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1. 发明授权

US6159455A Dimeric .alpha.-alkylstyrene derivatives as photostable UV filters in cosmetic and pharmaceutical preparations 失效
标题翻译：二甲基α-烷基苯乙烯衍生物作为化妆品和药物制剂中的稳定紫外线过滤剂
公开(公告)号：US6159455A
公开(公告)日：2000-12-12
申请号：US451859
申请日：1999-12-01
申请人： Thorsten Habeck , Frank Prechtl , Thomas Wunsch , Horst Westenfelder
发明人： Thorsten Habeck , Frank Prechtl , Thomas Wunsch , Horst Westenfelder
IPC分类号： A61K8/00 , A61K8/30 , A61K8/40 , A61K8/49 , A61K31/277 , A61Q1/00 , A61Q1/04 , A61Q17/04 , A61Q19/00 , C07C255/37 , A61K7/42 , A61K7/00 , A61K7/44
CPC分类号： A61K8/40 , A61K31/277 , A61Q17/04 , C07C255/37 , A61K2800/52
摘要： The invention relates to the use of substituted, dimeric .alpha.-alkylstyrene derivatives of the formula I ##STR1## in which the substituents are as defined in the description, as photostable UV filters in cosmetic and pharmaceutical preparations for protecting human skin or human hair against solar rays, alone or together with compounds which absorb in the UV region and which are known per se for cosmetic and pharmaceutical preparations.
摘要翻译：本发明涉及式I取代的二聚α-烷基苯乙烯衍生物在其中取代基如说明书中所定义的用作化妆品中的光稳定性UV滤光剂和单独用于保护人类皮肤或人类头发抵抗太阳光线的药物制剂或与在UV区域吸收的化合物一起，其化合物和药物制剂本身已知。

2. 发明授权

US6090374A Cosmetic and pharmaceutical preparations comprising photostable UV filters 失效
标题翻译：包含光稳定型紫外线过滤器的化妆品和药物制剂
公开(公告)号：US6090374A
公开(公告)日：2000-07-18
申请号：US172672
申请日：1998-10-15
申请人： Thorsten Habeck , Sylke Haremza , Volker Schehlmann , Horst Westenfelder , Thomas Wunsch
发明人： Thorsten Habeck , Sylke Haremza , Volker Schehlmann , Horst Westenfelder , Thomas Wunsch
IPC分类号： A61K8/00 , A61K8/40 , A61K31/00 , A61P17/00 , A61P17/16 , A61Q1/04 , A61Q17/04 , A61K7/42 , A61K7/00 , A61K7/44
CPC分类号： A61Q17/04 , A61K8/40 , A61Q1/04 , A61K2800/52
摘要： The use of substituted .alpha.-methylstyrene derivatives of the formula I, ##STR1## where the variables have the following meanings: R.sup.1 C.sub.4 -C.sub.10 -alkoxy, C.sub.1 -C.sub.12 -alkylamino, C.sub.1 -C.sub.12 -dialkylamino, substituents which confer solubility in water and which are selected from the group consisting of carboxylate, sulfonate or ammonium residues;R.sup.2 hydrogen, C.sub.2 -C.sub.10 -alkyl, C.sub.1 -C.sub.12 -alkoxy;R.sup.3 COOR.sup.5, COR.sup.5, CONR.sup.5 R.sup.6, CN;R.sup.4 COOR.sup.5, COR.sup.5, CONR.sup.5 R.sup.6, CN; where the substituents R.sup.3 and R.sup.4 are identical in each case;R.sup.5 andR.sup.6 independently of one another hydrogen, C.sub.1 -C.sub.12 -alkyl, C.sub.2 -C.sub.10 -alkenyl, C.sub.3 -C.sub.10 -cycloalkyl, C.sub.3 -C.sub.10 -cycloalkenyl, aryl, hetaryl, unsubstituted or substituted;as photostable UV filters in cosmetic and pharmaceutical preparations to protect the human skin or human hair from the sun's rays, alone or together with UV-absorbing compounds known per se for cosmetic and pharmaceutical preparations.
摘要翻译：使用式I的取代的α-甲基苯乙烯衍生物，其中变量具有以下含义：R 1 C 4 -C 10 - 烷氧基，C 1 -C 12 - 烷基氨基，C 1 -C 12 - 二烷基氨基，赋予在水中溶解度并且被选择的取代基由羧酸盐，磺酸盐或铵残基组成的组; R2氢，C2-C10-烷基，C1-C12-烷氧基; R3 COOR5，COR5，CONR5R6，CN; R4 COOR5，COR5，CONR5R6，CN; 其中取代基R 3和R 4在每种情况下相同; R 5和R 6彼此独立地为氢，C 1 -C 12 - 烷基，C 2 -C 10 - 烯基，C 3 -C 10 - 环烷基，C 3 -C 10 - 环烯基，芳基，杂芳基，未取代或取代的; 作为化妆品和药物制剂中的光稳定紫外线过滤器，用于保护人体皮肤或人体毛发免受太阳光线的照射，或者与本身已知的用于化妆品和药物制剂的紫外线吸收化合物一起使用。

3. 发明授权

US5945091A Photo-stable cosmetic and pharmaceutical formulations containing UV-filters 失效
标题翻译：光稳定的化妆品和药物配方含有紫外线过滤器
公开(公告)号：US5945091A
公开(公告)日：1999-08-31
申请号：US972391
申请日：1997-11-18
申请人： Thorsten Habeck , Alexander Aumuller , Volker Schehlmann , Horst Westenfelder , Thomas Wunsch
发明人： Thorsten Habeck , Alexander Aumuller , Volker Schehlmann , Horst Westenfelder , Thomas Wunsch
IPC分类号： A61K8/30 , A61K8/00 , A61K8/41 , A61K8/42 , A61K8/46 , A61K8/49 , A61Q1/00 , A61Q1/04 , A61Q17/04 , A61Q19/00 , C07C229/56 , C07C229/60 , C07C255/30 , C07C255/58 , C07C309/46 , C07D275/02 , C07D275/03 , C07D319/06 , C07D333/38 , A61K7/42 , A61K7/00 , A61K31/255 , A61K31/275 , A61K31/66
CPC分类号： C07D275/03 , A61K8/411 , A61K8/42 , A61K8/466 , A61K8/49 , A61K8/498 , A61K8/4986 , A61Q1/04 , A61Q17/04 , C07C229/56 , C07C229/60 , C07C255/30 , C07C255/58 , C07C309/46 , C07D319/06 , C07D333/38 , A61K2800/52
摘要： A method of using compounds of formula I ##STR1## in which the C.dbd.C double bond is present in E and/or Z configuration and the variables have the following meanings:R.sup.1 denotes COOR.sup.5, COR.sup.5, CONR.sup.5 R.sup.6, CN, O.dbd.S(--R.sup.5).dbd.O, O.dbd.S(--OR.sup.5).dbd.O, R.sup.7 O--P(--OR.sup.8).dbd.O;R.sup.2 denotes COOR.sup.6, COR.sup.6, CONR.sup.5 R.sup.6, CN, O.dbd.S(--R.sup.6).dbd.O, O.dbd.S(--OR.sup.6).dbd.O, R.sup.7 O--P(--OR.sup.8).dbd.O;R.sup.3 denotes hydrogen, an optionally substituted aliphatic, cycloaliphatic, araliphatic or aromatic radical having in each case up to 18 carbon atoms;R.sup.4 denotes an optionally substituted aromatic or heteroaromatic radical containing from 5 to 12 ring atoms;R.sup.5 toR.sup.8 independently denote hydrogen, an open-chain or branched-chain aliphatic, araliphatic, cycloaliphatic or optionally substituted aromatic radical containing in each case up to 18 carbon atoms,where the variables R.sup.3 to R.sup.8 may also form, together with the carbon atoms to which they are attached, a 5-membered or 6-membered ring, which may be anellated if desired,as UV filters, particularly UV-A filters, in cosmetic and pharmaceutical formulations for the protection of the human skin or human hair from solar radiation, alone or together with compounds known per se in cosmetic and pharmaceutical formulations and capable of absorbing radiation in the UV range.
摘要翻译：在E和/或Z构型中使用存在C = C双键的式I化合物的方法，并且变量具有以下含义：R 1表示COOR 5，COR 5，CONR 5 R 6，CN，O = S（-R 5） = O，O = S（-OR 5）= O，R 7 O-P（-OR 8）= O; R2表示COOR6，COR6，CONR5R6，CN，O = S（-R6）= O，O = S（-OR6）= O，R7O-P（-OR8）= O; R 3表示氢，任选取代的脂族，脂环族，芳脂族或芳族基团，其在每种情况下最多为18个碳原子; R4表示任选取代的芳族或杂芳族基团，其含有5至12个环原子; R5至R8独立地表示氢，开链或支链脂族，芳脂族，脂环族或任选取代的芳族基团，其在每种情况下含有至多18个碳原子，其中变量R3至R8也可与碳原子一起形成它们所连接的是5元或6元环，如果需要，可以作为UV过滤剂，特别是UV-A过滤器，在用于保护人类皮肤或人类头发免受太阳能的化妆品和药物制剂中的影响单独或与化妆品和药物制剂中本身已知的化合物一起辐射并且能够吸收UV范围内的辐射。

4. 发明授权

US6069258A Cosmetic preparations comprising photostable UV-A filters 失效
标题翻译：包含光稳定型UV-A过滤器的化妆品
公开(公告)号：US6069258A
公开(公告)日：2000-05-30
申请号：US296240
申请日：1999-04-22
申请人： Thorsten Habeck , Alexander Aumuller , Volker Schehlmann , Horst Westenfelder , Thomas Wunsch
发明人： Thorsten Habeck , Alexander Aumuller , Volker Schehlmann , Horst Westenfelder , Thomas Wunsch
IPC分类号： A61K8/00 , A61K8/30 , A61K8/40 , A61K8/49 , A61K8/92 , A61Q1/00 , A61Q1/04 , A61Q17/04 , C07C255/40 , C07D307/52 , C07D317/54 , C07D333/24 , C07D333/22 , A61K31/275 , A61K31/38 , C07D255/00
CPC分类号： C07C255/40 , A61K8/40 , A61K8/4973 , A61K8/4986 , A61Q1/04 , A61Q17/04 , C07D317/54 , C07D333/24 , A61K2800/52 , A61Q19/001
摘要： A cosmetic preparation which comprises a sunscreen agent for protecting the human epidermis against UV light in the range from 280 to 400 nm, which comprises, in a cosmetically suitable carrier, alone or together with compounds which absorb in the UV region and are known for cosmetic preparations, as photostable UV-A filters, effective amounts of compounds of the formula I ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are hydrogen or aliphatic or cycloaliphatic radicals each having up to 18 carbon atoms, it being possible for any two of the radicals R.sup.1, R.sup.2 and R.sup.3 together to form a 5- or 6-membered ring, and R.sup.4 and R.sup.5 are an unsubstituted or substituted aromatic or heteroaromatic radical having 5 to 12 ring atoms, and R.sup.5 can additionally be hydrogen.
摘要翻译：一种化妆品制剂，其包含用于保护人类表皮免受280至400nm范围内的紫外线的防晒剂，其在美容上合适的载体中单独或与在UV区域吸收且已知为化妆品的化合物一起制剂，作为光稳定的UV-A过滤器，有效量的式I化合物，其中R 1，R 2和R 3是氢或每个具有至多18个碳原子的脂族或脂环族基团，可以是任意两个基团R 1，R 2 和R 3一起形成5-或6-元环，并且R 4和R 5是具有5至12个环原子的未取代或取代的芳族或杂芳族基团，并且R 5可另外为氢。

5. 发明授权

US6093385A 4,4-diarylbutadienes as water-soluble photostable UV filters for cosmetic and pharmaceutical preparations 失效
标题翻译： 4,4-二芳基丁二烯作为化妆品和药物制剂的水溶性光稳定紫外线过滤剂
公开(公告)号：US6093385A
公开(公告)日：2000-07-25
申请号：US336733
申请日：1999-06-21
申请人： Thorsten Habeck , Horst Westenfelder , Thomas Wunsch
发明人： Thorsten Habeck , Horst Westenfelder , Thomas Wunsch
IPC分类号： A61K47/06 , A61K8/00 , A61K8/30 , A61K8/35 , A61K8/37 , A61K8/40 , A61K8/41 , A61K8/42 , A61K8/46 , A61K31/00 , A61K31/075 , A61K31/16 , A61K31/165 , A61K31/19 , A61K31/215 , A61K31/275 , A61P17/00 , A61P17/16 , A61Q1/00 , A61Q1/04 , A61Q5/00 , A61Q17/04 , C07C59/40 , C07C69/612 , C07C69/618 , C07C69/73 , C07C69/738 , C07C233/40 , C07C309/58 , C07C309/59 , C09K3/00 , A61K7/42 , A61K7/00 , A61K7/44
CPC分类号： A61K8/466 , A61K8/37 , A61K8/42 , A61Q17/04 , C07C233/40 , C07C309/58 , C07C309/59 , C07C69/618 , C07C69/738 , A61K2800/52
摘要： Use of 4,4-diarylbutadienes of the formula I, ##STR1## where the variables have the meanings explained in the description, as water-soluble photostable UV filters in cosmetic and pharmaceutical preparations for protecting the human skin or human hair from the sun's rays, alone or together with compounds which absorb in the UV region and are known per se for cosmetic and pharmaceutical preparations.
摘要翻译：使用式I的4,4-二芳基丁二烯，其中变量具有在说明书中解释的含义，作为用于保护人类皮肤或人类头发免受太阳光线的化妆品和药物制剂中的水溶性光稳定紫外线过滤器，单独或以及在UV区域吸收的化合物和本身已知的用于化妆品和药物制剂的化合物。

6. 发明授权

US06037487A Photo-stable cosmetic and pharmaceutical formulations containing UV-filters 失效
标题翻译：光稳定的化妆品和药物配方含有紫外线过滤器
公开(公告)号：US06037487A
公开(公告)日：2000-03-14
申请号：US266968
申请日：1999-03-12
申请人： Thorsten Habeck , Alexander Aumuller , Volker Schehlmann , Horst Westenfelder , Thomas Wunsch
发明人： Thorsten Habeck , Alexander Aumuller , Volker Schehlmann , Horst Westenfelder , Thomas Wunsch
IPC分类号： A61K8/30 , A61K8/00 , A61K8/41 , A61K8/42 , A61K8/46 , A61K8/49 , A61Q1/00 , A61Q1/04 , A61Q17/04 , A61Q19/00 , C07C229/56 , C07C229/60 , C07C255/30 , C07C255/58 , C07C309/46 , C07D275/02 , C07D275/03 , C07D319/06 , C07D333/38 , C07C255/04
CPC分类号： C07D275/03 , A61K8/411 , A61K8/42 , A61K8/466 , A61K8/49 , A61K8/498 , A61K8/4986 , A61Q1/04 , A61Q17/04 , C07C229/56 , C07C229/60 , C07C255/30 , C07C255/58 , C07C309/46 , C07D319/06 , C07D333/38 , A61K2800/52
摘要： A method of using compounds of formula I ##STR1## in which the C.dbd.C double bond is present in E and/or Z configuration and the variables R.sup.1, R.sup.2, R.sup.3 and R.sup.4 have the meanings defined in the specification disclosure, as UV filters, particularly UV-A filters, in cosmetic and pharmaceutical formulations for the protection of the human skin or human hair from solar radiation, alone or together with compounds known per se in cosmetic and pharmaceutical formulations and capable of absorbing radiation in the UV range.
摘要翻译：使用其中C = C双键存在于E和/或Z构型中的式I化合物的方法，并且变量R1，R2，R3和R4具有本说明书公开内容中定义的含义，因为UV滤光片，特别是UV -A在用于保护人类皮肤或人类头发免受太阳辐射的化妆品和药物制剂中的过滤器，单独或与化妆品和药物制剂本身已知的化合物一起并且能够吸收UV范围内的辐射。

7. 发明授权

US5968484A Cosmetic preparations comprising photostable UV-A filters 失效
公开(公告)号：US5968484A
公开(公告)日：1999-10-19
申请号：US916361
申请日：1997-08-22
申请人： Thorsten Habeck , Alexander Aumueller , Volker Schehlmann , Horst Westenfelder , Thomas Wunsch
发明人： Thorsten Habeck , Alexander Aumueller , Volker Schehlmann , Horst Westenfelder , Thomas Wunsch
IPC分类号： A61K8/00 , A61K8/30 , A61K8/40 , A61K8/49 , A61K8/92 , A61Q1/00 , A61Q1/04 , A61Q17/04 , C07C255/40 , C07D307/52 , C07D317/54 , C07D333/24 , A61K7/42 , A61K7/00 , C07C255/03
CPC分类号： C07C255/40 , A61K8/40 , A61K8/4973 , A61K8/4986 , A61Q1/04 , A61Q17/04 , C07D317/54 , C07D333/24 , A61K2800/52 , A61Q19/001
摘要： A cosmetic preparation which comprises a sunscreen agent for protecting the human epidermis against UV light in the range from 280 to 400 nm, which comprises, in a cosmetically suitable carrier, alone or together with compounds which absorb in the UV region and are known for cosmetic preparations, as photostable UV-A filters, effective amounts of compounds of the formula I ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are hydrogen or aliphatic or cycloaliphatic radicals each having up to 18 carbon atoms, it being possible for any two of the radicals R.sup.1, R.sup.2 and R.sup.3 together to form a 5- or 6-membered ring, and R.sup.4 and R.sup.5 are an unsubstituted or substituted aromatic or heteroaromatic radical having 5 to 12 ring atoms, and R.sup.5 can additionally be hydrogen.

8. 发明授权

US06153174A Cosmetic compositions comprising a combination of UV absorbers 失效
标题翻译：包含UV吸收剂组合的化妆品组合物
公开(公告)号：US06153174A
公开(公告)日：2000-11-28
申请号：US948254
申请日：1997-10-09
申请人： Karin Sperling , Thomas Wunsch , Horst Westenfelder , Beate Trentmann
发明人： Karin Sperling , Thomas Wunsch , Horst Westenfelder , Beate Trentmann
IPC分类号： C07D251/34 , A61K8/00 , A61K8/33 , A61K8/37 , A61K8/41 , A61K8/46 , A61K8/49 , A61Q1/00 , A61Q1/04 , A61Q5/00 , A61Q17/04 , A61K7/42
CPC分类号： A61Q17/04 , A61K8/4966
摘要： The present invention relates to cosmetic compositions comprising a combination of sunscreen filters of the formula ##STR1## with other sunscreen filters.
摘要翻译：本发明涉及化妆品组合物，其包含下式的防晒剂过滤器与其它防晒剂过滤器的组合。

9. 发明授权

US6129908A Cosmetic or pharmaceutical preparations comprising 1,3,5-triazine derivatives and zinc oxide 有权
标题翻译：包含1,3,5-三嗪衍生物和氧化锌的化妆品或药物制剂
公开(公告)号：US6129908A
公开(公告)日：2000-10-10
申请号：US432203
申请日：1999-11-02
申请人： Thomas Wunsch , Horst Westenfelder
发明人： Thomas Wunsch , Horst Westenfelder
IPC分类号： A61K8/00 , A61K8/19 , A61K8/27 , A61K8/49 , A61Q5/00 , A61Q17/04 , A61Q19/00 , A61K7/42 , A61K7/00 , A61K7/44 , A61K31/53
CPC分类号： A61K8/27 , A61K8/4966 , A61Q17/04
摘要： Cosmetic or pharmaceutical preparations for protecting human skin or human hair from solar rays which containa) from 0.1 to 10% by weight of one or more 1,3,5-triazine derivatives of the formula I, ##STR1## in which the substituents independently of one another have the following meanings:R.sup.1 to R.sup.3are C.sub.1 -C.sub.20 -alkyl, aryl, heteroaryl, optionally substituted;X is O, NR.sup.4 ;R.sup.4 is hydrogen, C.sub.1 -C.sub.20 -alkyl, aryl, heteroaryl, optionally substituted, andb) from 0.1 to 15% by weight of zinc oxide.
摘要翻译：用于保护人类皮肤或人类头发免受太阳光线影响的化妆品或药物制剂，其含有a）0.1至10重量％的一种或多种式I的1,3,5-三嗪衍生物，其中取代基彼此独立地具有以下含义：R 1至R 3为C 1 -C 20 - 烷基，芳基，杂芳基，任选取代的; X为O，NR4; R 4是氢，C 1 -C 20烷基，芳基，杂芳基，任选取代的，以及b）0.1-15重量％的氧化锌。

10. 发明授权

US6007828A Cosmetic preparations containing photostable UV-A filters 失效
标题翻译：含有光稳定UV-A过滤器的化妆品
公开(公告)号：US6007828A
公开(公告)日：1999-12-28
申请号：US68008
申请日：1998-04-29
申请人： Martin Holderbaum , Alexander Aumuller , Karin Sperling , Horst Westenfelder , Thomas Wunsch
发明人： Martin Holderbaum , Alexander Aumuller , Karin Sperling , Horst Westenfelder , Thomas Wunsch
IPC分类号： A61K8/00 , A61K8/40 , A61K8/92 , A61Q1/04 , A61Q17/04 , A61K7/00 , A61K7/42
CPC分类号： A61K8/40 , A61Q1/04 , A61Q17/04 , A61K2800/52
摘要： A sunscreen-containing cosmetic formulation to protect the human epidermis from UV light in the range from 280 to 400 nm, which formulation includes a cosmetically suitable carrier, together with compounds which absorb in the UV-B region and as photostable UV-A filters effective amounts of compounds of the formula I as defined in the specification.
摘要翻译： PCT No.PCT / EP96 / 04637 371日期：1998年4月29日 102（e）日期1998年4月29日PCT 1996年10月25日PCT公布。出版物WO97 / 17054 日期1997年5月15日一种含防晒霜的化妆品制剂，用于保护人类表皮免受紫外线在280至400nm范围内的影响，该配方包括美容上合适的载体，以及在UV-B区域吸收的化合物和紫外线 -A过滤有效量的本说明书中定义的式I化合物。

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