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1. 发明授权

US06371928B1 Guidewire for positioning a catheter against a lumen wall 失效
标题翻译：导管，用于将导管定位在管腔壁上
公开(公告)号：US06371928B1
公开(公告)日：2002-04-16
申请号：US09417228
申请日：1999-10-13
申请人： Timothy B. Mcfann , Kathy M. Mah , James D. Passafaro , Roger W. Perkins , Joan Huynh , Greg R. Patterson , Ronald G. Williams , David J. Kupiecki
发明人： Timothy B. Mcfann , Kathy M. Mah , James D. Passafaro , Roger W. Perkins , Joan Huynh , Greg R. Patterson , Ronald G. Williams , David J. Kupiecki
IPC分类号： A61B500
CPC分类号： A61B17/221 , A61B17/320758 , A61B2017/00867 , A61B2017/22042 , A61B2017/2217 , A61B2017/320766 , A61B2090/064 , A61M25/09 , A61M2025/09083 , A61M2025/09141 , A61M2025/09175 , A61M2205/0266
摘要： The present invention relates to a guidewire having a shaped three dimensional guide section. In the preferred embodiment the guide section is helical, and exerts an outward radial force on a lumen the guidewire is constrained in. The outward radial force can be measured or calculated according to methods of the present invention. Also described is a system comprising a guidewire and catheter where the force the catheter exerts on a body lumen can also be calculated. Apparatus and methods of making the guidewire are also disclosed, as well as alternative embodiments of the guidewire.
摘要翻译：本发明涉及具有成形三维引导部分的导丝。在优选实施例中，引导部分是螺旋形的，并且在导丝被限制在内腔上施加向外的径向力。可以根据本发明的方法来测量或计算向外的径向力。还描述了一种包括导丝和导管的系统，其中导管施加在体腔上的力也可以被计算。还公开了制造导丝的装置和方法，以及导丝的替代实施例。

2. 发明授权

US6156046A Methods and systems for treating obstructions in a body lumen 失效
标题翻译：治疗体腔障碍物的方法和系统
公开(公告)号：US6156046A
公开(公告)日：2000-12-05
申请号：US966001
申请日：1997-11-07
申请人： James D. Passafaro , Ronald G. Williams , David J. Kupiecki , Greg R. Patterson , Kathy M. Mah
发明人： James D. Passafaro , Ronald G. Williams , David J. Kupiecki , Greg R. Patterson , Kathy M. Mah
IPC分类号： A61B17/00 , A61B17/22 , A61M25/09
CPC分类号： A61B17/320758 , A61B17/221 , A61B50/30 , A61B2017/00685 , A61B2017/00867 , A61B2017/22042 , A61B2017/2217 , A61B2050/314 , A61M25/09
摘要： A system is provided having a catheter, a torque member extending longitudinally through a lumen of the catheter, a removal mechanism secured to a distal end of the torque member, and a guidewire having a guide section that extends through a lumen of the removal mechanism. The guide section defines a curved profile that is diametrically larger than the dimension of the removal mechanism. The guide section of the guidewire is adapted to be positioned inside a passageway of the occluding material, and provides a curved path along which the removal mechanism can be advanced inside the passageway of the occluding material to separate and remove occluding material.
摘要翻译：提供了一种具有导管，纵向延伸穿过导管的内腔的扭矩构件，固定到扭矩构件的远端的移除机构以及具有穿过移除机构的内腔延伸的引导部分的导丝的系统。引导部分限定了直径大于移除机构的尺寸的弯曲轮廓。引导线的引导部分适于位于封闭材料的通道内，并且提供弯曲路径，沿着该路径，移除机构可以在闭塞材料的通道内前进，以分离和去除阻塞材料。

3. 发明授权

US6165209A Vascular stent for reduction of restenosis 失效
标题翻译：用于减少再狭窄的血管支架
公开(公告)号：US6165209A
公开(公告)日：2000-12-26
申请号：US209233
申请日：1998-12-10
申请人： Greg R. Patterson , David J. Kupiecki , Kathy M. Mah , Ronald G. Williams , James J. Leary
发明人： Greg R. Patterson , David J. Kupiecki , Kathy M. Mah , Ronald G. Williams , James J. Leary
IPC分类号： A61F2/90 , A61F2/06
CPC分类号： A61F2/915 , A61F2/90 , A61F2/91 , A61F2/95 , A61F2002/91541 , A61F2002/9155 , A61F2002/91558 , A61F2210/0076 , A61F2220/005
摘要： Apparatus and methods are provided for restoring and maintaining an open passage or lumen in a body conduit, such as a blood vessel, which has become stenosed or occluded. The apparatus includes a stent which is specially adapted for inhibiting restenosis within the stent after implantation in a body passage. In various embodiments, the apparatus also includes a catheter or other device for operating the stent to inhibit restenosis within the stented region of the body passage. The methods presented include implanting the stent within a body passage, typically a blood vessel such as a coronary artery, which has become stenosed or occluded, and operating the stent to inhibit ingrowth of stenotic material which would result in restenosis of the stented region. The stent may be operated manually to inhibit or remove ingrowth of stenotic material, for example by introducing a catheter which acts on the stent, or the stent may operate automatically to inhibit or remove ingrowth of stenotic material without manual intervention.
摘要翻译：提供了用于恢复和维持已经变得狭窄或闭塞的体导管（例如血管）中的开放通道或内腔的装置和方法。该装置包括一种支架，其特别适用于在植入人体通道之后抑制支架内的再狭窄。在各种实施例中，该装置还包括用于操作支架的导管或其他装置，以抑制身体通道的支架区域内的再狭窄。所提出的方法包括将支架植入人体通道内，通常是已经变得狭窄或闭塞的冠状动脉血管如冠状动脉，以及操作支架以抑制狭窄材料的向内生长，这将导致支架区域的再狭窄。可以手动操作支架以抑制或消除狭窄材料的向内生长，例如通过引入作用在支架上的导管，或者支架可以自动操作以抑制或消除狭窄材料的向内生长而无需手动干预。

4. 发明授权

US08348924B2 Composite ophthalmic microcannula 有权
标题翻译：复合眼科微囊
公开(公告)号：US08348924B2
公开(公告)日：2013-01-08
申请号：US12789231
申请日：2010-05-27
申请人： Jeffrey J. Christian , Stanley R. Conston , David J. Kupiecki , John McKenzie
发明人： Jeffrey J. Christian , Stanley R. Conston , David J. Kupiecki , John McKenzie
IPC分类号： A61M25/00
CPC分类号： A61F9/00781 , A61B3/0008 , A61B17/3421 , A61F9/007 , A61M25/005 , A61M2025/0042
摘要： Microcannulae are constructed with multiple components in a composite design, allowing the microcannulae to have varying mechanical and delivery properties that will enable ophthalmic treatments by minimally invasive means. The microcannula includes at least one flexible, tubular communicating element with an outer diameter of 350 microns or less, a proximal connector for introduction of materials, energy or tools. It may also include a reinforcing member attached to the communicating element, which may be designed to create variable stiffness along the length of the microcannula. The microcannula may also include other features such as a signal beacon near the distal tip.
摘要翻译：微复合材料以复合材料设计的多个组分构成，允许微囊具有不同的机械和传递性能，可通过微创手段进行眼科治疗。微型插管包括至少一个具有350微米或更小外径的柔性管状连通元件，用于引入材料，能量或工具的近端连接件。其还可以包括附接到连通元件的加强构件，该加强构件可被设计成沿着微型插管的长度产生可变的刚度。微型插管还可以包括其他特征，例如靠近远端的信号信标。

5. 发明授权

US08172830B2 Composite ophthalmic microcannula 有权
标题翻译：复合眼科微囊
公开(公告)号：US08172830B2
公开(公告)日：2012-05-08
申请号：US11729603
申请日：2007-03-28
申请人： Jeffrey J. Christian , Stanley R. Conston , David J. Kupiecki , John McKenzie
发明人： Jeffrey J. Christian , Stanley R. Conston , David J. Kupiecki , John McKenzie
IPC分类号： A61M25/00
CPC分类号： A61F9/00781 , A61B3/0008 , A61B17/3421 , A61F9/007 , A61M25/005 , A61M2025/0042
摘要： Microcannulae are constructed with multiple components in a composite design, allowing the microcannulae to have varying mechanical and delivery properties that will enable ophthalmic treatments by minimally invasive means. The microcannula includes at least one flexible, tubular communicating element with an outer diameter of 350 microns or less, a proximal connector for introduction of materials, energy or tools. It may also include a reinforcing member attached to the communicating element, which may be designed to create variable stiffness along the length of the microcannula. The microcannula may also include other features such as a signal beacon near the distal tip.
摘要翻译：微复合材料以复合材料设计的多个组分构成，允许微囊具有不同的机械和传递性能，可通过微创手段进行眼科治疗。微型插管包括至少一个具有350微米或更小外径的柔性管状连通元件，用于引入材料，能量或工具的近端连接件。其还可以包括附接到连通元件的加强构件，该加强构件可被设计成沿着微型插管的长度产生可变的刚度。微型插管还可以包括其他特征，例如靠近远端的信号信标。

6. 发明申请

US20100274074A1 PELVIC FLOOR TREATMENTS AND RELATED TOOLS AND IMPLANTS 有权
标题翻译：皮肤地板处理及相关工具和植入物
公开(公告)号：US20100274074A1
公开(公告)日：2010-10-28
申请号：US12678923
申请日：2008-09-19
申请人： Chaouki A. Khamis , David J. Kupiecki , Jeffrey M. O'Hern , Shawn Michael Wignall
发明人： Chaouki A. Khamis , David J. Kupiecki , Jeffrey M. O'Hern , Shawn Michael Wignall
IPC分类号： A61B17/00 , A61F2/02
CPC分类号： A61F2/0063 , A61B17/00234 , A61B17/0401 , A61B17/3468 , A61B2017/00805 , A61B2017/0409 , A61B2017/0412 , A61B2017/0427 , A61B2017/0464 , A61B2090/0801 , A61B2090/08021 , A61F2/0045 , A61F2002/0072
摘要： Described are implants, tools, and methods useful for treating pelvic conditions such as prolapse, by placing an implant to support pelvic tissue, the implants, tools, and methods involving one or more of an insertion tool that works in coordination with a sheath, adjusting engagements, specific implants and pieces of implants, placement of implants at locations within the pelvic region, and insertion, adjusting, and grommet management tools.
摘要翻译：描述了可用于治疗盆腔状况的植入物，工具和方法，例如通过放置植入物来支撑骨盆组织，植入物，工具和涉及一种或多种与护套配合工作的插入工具的方法来调节接合，特定植入物和植入物，植入物在骨盆区域内的位置，以及插入，调整和护环管理工具。

7. 发明授权

US07207980B2 Composite ophthalmic microcannula 有权
公开(公告)号：US07207980B2
公开(公告)日：2007-04-24
申请号：US11042825
申请日：2005-01-24
申请人： Jeffrey Christian , Stanley R. Conston , David J. Kupiecki , John McKenzie
发明人： Jeffrey Christian , Stanley R. Conston , David J. Kupiecki , John McKenzie
IPC分类号： A61M25/00
CPC分类号： A61F9/00781 , A61B3/0008 , A61B17/3421 , A61F9/007 , A61M25/005 , A61M2025/0042
摘要： Microcannulae are constructed with multiple components in a composite design, allowing the microcannulae to have varying mechanical and delivery properties that will enable ophthalmic treatments by minimally invasive means. The microcannula includes at least one flexible, tubular communicating element with an outer diameter of 350 microns or less, a proximal connector for introduction of materials, energy or tools. It may also include a reinforcing member attached to the communicating element, which may be designed to create variable stiffness along the length of the microcannula. The microcannula may also include other features such as a signal beacon near the distal tip.

8. 发明申请

US20100240987A1 COMPOSITE OPHTHALMIC MICROCANNULA 有权
标题翻译：复合光学微孔
公开(公告)号：US20100240987A1
公开(公告)日：2010-09-23
申请号：US12789231
申请日：2010-05-27
申请人： Jeffrey J. Christian , Stanley R. Conston , David J. Kupiecki , John McKenzie
发明人： Jeffrey J. Christian , Stanley R. Conston , David J. Kupiecki , John McKenzie
IPC分类号： A61F9/007 , A61B6/12
CPC分类号： A61F9/00781 , A61B3/0008 , A61B17/3421 , A61F9/007 , A61M25/005 , A61M2025/0042
摘要： Microcannulae are constructed with multiple components in a composite design, allowing the microcannulae to have varying mechanical and delivery properties that will enable ophthalmic treatments by minimally invasive means. The microcannula includes at least one flexible, tubular communicating element with an outer diameter of 350 microns or less, a proximal connector for introduction of materials, energy or tools. It may also include a reinforcing member attached to the communicating element, which may be designed to create variable stiffness along the length of the microcannula. The microcannula may also include other features such as a signal beacon near the distal tip.
摘要翻译：微复合材料以复合材料设计的多个组分构成，允许微囊具有不同的机械和传递性能，可通过微创手段进行眼科治疗。微型插管包括至少一个具有350微米或更小外径的柔性管状连通元件，用于引入材料，能量或工具的近端连接件。其还可以包括附接到连通元件的加强构件，该加强构件可被设计成沿着微型插管的长度产生可变的刚度。微型插管还可以包括其他特征，例如靠近远端的信号信标。

9. 发明申请

US20090043321A1 Apparatus And Method For Surgical Enhancement Of Aqueous Humor Drainage 审中-公开
标题翻译：水性幽默排水手术增强装置及方法
公开(公告)号：US20090043321A1
公开(公告)日：2009-02-12
申请号：US11587785
申请日：2005-04-29
申请人： Stanley R. Conston , Michael Hee , David J. Kupiecki , John R. McKenzie , Ronald Yamamoto
发明人： Stanley R. Conston , Michael Hee , David J. Kupiecki , John R. McKenzie , Ronald Yamamoto
IPC分类号： A61M1/00 , A61F9/04
CPC分类号： A61F9/008 , A61B18/14 , A61F9/00781
摘要： An apparatus is provided for forming a tissue tract (8, 11A, 17A) from within a first passageway of an eye (11, 17) connecting to a second passageway in the eye (12, 16) comprising an elongated tool with a proximal end and distal end. The tool has an outer diameter in the range of about 50 to about 1000 microns. Methods of using the tool are provided for creating a fluid path for aqueous humor of an eye from a first passageway of the eye, such as the Schlemm's Canal, to a second passageway, such as the suprachoroidal space
摘要翻译：提供一种用于从连接到眼睛（12,16）中的第二通道的眼睛（11,17）的第一通道内形成组织管道（8,11A，17A）的装置，包括具有近端的细长工具和远端。该工具的外径在约50至约1000微米的范围内。提供了使用该工具的方法，用于从眼睛的第一通道（例如施莱姆氏管）产生到眼睛的房水的流体路径到第二通道，例如脉管外空间

10. 发明授权

US09364308B2 Implant systems with tensioning feedback 有权
标题翻译：具有张紧反馈的植入系统
公开(公告)号：US09364308B2
公开(公告)日：2016-06-14
申请号：US13520068
申请日：2010-12-30
申请人： Chaouki A. Khamis , Shawn M. Wignall , David J. Kupiecki
发明人： Chaouki A. Khamis , Shawn M. Wignall , David J. Kupiecki
IPC分类号： A61F2/08 , A61F2/02 , A61F2/00
CPC分类号： A61F2/0045 , A61F2250/0097
摘要： Pelvic or other types of implants are provided that can include tensioning feedback components or portions, such as color changing polymer materials, such as polyacetylene. The color changing polymer can be included with, coated on or otherwise provided with a portion of slings or implant devices to provide targeted feedback to the user or physician of the tension applied to a particular device. A first color can be used to indicate a first (initial) tension or compression stage, and a second color can be used to indicate tensioning of the device beyond a predefined threshold.
摘要翻译：提供骨盆或其他类型的植入物，其可以包括张紧反馈组分或部分，例如变色聚合物材料，例如聚乙炔。变色聚合物可以包括在其中，涂覆或以其他方式设置有一部分吊索或植入装置，以向用户或医师提供施加到特定装置的张力的目标反馈。第一颜色可用于指示第一（初始）张力或压缩级，并且第二颜色可用于指示装置的张紧超出预定义的阈值。

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