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1. 发明授权

US06391869B1 Compositions and methods for the treatment of anorectal disorders 失效
公开(公告)号：US06391869B1
公开(公告)日：2002-05-21
申请号：US09595390
申请日：2000-06-14
申请人： Thomas P. Parks , Vivien Mak , Jung-Chung Lee , Charles Lee
发明人： Thomas P. Parks , Vivien Mak , Jung-Chung Lee , Charles Lee
IPC分类号： A61K3155
CPC分类号： A61K31/00 , A61K9/0031 , A61K9/02 , A61K31/137 , A61K31/4015 , A61K31/444 , A61K31/519 , A61K31/52 , A61K31/522 , A61K31/554 , A61K45/06 , A61K47/06 , A61K47/10 , A61K2300/00
摘要： Compositions and methods for the treatment of anorectal disorders are provided in which certain combinations of NO donors, PDE inhibitors, superoxide (O2−) scavengers, &bgr;-adrenergic agonists, cAMP-dependent protein kinase activators, &agr;1-adrenergic antagonists, L-type Ca2+ channel blockers, estrogens, ATP-sensitive K+ channel activators and smooth muscle relaxants are used.

2. 发明授权

US06627632B2 Compositions and methods for the treatment of anorectal disorders 失效
标题翻译：用于治疗肛门直肠疾病的组合物和方法
公开(公告)号：US06627632B2
公开(公告)日：2003-09-30
申请号：US09919590
申请日：2001-07-30
申请人： Thomas P. Parks , Vivien Mak , Jung-Chung Lee , Charles Lee
发明人： Thomas P. Parks , Vivien Mak , Jung-Chung Lee , Charles Lee
IPC分类号： A61K3150
CPC分类号： A61K9/0031 , A61K31/198 , A61K31/21 , A61K31/505 , A61K31/513 , A61K31/519 , A61K31/52 , A61K31/522
摘要： Compositions and methods for the treatment of anorectal disorders are provided in which certain combinations of NO donors, PDE inhibitors, superoxide (O2−) scavengers, &bgr;-adrenergic agonists, cAMP-dependent protein kinase activators, &agr;1-adrenergic antagonists, L-type Ca2+ channel blockers, estrogens, ATP-sensitive K+ channel activators and smooth muscle relaxants are used.
摘要翻译：提供了用于治疗肛门直肠疾病的组合物和方法，其中NO供体，PDE抑制剂，超氧化物（O 2 - ）清除剂，β-肾上腺素能激动剂，cAMP依赖性蛋白激酶激活剂，α1-肾上腺素能拮抗剂，类型的Ca 2+通道阻滞剂，雌激素，ATP敏感性K +通道激活剂和平滑肌松弛剂。

3. 发明授权

US06395736B1 Compositions and methods for the treatment of anorectal disorders 失效
标题翻译：用于治疗肛门直肠疾病的组合物和方法
公开(公告)号：US06395736B1
公开(公告)日：2002-05-28
申请号：US09460306
申请日：1999-12-13
申请人： Thomas P. Parks , Vivien Mak , Jung-Chung Lee , Charles Lee
发明人： Thomas P. Parks , Vivien Mak , Jung-Chung Lee , Charles Lee
IPC分类号： A61K3150
CPC分类号： A61K31/21 , A61K31/198 , A61K31/505 , A61K31/52
摘要： Compositions and methods for the treatment of anorectal disorders are provided in which certain combinations of NO donors, PDE inhibitors, superoxide (O2−) scavengers, &bgr;-adrenergic agonists, cAMP-dependent protein kinase activators, &agr;1-adrenergic antagonists, L-type Ca2+ channel blockers, estrogens, ATP-sensitive K+ channel activators and smooth muscle relaxants are used.
摘要翻译：提供了治疗肛门直肠疾病的组合物和方法，其中NO供体，PDE抑制剂，超氧化物（O 2 - ）清除剂，β-肾上腺素能激动剂，cAMP依赖性蛋白激酶激活剂，α1-肾上腺素能拮抗剂，L型Ca2 + 使用通道阻滞剂，雌激素，ATP敏感性K +通道激活剂和平滑肌松弛剂。

4. 发明申请

US20060198883A1 Compositions and methods for the treatment of anorectal disorders 审中-公开
标题翻译：用于治疗肛门直肠疾病的组合物和方法
公开(公告)号：US20060198883A1
公开(公告)日：2006-09-07
申请号：US11356724
申请日：2006-02-16
申请人： Thomas Parks , Vivien Mak , Jung-Chung Lee , Charles Lee
发明人： Thomas Parks , Vivien Mak , Jung-Chung Lee , Charles Lee
IPC分类号： A61K31/522 , A61K31/519 , A61K31/513 , A61K31/198 , A61K9/48 , A61K9/20 , A61K31/21
CPC分类号： A61K9/0031 , A61K31/198 , A61K31/21 , A61K31/505 , A61K31/513 , A61K31/519 , A61K31/52 , A61K31/522
摘要： Compositions and methods for the treatment of anorectal disorders are provided in which certain combinations of NO donors, PDE inhibitors, superoxide (O2−) scavengers, β-adrenergic agonists, cAMP-dependent protein kinase activators, α1-adrenergic antagonists, L-type Ca2+ channel blockers, estrogens, ATP-sensitive K+ channel activators and smooth muscle relaxants are used.
摘要翻译：提供了用于治疗肛门直肠疾病的组合物和方法，其中NO供体，PDE抑制剂，超氧化物（O 2 - / - ）清除剂，β-肾上腺素能激动剂，cAMP 依赖性蛋白激酶激活剂，α1 - 肾上腺素能拮抗剂，L型Ca 2+通道阻滞剂，雌激素，ATP敏感性K + 使用活化剂和平滑肌松弛剂。

5. 发明授权

US5554384A High dose formulations of mycophenolate mofetil and mycophenolic acid 失效
标题翻译：霉酚酸酯和麦考酚酸的高剂量配方
公开(公告)号：US5554384A
公开(公告)日：1996-09-10
申请号：US459227
申请日：1995-06-02
申请人： Glenn J. Samuels , Jung-Chung Lee , Charles Lee , Stephen Berry , Paul J. Jarosz
发明人： Glenn J. Samuels , Jung-Chung Lee , Charles Lee , Stephen Berry , Paul J. Jarosz
IPC分类号： A61K31/5377 , A61K9/48 , A61K31/365 , A61K31/495 , A61K31/535 , A61K47/26 , A61K47/38 , A61P37/06
CPC分类号： A61K31/365 , A61K31/495 , A61K31/535 , A61K9/4833
摘要： Mycophenolate mofetil and mycophenolic acid can be conveniently manufactured into high dose oral formulations by the hot melt filling of a supercooled mycophenolate mofetil or mycophenolic acid liquid into a pharmaceutical dosage form. High dose oral pharmaceutical formulations and manufacturing methods therefor are disclosed.
摘要翻译：通过将过冷霉菌霉素或霉酚酸液体热熔填充到药物剂型中，霉酚酸酯和霉酚酸可以方便地制成高剂量口服制剂。公开了高剂量口服药物制剂及其制备方法。

6. 发明授权

US5472707A High dose ranolazine formulations 失效
标题翻译：高剂量雷诺嗪制剂
公开(公告)号：US5472707A
公开(公告)日：1995-12-05
申请号：US239621
申请日：1994-05-09
申请人： Glenn J. Samuels , Jung-Chung Lee , Charles Lee , Stephen Berry , Paul J. Jarosz
发明人： Glenn J. Samuels , Jung-Chung Lee , Charles Lee , Stephen Berry , Paul J. Jarosz
IPC分类号： A61K31/5377 , A61K9/48 , A61K31/365 , A61K31/495 , A61K31/535 , A61K47/26 , A61K47/38 , A61P37/06 , C07D265/30 , C07D295/00
CPC分类号： A61K31/365 , A61K31/495 , A61K31/535 , A61K9/4833
摘要： Mycophenolate mofetil, mycophenolic acid, and ranolazine can be conveniently manufactured into high dose oral formulations by the hot melt filling of a supercooled mycophenolate mofetil, mycophenolic acid, or ranolazine liquid into a pharmaceutical dosage form. High dose oral pharmaceutical formulations and manufacturing methods therefor are disclosed.
摘要翻译：霉酚酸酯，麦考酚酸和雷诺嗪可以通过将过冷的霉酚酸酯，麦考酚酸或雷诺嗪液体热熔填充到药物剂型中，方便地制成高剂量口服制剂。公开了高剂量口服药物制剂及其制备方法。

7. 发明授权

US5455045A High dose formulations 失效
标题翻译：高剂量配方
公开(公告)号：US5455045A
公开(公告)日：1995-10-03
申请号：US61656
申请日：1993-05-13
申请人： Glenn J. Samuels , Jung-Chung Lee , Charles Lee , Stephen Berry , Paul J. Jarosz
发明人： Glenn J. Samuels , Jung-Chung Lee , Charles Lee , Stephen Berry , Paul J. Jarosz
IPC分类号： A61K31/5377 , A61K9/48 , A61K31/365 , A61K31/495 , A61K31/535 , A61K47/26 , A61K47/38 , A61P37/06
CPC分类号： A61K31/365 , A61K31/495 , A61K31/535 , A61K9/4833
摘要： Mycophenolate mofetil and mycophenolic acid can be conveniently manufactured into high dose oral formulations by the hot melt filling of a supercooled mycophenolate mofetil or mycophenolic acid liquid into a pharmaceutical dosage form. High dose oral pharmaceutical formulations and manufacturing methods therefor are disclosed.
摘要翻译：通过将过冷霉菌霉素或霉酚酸液体热熔填充到药物剂型中，霉酚酸酯和霉酚酸可以方便地制成高剂量口服制剂。公开了高剂量口服药物制剂及其制备方法。

8. 发明申请

US20070205975A1 TEST SYSTEM FOR TESTING A LIQUID CRYSTAL DISPLAY MODULE AND METHOD THEREOF 审中-公开
标题翻译：用于测试液晶显示模块的测试系统及其方法
公开(公告)号：US20070205975A1
公开(公告)日：2007-09-06
申请号：US11382713
申请日：2006-05-11
申请人： Jung-Chung Lee
发明人： Jung-Chung Lee
IPC分类号： G09G3/36
CPC分类号： G09G3/006 , G09G3/3611
摘要： A test system includes a parameter control platform including a control unit for generating a signal corresponding to control parameters of an LCD module, and a signal output interface coupled to the control unit for outputting the signal generated by the control unit. The test system further includes a system board including a signal input interface coupled to the signal output interface of the parameter control platform for receiving the signal generated by the control unit of the parameter control platform, a micro control unit coupled to the signal input interface for controlling the LCD module to display a corresponding frame according to the signal transmitted from the signal input interface, and a signal output interface coupled to the micro control unit for outputting a control signal generated by the micro control unit to the LCD module.
摘要翻译：测试系统包括参数控制平台，该参数控制平台包括用于产生对应于LCD模块的控制参数的信号的控制单元和耦合到控制单元的信号输出接口，用于输出由控制单元产生的信号。测试系统还包括系统板，其包括耦合到参数控制平台的信号输出接口的信号输入接口，用于接收由参数控制平台的控制单元产生的信号;耦合到信号输入接口的微控制单元控制LCD模块根据从信号输入接口发送的信号显示相应的帧;以及信号输出接口，耦合到微控制单元，用于将由微控制单元产生的控制信号输出到LCD模块。

9. 发明授权

US5035891A Controlled release subcutaneous implant 失效
标题翻译：控制释放皮下植入
公开(公告)号：US5035891A
公开(公告)日：1991-07-30
申请号：US398106
申请日：1989-08-24
申请人： Richard A. Runkel , Jung-Chung Lee
发明人： Richard A. Runkel , Jung-Chung Lee
IPC分类号： A61K9/00 , A61K9/16 , A61K31/565
CPC分类号： A61K9/0092 , A61K31/565 , A61K9/0004 , A61K9/0024 , A61K9/1617 , A61K9/1641
摘要： A sustained release, reservoir-type subcutaneous implant device for the sustained administration to a subject of a biologically active compound comprises:an effective amount of a biologically active compound;an amount of a solid hydrophilic polymer sufficient to cause swelling of the device by osmotic pressure after implantation;an effective amount of a solubilizing agent; anda sufficient amount of a non-porous rate-controlling membrane which completely encapsulates said biologically active compound, wherein said rate-controlling membrane is permeable to said biologically active compound, but is impermeable to said solubilizing agent. This device is particularly advantageous for the administration of growth promoting compounds to livestock.
摘要翻译：用于持续施用生物活性化合物受试者的持续释放的储库型皮下植入装置包括：有效量的生物活性化合物; 一定量的固体亲水性聚合物，足以在植入后通过渗透压使器件膨胀; 有效量的增溶剂; 以及足量的完全封装所述生物活性化合物的无孔速率控制膜，其中所述速率控制膜对所述生物活性化合物是可渗透的，但对所述增溶剂是不可渗透的。该装置对于向家畜施用生长促进化合物是特别有利的。

10. 发明授权

US6022554A Polymeric microporous film coated subcutaneous implant 失效
标题翻译：聚合微孔薄膜皮下植入
公开(公告)号：US6022554A
公开(公告)日：2000-02-08
申请号：US990367
申请日：1997-12-15
申请人： Jung-Chung Lee , Shamim Pushpala , Charles E. Lee
发明人： Jung-Chung Lee , Shamim Pushpala , Charles E. Lee
IPC分类号： A61K9/00 , A61K9/28 , A61K9/50 , A61F2/00 , A61F2/10
CPC分类号： A61K9/0024 , A61K9/2846 , A61K9/2853 , A61K9/5026 , A61K9/5031
摘要： This invention relates to coating formulations for coating sustained-release drug implants. The coating formulations are capable of formulations are capable of forming a porous film coat over a biologically active agent to provide a release of the active agent at a constant rate over a prolonged period of time. The pore forming agent is used in the formulation of the invention in the amount effective to regulate the release of a biologically active compound at a desired rate. Preferably, the effective amount of the pore forming agent provides long term delivery of the active agent. The invention also provides an improved implant for the sustained administration of a biologically active compound suitable for subcutaneous implantation. The invention also relates to methods for making and using the formulation and the implant of the invention.
摘要翻译：本发明涉及用于涂覆缓释药物植入物的涂层制剂。涂层制剂能够制备能够在生物活性剂上形成多孔膜涂层，以在长时间内以恒定速率提供活性剂的释放。成孔剂在本发明的制剂中以有效调节生物活性化合物以所需速率释放的量使用。优选地，成孔剂的有效量提供活性剂的长期输送。本发明还提供了用于持续施用适于皮下植入的生物活性化合物的改进植入物。本发明还涉及制备和使用本发明的制剂和植入物的方法。

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