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1. 发明申请

US20120046538A1 METHOD FOR ESTIMATING THE PHYSIOLOGICAL PARAMETERS DEFINING THE EDEMA INDUCED UPON INFUSION OF FLUID FROM AN INTRAPARENCHYMALLY PLACED CATHETER 有权
标题翻译：估计生理参数的方法，该参数定义了从浸润式放置导管输入的流体引起的EDEMA
公开(公告)号：US20120046538A1
公开(公告)日：2012-02-23
申请号：US13241936
申请日：2011-09-23
申请人： Raghu Raghavan , Martin Brady
发明人： Raghu Raghavan , Martin Brady
IPC分类号： A61B5/055
CPC分类号： A61K49/06 , A61M2005/14292 , G01R33/5601 , G01R33/56341
摘要： A method for estimating the physiological parameters defining the edema induced upon infusion of fluid from an intraparenchymally placed catheter including; acquisition of patient-specific medical data; estimation of pertinent tissue microstructure based on the patient-specific medical data and/or generalized information derived or drawn from one or more of the following: experience, literature, modeling, studies, research, analysis; acquisition of information about delivery parameters, and/or delivery device geometry, and/or fluid properties, such as: delivery device trajectory, flow rate, pressure, catheter diameter, catheter profile, fluid viscosity, fluid molecular size; and computing a field of values of predicted extracellular volume fraction over the tissue region using the information obtained above. According to a further aspect, a method of infusing or planning and/or monitoring an infusion of a contrast agent such that the distribution of such agent can be detected by medical data acquisition and observing and/or measuring the backflow length along the catheter track.
摘要翻译：一种估计生理参数的方法，所述生理参数限定了从实施静脉内放置的导管输注流体时引起的水肿，包括：获取患者特定的医疗数据; 基于患者特异性医学数据和/或从以下一个或多个导出或得出的一般化信息估计相关组织微结构：经验，文献，建模，研究，研究，分析; 获取关于递送参数的信息和/或递送装置几何形状和/或流体性质，例如：递送装置轨迹，流速，压力，导管直径，导管轮廓，流体粘度，流体分子尺寸; 以及使用上面获得的信息计算组织区域上预测的细胞外体积分数值的一个领域。根据另一方面，一种输注或规划和/或监测造影剂的输注的方法，使得可以通过医学数据采集来检测这种药剂的分布，并且观察和/或测量沿导管轨迹的回流长度。

2. 发明授权

US08014848B2 Visualization of procedural guidelines for a medical procedure 有权
标题翻译：可视化医疗程序的程序指南
公开(公告)号：US08014848B2
公开(公告)日：2011-09-06
申请号：US11115093
申请日：2005-04-26
申请人： Rainer Birkenbach , Christoph Pedain , Andreas Hartlep , Raghu Raghavan , Martin Brady
发明人： Rainer Birkenbach , Christoph Pedain , Andreas Hartlep , Raghu Raghavan , Martin Brady
IPC分类号： A61B5/05
CPC分类号： A61B90/36 , A61B34/10 , A61B34/20 , A61B2034/107 , A61B2034/2055 , A61B2034/2068 , A61B2034/2072
摘要： The visualization of procedural guidelines for a medical procedure, in which a medical instrument is shown in an image representation of a body portion including an area in which a medical procedure is to be carried out, wherein, in the vicinity of the functional portion of the instrument, regions or locations are indicated which are of special relevance to the procedure according to established guidelines for said procedure.
摘要翻译：可视化的医疗程序的程序指南，其中医疗器械被显示在包括要执行医疗程序的区域的身体部位的图像表示中，其中在该功能部分的附近指示与所述程序的既定指导方针相关的手段，区域或位置。

3. 发明申请

US20080292160A1 METHOD FOR ESTIMATING THE PHYSIOLOGICAL PARAMETERS DEFINING THE EDEMA INDUCED UPON INFUSION OF FLUID FROM AN INTRAPARENCHYMALLY PLACED CATHETER 审中-公开
标题翻译：估计生理参数的方法，该参数定义了从浸润式放置导管输入的流体引起的EDEMA
公开(公告)号：US20080292160A1
公开(公告)日：2008-11-27
申请号：US12121103
申请日：2008-05-15
申请人： Raghu Raghavan , Martin Brady
发明人： Raghu Raghavan , Martin Brady
IPC分类号： A61B5/00
CPC分类号： A61K49/06 , A61M2005/14292 , G01R33/5601 , G01R33/56341
摘要： A method for estimating the physiological parameters defining the edema induced upon infusion of fluid from an intraparenchymally placed catheter including; a) acquisition of patient-specific medical data; b) estimation of pertinent tissue microstructure based on the patient-specific medical data and/or generalized information derived or drawn from one or more of the following: experience, literature, modeling, studies, research, analysis; c) acquisition of information about delivery parameters, and/or delivery device geometry, and/or fluid properties, such as: delivery device trajectory, flow rate, pressure, catheter diameter, catheter profile, fluid viscosity, fluid molecular size; and d) computing a field of values of predicted extracellular volume fraction over the tissue region using the information obtained in (b) and (c). According to a further aspect, a method of infusing or planning and/or monitoring an infusion of a contrast agent such that the distribution of such agent can be detected by means of medical data acquisition (e.g. MRI, CT, x-ray, ultrasound, SPECT, PET) and observing and/or measuring the backflow length along the catheter track.
摘要翻译：一种估计生理参数的方法，所述生理参数限定了从实施静脉内放置的导管输注流体时引起的水肿，包括： a）获取患者特定的医疗数据; b）基于患者特定的医学数据和/或从以下一个或多个中得出或得出的一般化信息来估计相关的组织微结构：经验，文献，建模，研究，研究，分析; c）获取关于递送参数和/或递送装置几何形状和/或流体特性的信息，例如：递送装置轨迹，流速，压力，导管直径，导管轮廓，流体粘度，流体分子尺寸; 以及d）使用（b）和（c）中获得的信息计算组织区域上预测的细胞外体积分数的值的场。根据另一方面，一种输注或规划和/或监测造影剂的输注的方法，使得可以通过医学数据采集（例如MRI，CT，X射线，超声波， SPECT，PET），并观察和/或测量沿着导管轨道的回流长度。

4. 发明授权

US09757543B2 Delivery of materials into margins of tissue cavities 有权
公开(公告)号：US09757543B2
公开(公告)日：2017-09-12
申请号：US14229876
申请日：2014-03-29
申请人： Raghu Raghavan , Martin Brady
发明人： Raghu Raghavan , Martin Brady
IPC分类号： A61M31/00 , A61M37/00 , A61M25/10
CPC分类号： A61M25/10 , A61M2025/105 , A61M2025/1086
摘要： Surgery is performed on a patient with a novel device by: excising tissue from tissue mass within a patient to create a cavity within the tissue mass; inserting a novel device of this invention into the cavity; shaping a flexible expandable component of the device to adjust dimensions on the flexible expandable component; providing a liquid into the component through the liquid input port; and controlling pressure or flow rate of the liquid in the component to move the liquid through the multiple openings and into the cavity. The device has a liquid inlet port, an exterior surface having length, width and depth, and multiple openings in the surface distributed throughout the length, width and depth to act as liquid delivery ports; the exterior surface of the liquid delivery device being shapeable by internal pneumatic pressure or hydraulic pressure to better fit inside dimensions of a surgical cavity; the multiple openings deliver the liquid through the multiple openings.

5. 发明授权

US09101282B2 Brain tissue classification 有权
标题翻译：脑组织分类
公开(公告)号：US09101282B2
公开(公告)日：2015-08-11
申请号：US11534383
申请日：2006-09-22
申请人： Andreas Hartlep , Christoph Pedain , Martin Brady , Raghu Raghavan
发明人： Andreas Hartlep , Christoph Pedain , Martin Brady , Raghu Raghavan
IPC分类号： A61B5/055 , G01R33/56 , A61B5/00 , G06T7/00
CPC分类号： A61B5/055 , A61B5/0042 , A61B5/4064 , A61B5/7264 , A61B2576/026 , G01R33/5608 , G06T7/12 , G06T2207/10088 , G06T2207/30016
摘要： A medical imaging processing method includes: using an imaging method to acquire at least first and second data sets of a region of interest of a patient's body, with at least one image acquisition parameter being changed so that first and second data sets yield different contrast levels relating to different substance and/or tissue types, and wherein the at least one acquisition parameter used to obtain the first data set is selected to enhance the contrast between one of the substance and/or tissue types relative to other substance and/or tissue types, and the at least one acquisition parameter used to obtain the second data set is selected to enhance the contrast between a different one of the substance and/or tissue types relative other substance and/or tissue types, thereby to optimize the contrast between at least three different substance and/or tissue types; and processing the two data sets to identify the different tissue types and/or boundaries therebetween.
摘要翻译：医疗成像处理方法包括：使用成像方法来获取患者身体的至少一个感兴趣区域的数据集，其中至少一个图像获取参数被改变，使得第一和第二数据组产生不同的对比度涉及不同的物质和/或组织类型，并且其中用于获得第一数据集的至少一个采集参数被选择以增强物质和/或组织类型之一相对于其他物质和/或组织类型之间的对比度，并且选择用于获得第二数据集的至少一个采集参数以增强物质和/或组织类型之间的不同物质与其他物质和/或组织类型之间的对比度，从而优化至少三种不同的物质和/或组织类型; 并且处理两个数据集以识别其间的不同组织类型和/或边界。

6. 发明授权

US07742630B2 Method and apparatus for determining a backflow of a substance 有权
标题翻译：用于确定物质回流的方法和装置
公开(公告)号：US07742630B2
公开(公告)日：2010-06-22
申请号：US11562262
申请日：2006-11-21
申请人： Andreas Hartlep , Christoph Pedain , Martin Brady , Raghu Raghavan
发明人： Andreas Hartlep , Christoph Pedain , Martin Brady , Raghu Raghavan
IPC分类号： G06K9/00
CPC分类号： A61M5/14 , A61M2005/14292 , A61M2210/0693 , G06F19/00 , G16H40/63 , G16H50/50
摘要： A method for determining a backflow of a substance along a track of a delivery device includes: a) obtaining parameters that influence the flow of the fluid or substance; b) acquiring information about delivery data; and c) computing the backflow along the delivery device using the information in steps a) and b).
摘要翻译：用于确定物质沿输送装置的轨道的回流的方法包括：a）获得影响流体或物质流动的参数; b）获取有关送货数据的信息; 以及c）使用步骤a）和b）中的信息来计算沿输送装置的回流。

7. 发明申请

US20090270712A1 MARGIN DETERMINATION/TUMOR CELL MIGRATION 审中-公开
标题翻译：标记确定/肿瘤细胞迁移
公开(公告)号：US20090270712A1
公开(公告)日：2009-10-29
申请号：US12423228
申请日：2009-04-14
申请人： Raghu Raghavan , Martin Brady , Maria Inmaculada Rodriguez-Ponce
发明人： Raghu Raghavan , Martin Brady , Maria Inmaculada Rodriguez-Ponce
IPC分类号： A61M37/00 , A61B6/00 , A61B19/00
CPC分类号： A61M5/1723 , A61B5/055 , A61B34/10 , A61B90/36 , A61M2005/14292 , A61M2210/0693 , G01R33/281 , G01R33/5608
摘要： A method for identifying target regions in a tissue for local drug delivery, wherein functional and/or structural anatomical data such as edema and/or resection cavity is captured by an imaging system, and wherein the anatomical data is evaluated by segmentation techniques such as region-growing-based methods with computer assistance to determine a margin around a resection cavity and/or the volume of edema, the margin and/or the volume of edema being the target tissue for local drug delivery.
摘要翻译：一种用于识别用于局部药物递送的组织中的目标区域的方法，其中由成像系统捕获功能和/或结构解剖学数据，例如水肿和/或切除腔，并且其中所述解剖数据通过分割技术（例如区域计算机辅助的基于成长的方法来确定切除腔周围的边缘和/或水肿体积，水肿的边缘和/或体积是用于局部药物递送的目标组织。

8. 发明申请

US20070167788A1 Brain tissue classification 有权
标题翻译：脑组织分类
公开(公告)号：US20070167788A1
公开(公告)日：2007-07-19
申请号：US11534383
申请日：2006-09-22
申请人： Andreas Hartlep , Christoph Pedain , Martin Brady , Raghu Raghavan
发明人： Andreas Hartlep , Christoph Pedain , Martin Brady , Raghu Raghavan
IPC分类号： A61B8/00
CPC分类号： A61B5/055 , A61B5/0042 , A61B5/4064 , A61B5/7264 , A61B2576/026 , G01R33/5608 , G06T7/12 , G06T2207/10088 , G06T2207/30016
摘要： A medical imaging processing method includes: using an imaging method to acquire at least first and second data sets of a region of interest of a patient's body, with at least one image acquisition parameter being changed so that first and second data sets yield different contrast levels relating to different substance and/or tissue types, and wherein the at least one acquisition parameter used to obtain the first data set is selected to enhance the contrast between one of the substance and/or tissue types relative to other substance and/or tissue types, and the at least one acquisition parameter used to obtain the second data set is selected to enhance the contrast between a different one of the substance and/or tissue types relative other substance and/or tissue types, thereby to optimize the contrast between at least three different substance and/or tissue types: and processing the two data sets to identify the different tissue types and/or boundaries therebetween.
摘要翻译：医疗成像处理方法包括：使用成像方法来获取患者身体的至少一个感兴趣区域的数据集，其中至少一个图像获取参数被改变，使得第一和第二数据组产生不同的对比度涉及不同的物质和/或组织类型，并且其中用于获得第一数据集的至少一个采集参数被选择以增强物质和/或组织类型之一相对于其他物质和/或组织类型之间的对比度，并且选择用于获得第二数据集的至少一个采集参数以增强物质和/或组织类型之间的不同物质与其他物质和/或组织类型之间的对比度，从而优化至少三种不同的物质和/或组织类型：并处理两个数据集以识别其间的不同组织类型和/或边界。

9. 发明申请

US20140303593A1 DELIVERY OF MATERIALS INTO MARGINS OF TISSUE CAVITIES 审中-公开
标题翻译：将材料输送到组织中心
公开(公告)号：US20140303593A1
公开(公告)日：2014-10-09
申请号：US14229876
申请日：2014-03-29
申请人： Raghu Raghavan , Martin Brady
发明人： Raghu Raghavan , Martin Brady
IPC分类号： A61M25/10
CPC分类号： A61M25/10 , A61M2025/105 , A61M2025/1086
摘要： Surgery is performed on a patient with a novel device by: excising tissue from tissue mass within a patient to create a cavity within the tissue mass; inserting a novel device of this invention into the cavity; shaping a flexible expandable component of the device to adjust dimensions on the flexible expandable component; providing a liquid into the component through the liquid input port; and controlling pressure or flow rate of the liquid in the component to move the liquid through the multiple openings and into the cavity. The device has a liquid inlet port, an exterior surface having length, width and depth, and multiple openings in the surface distributed throughout the length, width and depth to act as liquid delivery ports; the exterior surface of the liquid delivery device being shapeable by internal pneumatic pressure or hydraulic pressure to better fit inside dimensions of a surgical cavity; the multiple openings deliver the liquid through the multiple openings.
摘要翻译：通过以下方式对具有新颖装置的患者进行手术：从患者组织块切除组织以在组织块内形成空腔; 将本发明的新型装置插入空腔中; 使所述装置的柔性可膨胀部件成形以调整所述柔性可膨胀部件上的尺寸; 通过液体输入端口向组件提供液体; 并且控制所述部件中的液体的压力或流速以将所述液体移动通过所述多个开口并进入所述空腔。该装置具有液体入口，具有长度，宽度和深度的外表面，并且表面上的多个开口分布在整个长度，宽度和深度上以用作液体输送口; 液体输送装置的外表面可以通过内部气动压力或液压成形，以更好地适应手术腔的内部尺寸; 多个开口通过多个开口输送液体。

10. 发明申请

US20140243783A1 METHOD OF BACKFLOW REDUCTION DURING MATERIAL DELIVERY THROUGH A NEEDLE INTO TISSUE 审中-公开
标题翻译：通过将物体输送到组织中的回流减少方法
公开(公告)号：US20140243783A1
公开(公告)日：2014-08-28
申请号：US14046845
申请日：2013-10-04
申请人： Raghu Raghavan , Martin Brady
发明人： Raghu Raghavan , Martin Brady
IPC分类号： A61M25/10 , A61M25/01 , A61M5/158 , A61M25/00
CPC分类号： A61M5/158 , A61M25/02 , A61M25/04 , A61M25/10 , A61M2005/1588 , A61M2025/0002 , A61M2025/0293 , A61M2025/1047 , A61M2025/1093 , A61M2210/0693
摘要： Interstitial tissue structure is treated with a flowable liquid agent by: providing a delivery cannula having a proximal end and a distal end and an external surface with at least one expandable member located on the external surface of at least one catheter or needle. The delivery cannula is inserted into live tissue, creating a hole in the tissue surrounding the delivery cannula. Contact is made against an inner surface of the hole with contact pressure from the at least one expandable member, said contact pressure establishing a first level of stress in tissue surrounding the hole in the tissue. The expandable member is expanded to increase the contact pressure and provide a second level of stress in the tissue surrounding the hole in the tissue to a second level of stress that is greater than the first level of stress.
摘要翻译：用可流动的液体试剂处理间质组织结构，方法是：提供具有近端和远端的输送插管和具有位于至少一个导管或针的外表面上的至少一个可扩张构件的外表面。输送插管插入活组织中，在输送插管周围的组织中产生孔。接触是通过来自至少一个可膨胀构件的接触压力抵靠孔的内表面制成的，所述接触压力在围绕组织中的孔的组织中建立第一级应力。可膨胀构件被膨胀以增加接触压力，并且在围绕组织中的孔的组织中提供第二水平的应力至大于第一应力水平的第二水平的应力。

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