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1. 发明授权

US5554384A High dose formulations of mycophenolate mofetil and mycophenolic acid 失效
标题翻译：霉酚酸酯和麦考酚酸的高剂量配方
公开(公告)号：US5554384A
公开(公告)日：1996-09-10
申请号：US459227
申请日：1995-06-02
申请人： Glenn J. Samuels , Jung-Chung Lee , Charles Lee , Stephen Berry , Paul J. Jarosz
发明人： Glenn J. Samuels , Jung-Chung Lee , Charles Lee , Stephen Berry , Paul J. Jarosz
IPC分类号： A61K31/5377 , A61K9/48 , A61K31/365 , A61K31/495 , A61K31/535 , A61K47/26 , A61K47/38 , A61P37/06
CPC分类号： A61K31/365 , A61K31/495 , A61K31/535 , A61K9/4833
摘要： Mycophenolate mofetil and mycophenolic acid can be conveniently manufactured into high dose oral formulations by the hot melt filling of a supercooled mycophenolate mofetil or mycophenolic acid liquid into a pharmaceutical dosage form. High dose oral pharmaceutical formulations and manufacturing methods therefor are disclosed.
摘要翻译：通过将过冷霉菌霉素或霉酚酸液体热熔填充到药物剂型中，霉酚酸酯和霉酚酸可以方便地制成高剂量口服制剂。公开了高剂量口服药物制剂及其制备方法。

2. 发明授权

US5455045A High dose formulations 失效
标题翻译：高剂量配方
公开(公告)号：US5455045A
公开(公告)日：1995-10-03
申请号：US61656
申请日：1993-05-13
申请人： Glenn J. Samuels , Jung-Chung Lee , Charles Lee , Stephen Berry , Paul J. Jarosz
发明人： Glenn J. Samuels , Jung-Chung Lee , Charles Lee , Stephen Berry , Paul J. Jarosz
IPC分类号： A61K31/5377 , A61K9/48 , A61K31/365 , A61K31/495 , A61K31/535 , A61K47/26 , A61K47/38 , A61P37/06
CPC分类号： A61K31/365 , A61K31/495 , A61K31/535 , A61K9/4833
摘要： Mycophenolate mofetil and mycophenolic acid can be conveniently manufactured into high dose oral formulations by the hot melt filling of a supercooled mycophenolate mofetil or mycophenolic acid liquid into a pharmaceutical dosage form. High dose oral pharmaceutical formulations and manufacturing methods therefor are disclosed.
摘要翻译：通过将过冷霉菌霉素或霉酚酸液体热熔填充到药物剂型中，霉酚酸酯和霉酚酸可以方便地制成高剂量口服制剂。公开了高剂量口服药物制剂及其制备方法。

3. 发明授权

US5472707A High dose ranolazine formulations 失效
标题翻译：高剂量雷诺嗪制剂
公开(公告)号：US5472707A
公开(公告)日：1995-12-05
申请号：US239621
申请日：1994-05-09
申请人： Glenn J. Samuels , Jung-Chung Lee , Charles Lee , Stephen Berry , Paul J. Jarosz
发明人： Glenn J. Samuels , Jung-Chung Lee , Charles Lee , Stephen Berry , Paul J. Jarosz
IPC分类号： A61K31/5377 , A61K9/48 , A61K31/365 , A61K31/495 , A61K31/535 , A61K47/26 , A61K47/38 , A61P37/06 , C07D265/30 , C07D295/00
CPC分类号： A61K31/365 , A61K31/495 , A61K31/535 , A61K9/4833
摘要： Mycophenolate mofetil, mycophenolic acid, and ranolazine can be conveniently manufactured into high dose oral formulations by the hot melt filling of a supercooled mycophenolate mofetil, mycophenolic acid, or ranolazine liquid into a pharmaceutical dosage form. High dose oral pharmaceutical formulations and manufacturing methods therefor are disclosed.
摘要翻译：霉酚酸酯，麦考酚酸和雷诺嗪可以通过将过冷的霉酚酸酯，麦考酚酸或雷诺嗪液体热熔填充到药物剂型中，方便地制成高剂量口服制剂。公开了高剂量口服药物制剂及其制备方法。

4. 发明申请

US20060216242A1 Suspending vehicles and pharmaceutical suspensions for drug dosage forms 审中-公开
标题翻译：悬挂车辆和药物悬浮液用于药物剂型
公开(公告)号：US20060216242A1
公开(公告)日：2006-09-28
申请号：US11342445
申请日：2006-01-30
申请人： Catherine Rohloff , Stephen Berry , Eric Weeks
发明人： Catherine Rohloff , Stephen Berry , Eric Weeks
IPC分类号： A61K48/00 , A61K38/28 , A61K38/31 , A61K38/30 , A61K38/21 , A61K38/20 , A61K38/19 , A61K38/18 , A61K38/22 , A61K38/17 , A61L9/04
CPC分类号： A61K9/0004 , A61K9/10 , A61K47/10 , A61K47/14 , A61K47/32
摘要： Suspending vehicles and pharmaceutical suspensions that include a biocompatible polymer that can be combined with a hydrophobic solvent and a hydrophilic solvent to provide vehicles and suspensions that are substantially free of stiff gels upon contact with an aqueous medium are provided. Vehicles and suspensions remain flowable out of a pump-driven dosage form over the life of the dosage form. Such vehicles and suspensions are also biocompatible, suitable for creating and maintaining drug suspensions, and capable of providing stable drug formulations.
摘要翻译：提供了悬浮车辆和药物悬浮液，其包括可与疏水性溶剂和亲水溶剂组合的生物相容性聚合物，以提供在与水性介质接触时基本上不含刚性凝胶的载体和悬浮液。车辆和悬浮液在剂型的使用寿命期间可以从泵驱动的剂型中流出。这样的载体和悬浮液也是生物相容的，适于产生和维持药物悬浮液，并且能够提供稳定的药物制剂。

5. 发明申请

US20050276856A1 Non-aqueous single phase vehicles and formulations utilizing such vehicles 失效
标题翻译：非水单相车辆和使用这种车辆的配方
公开(公告)号：US20050276856A1
公开(公告)日：2005-12-15
申请号：US11183477
申请日：2005-07-18
申请人： Pamela Fereira , Michael Desjardin , Catherine Rohloff , Stephen Berry , Ekaterina Zlatkova-Karaslavova
发明人： Pamela Fereira , Michael Desjardin , Catherine Rohloff , Stephen Berry , Ekaterina Zlatkova-Karaslavova
IPC分类号： A61K9/00 , A61K9/14 , A61K38/00 , A61K38/09 , A61K38/18 , A61K38/22 , A61K48/00
CPC分类号： A61K47/32 , A61K9/0004
摘要： The present invention is related to materials and methods for forming polymeric delivery vehicles that reduces risk of oxidative degradation of a carried drug and the resulting compositions.
摘要翻译：本发明涉及用于形成聚合物递送载体的材料和方法，其降低被携带药物和所得组合物的氧化降解的风险。

6. 发明申请

US20090087408A1 Stable, non-aqueous, single-phase gels and formulations thereof for delivery from an implantable device 审中-公开
标题翻译：稳定的非水性单相凝胶及其制剂用于从可植入装置输送
公开(公告)号：US20090087408A1
公开(公告)日：2009-04-02
申请号：US12315194
申请日：2008-11-26
申请人： Stephen Berry , Pamela Fereira , Gunjan Junnarkar , Michael Desjardin
发明人： Stephen Berry , Pamela Fereira , Gunjan Junnarkar , Michael Desjardin
IPC分类号： A61K38/00 , A61K38/21
CPC分类号： A61K9/0004 , A61K9/0024 , A61K47/26 , A61L24/001
摘要： The present invention provides a suspension vehicle and suspension formulations deliverable from an implantable delivery device. In particular, the suspension vehicle of the present invention allows the formulation of beneficial agent suspensions that are stable over time at ambient and physiological temperatures. In addition, the beneficial agent suspensions formed using the suspension vehicle of the present invention allow controlled delivery of beneficial agent from an implanted delivery device over sustained periods of time, even when such delivery occurs at low flow rates, through a small-diameter delivery channel. Also included in the present invention are implantable delivery devices.
摘要翻译：本发明提供了可从可植入递送装置递送的悬浮液和悬浮液制剂。特别地，本发明的悬浮载体允许制备在环境和生理温度下随时间稳定的有益试剂悬浮液。此外，使用本发明的悬浮载体形成的有益剂悬浮液允许从持久的时间段内从植入的输送装置控制递送有益剂，即使当这种递送以低流速通过小直径输送通道。本发明还包括可植入递送装置。

7. 发明申请

US20050010196A1 Osmotic delivery system and method for decreasing start-up times for osmotic delivery systems 审中-公开
标题翻译：渗透输送系统和减少渗透输送系统启动时间的方法
公开(公告)号：US20050010196A1
公开(公告)日：2005-01-13
申请号：US10815169
申请日：2004-03-31
申请人： Pamela Fereira , Scott Lautenbach , Stephen Berry
发明人： Pamela Fereira , Scott Lautenbach , Stephen Berry
IPC分类号： A61K9/00 , A61K9/20 , A61K9/22 , A61K31/00 , A61K47/10
CPC分类号： A61K9/2013 , A61K9/0004 , A61K9/2027 , A61K9/205 , A61K9/2054 , A61K31/00 , A61K47/10
摘要： The present invention includes devices and methods for reducing the start-up time of osmotically driven drug delivery systems capable of delivering a desired drug at a controlled rate over time. In particular, the present invention includes osmotic pumps that have a preloaded membrane, which includes a semipermeable material that has been preloaded with a nonaqueous, incompressible liquid filler that is miscible with water. The present invention further includes methods for making such osmotic pumps. The preloaded membranes included in the osmotic pumps according to the present invention have proven to provide significant decreases in average start-up times relative to osmotic pumps that include semipermeable membranes that are not preloaded.
摘要翻译：本发明包括用于减少能够以受控速率随时间输送所需药物的渗透驱动的药物递送系统的启动时间的装置和方法。特别地，本发明包括具有预加载膜的渗透泵，其包括预先装有与水混溶的非水不可压缩液体填料的半透性材料。本发明还包括制造这种渗透泵的方法。包括在根据本发明的渗透泵中的预加载膜已被证明相对于包括未预加载的半透膜的渗透泵的平均启动时间显着减少。

8. 发明申请

US20050008661A1 Non-aqueous single phase vehicles and formulations utilizing such vehicles 审中-公开
标题翻译：非水单相车辆和使用这种车辆的配方
公开(公告)号：US20050008661A1
公开(公告)日：2005-01-13
申请号：US10814826
申请日：2004-03-31
申请人： Pamela Fereira , Michael Desjardin , Catherine Rohloff , Stephen Berry
发明人： Pamela Fereira , Michael Desjardin , Catherine Rohloff , Stephen Berry
IPC分类号： A61K9/00 , A61K9/14 , A61K38/00 , A61K38/09 , A61K38/18 , A61K38/22 , A61K48/00
CPC分类号： A61K47/32 , A61K9/0004
摘要： The present invention includes materials and methods for providing vehicles useful for providing drug formulations that address the potential drawbacks of known nonaqueous formulations. In particular, the present invention includes nonaqueous vehicles that are formed using a combination of polymer and solvent that results in a vehicle that is miscible in water. The nonaqueous vehicles facilitate the formulation of drug formulations that are stable over time, even when stored at, or exposed to, elevated temperatures. Moreover, the miscible vehicles of the present invention allow the preparation of drug formulations that work to reduce the occurrence of partial or complete occlusions of the delivery conduits included in delivery devices used to administer the drug formulations.
摘要翻译：本发明包括用于提供可用于提供药物制剂的载体的材料和方法，其解决已知非水性制剂的潜在缺点。特别地，本发明包括使用聚合物和溶剂的组合形成的非水载体，其导致在水中可混溶的载体。非水性载体促进药物制剂的配制，其随着时间的推移是稳定的，即使在高温下储存或暴露于其中时也是如此。此外，本发明的可混溶的载体允许制备药物制剂，其用于减少包括在用于施用药物制剂的递送装置中的输送管道的部分或完全闭塞的发生。

9. 发明授权

US06421257B2 Power converter control loop 失效
标题翻译：电源转换器控制回路
公开(公告)号：US06421257B2
公开(公告)日：2002-07-16
申请号：US09780607
申请日：2001-02-12
申请人： Stephen John MacKay , Stephen Berry
发明人： Stephen John MacKay , Stephen Berry
IPC分类号： H02M112
CPC分类号： H02M3/156
摘要： An apparatus for and method of control of a switch (102) in an electrical power converter (100) using pulse width modulation to regulate output voltage (112) and current The method allows precise output voltage regulation to be achieved whilst accurately controlling the proportion of load-current supplied by multiple modules connected in parallel. A ramped waveform (408), consisting of a component representing the instantaneous current and a component representing the input voltage applied since the switch (102) switched on in the current PWM cycle, is compared with an error signal (406) to determine the width of each PWM pulse.
摘要翻译：一种使用脉冲宽度调制来调节输出电压（112）和电流的电力转换器（100）中的开关（102）的控制装置和方法。该方法允许精确的输出电压调节，同时精确地控制由并联连接的多个模块提供的负载电流。将表示瞬时电流的分量和表示在当前PWM周期中接通的开关（102）所施加的输入电压的分量的斜坡波形（408）与误差信号（406）进行比较，以确定宽度的每个PWM脉冲。

10. 发明申请

US20060246138A1 Polyoxaester suspending vehicles for use with implantable delivery systems 有权
标题翻译： Polyoxaester悬挂车辆与植入式输送系统一起使用
公开(公告)号：US20060246138A1
公开(公告)日：2006-11-02
申请号：US11374228
申请日：2006-03-13
申请人： Catherine Rohloff , Stephen Berry , Ling-Ling Kang , Aruna Nathan
发明人： Catherine Rohloff , Stephen Berry , Ling-Ling Kang , Aruna Nathan
IPC分类号： A61K38/21 , A61K31/519 , A61K38/19 , A61K38/22 , A61K38/18 , A61K48/00 , A61K9/22 , A61K9/14
CPC分类号： A61K9/0024 , A61K9/0004
摘要： Liquid polyoxaester polymer materials are provided as suspending vehicles suitable for dispensing of pharmaceutically active agents, such as proteins, from delivery devices, for example, pump-driven dosage forms. Polyoxaesters are made from at least one diacid and at least one diol. Through the use of polyoxaesters virtually solvent-free pharmaceutical suspensions can be created.
摘要翻译：液态聚氧乙烯聚合物材料被提供为适合于从递送装置例如泵驱动剂型分配药物活性剂如蛋白质的悬浮载体。多氧酯由至少一种二酸和至少一种二醇制成。通过使用聚氧乙烯醚，可以制成无溶剂的药物悬浮液。

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