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1. 发明授权

US08673644B2 Serum markers for type II diabetes mellitus 有权
标题翻译： II型糖尿病血清标志物
公开(公告)号：US08673644B2
公开(公告)日：2014-03-18
申请号：US12120043
申请日：2008-05-13
申请人： Thomas O. Metz , Wei-Jun Qian , Jon M. Jacobs , Ashoka D. Polpitiya , David G. Camp, II , Richard D. Smith
发明人： Thomas O. Metz , Wei-Jun Qian , Jon M. Jacobs , Ashoka D. Polpitiya , David G. Camp, II , Richard D. Smith
IPC分类号： G01N33/00 , G01N33/48
CPC分类号： G01N33/6893 , G01N2800/042
摘要： A method for identifying persons with increased risk of developing type 2 diabetes mellitus utilizing selected biomarkers described hereafter either alone or in combination. The present invention allows for broad based, reliable, screening of large population bases and provides other advantages, including the formulation of effective strategies for characterizing, archiving, and contrasting data from multiple sample types under varying conditions.
摘要翻译：一种利用以下描述的选择的生物标志物来单独或组合地鉴定发生2型糖尿病风险增加的人的方法。本发明允许广泛的，可靠的筛选大量人口基础，并提供其他优点，包括在不同条件下制定表征，归档和对比来自多种样品类型的数据的有效策略。

2. 发明申请

US20090286324A1 SERUM MARKERS FOR TYPE II DIABETES MELLITUS 有权
标题翻译： II型糖尿病血清标记物
公开(公告)号：US20090286324A1
公开(公告)日：2009-11-19
申请号：US12120043
申请日：2008-05-13
申请人： Thomas O. Metz , Wei-Jun Qian , Jon M. Jacobs , Ashoka D. Polpitiya , David G. Camp, II , Richard D. Smith
发明人： Thomas O. Metz , Wei-Jun Qian , Jon M. Jacobs , Ashoka D. Polpitiya , David G. Camp, II , Richard D. Smith
IPC分类号： G01N33/00
CPC分类号： G01N33/6893 , G01N2800/042
摘要： A method for identifying persons with increased risk of developing type 2 diabetes mellitus utilizing selected biomarkers described hereafter either alone or in combination. The present invention allows for broad based, reliable, screening of large population bases and provides other advantages, including the formulation of effective strategies for characterizing, archiving, and contrasting data from multiple sample types under varying conditions.
摘要翻译：一种利用以下描述的选择的生物标志物来单独或组合地鉴定发生2型糖尿病风险增加的人的方法。本发明允许广泛的，可靠的筛选大量人口基础，并提供其他优点，包括在不同条件下制定表征，归档和对比来自多种样品类型的数据的有效策略。

3. 发明申请

US20090117578A1 Method for identifying type I diabetes mellitus in humans 有权
标题翻译：用于鉴定人类I型糖尿病的方法
公开(公告)号：US20090117578A1
公开(公告)日：2009-05-07
申请号：US12291173
申请日：2008-11-05
申请人： Thomas O. Metz , Weijun Qian , Jon M. Jacobs , David G. Camp, II , Richard D. Smith
发明人： Thomas O. Metz , Weijun Qian , Jon M. Jacobs , David G. Camp, II , Richard D. Smith
IPC分类号： C12Q1/68
CPC分类号： G01N33/6893 , G01N2333/4728 , G01N2333/723 , G01N2333/775 , G01N2333/79 , G01N2800/042 , G01N2800/50
摘要： A method and system for classifying subject populations utilizing predictive and diagnostic biomarkers for type I diabetes mellitus. The method including determining the levels of a variety of markers within the serum or plasma of a target organism and correlating this level to general populations as a screen for predisposition or progressive monitoring of disease presence or predisposition.
摘要翻译：一种利用I型糖尿病预测和诊断生物标志物分类受试者群体的方法和系统。该方法包括确定目标生物体的血清或血浆内的各种标志物的水平，并将该水平与一般群体相关联作为疾病存在或倾向性的倾向或逐步监测的屏幕。

4. 发明授权

US07923253B2 Method for identifying type I diabetes mellitus in humans 有权
标题翻译：用于鉴定人类I型糖尿病的方法
公开(公告)号：US07923253B2
公开(公告)日：2011-04-12
申请号：US12291173
申请日：2008-11-05
申请人： Thomas O Metz , Weijun Qian , Jon M. Jacobs , David G. Camp, II , Richard D. Smith
发明人： Thomas O Metz , Weijun Qian , Jon M. Jacobs , David G. Camp, II , Richard D. Smith
IPC分类号： G01N33/48 , G01N33/68
CPC分类号： G01N33/6893 , G01N2333/4728 , G01N2333/723 , G01N2333/775 , G01N2333/79 , G01N2800/042 , G01N2800/50
摘要： A method and system for classifying subject populations utilizing predictive and diagnostic biomarkers for type I diabetes mellitus. The method including determining the levels of a variety of markers within the serum or plasma of a target organism and correlating this level to general populations as a screen for predisposition or progressive monitoring of disease presence or predisposition.
摘要翻译：一种利用I型糖尿病预测和诊断生物标志物分类受试者群体的方法和系统。该方法包括确定目标生物体的血清或血浆内的各种标志物的水平，并将该水平与一般群体相关联作为疾病存在或倾向性的倾向或逐步监测的屏幕。

5. 发明申请

US20150357174A1 ION FUNNEL DEVICE 有权
公开(公告)号：US20150357174A1
公开(公告)日：2015-12-10
申请号：US14733517
申请日：2015-06-08
申请人： Yehia M. Ibrahim , Tsung-Chi Chen , Marques B. Harrer , Keqi Tang , Richard D. Smith
发明人： Yehia M. Ibrahim , Tsung-Chi Chen , Marques B. Harrer , Keqi Tang , Richard D. Smith
IPC分类号： H01J49/06
CPC分类号： H01J49/066
摘要： An ion funnel device is disclosed. A first pair of electrodes is positioned in a first direction. A second pair of electrodes is positioned in a second direction. The device includes an RF voltage source and a DC voltage source. A RF voltage with a superimposed DC voltage gradient is applied to the first pair of electrodes, and a DC voltage gradient is applied to the second pair of electrodes.
摘要翻译：公开了一种离子漏斗装置。第一对电极位于第一方向。第二对电极位于第二方向。该器件包括一个RF电压源和一个直流电压源。将具有叠加的DC电压梯度的RF电压施加到第一对电极，并且将直流电压梯度施加到第二对电极。

6. 发明申请

US20130299690A1 METHOD FOR ENHANCING THE RESOLVING POWER OF ION MOBILITY SEPARATIONS OVER A LIMITED MOBILITY RANGE 有权
标题翻译：提高移动能力分离功能的方法，有限的移动范围
公开(公告)号：US20130299690A1
公开(公告)日：2013-11-14
申请号：US13861511
申请日：2013-04-12
申请人： Alexandre A. Shvartsburg , Keqi Tang , Richard D. Smith
发明人： Alexandre A. Shvartsburg , Keqi Tang , Richard D. Smith
IPC分类号： H01J49/00
CPC分类号： H01J49/0031 , G01N27/622
摘要： A method for raising the resolving power, specificity, and peak capacity of conventional ion mobility spectrometry is disclosed. Ions are separated in a dynamic electric field comprising an oscillatory field wave and opposing static field, or at least two counter propagating waves with different parameters (amplitude, profile, frequency, or speed). As the functional dependencies of mean drift velocity on the ion mobility in a wave and static field or in unequal waves differ, only single species is equilibrated while others drift in either direction and are mobility-separated. An ion mobility spectrum over a limited range is then acquired by measuring ion drift times through a fixed distance inside the gas-filled enclosure. The resolving power in the vicinity of equilibrium mobility substantially exceeds that for known traveling-wave or drift-tube IMS separations, with spectra over wider ranges obtainable by stitching multiple segments. The approach also enables low-cutoff, high-cutoff, and bandpass ion mobility filters.
摘要翻译：公开了提高常规离子迁移光谱法的分辨能力，特异性和峰值能力的方法。离子在包括振荡场波和相对静电场的动态电场中分离，或至少两个具有不同参数（幅度，分布，频率或速度）的反向传播波。由于平均漂移速度对波和静电场或不相等波的离子迁移率的功能依赖性不同，只有单个物质平衡，而其他物质在任一方向上漂移并且是迁移率分离的。然后通过在充满气体的外壳内的固定距离测量离子漂移时间来获得在有限范围内的离子迁移谱。在平衡迁移附近的分辨能力基本上超过已知的行波或漂移管IMS分离的分辨能力，其中可以通过缝合多个段获得更宽范围的光谱。该方法还可实现低截止，高截止和带通离子迁移率滤波器。

7. 发明授权

US08454093B2 Mesh chair with open-end hoop 有权
标题翻译：网椅带开口箍
公开(公告)号：US08454093B2
公开(公告)日：2013-06-04
申请号：US12748823
申请日：2010-03-29
申请人： Richard D. Smith
发明人： Richard D. Smith
IPC分类号： A47C7/00
CPC分类号： A47C3/04 , A47C4/28 , A47C4/48 , A47C7/282
摘要： A folding or stacking chair has a seat and a backrest carried between opposite frame sides each with a backrest support, a front leg and a rear leg. One or both of the seat and the backrest has a continuous sheet of flexible and elastic knitted mesh or patterned open texture plastic held across and substantially covering an opening in an open-end hoop coupled between the frame sides. An open-end of the hoop faces in a front or a back orientation for the seat, or a top or a bottom orientation for the backrest, with sides of the hoop attached to the frame sides. The sheet of mesh or textured plastic has a finished edge spanning the open-end of the hoop.
摘要翻译：折叠或折叠椅子具有座椅和靠背，其在相对的框架侧面之间承载，每个座椅具有靠背支撑件，前腿部和后腿部。座椅和靠背中的一个或两个具有柔性和弹性的针织网或图案化的开放纹理塑料的连续片，该织物保持横跨并且基本上覆盖耦合在框架侧之间的开口箍中的开口。箍的开口端面朝向座椅的前方或后方，或用于靠背的顶部或底部方向，箍的侧面连接到框架侧。网状或纹理化的塑料片具有跨越箍的开口端的成品边缘。

8. 发明授权

US08038221B2 Folding mesh chair with nesting hoops 有权
标题翻译：折叠网椅与嵌套箍
公开(公告)号：US08038221B2
公开(公告)日：2011-10-18
申请号：US12422821
申请日：2009-04-13
申请人： Richard D. Smith , Orrin C. Farnsworth
发明人： Richard D. Smith , Orrin C. Farnsworth
IPC分类号： A47C7/00
CPC分类号： A47C4/44 , A47C3/04 , A47C4/28 , A47C4/38 , A47C5/06 , A47C7/002 , A47C7/282
摘要： A folding mesh chair includes a seat and a backrest carried between opposite frame sides. The chair has an unfolded seating position in which the seat pivots to extend from the frame sides and bottoms of front and rear legs move apart, and a folded position in which the seat pivots toward the frame sides and the front and rear legs move together. One or both of the seat and the backrest have a continuous sheet of flexible and elastic mesh or patterned open texture plastic held across and substantially covering an opening in an all-plastic hoop fixed between the frame sides. The hoop includes inner and outer plastic mating hoops with the mesh extending over an outer perimeter of the inner hoop and into an interface between the inner and outer hoops.
摘要翻译：折叠网椅包括座位和靠在相对的框架侧之间的靠背。椅子具有展开的就座位置，其中座椅从框架侧面枢转并从前腿和后腿的底部移开，折叠位置，座位朝向框架侧摆动，前后腿一起移动。座椅和靠背中的一个或两个具有连续的柔性和弹性网格片或图案化的开放纹理塑料，其保持横跨并且基本上覆盖固定在框架侧之间的全塑性环箍中的开口。箍包括内部和外部塑料配合箍，其中网状物在内箍的外周延伸并且进入内圈和外箍之间的界面。

9. 发明申请

US20100207022A1 PLATFORM FOR FIELD ASYMMETRIC WAVEFORM ION MOBILITY SPECTROMETRY WITH ION PROPULSION MODES EMPLOYING GAS FLOW AND ELECTRIC FIELD 有权
标题翻译：用于采用气体流动和电场的离子推进模式的场非对称波形离子移动光谱的平台
公开(公告)号：US20100207022A1
公开(公告)日：2010-08-19
申请号：US12690818
申请日：2010-01-20
申请人： Keqi Tang , Alexandre A. Shvartsburg , Richard D. Smith
发明人： Keqi Tang , Alexandre A. Shvartsburg , Richard D. Smith
IPC分类号： H01J49/04 , H01J49/26 , H01J49/02
CPC分类号： G01N27/624
摘要： A differential ion mobility spectrometry or field asymmetric waveform ion mobility spectrometry (FAIMS) platform is disclosed that utilizes both gas flow and electric field, consecutively or simultaneously, to move ions through the analytical gap. The consecutive combination of flow and field enables rapid and flexible switching of the FAIMS stage “on” (for ion separation) and “off” (for high non-selective transmission) with no hardware modifications. This capability is needed for effective use of multidimensional instrument systems that couple FAIMS to mass spectrometry and/or conventional ion mobility spectrometry. The joint application of flow and field allows controlling the discrimination against high-mobility ions, maximizing it to remove the chemical noise or minimizing it to make the analyses of complex samples more predictable and uniform.
摘要翻译：公开了差分离子迁移谱或场非对称波形离子迁移谱（FAIMS）平台，其利用气流和电场连续或同时地将离子移动通过分析间隙。流程和现场的连续组合使得无需硬件修改即可快速灵活地切换FAIMS阶段（离子分离）和“关闭”（用于高非选择性传输）。需要这种能力来有效利用将FAIMS耦合到质谱和/或常规离子迁移谱的多维仪器系统。流量和场的联合应用允许控制对高迁移率离子的鉴别，使其最大化以消除化学噪声或使其最小化，使得复杂样品的分析更可预测和均匀。

10. 发明申请

US20100156148A1 MESH FOLDING CHAIR 有权
标题翻译： MESH折叠椅
公开(公告)号：US20100156148A1
公开(公告)日：2010-06-24
申请号：US12422792
申请日：2009-04-13
申请人： Richard D. Smith , Orrin C. Farnsworth
发明人： Richard D. Smith , Orrin C. Farnsworth
IPC分类号： A47C4/28
CPC分类号： A47C4/44 , A47C3/04 , A47C4/28 , A47C4/38 , A47C5/06 , A47C7/002 , A47C7/282
摘要： A folding mesh chair includes a seat and a backrest carried between opposite frame sides. The chair has an unfolded seating position in which the seat pivots to extend from the frame sides and bottoms of front and rear legs move apart, and a folded position in which the seat pivots toward the frame sides and the front and rear legs move together. One or both of the seat and the backrest have a continuous sheet of flexible and elastic mesh or patterned open texture plastic held across and substantially covering an opening in an all-plastic hoop fixed between the frame sides.
摘要翻译：折叠网椅包括座位和靠在相对的框架侧之间的靠背。椅子具有展开的就座位置，其中座椅枢转以从框架侧面延伸，前后腿的底部移动分开，并且座椅朝向框架侧部枢转并且前后腿部一起移动的折叠位置。座椅和靠背中的一个或两个具有连续的柔性和弹性网格片或图案化的开放纹理塑料，其保持横跨并且基本上覆盖固定在框架侧之间的全塑性环箍中的开口。

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