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1. 发明申请

US20160303169A9 SKELETAL MUSCLE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS, AND TREATMENTS THEREOF 有权
公开(公告)号：US20160303169A9
公开(公告)日：2016-10-20
申请号：US12245379
申请日：2008-10-03
申请人： Thomas Payne , Ronald Jankowski , Ryan Pruchnic , Michael Chancellor
发明人： Thomas Payne , Ronald Jankowski , Ryan Pruchnic , Michael Chancellor
IPC分类号： A61K35/34
CPC分类号： A61K35/34 , A61K9/0019 , A61K35/12 , C12N5/0658 , C12N5/0659 , C12N2500/84 , C12N2501/70 , C12N2510/00 , C12N2510/02 , C12N2533/54
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. The invention also relates to novel uses of muscle-derived progenitor cells for the treatment of cosmetic or functional conditions, including, but not limited to skeletal muscle weakness, muscular dystrophy, muscle atrophy, spasticity, myoclonus and myalgia. The invention also relates to the novel use of MDCs for the increase of skeletal muscle mass in athletes or other organisms in need of greater than average skeletal muscle mass.

2. 发明授权

US09499791B2 Skeletal muscle augmentation utilizing muscle-derived progenitor compositions, and treatments thereof 有权
标题翻译：使用肌肉来源的祖细胞组合物的骨骼肌增强及其治疗
公开(公告)号：US09499791B2
公开(公告)日：2016-11-22
申请号：US12245379
申请日：2008-10-03
申请人： Thomas Payne , Ronald Jankowski , Ryan Pruchnic , Michael Chancellor
发明人： Thomas Payne , Ronald Jankowski , Ryan Pruchnic , Michael Chancellor
IPC分类号： A61K35/34 , C12N5/077 , A61K35/12
CPC分类号： A61K35/34 , A61K9/0019 , A61K35/12 , C12N5/0658 , C12N5/0659 , C12N2500/84 , C12N2501/70 , C12N2510/00 , C12N2510/02 , C12N2533/54
摘要： The present invention provides muscle-derived progenitor cells (MDCs) that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction into a site of soft tissue. Also provided are methods of isolating MDCs. The invention further provides methods of using compositions comprising MDCs for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. The invention also relates to uses of MDCs for the treatment of cosmetic or functional conditions, including, but not limited to skeletal muscle weakness, muscular dystrophy, muscle atrophy, spasticity, myoclonus and myalgia. The invention also relates to the use of MDCs for the increase of skeletal muscle.
摘要翻译：本发明提供了肌肉衍生的祖细胞（MDCs），其在移植到身体组织中后显示出长期存活，并且可以在引入软组织部位后增加软组织。还提供了隔离MDC的方法。本发明还提供了使用包含MDC的组合物的方法，用于在治疗各种美容或功能状况（包括畸形，损伤，无力，疾病或功能障碍）的哺乳动物包括人类软组织的增加和膨胀中。本发明还涉及MDC用于治疗化妆品或功能状况的用途，包括但不限于骨骼肌无力，肌营养不良，肌肉萎缩，痉挛状态，肌阵挛和肌痛。本发明还涉及MDCs用于增加骨骼肌的用途。

3. 发明申请

US20090098094A1 SKELETAL MUSCLE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS, AND TREATMENTS THEREOF 有权
标题翻译：使用肌肉衍生的孕激素组合物的骨骼肌肉康复治疗及其治疗
公开(公告)号：US20090098094A1
公开(公告)日：2009-04-16
申请号：US12245379
申请日：2008-10-03
申请人： Thomas Payne , Ronald Jankowski , Ryan Pruchnic , Michael Chancellor
发明人： Thomas Payne , Ronald Jankowski , Ryan Pruchnic , Michael Chancellor
IPC分类号： A61K35/34
CPC分类号： A61K35/34 , A61K9/0019 , A61K35/12 , C12N5/0658 , C12N5/0659 , C12N2500/84 , C12N2501/70 , C12N2510/00 , C12N2510/02 , C12N2533/54
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. The invention also relates to novel uses of muscle-derived progenitor cells for the treatment of cosmetic or functional conditions, including, but not limited to skeletal muscle weakness, muscular dystrophy, muscle atrophy, spasticity, myoclonus and myalgia. The invention also relates to the novel use of MDCs for the increase of skeletal muscle mass in athletes or other organisms in need of greater than average skeletal muscle mass.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）之后增加软组织到软组织部位中。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明进一步提供使用包含肌肉来源的祖细胞的组合物的方法，用于增加和膨胀哺乳动物，包括人类软组织，以治疗各种美容或功能状况，包括畸形，损伤，无力，疾病或功能障碍。本发明还涉及肌肉衍生的祖细胞用于治疗化妆品或功能状况的新用途，包括但不限于骨骼肌无力，肌营养不良，肌肉萎缩，痉挛状态，肌阵挛和肌痛。本发明还涉及MDC在需要大于平均骨骼肌质量的运动员或其他生物体中增加骨骼肌质量的新用途。

4. 发明申请

US20090155221A1 BONE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS, AND TREATMENTS THEREOF 审中-公开
标题翻译：使用肌肉衍生的孕激素组合物的骨质康复及其治疗
公开(公告)号：US20090155221A1
公开(公告)日：2009-06-18
申请号：US12129272
申请日：2008-05-29
申请人： Thomas Payne , Ronald Jankowski , Ryan Pruchnic
发明人： Thomas Payne , Ronald Jankowski , Ryan Pruchnic
IPC分类号： A61K35/34 , A61P19/00 , C12N5/02
CPC分类号： A61K35/34 , A61K35/12 , C12N5/0654 , C12N5/0658 , C12N5/0659 , C12N2501/105 , C12N2501/11 , C12N2501/115 , C12N2501/165 , C12N2501/39 , C12N2501/91 , C12N2506/13 , C12N2510/00
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone). Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.
摘要翻译：本发明提供肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如经由注射，移植或植入）之后增加非软组织到非软组织部位（例如，骨）。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明还提供了使用包含肌肉来源的祖细胞的组合物用于增加和膨胀哺乳动物（包括人类）骨组织以治疗各种功能状况的方法，包括骨质疏松症，佩吉特氏病，成骨不全，骨折，骨软化，减少在骨小梁强度，骨皮质强度下降和老年骨密度降低。

5. 发明申请

US20090010897A1 Muscle derived cells for the treatment of cardiac pathologies and methods of making and using the same 有权
标题翻译：用于治疗心脏病理学的肌源性细胞及其制备和使用方法
公开(公告)号：US20090010897A1
公开(公告)日：2009-01-08
申请号：US11998330
申请日：2007-11-28
申请人： Michael B. Chancellor , Thomas Payne , Ronald Jankowski , Ryan Pruchnic
发明人： Michael B. Chancellor , Thomas Payne , Ronald Jankowski , Ryan Pruchnic
IPC分类号： A61K35/12 , C12N5/00 , C12N5/08 , A61P9/00
CPC分类号： A61K35/34 , A61K35/12 , C12N5/0658
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for dermatological conditions, gastroesophageal reflux, vesico-ureteral reflux, urinary incontinence, fecal incontinence, heart failure, and myocardial infarction.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）之后增加软组织到软组织部位中。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明进一步提供使用包含肌肉来源的祖细胞的组合物的方法，用于增加和膨胀哺乳动物，包括人类软组织，以治疗各种美容或功能状况，包括畸形，损伤，无力，疾病或功能障碍。特别地，本发明提供了用于皮肤病学，胃食管反流，膀胱输尿管反流，尿失禁，大便失禁，心力衰竭和心肌梗死的治疗和改善。

6. 发明授权

US08211423B2 Muscle derived cells for the treatment of cardiac pathologies and methods of making and using the same 有权
标题翻译：用于治疗心脏病理学的肌源性细胞及其制备和使用方法
公开(公告)号：US08211423B2
公开(公告)日：2012-07-03
申请号：US11998330
申请日：2007-11-28
申请人： Michael B. Chancellor , Thomas Payne , Ronald Jankowski , Ryan Pruchnic
发明人： Michael B. Chancellor , Thomas Payne , Ronald Jankowski , Ryan Pruchnic
IPC分类号： A01N63/00 , C12N5/07
CPC分类号： A61K35/34 , A61K35/12 , C12N5/0658
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of soft tissue. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, soft tissues in the treatment of various cosmetic or functional conditions, including malformation, injury, weakness, disease, or dysfunction. In particular, the present invention provides treatments and amelioration for dermatological conditions, gastroesophageal reflux, vesico-ureteral reflux, urinary incontinence, fecal incontinence, heart failure, and myocardial infarction.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）之后增加软组织到软组织部位中。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明进一步提供使用包含肌肉来源的祖细胞的组合物的方法，用于在治疗各种美容或功能状况（包括畸形，损伤，无力，疾病或功能障碍）的哺乳动物（包括人）软组织的增加和膨胀中。特别地，本发明提供了用于皮肤病学，胃食管反流，膀胱输尿管反流，尿失禁，大便失禁，心力衰竭和心肌梗死的治疗和改善。

7. 发明申请

US20100233138A1 Vocal Cord Augmentation Utilizing Muscle-Derived Progenitor Compositions, and Treatments Thereof 审中-公开
标题翻译：声带增强利用肌肉衍生的祖细胞组合物及其治疗方法
公开(公告)号：US20100233138A1
公开(公告)日：2010-09-16
申请号：US12614650
申请日：2009-11-09
申请人： Thomas Payne , Ryan Pruchnic , Ronald Jankowski
发明人： Thomas Payne , Ryan Pruchnic , Ronald Jankowski
IPC分类号： A61K35/34
CPC分类号： A61K35/34 , A61K35/12 , C12N5/0658 , C12N5/0659
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment vocal cord tissue following introduction (e.g. via injection, transplantation, or implantation) into the vocal cords. Also provided are methods of isolating muscle-derived progenitor cells, and methods of genetically modifying the cells for gene transfer therapy. The invention further provides methods of using compositions comprising muscle-derived progenitor cells for the augmentation and bulking of mammalian, including human, vocal cords in the treatment of various cosmetic or functional conditions, including vocal cord tissue weakness, voice and swallowing disorders. The invention also relates to the novel use of MDCs for the increase of vocal cord tissue mass in speakers, singers or other people in need of greater than average vocal cord tissue mass.
摘要翻译：本发明提供了肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如通过注射，移植或植入）到声带中之后增加声带组织。还提供了分离肌肉来源的祖细胞的方法，以及遗传修饰细胞用于基因转移治疗的方法。本发明进一步提供了使用包含肌肉来源的祖细胞的组合物的方法，用于增加和膨胀哺乳动物，包括人类的声带，以治疗各种美容或功能状况，包括声带组织虚弱，声音和吞咽障碍。本发明还涉及MDC用于增加需要大于平均声带组织块的说话者，歌手或其他人中的声带组织块的新颖应用。

8. 发明申请

US20110319868A1 METHODS, SUBSTRATES, AND SYSTEMS USEFUL FOR CELL SEEDING OF MEDICAL GRAFTS 有权
标题翻译：方法，基质和系统用于细胞接种医疗用品
公开(公告)号：US20110319868A1
公开(公告)日：2011-12-29
申请号：US13115347
申请日：2011-05-25
申请人： Michael C. Hiles , Chad E. Johnson , Neal E. Fearnot , Thomas Payne , Ronald Jankowski
发明人： Michael C. Hiles , Chad E. Johnson , Neal E. Fearnot , Thomas Payne , Ronald Jankowski
IPC分类号： A61M37/00 , A61P43/00 , A61K35/12 , C12N5/071 , C12M1/00
CPC分类号： A61L27/50 , A61L27/24 , A61L27/3604 , A61L27/3633 , A61L27/3808 , A61L27/3826 , A61L2430/02 , A61L2430/06 , A61L2430/26 , A61L2430/28 , A61L2430/30 , A61L2430/32 , A61L2430/34 , C12M21/08 , C12M23/06 , C12M23/34 , C12M25/14 , C12N5/0062 , C12N2533/54
摘要： Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.
摘要翻译：描述了可用于制备用于给予患者的含细胞的移植材料的方法，细胞生长底物和装置。可以在细胞生长底物中定义管状通道以促进细胞分布到底物中。还描述了用于制备细胞接种组合物的方法和装置，在施用细胞之前预处理细胞生长底物的方法和装置，以及具有新基底的细胞接种移植物及其用途。

9. 发明授权

US09115336B2 Methods, substrates, and systems useful for cell seeding of medical grafts 有权
标题翻译：用于医疗移植物细胞接种的方法，底物和系统
公开(公告)号：US09115336B2
公开(公告)日：2015-08-25
申请号：US13115347
申请日：2011-05-25
申请人： Michael C. Hiles , Chad E. Johnson , Neal E. Fearnot , Thomas Payne , Ronald Jankowski
发明人： Michael C. Hiles , Chad E. Johnson , Neal E. Fearnot , Thomas Payne , Ronald Jankowski
IPC分类号： C12M3/02 , C12M3/00 , A61L27/24 , A61L27/36 , A61L27/38 , C12M1/00 , C12M1/12 , C12N5/00
CPC分类号： A61L27/50 , A61L27/24 , A61L27/3604 , A61L27/3633 , A61L27/3808 , A61L27/3826 , A61L2430/02 , A61L2430/06 , A61L2430/26 , A61L2430/28 , A61L2430/30 , A61L2430/32 , A61L2430/34 , C12M21/08 , C12M23/06 , C12M23/34 , C12M25/14 , C12N5/0062 , C12N2533/54
摘要： Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.
摘要翻译：描述了可用于制备用于给予患者的含细胞的移植材料的方法，细胞生长底物和装置。可以在细胞生长底物中定义管状通道以促进细胞分布到底物中。还描述了用于制备细胞接种组合物的方法和装置，在施用细胞之前预处理细胞生长底物的方法和装置，以及具有新基底的细胞接种移植物及其用途。

10. 发明申请

US20100215623A1 BONE AUGMENTATION UTILIZING MUSCLE-DERIVED PROGENITOR COMPOSITIONS IN BIOCOMPATIBLE MATRIX, AND TREATMENTS THEREOF 有权
标题翻译：使用生物化学基质中的肌肉衍生的原料组合物的骨质保护及其治疗
公开(公告)号：US20100215623A1
公开(公告)日：2010-08-26
申请号：US12543311
申请日：2009-08-18
申请人： Arvydas Usas , Karin Payne , Thomas Payne , Ronald Jankowski , Johnny Huard
发明人： Arvydas Usas , Karin Payne , Thomas Payne , Ronald Jankowski , Johnny Huard
IPC分类号： A61K35/34 , A61K35/32 , A61P19/08
CPC分类号： A61L27/3895 , A61K35/12 , A61K35/38 , A61L27/3629 , A61L27/365 , A61L27/3847 , A61L27/54 , A61L27/58 , A61L2300/64 , A61L2430/02 , A61L2430/40 , C12N5/0659 , C12N11/02 , C12N2533/92
摘要： The present invention provides muscle-derived progenitor cells that show long-term survival following transplantation into body tissues and which can augment non-soft tissue following introduction (e.g. via injection, transplantation, or implantation) into a site of non-soft tissue (e.g. bone) when combined with a biocompatible matrix, preferably SIS. The invention further provides methods of using compositions comprising muscle-derived progenitor cells with a biocompatible matrix for the augmentation and bulking of mammalian, including human, bone tissues in the treatment of various functional conditions, including osteoporosis, Paget's Disease, osteogenesis imperfecta, bone fracture, osteomalacia, decrease in bone trabecular strength, decrease in bone cortical strength and decrease in bone density with old age.
摘要翻译：本发明提供肌肉衍生的祖细胞，其在移植到身体组织中后显示出长期存活，并且可以在引入（例如经由注射，移植或植入）之后增加非软组织到非软组织部位（例如，骨）与生物相容性基质（优选SIS）组合时。本发明还提供了使用包含肌源性祖细胞的组合物与生物相容性基质的方法，用于在治疗各种功能状况（包括骨质疏松症，佩吉特氏病，成骨不全，骨折）中增加和膨胀哺乳动物，包括人类骨组织，骨软化，骨小梁强度降低，骨皮质强度下降，老年骨密度降低。

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