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    • 7. 发明申请
    • METHOD FOR ESTIMATING THE PHYSIOLOGICAL PARAMETERS DEFINING THE EDEMA INDUCED UPON INFUSION OF FLUID FROM AN INTRAPARENCHYMALLY PLACED CATHETER
    • 估计生理参数的方法,该参数定义了从浸润式放置导管输入的流体引起的EDEMA
    • US20120046538A1
    • 2012-02-23
    • US13241936
    • 2011-09-23
    • Raghu RaghavanMartin Brady
    • Raghu RaghavanMartin Brady
    • A61B5/055
    • A61K49/06A61M2005/14292G01R33/5601G01R33/56341
    • A method for estimating the physiological parameters defining the edema induced upon infusion of fluid from an intraparenchymally placed catheter including; acquisition of patient-specific medical data; estimation of pertinent tissue microstructure based on the patient-specific medical data and/or generalized information derived or drawn from one or more of the following: experience, literature, modeling, studies, research, analysis; acquisition of information about delivery parameters, and/or delivery device geometry, and/or fluid properties, such as: delivery device trajectory, flow rate, pressure, catheter diameter, catheter profile, fluid viscosity, fluid molecular size; and computing a field of values of predicted extracellular volume fraction over the tissue region using the information obtained above. According to a further aspect, a method of infusing or planning and/or monitoring an infusion of a contrast agent such that the distribution of such agent can be detected by medical data acquisition and observing and/or measuring the backflow length along the catheter track.
    • 一种估计生理参数的方法,所述生理参数限定了从实施静脉内放置的导管输注流体时引起的水肿,包括: 获取患者特定的医疗数据; 基于患者特异性医学数据和/或从以下一个或多个导出或得出的一般化信息估计相关组织微结构:经验,文献,建模,研究,研究,分析; 获取关于递送参数的信息和/或递送装置几何形状和/或流体性质,例如:递送装置轨迹,流速,压力,导管直径,导管轮廓,流体粘度,流体分子尺寸; 以及使用上面获得的信息计算组织区域上预测的细胞外体积分数值的一个领域。 根据另一方面,一种输注或规划和/或监测造影剂的输注的方法,使得可以通过医学数据采集来检测这种药剂的分布,并且观察和/或测量沿导管轨迹的回流长度。
    • 9. 发明申请
    • METHOD FOR ESTIMATING THE PHYSIOLOGICAL PARAMETERS DEFINING THE EDEMA INDUCED UPON INFUSION OF FLUID FROM AN INTRAPARENCHYMALLY PLACED CATHETER
    • 估计生理参数的方法,该参数定义了从浸润式放置导管输入的流体引起的EDEMA
    • US20080292160A1
    • 2008-11-27
    • US12121103
    • 2008-05-15
    • Raghu RaghavanMartin Brady
    • Raghu RaghavanMartin Brady
    • A61B5/00
    • A61K49/06A61M2005/14292G01R33/5601G01R33/56341
    • A method for estimating the physiological parameters defining the edema induced upon infusion of fluid from an intraparenchymally placed catheter including; a) acquisition of patient-specific medical data; b) estimation of pertinent tissue microstructure based on the patient-specific medical data and/or generalized information derived or drawn from one or more of the following: experience, literature, modeling, studies, research, analysis; c) acquisition of information about delivery parameters, and/or delivery device geometry, and/or fluid properties, such as: delivery device trajectory, flow rate, pressure, catheter diameter, catheter profile, fluid viscosity, fluid molecular size; and d) computing a field of values of predicted extracellular volume fraction over the tissue region using the information obtained in (b) and (c). According to a further aspect, a method of infusing or planning and/or monitoring an infusion of a contrast agent such that the distribution of such agent can be detected by means of medical data acquisition (e.g. MRI, CT, x-ray, ultrasound, SPECT, PET) and observing and/or measuring the backflow length along the catheter track.
    • 一种估计生理参数的方法,所述生理参数限定了从实施静脉内放置的导管输注流体时引起的水肿,包括: a)获取患者特定的医疗数据; b)基于患者特定的医学数据和/或从以下一个或多个中得出或得出的一般化信息来估计相关的组织微结构:经验,文献,建模,研究,研究,分析; c)获取关于递送参数和/或递送装置几何形状和/或流体特性的信息,例如:递送装置轨迹,流速,压力,导管直径,导管轮廓,流体粘度,流体分子尺寸; 以及d)使用(b)和(c)中获得的信息计算组织区域上预测的细胞外体积分数的值的场。 根据另一方面,一种输注或规划和/或监测造影剂的输注的方法,使得可以通过医学数据采集(例如MRI,CT,X射线,超声波, SPECT,PET),并观察和/或测量沿着导管轨道的回流长度。