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1. 发明授权

US09498563B2 Medical articles having therapeutic-agent-containing regions formed from coalesced polymer particles 有权
标题翻译：具有由聚结聚合物颗粒形成的含治疗剂的区域的医疗制品
公开(公告)号：US09498563B2
公开(公告)日：2016-11-22
申请号：US10830950
申请日：2004-04-23
申请人： Marlene C. Schwarz , Robert E. Richard , Sheng-Ping Zhong
发明人： Marlene C. Schwarz , Robert E. Richard , Sheng-Ping Zhong
IPC分类号： A61F2/82 , A61L29/16 , A61L27/34 , A61L27/54 , A61L29/08 , A61L31/10 , A61L31/16
CPC分类号： A61L29/16 , A61F2250/0067 , A61L27/34 , A61L27/54 , A61L29/085 , A61L31/10 , A61L31/16 , A61L2300/606
摘要： Medical articles, such as drug-releasing patches or implantable or insertable medical devices, which are made up of a medical article substrate and a therapeutic-agent-containing region. The therapeutic-agent-containing region is made up of (i) a water-dispersible therapeutic agent and (ii) coalesced polymer particles supplied by an aqueous dispersion. Also described are methods of forming such medical articles, and methods of releasing a therapeutic agent within a patient using such medical articles.
摘要翻译：医疗制品，例如药物释放贴剂或可植入或可插入的医疗装置，其由医用制品基底和含治疗剂的区域构成。含有治疗剂的区域由（i）水分散性治疗剂和（ii）由水分散体供给的聚结聚合物颗粒组成。还描述了形成这种医疗制品的方法，以及使用这种医疗用品在患者体内释放治疗剂的方法。

2. 发明授权

US08263103B2 Medical articles containing biodegradable polymers and acid-neutralizing cationic species 有权
标题翻译：含有可生物降解聚合物和酸中和阳离子物质的医药制品
公开(公告)号：US08263103B2
公开(公告)日：2012-09-11
申请号：US11343628
申请日：2006-01-31
申请人： Sheng-Ping Zhong
发明人： Sheng-Ping Zhong
IPC分类号： A61F2/00
CPC分类号： A61L31/148 , A61L31/041 , A61L31/06 , A61L31/10 , A61L31/16 , A61L2300/80 , C08L101/005 , C08L79/02 , C08L77/12 , C08L75/06 , C08L67/04
摘要： According to an aspect of the present invention, medical articles are provided, which are at least partially biodegradable. The medical articles comprise (a) biodegradable polymers that produce acidic molecules upon degradation; and (b) acid neutralizing cationic species.
摘要翻译：根据本发明的一个方面，提供了至少部分可生物降解的医疗制品。医疗制品包括（a）降解时产生酸性分子的可生物降解的聚合物; 和（b）酸中和阳离子物质。

3. 发明授权

US07906125B2 Solid or semi-solid therapeutic formulations 失效
标题翻译：固体或半固体治疗剂型
公开(公告)号：US07906125B2
公开(公告)日：2011-03-15
申请号：US10664601
申请日：2003-09-18
申请人： Weenna Bucay-Couto , Sheng-Ping Zhong , Arthur Madenjian , Enxin Ma , Barry N. Gellman
发明人： Weenna Bucay-Couto , Sheng-Ping Zhong , Arthur Madenjian , Enxin Ma , Barry N. Gellman
IPC分类号： A61K9/00 , A01N63/00
CPC分类号： A61K9/0024 , A61K9/0034 , A61K9/0092 , A61K9/1652 , A61K9/204 , A61K9/205 , A61K9/2054 , A61K45/06
摘要： An injectable or insertable dosage form comprising a biodisintegrable binder and an ablation agent in a concentration effective to cause tissue necrosis. The injectable dosage form is a solid or semi-solid dosage form. Due to the solid or semi-solid nature of the dosage form, retention at the site of injection or insertion is improved, thereby improving delivery efficiency of the ablation agents within the dosage form and/or reducing the nonspecific tissue damage associated with the dosage form.
摘要翻译：一种可注射或可插入的剂型，其包含生物可分解的粘合剂和消融剂，其浓度有效地引起组织坏死。可注射剂型是固体或半固体剂型。由于剂型的固体或半固体性质，提高注射或插入部位的保留性，从而提高剂型内消融剂的输送效率和/或减少与剂型相关的非特异性组织损伤。

4. 发明申请

US20070167735A1 Implantable or insertable medical devices visible under magnetic resonance imaging 有权
标题翻译：可植入或可插入的医疗器械在磁共振成像下可见
公开(公告)号：US20070167735A1
公开(公告)日：2007-07-19
申请号：US11637263
申请日：2006-12-12
申请人： Sheng-Ping Zhong , Ronald Sahatjian , Enxin Ma
发明人： Sheng-Ping Zhong , Ronald Sahatjian , Enxin Ma
IPC分类号： A61B5/05
CPC分类号： G01R33/286 , A61L29/145 , A61L29/18 , A61L31/145 , A61L31/18 , A61M25/0045 , A61M25/0108
摘要： Disclosed is an implantable or insertable medical device comprising (a) a substrate and (b) a hydrogel polymer coating at a least a portion of the surface of the substrate, wherein the hydrogel polymer is adapted to render the medical device visible under magnetic resonance imaging (MRI) upon insertion or implantation of the medical device into a patient. Also disclosed is the use of such a hydrogel coated implantable or insertable medical device in a medical procedure, wherein during or after insertion or implantation of the medical device in a patient, the position of the medical device is viewed under MRI. The use of a hydrogel polymer for coating a medical device wherein the hydrogel polymer is adapted to render a medical device coated with the hydrogel polymer visible under MRI and a hydrogel polymer adapted to render a medical device coated therewith visible under MRI are also disclosed.
摘要翻译：公开了一种可植入或可插入的医疗装置，其包括（a）基底和（b）在所述基底表面的至少一部分表面上的水凝胶聚合物涂层，其中所述水凝胶聚合物适于使所述医疗装置在磁共振成像（MRI）在将医疗装置插入或植入患者体内时。还公开了在医疗过程中使用这种水凝胶涂覆的可植入或可插入的医疗装置，其中在将医疗装置插入或植入患者体内或之后，在MRI下观察医疗装置的位置。还公开了使用水凝胶聚合物涂覆医疗装置，其中水凝胶聚合物适于使涂覆有水凝胶聚合物的医疗装置在MRI下可见，并且还公开了适于使其涂覆的医疗装置在MRI下可见的水凝胶聚合物。

5. 发明申请

US20060069305A1 Device with enhanced indication of use and prevention of re-use 审中-公开
标题翻译：具有增强的使用指示和防止再次使用的装置
公开(公告)号：US20060069305A1
公开(公告)日：2006-03-30
申请号：US10955905
申请日：2004-09-30
申请人： Lucien Couvillon , Sheng-Ping Zhong , Michael Banik , Ronald Sahatjian
发明人： Lucien Couvillon , Sheng-Ping Zhong , Michael Banik , Ronald Sahatjian
IPC分类号： A61B1/00 , A61B17/00
CPC分类号： A61B1/00055 , A61B1/00062 , A61B1/00103 , A61B2090/0814 , A61B2560/0276
摘要： In one aspect, the present invention is a medical device that reduces the likelihood of an operator improperly reusing it. The medical device includes (a) a device body; (b) a substrate comprising a contrast material that covers at least a portion of the device body; and (c) an outer layer comprising a hydrophilic material that covers at least a portion of the substrate. The outer layer comprising hydrophilic material is capable of absorbing water-soluble contaminants during clinical use that, once absorbed, are visible against the background of the substrate comprising the contrast material. In another aspect, the device includes (a) a device body and (b) an outer layer comprising a usage indicator reagent. In another aspect, the invention provides methods of preventing re-use of a single use medical device.
摘要翻译：一方面，本发明是减少操作者不当地重用它的可能性的医疗装置。医疗装置包括（a）装置主体; （b）包括覆盖所述装置主体的至少一部分的对比材料的基板; 和（c）包含覆盖基材的至少一部分的亲水材料的外层。包含亲水材料的外层能够在临床使用期间吸收水溶性污染物，其一旦被吸收就可以抵抗包含造影剂材料的底物的背景而可见。在另一方面，该装置包括（a）装置主体和（b）包含使用指示剂试剂的外层。在另一方面，本发明提供了防止单次使用的医疗装置的再次使用的方法。

6. 发明申请

US20050101988A1 Low profile emboli capture device 失效
公开(公告)号：US20050101988A1
公开(公告)日：2005-05-12
申请号：US10975851
申请日：2004-10-28
申请人： Ulf Stanford , Yem Chin , John Griego , Sheng-Ping Zhong
发明人： Ulf Stanford , Yem Chin , John Griego , Sheng-Ping Zhong
IPC分类号： A61B17/22 , A61B17/00 , A61F2/01 , A61F2/84 , A61M25/00 , A61M25/01 , B29C53/66 , A61M29/00
CPC分类号： A61F2/013 , A61B2017/00336 , A61F2002/018 , A61F2230/0006 , A61F2230/0008 , A61F2230/0019 , A61F2230/0067 , A61F2230/0097 , A61M25/0119 , B29C53/66
摘要： A low profile emboli capture device is provided for use in angioplasty and other intravascular procedures. A standard guidewire is utilized having a reduced cross-sectional area formed near its distal end. A filter and self-expanding stent are packaged on the reduced cross-sectional area of the guidewire. A movable sleeve extends over the guidewire and holds the self-expanding stent and filter in their retracted positions while the device is being positioned in the artery. The sheath is moved relative to the self-expanding stent and filter, whereupon the self-expanding stent and filter become deployed.

7. 发明授权

US06840950B2 Low profile emboli capture device 有权
标题翻译：薄型栓塞捕获装置
公开(公告)号：US06840950B2
公开(公告)日：2005-01-11
申请号：US09789332
申请日：2001-02-20
申请人： Ulf Harry Stanford , Yem Chin , Sheng-Ping Zhong , John Griego
发明人： Ulf Harry Stanford , Yem Chin , Sheng-Ping Zhong , John Griego
IPC分类号： A61B17/22 , A61B17/00 , A61F2/01 , A61F2/84 , A61M25/00 , A61M25/01 , B29C53/66 , A61M29/00 , A61B5/00 , A61F2/06
CPC分类号： A61F2/013 , A61B2017/00336 , A61F2002/018 , A61F2230/0006 , A61F2230/0008 , A61F2230/0019 , A61F2230/0067 , A61F2230/0097 , A61M25/0119 , B29C53/66
摘要： A low profile emboli capture device is provided for use in angioplasty and other intravascular procedures. A standard guidewire is utilized having a reduced cross-sectional area formed near its distal end. A filter and self-expanding stent are packaged on the reduced cross-sectional area of the guidewire. A movable sleeve extends over the guidewire and holds the self-expanding stent and filter in their retracted positions while the device is being positioned in the artery. The sheath is moved relative to the self-expanding stent and filter, whereupon the self-expanding stent and filter become deployed.
摘要翻译：提供了一种用于血管成形术和其他血管内手术的低调栓塞捕获装置。使用在其远端附近形成的具有减小的横截面积的标准导丝。过滤器和自扩张支架被包装在导丝的减小的横截面面积上。可移动的套筒延伸穿过导丝，并且将自扩张支架和过滤器保持在其缩回位置，同时该装置被定位在动脉中。护套相对于自扩张支架和过滤器移动，随后展开自扩张支架和过滤器。

8. 发明授权

US06723121B1 Polycarbonate-polyurethane dispersions for thrombo-resistant coatings 有权
标题翻译：用于抗血栓涂层的聚碳酸酯 - 聚氨酯分散体
公开(公告)号：US06723121B1
公开(公告)日：2004-04-20
申请号：US09671418
申请日：2000-09-27
申请人： Sheng-Ping Zhong
发明人： Sheng-Ping Zhong
IPC分类号： A61F206
CPC分类号： A61L33/062 , C08L75/04
摘要： A coating for a medical device is described which enhances the bio-activity of the surface of a medical device, rendering the surface substantially bio-compatible. The bio-compatible coating is formed from a composition which includes an aqueous emulsion or dispersion of a polycarbonate-polyurethane composition and an excess of polyfunctional cross-linking agent.
摘要翻译：描述了用于医疗装置的涂层，其增强医疗装置的表面的生物活性，使得表面基本上与生物相容。生物相容性涂层由包含聚碳酸酯 - 聚氨酯组合物和过量的多官能交联剂的水性乳液或分散体的组合物形成。

9. 发明授权

US6048620A Hydrophilic coating and substrates, particularly medical devices, provided with such a coating 失效
标题翻译：亲水涂层和基材，特别是医疗装置，具有这样的涂层
公开(公告)号：US6048620A
公开(公告)日：2000-04-11
申请号：US929948
申请日：1997-09-15
申请人： Sheng-Ping Zhong
发明人： Sheng-Ping Zhong
IPC分类号： A61M25/00 , A61L29/00 , A61L29/08 , A61L29/16 , A61L31/00 , A61L31/16 , C03C17/32 , C08J7/04 , C08L33/02 , C08L75/00 , C08L75/04 , C09D201/00 , B32B27/00
CPC分类号： A61L31/16 , A61L29/085 , A61L29/16 , A61L2300/21 , A61L2300/608 , A61L2420/08 , Y10T428/31565 , Y10T428/31573 , Y10T428/31576 , Y10T428/3158
摘要： A substrate such as a catheter or a guide wire is provided with a lubricous, hydrophilic abrasion-resistant coating by:a) coating said substrate with a first aqueous coating composition comprising an aqueous dispersion or emulsion of a polymer having organic acid functional groups and a polyfunctional crosslinking agent having functional groups being capable of reacting with organic acid groups, and drying the coating to obtain a substantially water-insoluble coating layer still including functional groups being reactive with organic acid groups, andb) contacting the dried coating layer obtained in a) with a second aqueous coating composition comprising an aqueous solution or dispersion of a hydrophilic polymer having organic acid functional groups, and drying the combined coating, the hydrophilic polymer thereby becoming bonded to the polymer of the first coating composition through the crosslinking agent.The drying can be carried out at ambient (room) temperature.
摘要翻译：诸如导管或引导线之类的基材通过以下方式设置有润滑的亲水性耐磨涂层：a）用第一含水涂料组合物涂覆所述基材，所述第一水性涂料组合物包含具有有机酸官能团的聚合物的水性分散体或乳液，和具有能够与有机酸基反应的官能团的多官能交联剂，干燥该涂层，得到仍含有与有机酸基反应的官能团的基本上不溶于水的涂层，以及b）使）与包含具有有机酸官能团的亲水聚合物的水溶液或分散体的第二水性涂料组合物，并干燥组合的涂层，亲水性聚合物因此通过交联剂与第一涂料组合物的聚合物结合。干燥可在室温下进行。

10. 发明授权

US08722074B2 Medical devices containing radiation resistant polymers 有权
标题翻译：含抗辐射聚合物的医疗器械
公开(公告)号：US08722074B2
公开(公告)日：2014-05-13
申请号：US11184196
申请日：2005-07-19
申请人： Sheng-Ping Zhong , Enxin Ma , Eun-Hyun Jang
发明人： Sheng-Ping Zhong , Enxin Ma , Eun-Hyun Jang
IPC分类号： A61F2/02
CPC分类号： A61L31/10 , C08L71/02 , C08L63/04
摘要： The present invention relates generally to radiation-resistant medical devices which contain polymer regions for release of therapeutic agents. The present invention also relates to radiation-resistant copolymer materials for use in connection with insertable or implantable medical devices. The radiation-sterilized medical device comprises (a) a release region and (b) at least one therapeutic agent and the release region comprises a phenoxy resin block.
摘要翻译：本发明一般涉及含有用于释放治疗剂的聚合物区域的耐辐射医疗装置。本发明还涉及用于与可插入或可植入的医疗装置相结合的耐辐射共聚物材料。辐射消毒的医疗装置包括（a）释放区和（b）至少一种治疗剂，并且释放区包含苯氧树脂嵌段。

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