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1. 发明授权

US06371928B1 Guidewire for positioning a catheter against a lumen wall 失效
标题翻译：导管，用于将导管定位在管腔壁上
公开(公告)号：US06371928B1
公开(公告)日：2002-04-16
申请号：US09417228
申请日：1999-10-13
申请人： Timothy B. Mcfann , Kathy M. Mah , James D. Passafaro , Roger W. Perkins , Joan Huynh , Greg R. Patterson , Ronald G. Williams , David J. Kupiecki
发明人： Timothy B. Mcfann , Kathy M. Mah , James D. Passafaro , Roger W. Perkins , Joan Huynh , Greg R. Patterson , Ronald G. Williams , David J. Kupiecki
IPC分类号： A61B500
CPC分类号： A61B17/221 , A61B17/320758 , A61B2017/00867 , A61B2017/22042 , A61B2017/2217 , A61B2017/320766 , A61B2090/064 , A61M25/09 , A61M2025/09083 , A61M2025/09141 , A61M2025/09175 , A61M2205/0266
摘要： The present invention relates to a guidewire having a shaped three dimensional guide section. In the preferred embodiment the guide section is helical, and exerts an outward radial force on a lumen the guidewire is constrained in. The outward radial force can be measured or calculated according to methods of the present invention. Also described is a system comprising a guidewire and catheter where the force the catheter exerts on a body lumen can also be calculated. Apparatus and methods of making the guidewire are also disclosed, as well as alternative embodiments of the guidewire.
摘要翻译：本发明涉及具有成形三维引导部分的导丝。在优选实施例中，引导部分是螺旋形的，并且在导丝被限制在内腔上施加向外的径向力。可以根据本发明的方法来测量或计算向外的径向力。还描述了一种包括导丝和导管的系统，其中导管施加在体腔上的力也可以被计算。还公开了制造导丝的装置和方法，以及导丝的替代实施例。

2. 发明授权

US6156046A Methods and systems for treating obstructions in a body lumen 失效
标题翻译：治疗体腔障碍物的方法和系统
公开(公告)号：US6156046A
公开(公告)日：2000-12-05
申请号：US966001
申请日：1997-11-07
申请人： James D. Passafaro , Ronald G. Williams , David J. Kupiecki , Greg R. Patterson , Kathy M. Mah
发明人： James D. Passafaro , Ronald G. Williams , David J. Kupiecki , Greg R. Patterson , Kathy M. Mah
IPC分类号： A61B17/00 , A61B17/22 , A61M25/09
CPC分类号： A61B17/320758 , A61B17/221 , A61B50/30 , A61B2017/00685 , A61B2017/00867 , A61B2017/22042 , A61B2017/2217 , A61B2050/314 , A61M25/09
摘要： A system is provided having a catheter, a torque member extending longitudinally through a lumen of the catheter, a removal mechanism secured to a distal end of the torque member, and a guidewire having a guide section that extends through a lumen of the removal mechanism. The guide section defines a curved profile that is diametrically larger than the dimension of the removal mechanism. The guide section of the guidewire is adapted to be positioned inside a passageway of the occluding material, and provides a curved path along which the removal mechanism can be advanced inside the passageway of the occluding material to separate and remove occluding material.
摘要翻译：提供了一种具有导管，纵向延伸穿过导管的内腔的扭矩构件，固定到扭矩构件的远端的移除机构以及具有穿过移除机构的内腔延伸的引导部分的导丝的系统。引导部分限定了直径大于移除机构的尺寸的弯曲轮廓。引导线的引导部分适于位于封闭材料的通道内，并且提供弯曲路径，沿着该路径，移除机构可以在闭塞材料的通道内前进，以分离和去除阻塞材料。

3. 发明授权

US6165209A Vascular stent for reduction of restenosis 失效
标题翻译：用于减少再狭窄的血管支架
公开(公告)号：US6165209A
公开(公告)日：2000-12-26
申请号：US209233
申请日：1998-12-10
申请人： Greg R. Patterson , David J. Kupiecki , Kathy M. Mah , Ronald G. Williams , James J. Leary
发明人： Greg R. Patterson , David J. Kupiecki , Kathy M. Mah , Ronald G. Williams , James J. Leary
IPC分类号： A61F2/90 , A61F2/06
CPC分类号： A61F2/915 , A61F2/90 , A61F2/91 , A61F2/95 , A61F2002/91541 , A61F2002/9155 , A61F2002/91558 , A61F2210/0076 , A61F2220/005
摘要： Apparatus and methods are provided for restoring and maintaining an open passage or lumen in a body conduit, such as a blood vessel, which has become stenosed or occluded. The apparatus includes a stent which is specially adapted for inhibiting restenosis within the stent after implantation in a body passage. In various embodiments, the apparatus also includes a catheter or other device for operating the stent to inhibit restenosis within the stented region of the body passage. The methods presented include implanting the stent within a body passage, typically a blood vessel such as a coronary artery, which has become stenosed or occluded, and operating the stent to inhibit ingrowth of stenotic material which would result in restenosis of the stented region. The stent may be operated manually to inhibit or remove ingrowth of stenotic material, for example by introducing a catheter which acts on the stent, or the stent may operate automatically to inhibit or remove ingrowth of stenotic material without manual intervention.
摘要翻译：提供了用于恢复和维持已经变得狭窄或闭塞的体导管（例如血管）中的开放通道或内腔的装置和方法。该装置包括一种支架，其特别适用于在植入人体通道之后抑制支架内的再狭窄。在各种实施例中，该装置还包括用于操作支架的导管或其他装置，以抑制身体通道的支架区域内的再狭窄。所提出的方法包括将支架植入人体通道内，通常是已经变得狭窄或闭塞的冠状动脉血管如冠状动脉，以及操作支架以抑制狭窄材料的向内生长，这将导致支架区域的再狭窄。可以手动操作支架以抑制或消除狭窄材料的向内生长，例如通过引入作用在支架上的导管，或者支架可以自动操作以抑制或消除狭窄材料的向内生长而无需手动干预。

4. 发明授权

US06319242B1 Apparatus and method for controlled removal of stenotic material from stents 失效
标题翻译：从支架中控制切除狭窄材料的装置和方法
公开(公告)号：US06319242B1
公开(公告)日：2001-11-20
申请号：US09260935
申请日：1999-03-02
申请人： Greg R. Patterson , Ronald G. Williams , James J. Leary
发明人： Greg R. Patterson , Ronald G. Williams , James J. Leary
IPC分类号： A61M3100
CPC分类号： A61B17/3207 , A61B17/221 , A61B17/320725 , A61B2017/00026 , A61B2017/00119 , A61B2017/2212 , A61B2090/378 , A61B2217/005 , A61F2/82
摘要： Apparatus and methods for treating in-stent restenosis are described for removing stenotic material from within previously stented regions of a patient's vasculature. The apparatus includes a catheter system having a stenotic material removal mechanism mounted on a distal portion of an elongated inner catheter. A sensing means, such as one or more sensing electrodes, are positioned on an outer surface of the apparatus. In addition, the apparatus optionally includes control means for diametrically expanding the stenotic material removal mechanism for effective recanalization of the stent. A coaxial outer catheter is provided for aspirating stenotic material which is removed from within the stent. In addition, embolic filter apparatus are described for collecting the stenotic material removed from within the stent. The methods comprise operating the stenotic material removal mechanism within a body vessel, typically a coronary artery or other artery, which has become restenosed or otherwise occluded following the initial stent placement, and sensing the proximity or contact between the stenotic material removal mechanism and the stent within the arterial wall so that the stenosis can be effectively recanalized without damaging the stent. The sensing means may be used to indicate an unsafe condition that might lead to stent damage, in response to which, the stenotic material removal mechanism may be manually or automatically deactivated. Alternatively or additionally, the sensing means may be used to indicate an appropriate endpoint for the stenotic material removal process.
摘要翻译：描述了用于治疗支架内再狭窄的装置和方法，用于从患者脉管系统的先前支架区域内移除狭窄材料。该装置包括具有安装在细长内导管的远端部分上的狭窄材料去除机构的导管系统。诸如一个或多个感测电极的感测装置位于装置的外表面上。此外，该装置还可选择地包括用于直径地扩张狭窄材料去除机构以控制支架有效再通的控制装置。提供同轴的外导管用于吸入从支架内移除的狭窄材料。此外，描述了用于收集从支架内移除的狭窄材料的栓塞过滤装置。所述方法包括在主体容器（通常是冠状动脉或其他动脉）中操作狭窄材料去除机构，所述冠状动脉或其它动脉在初始支架放置之后已经被再次闭合或者被封闭，并且感测狭窄材料移除机构和支架之间的接近或接触在动脉壁内，使得狭窄可以有效再通，而不会损伤支架。感测装置可以用于指示可能导致支架损伤的不安全状态，响应于此，可以手动或自动停用狭窄材料去除机构。或者或另外，感测装置可以用于指示用于狭窄材料去除过程的适当端点。

5. 发明授权

US07166125B1 Intraluminal grafting system 失效
标题翻译：腔内移植系统
公开(公告)号：US07166125B1
公开(公告)日：2007-01-23
申请号：US09686264
申请日：2000-10-10
申请人： Steven G. Baker , Dinah B. Quiachon , Alec A. Piplani , Wesley D. Sterman , Ronald G. Williams
发明人： Steven G. Baker , Dinah B. Quiachon , Alec A. Piplani , Wesley D. Sterman , Ronald G. Williams
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61B17/11 , A61F2/04 , A61F2/82 , A61F2/848 , A61F2/89 , A61F2/958 , A61F2002/075 , A61F2002/3008 , A61F2002/30451 , A61F2002/8486 , A61F2220/0016 , A61F2220/005 , A61F2220/0058 , A61F2220/0075 , A61F2230/0054 , A61F2250/0098 , A61M25/10 , A61M2025/1068
摘要： An intraluminal grafting system having a delivery catheter comprising a flexible elongate tubular member having proximal and distal extremities and a capsule mounted on the distal extremity of the tubular member and including a graft disposed within the capsule. The graft is comprised of a tubular body configured to be secured to a blood vessel by a self expanding attachment system. The attachment system comprises a generally sinusoidal wire frame having apices which extend longitudinally outward from the end of the tubular body apices which are secured within the tubular body. Both the protruding apices and the base apices are formed with helices which bias the attachment system radially outward. The attachment system further includes a plurality of lumen piercing members that are oriented in a responsive relationship to the radially outward bias of the attachment system. Furthermore, the graft may be configured with a plurality of synthetic fiber tufts secured to the outer surface of the tubular body to facilitate sealing the graft within the vessel. The graft may also include a plurality of crimps formed in the tubular body of the graft.
摘要翻译：一种管腔内接枝系统，其具有递送导管，其包括具有近端和远端的柔性细长管状构件和安装在管状构件的远端上的胶囊，并且包括设置在囊内的移植物。移植物由构造成通过自扩张附接系统固定到血管的管状体构成。连接系统包括大致正弦的线框架，其具有从管状体顶点的端部纵向向外延伸的顶点，其固定在管状体内。突出的顶点和基部顶点均形成有将附件系统径向向外偏置的螺旋。附接系统还包括多个内腔穿刺构件，其以与附接系统的径向向外偏置成反应的关系定向。此外，移植物可以配置有固定到管状体的外表面的多个合成纤维簇，以便于将移植物密封在血管内。移植物还可以包括在移植物的管状体中形成的多个卷曲。

6. 发明授权

US5174295A Apparatus, system and method for measuring spatial average velocity and/or volumetric flow of blood in a vessel and screw joint for use therewith 失效
标题翻译：用于测量容器和螺旋接头中的血液的空间平均速度和/或体积流量的装置，系统和方法
公开(公告)号：US5174295A
公开(公告)日：1992-12-29
申请号：US759403
申请日：1991-09-13
申请人： Jeffrey J. Christian , Paul D. Corl , Jerome Segal , Ronald G. Williams , Wayne C. Haase
发明人： Jeffrey J. Christian , Paul D. Corl , Jerome Segal , Ronald G. Williams , Wayne C. Haase
IPC分类号： A61B8/06 , G01F1/66
CPC分类号： A61B8/06 , A61B8/12 , A61B8/445 , A61M25/09 , G01F1/663 , A61M2025/09175
摘要： System for measuring a characteristic of flow of liquid in a vessel of a patient comprising a transducer positioned in a vessel in a patient for supplying ultrasonic energy. The transducer produces a substantially inform beam which encompasses the vessel. The transducer receives ultrasonic energy back scattered from the red blood cells and provides an electrical output signal. A first moment detector is provided which receives the electrical output from the transducer and provides a first moment signal. Normalization is provided to the output of the first moment detector to provide an electrical output representing a characteristic of the flow of the liquid in the vessel.
摘要翻译：用于测量患者容器中液体流动特性的系统，包括位于病人容器中的换能器，用于提供超声能量。换能器产生包围血管的基本通知束。传感器接收从红细胞反向散射的超声能量，并提供电输出信号。提供了第一时刻检测器，其接收来自换能器的电输出并提供第一力矩信号。将标准化提供给第一力矩检测器的输出，以提供表示容器中液体流动的特性的电输出。

7. 发明授权

US07118594B2 Bifurcated multicapsule intraluminal grafting system and method 有权
标题翻译：分叉多囊腔腔内植入系统及方法
公开(公告)号：US07118594B2
公开(公告)日：2006-10-10
申请号：US10700795
申请日：2004-09-28
申请人： Dinah B. Quiachon , Alec A. Piplani , Steve G. Baker , Ronald G. Williams , Richard S. Williams , Kenneth L. Osborn , Ted W. Layman , Peter K. Johansson
发明人： Dinah B. Quiachon , Alec A. Piplani , Steve G. Baker , Ronald G. Williams , Richard S. Williams , Kenneth L. Osborn , Ted W. Layman , Peter K. Johansson
IPC分类号： A61F2/06
CPC分类号： A61F2/07 , A61B90/39 , A61F2/88 , A61F2/89 , A61F2/954 , A61F2/958 , A61F2002/065 , A61F2002/075 , A61F2002/8483 , A61F2002/8486 , A61F2002/9517 , A61F2250/0098
摘要： An apparatus for repairing a vessel using a multicapsule catheter having first, second and third capsules for releasably retaining each terminal end of a bifurcated graft. The method for repairing the vessel includes the steps of performing a surgical technique to gain remote access to the vessel, advancing the multicapsule catheter within the vessel and releasing the bifurcated graft within the vessel to thereby repair the vessel.
摘要翻译：一种使用具有第一，第二和第三胶囊的多囊导管修复血管的装置，用于可释放地保持分叉移植物的每个末端。用于修复血管的方法包括以下步骤：执行外科技术以获得对血管的远程访问，使血管内的多囊导管推进并释放血管内的分叉移植物，从而修复血管。

8. 发明授权

US06663666B1 Delivery catheter for intraluminally deploying a graft 失效
标题翻译：用于内窥镜部署移植物的输送导管
公开(公告)号：US06663666B1
公开(公告)日：2003-12-16
申请号：US09864822
申请日：2001-05-22
申请人： Dinah B. Quiachon , Alec A. Piplani , Steve G. Baker , Ronald G. Williams , Richard S. Williams , Kenneth L. Osborn , Ted W. Layman
发明人： Dinah B. Quiachon , Alec A. Piplani , Steve G. Baker , Ronald G. Williams , Richard S. Williams , Kenneth L. Osborn , Ted W. Layman
IPC分类号： A61F206
CPC分类号： A61F2/07 , A61B90/39 , A61F2/88 , A61F2/89 , A61F2/954 , A61F2/958 , A61F2002/065 , A61F2002/075 , A61F2002/8483 , A61F2002/8486 , A61F2002/9517 , A61F2250/0098
摘要： An apparatus for repairing a vessel using a multicapsule catheter having first, second and third capsules for releasably retaining each terminal end of a bifurcated graft. The method for repairing the vessel includes the steps of performing a surgical technique to gain remote access to the vessel, advancing the multicapsule catheter within the vessel and releasing the bifurcated graft within the vessel to thereby repair the vessel.
摘要翻译：一种使用具有第一，第二和第三胶囊的多囊导管修复血管的装置，用于可释放地保持分叉移植物的每个末端。用于修复血管的方法包括以下步骤：执行外科技术以获得对血管的远程访问，使血管内的多囊导管推进并释放血管内的分叉的移植物，从而修复血管。

9. 发明授权

US5824044A Bifurcated multicapsule intraluminal grafting system 失效
标题翻译：分叉多囊腔腔内植入系统
公开(公告)号：US5824044A
公开(公告)日：1998-10-20
申请号：US707179
申请日：1996-09-03
申请人： Dinah B. Quiachon , Alec A. Piplani , Steve G. Baker , Ronald G. Williams , Richard S. Williams , Kenneth L. Osborn , Ted W. Layman , Peter K. Johansson
发明人： Dinah B. Quiachon , Alec A. Piplani , Steve G. Baker , Ronald G. Williams , Richard S. Williams , Kenneth L. Osborn , Ted W. Layman , Peter K. Johansson
IPC分类号： A61B17/00 , A61B17/11 , A61B19/00 , A61F2/00 , A61F2/06 , A61F2/88 , A61F11/00 , A61M25/12 , A61F2/04
CPC分类号： A61F2/07 , A61F2/954 , A61F2/958 , A61B90/39 , A61F2/88 , A61F2/89 , A61F2002/065 , A61F2002/075 , A61F2002/8483 , A61F2002/8486 , A61F2002/9517 , A61F2250/0098
摘要： An improved intraluminal grafting system incorporating novel structural features for enhancing the effective and efficient deployment of a bifurcated prosthesis having a plurality of attachment systems, in the vessel of an animal body, the system including a balloon catheter assembly, an ipsilateral capsule catheter assembly, distal and contralateral capsule assemblies and means interacting therewith, and a capsule jacket assembly. The capsule assemblies include an ipsilateral capsule assembly, a contralateral capsule assembly and a distal capsule assembly, wherein the attachment systems of the bifurcated prosthesis are disposed within the three capsule assemblies. The capsule jacket assembly includes a removable sheath that covers the bifurcated prosthesis and capsule assemblies to provide a smooth transition along the length of the deployment catheters. The bifurcated prosthesis is comprised of a main tubular member and two tubular legs, having attachment systems secured to the superior end of the main tubular member and the inferior ends of the tubular legs. An inflatable membrane configured on the balloon catheter is used to firmly implant the attachment systems within the vessel. The bifurcated prosthesis and attachment systems are configured to remain in the vessel after the deployment catheters are withdrawn. A novel method of use of the present intraluminal grafting system is also disclosed, for example, for deploying a bifurcated prosthesis proximate the abdominal aortic bifurcation.
摘要翻译：一种改进的腔内移植系统，其结合新颖的结构特征，用于在动物体的血管中增强有多个附着系统的分叉假体的有效和有效部署，所述系统包括气囊导管组件，同侧囊导管组件，远端和对侧胶囊组件以及与其相互作用的装置，以及胶囊护套组件。胶囊组件包括同侧胶囊组件，对侧胶囊组件和远端胶囊组件，其中分叉假体的附接系统设置在三个胶囊组件内。胶囊护套组件包括可拆卸的护套，其覆盖分叉的假体和胶囊组件以沿着展开导管的长度提供平滑的过渡。分叉的假体由主管状构件和两个管状腿组成，具有固定到主管状构件的上端和管状腿的下端的附接系统。构造在球囊导管上的充气膜用于将附着系统牢固地植入容器内。分叉的假体和附件系统构造成在展开导管被抽出之后保留在容器中。还公开了一种使用本发明的管腔内接枝系统的新方法，例如用于在腹主动脉分叉附近部署分叉假体。

10. 发明授权

US5562728A Endovascular grafting apparatus, system and method and devices for use therewith 失效
标题翻译：血管内移植装置，与其一起使用的系统和方法和装置
公开(公告)号：US5562728A
公开(公告)日：1996-10-08
申请号：US420623
申请日：1995-04-12
申请人： Harrison M. Lazarus , Ronald G. Williams , Wesley D. Sterman , Alec A. Piplani
发明人： Harrison M. Lazarus , Ronald G. Williams , Wesley D. Sterman , Alec A. Piplani
IPC分类号： A61B17/11 , A61B19/00 , A61F2/00 , A61F2/04 , A61F2/82 , A61F2/06
CPC分类号： A61F2/82 , A61B17/11 , A61F2/04 , A61F2/07 , A61F2/958 , A61M25/10 , A61B90/39 , A61F2/848 , A61F2/89 , A61F2002/075 , A61F2002/3008 , A61F2002/30451 , A61F2002/8486 , A61F2220/0016 , A61F2220/0058 , A61F2220/0075 , A61F2250/0098 , A61M2025/1068
摘要： Endovascular grafting system having a capsule catheter comprising a flexible elongate tubular member having proximal and distal extremities and a capsule mounted on the distal extremity of the tubular member. The capsule is generally cylindrical in shape and is formed of a helical wrap of a metal ribbon. The wraps are bonded into a unitary capsule permitting bending of said unitary capsule. A graft is disposed within the capsule. The graft is comprised of a tubular member having proximal and distal ends. Hooks are secured to the proximal and distal ends of the tubular member and face in a direction outwardly towards the inner wall of the capsule. A push rod is disposed within the capsule catheter and engages the graft whereby upon relative movement between the push rod and the capsule catheter, the graft can be forced out of the capsule.
摘要翻译：具有胶囊导管的血管内移植系统包括具有近端和远端的柔性细长管状构件和安装在管状构件的远端上的胶囊。胶囊通常为圆柱形，由金属色带的螺旋形卷纸形成。包裹物被结合成一体的胶囊，允许所述整体胶囊的弯曲。移植物置于胶囊内。移植物由具有近端和远端的管状构件组成。钩被固定到管状构件的近端和远端，并且朝着胶囊内壁向外的方向。推杆设置在胶囊导管内并与移植物接合，由此在推杆和胶囊导管之间相对运动时，移植物可被迫离开胶囊。

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