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1. 发明申请

US20160318915A1 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH 有权
标题翻译： 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES作为突变体IDH的抑制剂
公开(公告)号：US20160318915A1
公开(公告)日：2016-11-03
申请号：US15209731
申请日：2016-07-13
申请人： Thomas Raymond CAFERRO , Zhuoliang CHEN , Young Shin CHO , Abran Q. COSTALES , Julian Roy LEVELL , Gang LIU , James R. MANNING , Martin SENDZIK , Cynthia SHAFER , Michael David SHULTZ , James Clifford SUTTON , Yaping WANG , Qian ZHAO
发明人： Thomas Raymond CAFERRO , Zhuoliang CHEN , Young Shin CHO , Abran Q. COSTALES , Julian Roy LEVELL , Gang LIU , James R. MANNING , Martin SENDZIK , Cynthia SHAFER , Michael David SHULTZ , James Clifford SUTTON , Yaping WANG , Qian ZHAO
IPC分类号： C07D413/14 , C07D413/04 , C07D417/14
CPC分类号： C07D413/14 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D413/04 , C07D417/14
摘要： The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
摘要翻译：或其药学上可接受的盐，其中R1，R2a，R2b和R3-R7为本文。本发明还涉及含有式（I）化合物的组合物以及这些化合物在抑制具有新形态活性的突变体IDH蛋白质中的用途。本发明还涉及式（I）化合物在治疗与这种突变体IDH蛋白相关的疾病或病症中的用途，包括但不限于细胞增殖病症如癌症。

2. 发明申请

US20140275083A1 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH 审中-公开
标题翻译： 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES作为突变体IDH的抑制剂
公开(公告)号：US20140275083A1
公开(公告)日：2014-09-18
申请号：US14208015
申请日：2014-03-13
申请人： Thomas Raymond CAFERRO , Zhuoliang CHEN , Young Shin CHO , Abran Q. COSTALES , Julian Roy LEVELL , Gang LIU , James R. MANNING , Martin SENDZIK , Cynthia SHAFER , Michael David SHULTZ , James SUTTON , Yaping WANG , Qian ZHAO
发明人： Thomas Raymond CAFERRO , Zhuoliang CHEN , Young Shin CHO , Abran Q. COSTALES , Julian Roy LEVELL , Gang LIU , James R. MANNING , Martin SENDZIK , Cynthia SHAFER , Michael David SHULTZ , James SUTTON , Yaping WANG , Qian ZHAO
IPC分类号： C07D413/04 , A61K31/5377 , C07D417/14 , C07D413/14 , A61K31/506
CPC分类号： C07D413/14 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D413/04 , C07D417/14
摘要： The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
摘要翻译：本发明涉及式（I）：或其药学上可接受的盐，其中R1，R2a，R2b和R3-R7为本文。本发明还涉及含有式（I）化合物的组合物以及这些化合物在抑制具有新形态活性的突变体IDH蛋白质中的用途。本发明还涉及式（I）化合物在治疗与这种突变体IDH蛋白相关的疾病或病症中的用途，包括但不限于细胞增殖病症如癌症。

3. 发明申请

US20160039802A1 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES AS INHIBITORS OF MUTANT IDH 审中-公开
标题翻译： 3-PYRIMIDIN-4-YL-OXAZOLIDIN-2-ONES作为突变体IDH的抑制剂
公开(公告)号：US20160039802A1
公开(公告)日：2016-02-11
申请号：US14774741
申请日：2014-03-13
申请人： Young Shin CHO , Julian Roy LEVELL , Gang LIU , Michael David SHULTZ , Simon Cornelis VAN DER PLAS , NOVARTIS AG
发明人： Young Shin CHO , Julian Roy LEVELL , Gang LIU , Michael David SHULTZ , Simon Cornelis VAN DER PLAS
IPC分类号： C07D413/04 , C07D487/08 , C07D417/14 , A61K31/5377 , A61K31/506 , C07D413/14
CPC分类号： C07D413/04 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D413/14 , C07D417/14 , C07D487/08 , A61K2300/00
摘要： The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are described herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant I DH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
摘要翻译：本发明涉及式（I）：或其药学上可接受的盐，其中R1，R2a，R2b和R3-R7如本文所述。本发明还涉及含有式（I）化合物的组合物以及这些化合物在抑制具有新形态活性的突变体IDH蛋白质中的用途。本发明还涉及式（I）化合物在治疗与这种突变体I DH蛋白相关的疾病或病症中的应用，包括但不限于细胞增殖病症如癌症。

4. 发明申请

US20120207769A1 Inhibitors of IAP 有权
标题翻译： IAP抑制剂
公开(公告)号：US20120207769A1
公开(公告)日：2012-08-16
申请号：US13456274
申请日：2012-04-26
申请人： Mark G. PALERMO , Sushil Kumar SHARMA , Christopher STRAUB , Run-Ming WANG , Leigh ZAWEL , Yanlin ZHANG , Zhuoliang CHEN , Yaping WANG , Fan YANG , Wojciech WRONA , Gang LIU , Mark G. CHAREST , Feng HE
发明人： Mark G. PALERMO , Sushil Kumar SHARMA , Christopher STRAUB , Run-Ming WANG , Leigh ZAWEL , Yanlin ZHANG , Zhuoliang CHEN , Yaping WANG , Fan YANG , Wojciech WRONA , Gang LIU , Mark G. CHAREST , Feng HE
IPC分类号： A61K31/40 , A61K31/663 , A61K31/55 , A61K31/53 , A61K31/519 , A61K31/497 , A61K31/506 , A61K31/437 , A61K31/444 , A61K31/4439 , A61K31/4245 , A61K31/427 , A61K31/422 , A61K31/41 , A61K31/4178 , A61K31/4025 , A61P35/00 , A61P5/26 , A61K39/395
CPC分类号： C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
摘要： Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).
摘要翻译：抑制Smac蛋白与式（I）的凋亡蛋白抑制剂（IAP）结合的新型化合物。

5. 发明申请

US20110281875A1 Inhibitors of IAP 有权
标题翻译： IAP抑制剂
公开(公告)号：US20110281875A1
公开(公告)日：2011-11-17
申请号：US13178946
申请日：2011-07-08
申请人： Mark G. PALERMO , Sushil Kumar SHARMA , Christopher STRAUB , Run-Ming WANG , Leigh ZAWEL , Yanlin ZHANG , Zhuoliang CHEN , Yaping WANG , Fan YANG , Wojciech WRONA , Gang LIU , Mark G. CHAREST , Feng HE
发明人： Mark G. PALERMO , Sushil Kumar SHARMA , Christopher STRAUB , Run-Ming WANG , Leigh ZAWEL , Yanlin ZHANG , Zhuoliang CHEN , Yaping WANG , Fan YANG , Wojciech WRONA , Gang LIU , Mark G. CHAREST , Feng HE
IPC分类号： A61K31/53 , A61K31/444 , C07D401/04 , A61K31/4245 , A61K31/427 , A61K31/422 , A61K31/41 , A61K31/4178 , A61K31/4155 , A61K31/4025 , A61K31/40 , C07D401/14 , A61K31/4439 , C07D413/04 , C07D417/04 , C07D403/04 , C07D207/16 , A61K31/506
CPC分类号： C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
摘要： Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).
摘要翻译：抑制Smac蛋白与式（I）的凋亡蛋白抑制剂（IAP）结合的新型化合物。

6. 发明申请

US20110060009A1 Hydroxamate-Based Inhibitors of Deacetylases 审中-公开
标题翻译：基于羟基甲酸酯的去乙酰化酶抑制剂
公开(公告)号：US20110060009A1
公开(公告)日：2011-03-10
申请号：US12870186
申请日：2010-08-27
申请人： Clinton A. BROOKS , Christine Hiu-Tung CHEN , Young Shin CHO , Lei JIANG , Gang LIU , Michael SHULTZ
发明人： Clinton A. BROOKS , Christine Hiu-Tung CHEN , Young Shin CHO , Lei JIANG , Gang LIU , Michael SHULTZ
IPC分类号： A61K31/4439 , C07D403/06 , A61K31/4045 , C07D401/06 , C07D401/14 , A61K31/4155 , A61K31/4192 , A61P35/00 , A61P25/28 , A61P25/16 , A61P9/00 , A61P19/02 , C12N9/99
CPC分类号： C07D403/06 , C07D401/14 , C07D403/04 , C07D498/06
摘要： The present teachings relate to compounds of Formula I: and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, R4, R5, ring A, and Z are as defined herein.The present teachings also provide methods of preparing compounds of Formula I and methods of use compounds of Formula I in treating pathologic conditions or disorders mediated wholly or in part by deacetylases.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐，水合物，酯和前药，其中R 1，R 2，R 3，R 4，R 5，环A和Z如本文所定义。本教导还提供制备式I化合物的方法和使用式I化合物治疗全部或部分由脱乙酰酶介导的病理状况或病症的方法。

7. 发明申请

US20110183964A1 HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES B 有权
标题翻译：脱乙酰壳多糖基抑制剂B
公开(公告)号：US20110183964A1
公开(公告)日：2011-07-28
申请号：US13082956
申请日：2011-04-08
申请人： Michael SHULTZ , Christine Hiu-Tung CHEN , Young Shin CHO , Lei JIANG , Jianmei FAN , Gang LIU , Dyuti MAJUMDAR , Jianke LI
发明人： Michael SHULTZ , Christine Hiu-Tung CHEN , Young Shin CHO , Lei JIANG , Jianmei FAN , Gang LIU , Dyuti MAJUMDAR , Jianke LI
IPC分类号： A61K31/55 , A61P35/00 , A61P35/02 , A61K31/404 , A61K31/4155 , A61K31/437 , A61K31/40 , A61K31/4025 , A61K31/497 , A61K31/422 , A61K31/41 , A61K31/496
CPC分类号： C07D207/08 , C07D401/06 , C07D403/06 , C07D405/06 , C07D413/06 , C07D471/04
摘要： The present teachings relate to compounds of Formula I: and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, Y, Z, and are as defined herein.The present teachings also provide methods of preparing compounds of Formula I and methods of using compounds of Formula I in treating, inhibiting, or preventing pathologic conditions or disorders mediated wholly or in part by deacetylases.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐，水合物，酯和前药，其中R 1，R 2，R 3，Y，Z如本文所定义。本教导还提供制备式I化合物的方法和使用式I化合物治疗，抑制或预防全部或部分由脱乙酰酶介导的病理状况或病症的方法。

8. 发明申请

US20110053925A1 Hydroxamate-Based Inhibitors of Deacetylases 审中-公开
标题翻译：基于羟基甲酸酯的去乙酰化酶抑制剂
公开(公告)号：US20110053925A1
公开(公告)日：2011-03-03
申请号：US12870123
申请日：2010-08-27
申请人： Young Shin CHO , Lei JIANG , Michael SHULTZ , Christine Hiu-Tung CHEN , Gang LIU , Jianke LI
发明人： Young Shin CHO , Lei JIANG , Michael SHULTZ , Christine Hiu-Tung CHEN , Gang LIU , Jianke LI
IPC分类号： A61K31/537 , C12N5/00 , A61K31/5377 , A61K31/495 , A61K31/438 , A61K31/437 , A61K31/454 , C07D498/10 , C07D413/14 , C07D413/02 , C07D295/205 , C07D471/10 , C07D471/04 , C07D401/02 , A61P25/16 , A61P25/28 , A61P9/04 , A61P7/02 , A61P19/02 , A61P9/10 , A61P35/00
CPC分类号： C07D295/205 , C07D213/74 , C07D217/22 , C07D235/30 , C07D241/42 , C07D241/50 , C07D295/155 , C07D295/185 , C07D295/26 , C07D401/04 , C07D401/10 , C07D405/04 , C07D409/04 , C07D413/04 , C07D471/04 , C07D491/107 , C07D491/113 , C07D498/10
摘要： The present teachings relate to compounds of Formula I: and pharmaceutically acceptable salts, hydrates, esters, and prodrugs thereof, wherein R1, R2, R3, ring A, and are as defined herein.The present teachings also provide methods of preparing compounds of Formula I and methods of using compounds of Formula I in treating, inhibiting, or preventing pathologic conditions or disorders mediated wholly or in part by deacetylases.
摘要翻译：本发明涉及式I化合物及其药学上可接受的盐，水合物，酯和前药，其中R1，R2，R3，环A，如本文所定义。本教导还提供制备式I化合物的方法和使用式I化合物治疗，抑制或预防全部或部分由脱乙酰酶介导的病理状况或病症的方法。

9. 发明申请

US20180216732A1 MOTOR 审中-公开
公开(公告)号：US20180216732A1
公开(公告)日：2018-08-02
申请号：US15939342
申请日：2018-03-29
申请人： Gang LIU
发明人： Gang LIU
IPC分类号： F16H61/662 , H02K21/16 , F16H61/14 , F16H1/32
摘要： A motor with a variable-speed torque converter is disclosed. A rotor of the motor has a common permanent magnet structure. Permanent magnets are disposed on the rotor. The variable-speed torque converter includes a wheel disc, a wheel ring, a roller, a transmission gear II, a transmission gear III, a round wheel, an annular gear, a driving gear, turning discs, a transmission shaft, and an output shaft. The driving gear fixedly connected to the transmission shaft of the motor drives the transmission gear. The transmission gear is in contact with the annular gear. The transmission gear rotates around the driving gear to drive the wheel disc to rotate together. The wheel disc is fixedly connected to the output shaft to drive a driving wheel to rotate. Therefore, a working capability of the motor is enhanced. The converter can be applied to an electromotor, a generator, or any other power device.

10. 发明申请

US20130017724A1 EMI-PREVENTING SOCKET AND MANUFACTURING METHOD THEREOF 有权
标题翻译：防EMI插座及其制造方法
公开(公告)号：US20130017724A1
公开(公告)日：2013-01-17
申请号：US13355305
申请日：2012-01-20
申请人： Gang LIU
发明人： Gang LIU
IPC分类号： H01R13/648 , B29C45/14
CPC分类号： H01R43/24 , H01R13/6581 , Y10T29/49117 , Y10T29/49169
摘要： A manufacturing method for an EMI-preventing socket comprises the following steps of: providing an EMI-preventing element and a plurality of pins that include a ground pin; connecting a connecting portion of the EMI-preventing element to the ground pin; providing a mold; placing the EMI-preventing element, the ground pin and the other pins in the mold in such a manner that the EMI-preventing element surrounds the pins; and providing a molding material into the mold to wrap the pins, and a joint of the connection portion of the EMI-preventing element and the ground pin to form a socket body of the EMI-preventing socket. Parts of the EMI-preventing element and one ends of the pins are exposed out of the socket body of the EMI-preventing socket. An EMI-preventing socket made by the manufacturing method is also disclosed.
摘要翻译：防EMI插座的制造方法包括以下步骤：提供防EMI元件和包括接地引脚的多个引脚; 将防EMI元件的连接部分连接到接地引脚; 提供模具; 将防EMI元件，接地销和其他销放置在模具中，使得防EMI元件围绕销; 以及将模制材料提供到模具中以包裹销，以及防EMI元件的连接部分和接地销的接头，以形成防EMI插座的插座主体。防EMI元件的一部分和销的一端从防EMI插座的插座主体露出。还公开了一种通过制造方法制造的防EMI插座。

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