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1. 发明授权

US09090628B2 Benzoxazepin compounds selective for PI3K P110 delta and methods of use 有权
标题翻译：苯并西泮化合物选择性PI3K P110 delta及其使用方法
公开(公告)号：US09090628B2
公开(公告)日：2015-07-28
申请号：US13424500
申请日：2012-03-20
申请人： Timothy Heffron , Brian Safina , Steven Staben , Daniel P. Sutherlin , BinQing Wei , Richard Elliott , Robert Heald , Eileen M. Seward , Emanuela Gancia , Bohdan Waszkowycz
发明人： Timothy Heffron , Brian Safina , Steven Staben , Daniel P. Sutherlin , BinQing Wei , Richard Elliott , Robert Heald , Eileen M. Seward , Emanuela Gancia , Bohdan Waszkowycz
IPC分类号： A61K31/553 , C07D498/04 , C07D498/14 , C07D519/00
CPC分类号： C07D498/14 , C07D498/04 , C07D519/00
摘要： Benzoxazepin Formula I compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological disorders, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
摘要翻译：苯并西泮配方I化合物，包括立体异构体，几何异构体，互变异构体，代谢物及其药学上可接受的盐，可用于抑制PI3K的δ同种型，以及用于治疗脂质激酶如炎症，免疫学障碍和癌症介导的病症。公开了使用式I化合物在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

2. 发明申请

US20120245144A1 BENZOXAZEPIN COMPOUNDS SELECTIVE FOR PI3K P110 DELTA AND METHODS OF USE 有权
标题翻译：选择PI3K P110 DELTA的BENZOXAZEPIN化合物及其使用方法
公开(公告)号：US20120245144A1
公开(公告)日：2012-09-27
申请号：US13424500
申请日：2012-03-20
申请人： Timothy Heffron , Brian Safina , Steven Staben , Daniel P. Sutherlin , BinQing Wei , Richard Elliott , Robert Heald , Eileen M. Seward , Emanuela Gancia , Bohdan Waskowycz
发明人： Timothy Heffron , Brian Safina , Steven Staben , Daniel P. Sutherlin , BinQing Wei , Richard Elliott , Robert Heald , Eileen M. Seward , Emanuela Gancia , Bohdan Waskowycz
IPC分类号： A61K31/553 , C07D498/04 , A61P35/00 , A61P37/00 , A61P9/00 , A61P31/12 , A61P29/00 , A61P3/00 , A61P5/00 , A61P25/00 , A61P19/02 , A61P37/06 , A61P37/08 , A61P1/04 , A61P1/00 , A61P17/00 , A61P11/06 , A61P43/00 , A61P7/00 , A61P11/00 , A61P17/06 , A61P35/02 , C07D498/14
CPC分类号： C07D498/14 , C07D498/04 , C07D519/00
摘要： Benzoxazepin Formula I compounds, including stereoisomers, geometric isomers, tautomers, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting the delta isoform of PI3K, and for treating disorders mediated by lipid kinases such as inflammation, immunological disorders, and cancer. Methods of using compounds of Formula I for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
摘要翻译：苯并西泮配方I化合物，包括立体异构体，几何异构体，互变异构体，代谢物及其药学上可接受的盐，可用于抑制PI3K的δ同种型，以及用于治疗脂质激酶如炎症，免疫学障碍和癌症介导的病症。公开了使用式I化合物在体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。

3. 发明申请

US20060271311A1 ON-LINE SYSTEM AND METHOD FOR PROCESSING INFORMATION RELATING TO THE WEAR OF TURBINE COMPONENTS 失效
标题翻译：在线系统和处理与涡轮机组件磨损有关的信息的方法
公开(公告)号：US20060271311A1
公开(公告)日：2006-11-30
申请号：US10249015
申请日：2003-03-10
申请人： Dongming Gao , Hamid Sarshar , Hong Xia , Richard Elliott
发明人： Dongming Gao , Hamid Sarshar , Hong Xia , Richard Elliott
IPC分类号： G06F19/00
CPC分类号： G06Q10/00 , F01D9/023
摘要： A method comprises storing data relating to the wear of a component of at least one turbine system in a database of a system for processing wear related information, generating a displayable menu containing a plurality of user-selectable links respectively associated with software modules of the system, and receiving an on-line selection of one of the user-selectable links to enable the associated software module of the system to generate displayable content including information relating to the wear of the component of the turbine system. The selected module may enable a quantitative amount of the wear of the component or qualitative wear range characterizing the amount of the wear of the component to be input and received on-line. Alternatively, the selected module may enable a component type to be input and received on-line and display a component fleet leader.
摘要翻译：一种方法包括将与至少一个涡轮机系统的部件的磨损相关的数据存储在用于处理磨损相关信息的系统的数据库中，生成包含分别与系统的软件模块相关联的多个用户可选择链接的可显示菜单以及接收所述用户可选链接中的一个的在线选择，以使得所述系统的相关联的软件模块能够生成包括与所述涡轮机系统的部件的磨损有关的信息的可显示内容。所选择的模块可以实现元件的磨损的定量量或定性磨损范围，其特征在于在线输入和接收的部件的磨损量。或者，所选择的模块可以使得组件类型能够被在线输入和接收并且显示组件队列引导器。

4. 发明申请

US20060201250A1 Force compensated comb drive 有权
标题翻译：强制补偿梳驱动
公开(公告)号：US20060201250A1
公开(公告)日：2006-09-14
申请号：US11076649
申请日：2005-03-10
申请人： Anthony Kourepenis , Marc Weinberg , Richard Elliott , Steven Daley
发明人： Anthony Kourepenis , Marc Weinberg , Richard Elliott , Steven Daley
IPC分类号： G01P15/08
CPC分类号： G01C19/5719 , G01P15/125 , H02N1/008
摘要： A force compensated comb drive for a microelectromechanical system includes a MEMS mechanism for providing an output signal representative of a physical quantity; a comb drive for actuating the MEMS mechanism; a comb drive circuit for providing a drive signal to the comb drive for developing a predetermined displacement applied by the comb drive to the MEMS mechanism; an automatic gain control responsive to a change in the force to provide a correction signal to the comb drive circuit to maintain the predetermined motion; and a compensation device responsive to the correction signal for adjusting the output signal of the MEMS mechanism to compensate for errors in the output signal due to a change in the predetermined force.
摘要翻译：用于微机电系统的力补偿梳驱动器包括用于提供代表物理量的输出信号的MEMS机构; 用于致动MEMS机构的梳齿驱动器; 梳状驱动电路，用于向梳状驱动器提供驱动信号，用于将由梳状驱动器施加的预定位移显影到MEMS机构; 响应于力的变化的自动增益控制，以向梳状驱动电路提供校正信号以维持预定的运动; 以及响应于校正信号的补偿装置，用于调整MEMS机构的输出信号，以补偿由于预定力的变化导致的输出信号中的误差。

5. 发明授权

US08187902B2 High performance sensors and methods for forming the same 有权
标题翻译：高性能传感器及其形成方法
公开(公告)号：US08187902B2
公开(公告)日：2012-05-29
申请号：US12170190
申请日：2008-07-09
申请人： Marc S. Weinberg , Mirela G. Bancu , James A. Bickford , Jonathan J. Bernstein , Richard Elliott
发明人： Marc S. Weinberg , Mirela G. Bancu , James A. Bickford , Jonathan J. Bernstein , Richard Elliott
IPC分类号： H01L21/00 , G01P15/125 , G01C19/56
CPC分类号： G01C19/574 , G01C19/5719 , Y10T156/1039 , Y10T428/2495
摘要： A sensor includes a proof mass suspended by a suspension beam, the suspension beam having a thickness less than a thickness of the proof mass.
摘要翻译：传感器包括由悬挂梁悬挂的检验质量块，悬挂梁的厚度小于检验质量块的厚度。

6. 发明授权

US08423453B1 Systems and methods for processing a transaction 有权
标题翻译：用于处理事务的系统和方法
公开(公告)号：US08423453B1
公开(公告)日：2013-04-16
申请号：US12574950
申请日：2009-10-07
申请人： Richard Elliott
发明人： Richard Elliott
IPC分类号： G06Q40/00
CPC分类号： G06Q20/4037 , G06Q20/10 , G06Q20/227 , G06Q20/403 , G06Q40/02
摘要： A system and method for processing a transaction by identifying a credit account and a demand deposit account, receiving transaction data associated with a transaction initiated by an account holder with a merchant using the credit account, determining whether the transaction amount exceeds the available credit amount, requesting via a network a transfer of the transaction amount from the demand deposit account, and transferring at least a portion of the transaction amount to pay the merchant. The transfer may be a first type of transfer or a second type of transfer depending on whether the transaction amount exceeds the available credit amount.
摘要翻译：一种用于通过识别信用账户和需求存款账户来处理交易的系统和方法，接收与由使用该信用账户的商户的帐户持有人发起的交易相关联的交易数据，确定交易金额是否超过可用信用量，通过网络请求从请求存款账户转移交易金额，并且转移交易金额的至少一部分以支付商家。根据交易金额是否超过可用信用额度，转账可能是第一类转账或第二类转账。

7. 发明授权

US08318762B2 Pyrazolospiroketone acetyl-CoA carboxylase inhibitors 有权
标题翻译：吡唑酮酮乙酰辅酶A羧化酶抑制剂
公开(公告)号：US08318762B2
公开(公告)日：2012-11-27
申请号：US12934375
申请日：2009-05-18
申请人： Jeffrey W. Corbett , Richard Elliott , Kevin Freeman-Cook , David A. Griffith , Dennis P. Phillion
发明人： Jeffrey W. Corbett , Richard Elliott , Kevin Freeman-Cook , David A. Griffith , Dennis P. Phillion
IPC分类号： C07D491/107 , A61K31/436 , A61K31/438
CPC分类号： C07D491/20
摘要： The invention provides compounds of Formula (1) or a pharmaceutically acceptable salt of said compound, wherein R1, R2, and R3 are as described herein; pharmaceutical compositions thereof; and the use thereof in treating diseases, conditions or disorders modulated by the inhibition of acetyl-CoA carboxylase enzyme(s) in an animal.
摘要翻译：本发明提供式（1）的化合物或所述化合物的药学上可接受的盐，其中R 1，R 2和R 3如本文所述; 其药物组合物; 以及其在治疗通过抑制动物体内的乙酰辅酶A羧化酶调节的疾病，病症或病症中的用途。

8. 发明申请

US20100005884A1 High Performance Sensors and Methods for Forming the Same 有权
标题翻译：高性能传感器及其形成方法
公开(公告)号：US20100005884A1
公开(公告)日：2010-01-14
申请号：US12170190
申请日：2008-07-09
申请人： Marc S. Weinberg , Mirela G. Bancu , James A. Bickford , Jonathan J. Bernstein , Richard Elliott
发明人： Marc S. Weinberg , Mirela G. Bancu , James A. Bickford , Jonathan J. Bernstein , Richard Elliott
IPC分类号： G01P3/46 , B32B7/02 , B44C3/08
CPC分类号： G01C19/574 , G01C19/5719 , Y10T156/1039 , Y10T428/2495
摘要： A sensor includes a proof mass suspended by a suspension beam, the suspension beam having a thickness less than a thickness of the proof mass.
摘要翻译：传感器包括由悬挂梁悬挂的检验质量块，悬挂梁的厚度小于检验质量块的厚度。

9. 发明授权

US07055387B2 Apparatus for and method of sensing a measured input 有权
标题翻译：用于感测测量输入的装置和方法
公开(公告)号：US07055387B2
公开(公告)日：2006-06-06
申请号：US10898009
申请日：2004-07-23
申请人： Richard Elliott , Paul A. Ward
发明人： Richard Elliott , Paul A. Ward
IPC分类号： G01P15/00
CPC分类号： G01D5/24 , G01D5/2417 , G01P15/125
摘要： Apparatus is used in sensing a measured input. The apparatus includes a capacitor with a capacitance that varies non-linearly in response to the measured input, and a circuitry that derives, from the capacitance, a signal that varies substantially linearly with the measured input. The capacitor includes a first electrode, a second electrode, and a gap defined by a space between the electrode. The circuitry includes an amplifier with a first input terminal in electrical communication with the first electrode, a second input terminal, and an output terminal in electrical communication with the second electrode. The capacitance of the capacitor varies as an inverse of the gap of the capacitor, the gap of the capacitor varies in response to changes in the measured input, and the signal is derived from an output of the amplifier.
摘要翻译：仪器用于感测测量输入。该装置包括具有响应于测量的输入而非线性变化的电容的电容器，以及从电容导出与测量输入基本上线性变化的信号的电路。电容器包括第一电极，第二电极和由电极之间的空间限定的间隙。电路包括具有与第一电极电连通的第一输入端的放大器，第二输入端和与第二电极电连通的输出端。电容器的电容随电容器间隙的倒数而变化，电容器的间隙根据测量输入的变化而变化，信号从放大器的输出导出。

10. 发明申请

US20050033048A1 Spiro[isobenzofuran-1,4'-piperidin]-3-ones and 3h-spiroisobenzofuran-1,4'-piperidines 审中-公开
标题翻译：螺[异苯并呋喃-1,4'-哌啶] -3-酮和3h-螺二苯并呋喃-1,4'-哌啶
公开(公告)号：US20050033048A1
公开(公告)日：2005-02-10
申请号：US10415457
申请日：2001-12-11
申请人： Rajagopal Bakthavatchalam , Charles Blum , Harry Brielmann , James Darrow , Stephane De Lombaert , Alan Hutchison , Jennifer Tran , Xiaozhang Zheng , Richard Elliott , Marlys Hammond
发明人： Rajagopal Bakthavatchalam , Charles Blum , Harry Brielmann , James Darrow , Stephane De Lombaert , Alan Hutchison , Jennifer Tran , Xiaozhang Zheng , Richard Elliott , Marlys Hammond
IPC分类号： C07D491/107 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/497 , A61K31/4985 , A61K31/506 , A61K31/517 , A61K31/519 , A61K51/00 , A61P3/04 , A61P3/10 , A61P9/00 , A61P25/00 , A61P25/18 , A61P25/24 , A61P43/00 , C07D487/04 , C07D487/10 , C07D491/10 , C07D519/00
CPC分类号： C07D487/04 , C07D491/10
摘要： Substituted spiro[isobenzofuran-1,4′-piperidin]-3-ones and 3H-spiroisobenzofuran-1,4′-piperidines capable of modulating NPY5 receptor activity are provided. Such compounds may be used to modulate ligand binding to NPY5 receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of disorders (e.g., eating disorders such as obesity or bulimia, psychiatric disorders, diabetes and cardiovascular disorders such as hypertension) in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and method for treating such disorders are provided, as are methods for using such compounds for detecting NPY5 receptors.
摘要翻译：提供了能够调节NPY5受体活性的取代螺[异苯并呋喃-1,4'-哌啶] -3-酮和3H-螺异苯并呋喃-1,4'-哌啶。这样的化合物可用于在体内或体外调节配体与NPY5受体的结合，并且特别可用于治疗多种疾病（例如，进食障碍，例如肥胖或贪食症，精神疾病，糖尿病和心血管疾病，例如高血压），驯养的伴侣动物和家畜。还提供了用于治疗这种病症的药物组合物和方法，以及使用这些化合物检测NPY5受体的方法。

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