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1. 发明申请

US20110319868A1 METHODS, SUBSTRATES, AND SYSTEMS USEFUL FOR CELL SEEDING OF MEDICAL GRAFTS 有权
标题翻译：方法，基质和系统用于细胞接种医疗用品
公开(公告)号：US20110319868A1
公开(公告)日：2011-12-29
申请号：US13115347
申请日：2011-05-25
申请人： Michael C. Hiles , Chad E. Johnson , Neal E. Fearnot , Thomas Payne , Ronald Jankowski
发明人： Michael C. Hiles , Chad E. Johnson , Neal E. Fearnot , Thomas Payne , Ronald Jankowski
IPC分类号： A61M37/00 , A61P43/00 , A61K35/12 , C12N5/071 , C12M1/00
CPC分类号： A61L27/50 , A61L27/24 , A61L27/3604 , A61L27/3633 , A61L27/3808 , A61L27/3826 , A61L2430/02 , A61L2430/06 , A61L2430/26 , A61L2430/28 , A61L2430/30 , A61L2430/32 , A61L2430/34 , C12M21/08 , C12M23/06 , C12M23/34 , C12M25/14 , C12N5/0062 , C12N2533/54
摘要： Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.
摘要翻译：描述了可用于制备用于给予患者的含细胞的移植材料的方法，细胞生长底物和装置。可以在细胞生长底物中定义管状通道以促进细胞分布到底物中。还描述了用于制备细胞接种组合物的方法和装置，在施用细胞之前预处理细胞生长底物的方法和装置，以及具有新基底的细胞接种移植物及其用途。

2. 发明授权

US09115336B2 Methods, substrates, and systems useful for cell seeding of medical grafts 有权
标题翻译：用于医疗移植物细胞接种的方法，底物和系统
公开(公告)号：US09115336B2
公开(公告)日：2015-08-25
申请号：US13115347
申请日：2011-05-25
申请人： Michael C. Hiles , Chad E. Johnson , Neal E. Fearnot , Thomas Payne , Ronald Jankowski
发明人： Michael C. Hiles , Chad E. Johnson , Neal E. Fearnot , Thomas Payne , Ronald Jankowski
IPC分类号： C12M3/02 , C12M3/00 , A61L27/24 , A61L27/36 , A61L27/38 , C12M1/00 , C12M1/12 , C12N5/00
CPC分类号： A61L27/50 , A61L27/24 , A61L27/3604 , A61L27/3633 , A61L27/3808 , A61L27/3826 , A61L2430/02 , A61L2430/06 , A61L2430/26 , A61L2430/28 , A61L2430/30 , A61L2430/32 , A61L2430/34 , C12M21/08 , C12M23/06 , C12M23/34 , C12M25/14 , C12N5/0062 , C12N2533/54
摘要： Described are methods, cell growth substrates, and devices that are useful in preparing cell-containing graft materials for administration to patients. Tubular passages can be defined in cell growth substrates to promote distribution of cells into the substrates. Also described are methods and devices for preparing cell-seeded graft compositions, methods and devices for preconditioning cell growth substrates prior to application of cells, and cell seeded grafts having novel substrates, and uses thereof.
摘要翻译：描述了可用于制备用于给予患者的含细胞的移植材料的方法，细胞生长底物和装置。可以在细胞生长底物中定义管状通道以促进细胞分布到底物中。还描述了用于制备细胞接种组合物的方法和装置，在施用细胞之前预处理细胞生长底物的方法和装置，以及具有新基底的细胞接种移植物及其用途。

3. 发明授权

US07815923B2 Implantable graft material 失效
标题翻译：植入式移植材料
公开(公告)号：US07815923B2
公开(公告)日：2010-10-19
申请号：US11616159
申请日：2006-12-26
申请人： Chad E. Johnson , Michael C. Hiles
发明人： Chad E. Johnson , Michael C. Hiles
IPC分类号： A61F2/86
CPC分类号： A61F2/2415 , A61B90/90 , A61B2050/0065 , A61F2/0095 , A61F2/07 , A61F2/08 , A61F2/2412 , A61F2/2475 , A61F2/32 , A61F2/3603 , A61F2/40 , A61F2/86 , A61F2002/072 , A61F2002/30062 , A61F2002/30247 , A61F2002/3025 , A61F2002/30649 , A61F2002/30754 , A61F2002/30971 , A61F2002/4007 , A61F2210/0004 , A61F2230/0071 , A61F2240/001 , A61F2310/00365 , A61L27/3633 , A61L27/3641 , A61L27/3645 , A61L27/3683 , A61L27/3804 , A61L27/3843 , A61L31/005
摘要： Described are graft materials suitable for implantation within a patient including isolated tissue material remodeled in a body cavity. Also described are methods of treating a patient that include implanting these materials and prosthetic devices comprising these materials within the patient's body.
摘要翻译：描述了适合于在患者体内植入的移植材料，包括在体腔中改造的分离的组织材料。还描述了治疗患者的方法，所述方法包括将这些材料植入，以及在患者体内包括这些材料的假体装置。

4. 发明申请

US20080181950A1 BIOFILM-INHIBITING MEDICAL PRODUCTS 有权
标题翻译：生物膜抑制医疗产品
公开(公告)号：US20080181950A1
公开(公告)日：2008-07-31
申请号：US12019477
申请日：2008-01-24
申请人： Brian L. Bates , Michael C. Hiles , Chad E. Johnson
发明人： Brian L. Bates , Michael C. Hiles , Chad E. Johnson
IPC分类号： A01N25/00 , A01N31/00 , A61P17/02
CPC分类号： A61L15/40 , A61L15/44 , A61L2300/102 , A61L2300/404
摘要： A biofilm-inhibiting medical product includes a carrier formed from a natural, bioremodelable material, whereby the carrier includes a biocidal bismuth thiol agent and/or one or more other biofilm-inhibiting or wound healing agents. A method for using the biofilm-inhibiting medical product to treat a wound or tissue defect in a patient's body is described.
摘要翻译：生物膜抑制医疗产品包括由天然的生物可重塑材料形成的载体，由此所述载体包含杀生物铋硫醇试剂和/或一种或多种其它生物膜抑制或伤口愈合剂。描述了使用生物膜抑制医疗产品来治疗患者体内的伤口或组织缺陷的方法。

5. 发明申请

US20070154515A1 IMPLANTABLE GRAFT MATERIAL 失效
标题翻译：可植入材料
公开(公告)号：US20070154515A1
公开(公告)日：2007-07-05
申请号：US11616159
申请日：2006-12-26
申请人： Chad E. Johnson , Michael C. Hiles
发明人： Chad E. Johnson , Michael C. Hiles
IPC分类号： A61K35/12
CPC分类号： A61F2/2415 , A61B90/90 , A61B2050/0065 , A61F2/0095 , A61F2/07 , A61F2/08 , A61F2/2412 , A61F2/2475 , A61F2/32 , A61F2/3603 , A61F2/40 , A61F2/86 , A61F2002/072 , A61F2002/30062 , A61F2002/30247 , A61F2002/3025 , A61F2002/30649 , A61F2002/30754 , A61F2002/30971 , A61F2002/4007 , A61F2210/0004 , A61F2230/0071 , A61F2240/001 , A61F2310/00365 , A61L27/3633 , A61L27/3641 , A61L27/3645 , A61L27/3683 , A61L27/3804 , A61L27/3843 , A61L31/005
摘要： Described are graft materials suitable for implantation within a patient including isolated tissue material remodeled in a body cavity. Also described are methods of treating a patient that include implanting these materials and prosthetic devices comprising these materials within the patient's body.
摘要翻译：描述了适合于在患者体内植入的移植材料，包括在体腔中改造的分离的组织材料。还描述了治疗患者的方法，所述方法包括将这些材料植入，以及在患者体内包括这些材料的假体装置。

6. 发明授权

US08343536B2 Biofilm-inhibiting medical products 有权
标题翻译：生物膜抑制医疗产品
公开(公告)号：US08343536B2
公开(公告)日：2013-01-01
申请号：US12019477
申请日：2008-01-24
申请人： Brian L. Bates , Michael C. Hiles , Chad E. Johnson
发明人： Brian L. Bates , Michael C. Hiles , Chad E. Johnson
IPC分类号： A61L15/00 , A61K35/12 , C12N15/00
CPC分类号： A61L15/40 , A61L15/44 , A61L2300/102 , A61L2300/404
摘要： A biofilm-inhibiting medical product includes a carrier formed from a natural, bioremodelable material, whereby the carrier includes a biocidal bismuth thiol agent and/or one or more other biofilm-inhibiting or wound healing agents. A method for using the biofilm-inhibiting medical product to treat a wound or tissue defect in a patient's body is described.
摘要翻译：生物膜抑制医疗产品包括由天然的生物可重塑材料形成的载体，由此所述载体包含杀生物铋硫醇试剂和/或一种或多种其它生物膜抑制或伤口愈合剂。描述了使用生物膜抑制医疗产品来治疗患者体内的伤口或组织缺陷的方法。

7. 发明申请

US20110150998A1 Methods For Producing ECM-Based Biomaterials 有权
标题翻译：生产基于ECM的生物材料的方法
公开(公告)号：US20110150998A1
公开(公告)日：2011-06-23
申请号：US12644607
申请日：2009-12-22
申请人： Laura-Lee Farrell , Chad E. Johnson
发明人： Laura-Lee Farrell , Chad E. Johnson
IPC分类号： A61K9/14 , B29C41/04 , A61P17/02
CPC分类号： A61K9/0087 , A61K38/39 , A61L27/3633 , A61L31/005 , B29C39/08 , B29C67/20
摘要： A method for forming an extracellular matrix material (ECM) material includes providing at least an ECM composition containing ECM particles varying in their capacity for migration through a fluid medium, including at least one population of expanded ECM particles. The ECM composition is combined in a fluid medium to form a flowable ECM composition. The flowable ECM composition is subjected to a centrifugal force in a mold for a period of time sufficient to distribute the ECM particles according to differences in their physical characteristics. The ECM composition is dried to form a dried ECM material having a density gradient extending from a less dense region to a more dense region. The dried ECM material may formed as a porous, substantially acellular ECM material expandable in an aqueous fluid environment by at least 100% in volume.
摘要翻译：用于形成细胞外基质材料（ECM）材料的方法包括提供至少一种含有ECM颗粒的ECM组合物，其中ECM颗粒的能力通过流体介质（包括至少一个扩展的ECM颗粒群体）迁移。 ECM组合物在流体介质中组合以形成可流动的ECM组合物。可流动的ECM组合物在模具中经受足够的离心力足以根据它们的物理特性的差异分布ECM颗粒。将ECM组合物干燥以形成具有从较不密集区域延伸至更致密区域的密度梯度的干燥的ECM材料。干燥的ECM材料可以形成为在水性流体环境中可膨胀至少100体积的多孔，基本上无细胞的ECM材料。

8. 发明申请

US20090138078A1 Remodelable Prosthetic Valve 有权
标题翻译：可重塑假肢瓣膜
公开(公告)号：US20090138078A1
公开(公告)日：2009-05-28
申请号：US12273284
申请日：2008-11-18
申请人： Ram H. Paul, JR. , Sean D. Chambers , Chad E. Johnson
发明人： Ram H. Paul, JR. , Sean D. Chambers , Chad E. Johnson
IPC分类号： A61F2/24
CPC分类号： A61F2/2418 , A61F2/2475 , A61F2230/0026 , A61F2230/0095 , A61F2250/0031
摘要： Prosthetic medical devices with delayed valve function and in situ remodeling of a portion thereof are provided, as well as methods of manufacturing the medical devices and methods of treatment using the medical devices. The medical devices may be adapted to initially maintain a remodelable material within a body vessel in a first configuration suitable to contact the remodelable material with a body fluid contacting the remodelable material for a first time period or a second configuration adapted to regulate the flow of body fluid contacting the remodelable material. The medical devices may include a releasable holding member configured to retain the remodelable material in the first configuration.
摘要翻译：提供具有延迟阀功能和其一部分的原位重塑的假体医疗装置，以及制造医疗装置的方法和使用医疗装置的治疗方法。医疗装置可以适于以适于使可重塑材料接触第一时间段接触可重塑材料的体液或适于调节身体流动的第二构型的第一构型在体体容器内最初维持可重塑材料液体接触可重塑材料。医疗装置可以包括被配置为将可重塑材料保持在第一构造中的可释放保持构件。

9. 发明申请

US20080286268A1 PROCESSED ECM MATERIALS WITH ENHANCED COMPONENT PROFILES 有权
标题翻译：加工的ECM材料与增强的组件型材
公开(公告)号：US20080286268A1
公开(公告)日：2008-11-20
申请号：US12178321
申请日：2008-07-23
申请人： Chad E. Johnson
发明人： Chad E. Johnson
IPC分类号： A61K39/395 , A61K38/18
CPC分类号： A61L27/3633 , A61L27/3604 , A61L27/3695
摘要： Described are medical graft materials and devices having improved properties relating to their component profiles.
摘要翻译：描述了具有改进的与其组分轮廓相关的性质的医用移植材料和装置。

10. 发明授权

US09474514B2 Devices and methods for treating fistulae and other bodily openings and passageways 有权
标题翻译：用于治疗瘘管和其他身体开口和通道的装置和方法
公开(公告)号：US09474514B2
公开(公告)日：2016-10-25
申请号：US13247156
申请日：2011-09-28
申请人： Charles W. Agnew , Mark Duncan , Chad E. Johnson
发明人： Charles W. Agnew , Mark Duncan , Chad E. Johnson
IPC分类号： A61B17/08 , A61B17/00 , A61B17/12
CPC分类号： A61B17/0057 , A61B17/12099 , A61B17/12159 , A61B17/12181 , A61B17/1219 , A61B2017/00004 , A61B2017/00579 , A61B2017/00601 , A61B2017/00628 , A61B2017/00641 , A61B2017/0065 , A61B2017/00884
摘要： Some aspects of the present invention are directed to unique products and methods for treating fistulae and other passageways and openings in the body. In some preferred forms, an inventive construct will include an elongate graft body that incorporates a plurality of sheet or sheet-like segments. The plurality of sheet or sheet-like segments, in some arrangements, will be stacked in a generally longitudinal direction along the length of the plug body, and optionally, the segments will be received over one or more elongate elements. Elongate elements of this sort can take a variety of forms including a suture, wire, filament, or other relatively thin-bodied elongate member, although in some forms, an elongate element will be or include a somewhat heftier structure such as a biodegradable or non-biodegradable three-dimensional body.
摘要翻译：本发明的一些方面涉及用于治疗瘘管和身体其它通道和开口的独特产品和方法。在一些优选形式中，本发明的构造将包括结合有多个片状或片状片段的细长移植体。在一些布置中，多个片状或片状片段将沿着插塞体的长度沿大致纵向的方向堆叠，并且可选地，片段将被接收在一个或多个细长元件上。这种细长的元件可以采取各种形式，包括缝合线，丝线，细丝或其他相对细长的细长构件，尽管在某些形式中，细长元件将是或包括一些较高的结构，例如可生物降解的或不可生物降解的可生物降解的三维体。

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