的对应像素之间的差值。通过在断层图像中添加软骨组织区域中的所有像素来确定验证数。

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