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1. 发明授权

US07972350B2 Catheter tip 有权
标题翻译：导管尖
公开(公告)号：US07972350B2
公开(公告)日：2011-07-05
申请号：US10767675
申请日：2004-01-29
申请人： Thomas McHale , Jan Weber
发明人： Thomas McHale , Jan Weber
IPC分类号： A61M25/10
CPC分类号： A61M25/0068 , A61F2/958 , A61F2002/9583 , A61F2250/0098 , A61M25/001 , A61M25/0052 , A61M25/0054 , A61M25/0069 , A61M25/008 , A61M25/0108 , A61M25/0127 , A61M25/1027 , A61M2025/1079 , A61M2025/1093 , A61M2205/32
摘要： A catheter tip may be coupled to a catheter shaft. The catheter tip may include markers, such as radiopaque markers and MRI markers, securement hubs, recessed portions, a radiused tip, and varying axial flexibility. The catheter tip may be a molded tip, and the markers may be insert molded. Recessed portions and raised securement hubs may be formed during the molding process. The raised hubs may be integrally formed and made from the same material as the catheter tip.
摘要翻译：导管尖端可以联接到导管轴。导管尖端可以包括标记，例如不透射线标记和MRI标记，固定轮毂，凹陷部分，圆角末端和变化的轴向柔性。导管尖端可以是模制尖端，并且标记可以是嵌入模制的。嵌入部分和凸起的固定轮毂可以在模制过程中形成。凸起的轮毂可以由与导管尖端相同的材料一体地形成并制成。

2. 发明授权

US09220818B2 Medical devices having inorganic barrier coatings 有权
标题翻译：具有无机屏障涂层的医疗器械
公开(公告)号：US09220818B2
公开(公告)日：2015-12-29
申请号：US12501671
申请日：2009-07-13
申请人： Torsten Scheuermann , Michael Kuehling , Jan Weber , Dominique Seidel
发明人： Torsten Scheuermann , Michael Kuehling , Jan Weber , Dominique Seidel
IPC分类号： A61F2/82 , A61K9/22 , A61L27/34 , A61L31/16 , A61L31/08 , A61L31/14
CPC分类号： A61L31/16 , A61L31/082 , A61L31/146 , A61L2300/608 , A61L2420/08
摘要： Medical devices having a barrier layer comprising an inorganic material. The medical device has a reservoir containing a therapeutic agent and the barrier layer is disposed over the reservoir. In one aspect, the barrier layer has one permeability to the therapeutic agent at one portion of the medical device and a different permeability at another portion of the medical device. In another aspect, the dosage amount of the therapeutic agent in the reservoir at one portion of the medical device is different from the dosage amount of the therapeutic agent in the reservoir at another portion of the medical device. In another aspect, a bioresorbable layer is disposed over the barrier layer at one or more portions of the medical device, wherein the bioresorbable layer comprises a bioresorbable material. Also, methods of coating a medical device are disclosed, in which a barrier layer over a medical device is formed using a lithographic etching process where a plurality of particles serve as an etch mask.
摘要翻译：具有包含无机材料的阻挡层的医疗装置。医疗装置具有含有治疗剂的储液器，并且阻挡层设置在贮存器的上方。在一个方面，阻挡层在医疗装置的一部分处具有对治疗剂的一种渗透性，并且在医疗装置的另一部分具有不同的渗透性。另一方面，医疗器械的一部分处的储存器中的治疗剂的剂量与医疗器械的另一部分处的储存器中的治疗剂的剂量不同。在另一方面，生物可再吸收层设置在医疗装置的一个或多个部分的阻挡层之上，其中生物可再吸收层包括生物可再吸收材料。此外，公开了涂覆医疗装置的方法，其中使用光刻蚀刻工艺形成医疗装置上的阻挡层，其中多个颗粒用作蚀刻掩模。

3. 发明授权

US09186209B2 Nerve modulation system having helical guide 有权
标题翻译：神经调制系统具有螺旋引导
公开(公告)号：US09186209B2
公开(公告)日：2015-11-17
申请号：US13554459
申请日：2012-07-20
申请人： Jan Weber , Aiden Flanagan , Tim O'Connor
发明人： Jan Weber , Aiden Flanagan , Tim O'Connor
IPC分类号： A61B18/14 , A61N1/05 , A61B18/00
CPC分类号： A61N1/0551 , A61B2018/00511 , A61B2018/00577 , F04C2270/0421
摘要： Systems for nerve modulation and methods for making and using the same are disclosed. An example system for nerve modulation may include a first elongate element having a distal end and a proximal end and having a helical guide having a proximal end and a distal end. The system may also include a second elongate element having a distal end and a proximal end and having a nerve modulation element proximate the distal end. A sheath may be disposed about both the first and second elongate elements. Pulling proximally on the proximal end of the first elongate element may cause simultaneous radial and longitudinal displacement of the nerve modulation element.
摘要翻译：公开了神经调制系统及其制造和使用方法。用于神经调节的示例性系统可以包括具有远端和近端的具有近端和远端的螺旋引导件的第一细长元件。该系统还可以包括具有远端和近端并且具有靠近远端的神经调制元件的第二细长元件。鞘可围绕第一和第二细长元件设置。在第一细长元件的近端上向近侧拉动可引起神经调制元件的同时径向和纵向位移。

4. 发明授权

US09078777B2 Stent with non-round cross-section in an unexpanded state 有权
标题翻译：支架具有非膨胀状态的非圆形横截面
公开(公告)号：US09078777B2
公开(公告)日：2015-07-14
申请号：US12170222
申请日：2008-07-09
申请人： Jan Weber
发明人： Jan Weber
IPC分类号： A61F2/06 , A61F2/915 , A61F2/91 , A61F2/90 , A61F2/844 , A61F2/95
CPC分类号： A61F2/89 , A61F2/844 , A61F2/90 , A61F2/91 , A61F2/915 , A61F2/95 , A61F2002/91508 , A61F2002/91516 , A61F2002/9155 , A61F2002/91558 , A61F2002/91575 , A61F2002/91583 , A61F2210/0004 , A61F2210/0014 , A61F2230/0002 , A61F2230/0006 , A61F2230/0008 , A61F2230/001 , A61F2230/0013 , A61F2230/0015 , A61F2230/0034 , A61F2230/0045 , A61F2230/0069 , A61F2250/001 , A61F2250/0039 , A61F2250/0048 , A61F2250/0067 , A61F2250/0098 , A61F2310/00017 , A61F2310/00041 , A61F2310/00083 , A61F2310/00389
摘要： A stent has a circumference and a plurality of members that define a lumen. The stent has three stable states, which include an unexpanded state, a partially deployed state, and a deployed state. The lumen has a first cross-sectional shape in the unexpanded state, a second cross-sectional shape in the partially deployed state and a third cross-sectional shape in the deployed state. The first cross-sectional shape of the lumen is different from the second and third cross-sectional shapes of the lumen, and the first cross-sectional shape of the lumen is a non-round shaped cross-sectional shape.
摘要翻译：支架具有限定内腔的圆周和多个构件。支架具有三个稳定状态，包括未展开状态，部分部署状态和部署状态。内腔在未展开状态下具有第一横截面形状，处于部分展开状态的第二横截面形状和处于展开状态的第三横截面形状。内腔的第一截面形状不同于内腔的第二和第三横截面形状，并且内腔的第一截面形状是非圆形横截面形状。

5. 发明授权

US08864816B2 Implantable medical devices incorporating x-ray mirrors 有权
标题翻译：可植入的医疗设备，包含x射线镜
公开(公告)号：US08864816B2
公开(公告)日：2014-10-21
申请号：US13419864
申请日：2012-03-14
申请人： Jan Weber , Aiden Flanagan
发明人： Jan Weber , Aiden Flanagan
IPC分类号： A61F2/06 , A61L27/10 , A61L29/18 , A61L31/02 , A61L27/04 , A61L31/18 , G21K1/06 , A61F2/915
CPC分类号： A61L31/18 , A61F2/915 , A61F2002/91575 , A61F2230/0054 , A61L27/04 , A61L27/10 , A61L29/18 , A61L31/022 , A61L31/026 , B82Y10/00 , G21K1/062
摘要： An implantable medical device includes a radiolucent member provided with an x-ray mirror that reflects incident x-ray radiation to enable visualization of the device. The x-ray mirror includes a multilayer nanolaminate having alternating layers of a first metal or ceramic layer deposited by atomic layer deposition having a first refractive index, and a second metal or ceramic layer deposited by atomic layer deposition having a second refractive index that is different from the first refractive index. The nanolaminate includes a total of at least four layers.
摘要翻译：可植入医疗装置包括设置有x射线反射镜的射线可透射部件，该X射线反射镜反射入射的X射线辐射以使装置可视化。 x射线镜包括具有通过具有第一折射率的原子层沉积沉积的第一金属或陶瓷层的交替层的多层纳米材料，以及通过原子层沉积而沉积的第二金属或陶瓷层，其具有不同的第二折射率从第一折射率。纳米层压材料总共包括至少四层。

6. 发明授权

US08852146B2 Reinforced medical balloon 有权
标题翻译：加强医疗气球
公开(公告)号：US08852146B2
公开(公告)日：2014-10-07
申请号：US13285518
申请日：2011-10-31
申请人： Daniel J. Horn , John Jianhua Chen , Jan Weber , Thomas J. Holman
发明人： Daniel J. Horn , John Jianhua Chen , Jan Weber , Thomas J. Holman
IPC分类号： A61M25/10 , A61L29/12 , A61F2/958
CPC分类号： A61M25/104 , A61F2002/9583 , A61F2250/0068 , A61L29/126 , A61M2025/1086
摘要： The invention relates to medical balloons, and methods of modifying said balloons by forming a void pattern in their exterior surfaces and filling the voids with a material, such as a fiber or a nanomaterial (e.g., nanotubes, such as carbon nanotubes) and a matrix material, e.g., a polymer.
摘要翻译：本发明涉及医用气囊，以及通过在其外表面上形成空隙图案并用诸如纤维或纳米材料（例如纳米管，例如碳纳米管）和基体材料，例如聚合物。

7. 发明授权

US08747529B2 Device for drying a medium flow 有权
标题翻译：用于干燥介质流的装置
公开(公告)号：US08747529B2
公开(公告)日：2014-06-10
申请号：US13261263
申请日：2010-10-01
申请人： Volker Backes , Achim Pfeiffer , Jan Weber
发明人： Volker Backes , Achim Pfeiffer , Jan Weber
IPC分类号： B01D53/02
CPC分类号： B01D53/261 , B01D2253/104 , B01D2253/106 , B01D2253/108 , B01D2259/4148 , B01J20/103 , B01J20/18 , B01J20/28052 , B01J2220/42
摘要： A device for drying medium flow (8), in particular an air flow, includes a device housing (2), in which at least first and second drying agents (4, 6) are received. The first and second drying agents have a high moisture absorption capacity in the case of low and high moisture values of the medium flow (8), respectively. The amount of the respective drying agent (4, 6) can be selectively set depending on the actual moisture present in the medium flow (8).
摘要翻译：用于干燥介质流（8），特别是空气流的装置包括装置壳体（2），其中至少接收第一和第二干燥剂（4,6）。第一和第二干燥剂分别在中等流量（8）的低和高水分值的情况下具有高的吸湿能力。可以根据存在于介质流（8）中的实际水分来选择性地设定各干燥剂（4,6）的量。

8. 发明授权

US08703168B2 Medical devices for releasing therapeutic agent and methods of making the same 有权
标题翻译：用于释放治疗剂的医疗装置及其制造方法
公开(公告)号：US08703168B2
公开(公告)日：2014-04-22
申请号：US12109677
申请日：2008-04-25
申请人： Aiden Flanagan , Robert Herrmann , Ken Merdan , Michael Kuehling , Barry O'Brien , Rajesh Radhakishnan , Torsten Scheuermann , Scott Schewe , Anurag Singhal , Young-Ho Song , Mary Joe Timm , Jan Weber , Yixin Xu
发明人： Aiden Flanagan , Robert Herrmann , Ken Merdan , Michael Kuehling , Barry O'Brien , Rajesh Radhakishnan , Torsten Scheuermann , Scott Schewe , Anurag Singhal , Young-Ho Song , Mary Joe Timm , Jan Weber , Yixin Xu
IPC分类号： A61F2/00
CPC分类号： A61F2/91 , A61F2/3094 , A61F2002/30677 , A61F2002/3068 , A61F2210/0076 , A61F2230/0013 , A61F2240/001 , A61F2250/0067 , A61F2250/0068
摘要： An implantable medical device for releasing therapeutic agent having a medical device body and a plurality of reservoir-defining structures disposed on a surface of the body. A reservoir can be defined by the reservoir-defining structures and therapeutic agent may be located in the reservoir. A cover may extend over the reservoir so that the therapeutic agent is released from the reservoir when the medical device implanted. Methods for making the medical device may also include providing a medical device body, positioning a plurality of reservoir-defining structures on a surface of the body to form a reservoir, loading therapeutic agent into the reservoir, and covering the reservoir so that the therapeutic agent may release when the medical device is implanted. Alternatively, the reservoir may be covered with a cover and an opening formed in the cover so that the therapeutic agent may release when the medical device is implanted.
摘要翻译：一种用于释放具有医疗装置主体的治疗剂的可植入医疗装置和设置在身体表面上的多个储存器限定结构。储存器可以由储存器限定结构限定，并且治疗剂可以位于储存器中。覆盖物可以延伸到储存器上方，使得当植入医疗装置时治疗剂从储存器释放。用于制造医疗装置的方法还可以包括提供医疗装置主体，在身体的表面上定位多个储存器限定结构以形成储存器，将治疗剂装载到储存器中并覆盖储存器，使得治疗剂当植入医疗器械时可能释放。或者，储存器可覆盖有形成在盖中的盖和开口，使得治疗剂可以在植入医疗装置时释放。

9. 发明授权

US08620406B2 Medical devices visible by magnetic resonance imaging 有权
标题翻译：磁共振成像可见的医疗器械
公开(公告)号：US08620406B2
公开(公告)日：2013-12-31
申请号：US10763690
申请日：2004-01-23
申请人： Scott R. Smith , Steven E. Walak , Lixiao Wang , Jan Weber , Sheng-Ping Zhong
发明人： Scott R. Smith , Steven E. Walak , Lixiao Wang , Jan Weber , Sheng-Ping Zhong
IPC分类号： A61B5/05
CPC分类号： G01R33/285 , A61B2090/3954 , A61M25/0043 , A61M25/0127 , G01R33/286
摘要： Medical devices that are visible by magnetic resonance imaging (MRI), and optionally, other imaging techniques, are described. In some embodiments, a medical device adapted for insertion into the body includes an elongated shaft and an electrically conductive path extending spirally about a portion of the shaft. The conductive path is capable of being connected to a current source. The medical device can further include one or more contrast agents (such as MRI contrast agents, radiopaque materials, and/or ultrasound visible materials), which can be arranged in a predetermined manner.
摘要翻译：描述了通过磁共振成像（MRI）可视的医疗装置，以及可选的其他成像技术。在一些实施例中，适于插入到本体中的医疗装置包括细长轴和围绕轴的一部分螺旋地延伸的导电路径。导电路径能够连接到电流源。医疗装置还可以包括一种或多种可以以预定方式布置的造影剂（例如MRI造影剂，不透射线材料和/或超声可见材料）。

10. 发明授权

US08586072B2 Medical devices having coatings for controlled therapeutic agent delivery 有权
公开(公告)号：US08586072B2
公开(公告)日：2013-11-19
申请号：US11983796
申请日：2007-11-09
申请人： Jan Weber , Aiden Flanagan , Tim O'Connor , Barry J. O'Brien , John Clarke , David McMorrow
发明人： Jan Weber , Aiden Flanagan , Tim O'Connor , Barry J. O'Brien , John Clarke , David McMorrow
IPC分类号： A61F2/00 , A61L27/30 , A61L31/16 , A61N1/05
CPC分类号： A61F2/06 , A61F2250/0068 , A61L27/30 , A61L27/54 , A61L31/082 , A61L31/16 , A61L2300/00 , A61L2400/12 , A61N1/05
摘要： According to an aspect of the invention, medical devices are provided, which include a nanoparticle-derived inorganic layer disposed over a least a portion of structure that includes a substrate, and optionally, a therapeutic-agent-containing layer disposed over at least a portion of the substrate. In some embodiments, the inorganic layer is a nanoporous inorganic layer. Other aspects of the invention comprise methods for forming such medical device.

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