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1. 发明授权

US06348195B1 Method for treating cancers 有权
标题翻译：治疗癌症的方法
公开(公告)号：US06348195B1
公开(公告)日：2002-02-19
申请号：US09602709
申请日：2000-06-26
申请人： Thomas Paul Wallace , William Joseph Harris , Francis Joseph Carr , Wolfgang J. Rettig , Pilar Garin-Chesa , Lloyd J. Old
发明人： Thomas Paul Wallace , William Joseph Harris , Francis Joseph Carr , Wolfgang J. Rettig , Pilar Garin-Chesa , Lloyd J. Old
IPC分类号： A61K39395
CPC分类号： G01N33/6854 , G01N33/57484 , G01N33/6833
摘要： The invention provides for the production of several humanized murine antibodies specific for the antigen LK26, which is recognized by the murine antibody LK26. This antigen is expressed on all choriocarcinoma, teratocarcinoma and renal cancer cell lines whereas it is not expressed on cell lines of leukaemias, lymphomas, neuroectodermally-derived and epithelial tumor cell lines (excepting a small subset of epithelial cell lines). Furthermore, whereas renal cancer cell lines express the LK26 antigen, normal renal epithelial cells do not. Similarly, with the exception of the trophoblast, all normal adult and fetal tissues tested are negative for the LK26 phenotype. The invention also provides for numerous polynucleotide encoding humanized LK26 specific antibodies, expression vectors for producing humanized LK26 specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized LK26 specific antibodies. Additionally, the invention provides methods of treating cancer using LK26 specific antibodies.
摘要翻译：本发明提供了针对抗原LK26特异的几种人源化鼠抗体的产生，其被鼠抗体LK26识别。该抗原在所有绒毛膜癌，畸胎癌和肾癌细胞系中表达，而不在白血病，淋巴瘤，神经外胚层衍生的和上皮性肿瘤细胞系的细胞系（除了上皮细胞系的一小部分之外）上表达。此外，肾癌细胞株表达LK26抗原时，肾上皮细胞不正常。类似地，除了滋养层之外，所有正常的成年和胎儿组织都检测到LK26表型阴性。本发明还提供编码人源化LK26特异性抗体的许多多核苷酸，用于产生人源化LK26特异性抗体的表达载体和用于重组产生人源化抗体的宿主细胞。本发明还提供了使用人源化LK26特异性抗体检测癌细胞（体外和体内）的方法。另外，本发明提供使用LK26特异性抗体治疗癌症的方法。

2. 发明授权

US5646253A Recombinant human anti-LK26 antibodies 失效
标题翻译：重组人抗LK26抗体
公开(公告)号：US5646253A
公开(公告)日：1997-07-08
申请号：US207996
申请日：1994-03-08
申请人： Thomas Paul Wallace , William Joseph Harris , Francis Joseph Carr , Wolfgang J. Rettig , Pilar Garin-Chesa , Lloyd J. Old
发明人： Thomas Paul Wallace , William Joseph Harris , Francis Joseph Carr , Wolfgang J. Rettig , Pilar Garin-Chesa , Lloyd J. Old
IPC分类号： G01N33/574 , G01N33/68 , C07K16/46
CPC分类号： G01N33/6854 , G01N33/57484 , G01N33/6833
摘要： The invention provides for the production of several humanized murine antibodies specific for the antigen LK26, which is recognized by the murine antibody LK26. This antigen is expressed on all choriocarcinoma, teratocarcinoma and renal cancer cell lines whereas it is not expressed on cell lines of leukaemias, lymphomas, neuroectodermally-derived and epithelial tumour cell lines (excepting a small subset of epithelial cell lines). Furthermore, whereas renal cancer cell lines express the LK26 antigen, normal renal epithelial cells do not. Similarly, with the exception of the trophoblast, all normal adult and fetal tissues tested are negative for the LK26 phenotype. The invention also provides for numerous polynucleotide encoding humanized LK26 specific antibodies, expression vectors for producing humanized LK26 specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized LK26 specific antibodies. Additionally, the invention provides methods of treating cancer using LK26 specific antibodies.
摘要翻译：本发明提供了针对抗原LK26特异的几种人源化鼠抗体的产生，其被鼠抗体LK26识别。该抗原在所有绒毛膜癌，畸胎癌和肾癌细胞系中表达，而不在白血病，淋巴瘤，神经外胚层衍生的和上皮性肿瘤细胞系的细胞系（除了上皮细胞系的一小部分之外）上表达。此外，肾癌细胞株表达LK26抗原时，肾上皮细胞不正常。类似地，除了滋养层之外，所有正常的成年和胎儿组织检测对于LK26表型是阴性的。本发明还提供编码人源化LK26特异性抗体的许多多核苷酸，用于产生人源化LK26特异性抗体的表达载体和用于重组产生人源化抗体的宿主细胞。本发明还提供了使用人源化LK26特异性抗体检测癌细胞（体外和体内）的方法。另外，本发明提供使用LK26特异性抗体治疗癌症的方法。

3. 发明授权

US5952484A Recombinant human anti-LK26 antibodies 失效
标题翻译：重组人抗LK26抗体
公开(公告)号：US5952484A
公开(公告)日：1999-09-14
申请号：US760840
申请日：1996-12-05
申请人： Thomas Paul Wallace , William Joseph Harris , Francis Joseph Carr , Wolfgang J. Rettig , Pilar Garin-Chesa , Lloyd J. Old
发明人： Thomas Paul Wallace , William Joseph Harris , Francis Joseph Carr , Wolfgang J. Rettig , Pilar Garin-Chesa , Lloyd J. Old
IPC分类号： G01N33/574 , G01N33/68 , C07H21/02
CPC分类号： G01N33/6854 , G01N33/57484 , G01N33/6833
摘要： The invention provides for the production of several humanized murine antibodies specific for the antigen LK26, which is recognized by the murine antibody LK26. This antigen is expressed on all choriocarcinoma, teratocarcinoma and renal cancer cell lines whereas it is not expressed on cell lines of leukaemias, lymphomas, neuroectodermally-derived and epithelial tumour cell lines (excepting a small subset of epithelial cell lines). Furthermore, whereas renal cancer cell lines express the LK26 antigen, normal renal epithelial cells do not. Similarly, with the exception of the trophoblast, all normal adult and fetal tissues tested are negative for the LK26 phenotype. The invention also provides for numerous polynucleotide encoding humanized LK26 specific antibodies, expression vectors for producing humanized LK26 specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized LK26 specific antibodies. Additionally, the invention provides methods of treating cancer using LK26 specific antibodies.
摘要翻译：本发明提供了针对抗原LK26特异的几种人源化鼠抗体的产生，其被鼠抗体LK26识别。该抗原在所有绒毛膜癌，畸胎癌和肾癌细胞系中表达，而不在白血病，淋巴瘤，神经外胚层衍生的和上皮性肿瘤细胞系的细胞系（除了上皮细胞系的一小部分之外）上表达。此外，肾癌细胞株表达LK26抗原时，肾上皮细胞不正常。类似地，除了滋养层之外，所有正常的成年和胎儿组织都检测到LK26表型阴性。本发明还提供编码人源化LK26特异性抗体的许多多核苷酸，用于产生人源化LK26特异性抗体的表达载体和用于重组产生人源化抗体的宿主细胞。本发明还提供了使用人源化LK26特异性抗体检测癌细胞（体外和体内）的方法。另外，本发明提供使用LK26特异性抗体治疗癌症的方法。

4. 发明授权

US6124106A Method for detecting cancers 有权
标题翻译：检测癌症的方法
公开(公告)号：US6124106A
公开(公告)日：2000-09-26
申请号：US266119
申请日：1999-03-10
申请人： Thomas Paul Wallace , William Joseph Harris , Francis Joseph Carr , Wolfgang J. Rettig , Pilar Garin-Chesa , Lloyd J. Old
发明人： Thomas Paul Wallace , William Joseph Harris , Francis Joseph Carr , Wolfgang J. Rettig , Pilar Garin-Chesa , Lloyd J. Old
IPC分类号： G01N33/574 , G01N33/68
CPC分类号： G01N33/6854 , G01N33/57484 , G01N33/6833
摘要： The invention provides for the production of several humanized murine antibodies specific for the antigen LK26, which is recognized by the murine antibody LK26. This antigen is expressed in all choriocarcinoma, teratocarcinoma and renal cancer cell lines whereas it is not expressed on cell lines of leukaemias, lymphomas, neuroectodermally-derived and epithelial tumour cell lines (excepting a small subset of epithelial cell lines). Furthermore, whereas renal cancer cell lines express the LK26 antigen, normal renal epithelial cells do not. Similarly, with the exception of the trophoblast, all normal adult and fetal tissues tested are negative for the LK26 phenotype. The invention also provides for numerous polynucleotide encoding humanized LK26 specific antibodies, expression vectors for producing humanized LK26 specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized LK26 specific antibodies. Additionally, the invention provides methods of treating cancer using LK26 specific antibodies.
摘要翻译：本发明提供了针对抗原LK26特异的几种人源化鼠抗体的产生，其被鼠抗体LK26识别。该抗原在所有绒癌，畸胎癌和肾癌细胞系中表达，而在白血病，淋巴瘤，神经外胚层衍生和上皮肿瘤细胞系（除了上皮细胞系的一小部分）的细胞系上不表达。此外，肾癌细胞株表达LK26抗原时，肾上皮细胞不正常。类似地，除了滋养层之外，所有正常的成年和胎儿组织检测对于LK26表型是阴性的。本发明还提供编码人源化LK26特异性抗体的多种多核苷酸，用于产生人源化LK26特异性抗体的表达载体和用于重组产生人源化抗体的宿主细胞。本发明还提供了使用人源化LK26特异性抗体检测癌细胞（体外和体内）的方法。另外，本发明提供使用LK26特异性抗体治疗癌症的方法。

5. 发明授权

US6090930A Recombinant human anti-FB5 antibodies 失效
标题翻译：重组人抗FB5抗体
公开(公告)号：US6090930A
公开(公告)日：2000-07-18
申请号：US013872
申请日：1998-01-27
申请人： Thomas Paul Wallace , Francis Carr , Wolfgang J. Rettig , Pilar Garin-Chesa , Lloyd J. Old
发明人： Thomas Paul Wallace , Francis Carr , Wolfgang J. Rettig , Pilar Garin-Chesa , Lloyd J. Old
IPC分类号： C07K16/30 , C12N15/13 , C07H21/04 , C12N1/20
CPC分类号： C07K16/30 , C07K2317/24 , C07K2319/00
摘要： The invention provides for the production of several humanized murine antibodies specific for the antigen FB5, which is recognized by the murine antibody FB5. The FB5 antigen is expressed on the luminal surface of vascular endothelial cells of a wide range of malignant tumors. The invention also provides for numerous polynucleotide encoding humanized FB5 specific antibodies, expression vectors for producing humanized FB5 specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized FB5 specific antibodies. Additionally, the invention provides methods of treating cancer using FB5 specific antibodies.
摘要翻译：本发明提供了针对抗原FB5特异的几种人源化鼠抗体的产生，其被鼠抗体FB5识别。 FB5抗原在广泛恶性肿瘤的血管内皮细胞的腔表面上表达。本发明还提供编码人源化FB5特异性抗体的许多多核苷酸，用于产生人源化FB5特异性抗体的表达载体和用于重组产生人源化抗体的宿主细胞。本发明还提供使用人源化FB5特异性抗体检测癌细胞（体外和体内）的方法。另外，本发明提供了使用FB5特异性抗体治疗癌症的方法。

6. 发明授权

US06217868B1 Methods for detecting cancer cells by using humanized antibodies which bind specifically to FB5 antigen 有权
标题翻译：通过使用特异性结合FB5抗原的人源化抗体检测癌细胞的方法
公开(公告)号：US06217868B1
公开(公告)日：2001-04-17
申请号：US09184198
申请日：1998-11-02
申请人： Thomas Paul Wallace , Francis Carr , Wolfgang J. Rettig , Pilar Garin-Chesa , Lloyd J. Old
发明人： Thomas Paul Wallace , Francis Carr , Wolfgang J. Rettig , Pilar Garin-Chesa , Lloyd J. Old
IPC分类号： A61K39395
CPC分类号： C07K16/30 , C07K2317/24 , C07K2319/00
摘要： The invention provides for the production of several humanized murine antibodies specific for the antigen FB5, which is recognized by the murine antibody FB5. The FB5 antigen is expressed on the luminal surface of vascular endothelial cells of a wide range of malignant tumors. The invention also provides for numerous polynucleotide encoding humanized FB5 specific antibodies, expression vectors for producing humanized FB5 specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized FB5 specific antibodies. Additionally, the invention provides methods of treating cancer using FB5 specific antibodies.
摘要翻译：本发明提供了针对抗原FB5特异的几种人源化鼠抗体的产生，其被鼠抗体FB5识别。 FB5抗原在广泛恶性肿瘤的血管内皮细胞的腔表面上表达。本发明还提供编码人源化FB5特异性抗体的许多多核苷酸，用于产生人源化FB5特异性抗体的表达载体和用于重组产生人源化抗体的宿主细胞。本发明还提供使用人源化FB5特异性抗体检测癌细胞（体外和体内）的方法。另外，本发明提供了使用FB5特异性抗体治疗癌症的方法。

7. 发明授权

US5811522A Recombinant humanized anti-FB5 antibodies 失效
标题翻译：重组人源化抗FB5抗体
公开(公告)号：US5811522A
公开(公告)日：1998-09-22
申请号：US657012
申请日：1996-05-20
申请人： Thomas Paul Wallace , Francis Carr , Wolfgang J. Rettig , Pilar Garin-Chesa , Lloyd J. Old
发明人： Thomas Paul Wallace , Francis Carr , Wolfgang J. Rettig , Pilar Garin-Chesa , Lloyd J. Old
IPC分类号： C07K16/30 , C12N15/13 , C07K16/46 , C07K14/00
CPC分类号： C07K16/30 , C07K2317/24 , C07K2319/00
摘要： The invention provides for the production of several humanized murine antibodies specific for the antigen FB5, which is recognized by the murine antibody FB5. The FB5 antigen is expressed on the luminal surface of vascular endothelial cells of a wide range of malignant tumours. The invention also provides for numerous polynucleotide encoding humanized FB5 specific antibodies, expression vectors for producing humanized FB5 specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized FB5 specific antibodies. Additionally, the invention provides methods of treating cancer using FB5 specific antibodies.
摘要翻译：本发明提供了针对抗原FB5特异的几种人源化鼠抗体的产生，其被鼠抗体FB5识别。 FB5抗原在广泛恶性肿瘤的血管内皮细胞的腔表面上表达。本发明还提供编码人源化FB5特异性抗体的许多多核苷酸，用于产生人源化FB5特异性抗体的表达载体和用于重组产生人源化抗体的宿主细胞。本发明还提供使用人源化FB5特异性抗体检测癌细胞（体外和体内）的方法。另外，本发明提供了使用FB5特异性抗体治疗癌症的方法。

8. 发明授权

US06391302B1 Method for treating cancers which present antigen FB5 with humanized antibodies 有权
标题翻译：用人源化抗体治疗呈现抗原FB5的癌症的方法
公开(公告)号：US06391302B1
公开(公告)日：2002-05-21
申请号：US09633653
申请日：2000-08-07
申请人： Thomas Paul Wallace , Francis Carr , Wolfgang J. Rettig , Pilar Garin-Chesa , Lloyd J. Old
发明人： Thomas Paul Wallace , Francis Carr , Wolfgang J. Rettig , Pilar Garin-Chesa , Lloyd J. Old
IPC分类号： A61K39395
CPC分类号： C07K16/30 , C07K2317/24 , C07K2319/00
摘要： The invention provides for the production of several humanized murine antibodies specific for the antigen FB5, which is recognized by the murine antibody FB5. The FB5 antigen is expressed on the luminal surface of vascular endothelial cells of a wide range of malignant tumours. The invention also provides for numerous polynucleotide encoding humanized FB5 specific antibodies, expression vectors for producing humanized FB5 specific antibodies, and host cells for the recombinant production of the humanized antibodies. The invention also provides methods for detecting cancerous cells (in vitro and in vivo) using humanized FB5 specific antibodies. Additionally, the invention provides methods of treating cancer using FB5 specific antibodies.
摘要翻译：本发明提供了针对抗原FB5特异的几种人源化鼠抗体的产生，其被鼠抗体FB5识别。 FB5抗原在广泛恶性肿瘤的血管内皮细胞的腔表面上表达。本发明还提供编码人源化FB5特异性抗体的许多多核苷酸，用于产生人源化FB5特异性抗体的表达载体和用于重组产生人源化抗体的宿主细胞。本发明还提供使用人源化FB5特异性抗体检测癌细胞（体外和体内）的方法。另外，本发明提供了使用FB5特异性抗体治疗癌症的方法。

9. 发明授权

US5342757A Monoclonal antibodies which specifically binds to endosialin, a 165 Kd glycoprotein found on tumor vascular endothelium, and uses thereof 失效
标题翻译：特异性结合内皮糖蛋白的单克隆抗体，在肿瘤血管内皮上发现的165Kd糖蛋白及其用途
公开(公告)号：US5342757A
公开(公告)日：1994-08-30
申请号：US976405
申请日：1992-11-13
申请人： Pilar Garin-Chesa , Wolfgang J. Rettig , Lloyd J. Old
发明人： Pilar Garin-Chesa , Wolfgang J. Rettig , Lloyd J. Old
IPC分类号： G01N33/53 , A61K9/127 , A61K38/00 , A61K39/00 , A61K39/395 , A61K45/00 , A61P35/00 , C07H21/04 , C07K14/47 , C07K16/30 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , G01N33/574 , C07K15/28
CPC分类号： C07K16/30 , A61K38/00 , Y10S530/857
摘要： The invention involves monoclonal antibodies which specifically bind to a cell surface antigen characteristic of tumor vascular endothelium. The antigen, referred to as endosialin, is a glycoprotein and has a molecular weight of about 165 kDa as determined by SDS-PAGE. The protein portion of the molecule has a molecular weight of about 95 kDa. Also disclosed are various uses of the monoclonal antibody and the antigen.
摘要翻译：本发明涉及特异性结合肿瘤血管内皮细胞表面抗原特征的单克隆抗体。被称为内皮唾液酸的抗原是糖蛋白，通过SDS-PAGE测定具有约165kDa的分子量。分子的蛋白质部分具有约95kDa的分子量。还公开了单克隆抗体和抗原的各种用途。

10. 发明授权

US5843448A Tumor rejection antigen precursor 失效
标题翻译：肿瘤排斥抗原前体
公开(公告)号：US5843448A
公开(公告)日：1998-12-01
申请号：US560024
申请日：1995-11-17
申请人： Yao-Tseng Chen , Elisabeth Stockert , Yachi Chen , Pilar Garin-Chesa , Wolfgang J. Rettig , Lloyd J. Old
发明人： Yao-Tseng Chen , Elisabeth Stockert , Yachi Chen , Pilar Garin-Chesa , Wolfgang J. Rettig , Lloyd J. Old
IPC分类号： C12N15/02 , A61K38/00 , A61K39/00 , A61K39/395 , A61P35/00 , C07H21/04 , C07K20060101 , C07K7/08 , C07K14/47 , C07K14/705 , C07K16/30 , C12N5/10 , C12N5/20 , C12P21/08 , C12R1/91 , G01N33/574 , A61K38/10 , C07K14/82
CPC分类号： C07K14/4748 , C07K16/30 , A61K38/00 , A61K39/00
摘要： The invention relates to monoclonal antibodies which specifically bind to the tumor rejection antigen precursor molecule MAGE-1, hybridomas which produce these monoclonal antibodies, and their use. Also described is a recombinant form of MAGE-1, peptides which are useful as immunogens, and immunogenic compositions containing the peptides and an adjuvant.
摘要翻译：本发明涉及与肿瘤排斥抗原前体分子MAGE-1特异性结合的单克隆抗体，产生这些单克隆抗体的杂交瘤及其应用。还描述了重组形式的MAGE-1，可用作免疫原的肽和含有肽和佐剂的免疫原性组合物。

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