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1. 发明授权

US07177758B2 Method for optimizing characteristics map 有权
标题翻译：优化特征图的方法
公开(公告)号：US07177758B2
公开(公告)日：2007-02-13
申请号：US11133749
申请日：2005-05-19
申请人： Thomas Kruse , Volker Imhof , Ernst Kloppenburg , Harald Stuhler
发明人： Thomas Kruse , Volker Imhof , Ernst Kloppenburg , Harald Stuhler
IPC分类号： G06F19/00 , G01L3/26
CPC分类号： F02D41/2422 , F02D41/1406 , F02D41/2416 , F02D2041/1433 , G01M15/05
摘要： A method for optimizing characteristics maps for the control of an internal combustion engine in which a model of the internal combustion engine is first formed by measurements on the internal combustion engine. In the process, a dependency of output variables of the internal combustion engine on the characteristics maps is illustrated. In the optimization, the dependency of the output variables of the internal combustion engine on the characteristics maps and the smoothing of the characteristics maps are optimized simultaneously.
摘要翻译：一种用于优化用于内燃机控制的特性图的方法，其中内燃机的型号首先通过在内燃机上的测量形成。在此过程中，说明内燃机输出变量对特征图的依赖性。在优化中，内燃机的输出变量对特征图的依赖性和特征图的平滑同时优化。

2. 发明申请

US20050273242A1 Method for optimizing characteristics map 有权
标题翻译：优化特征图的方法
公开(公告)号：US20050273242A1
公开(公告)日：2005-12-08
申请号：US11133749
申请日：2005-05-19
申请人： Thomas Kruse , Volker Imhof , Ernst Kloppenburg , Harald Stuhler
发明人： Thomas Kruse , Volker Imhof , Ernst Kloppenburg , Harald Stuhler
IPC分类号： F02D41/00 , F02D41/14 , F02D41/24 , F02D45/00 , F02M51/00 , G01M15/05 , G05D1/00
CPC分类号： F02D41/2422 , F02D41/1406 , F02D41/2416 , F02D2041/1433 , G01M15/05
摘要： A method for optimizing characteristics maps for the control of an internal combustion engine in which a model of the internal combustion engine is first formed by measurements on the internal combustion engine. In the process, a dependency of output variables of the internal combustion engine on the characteristics maps is illustrated. In the optimization, the dependency of the output variables of the internal combustion engine on the characteristics maps and the smoothing of the characteristics maps are optimized simultaneously.
摘要翻译：一种用于优化用于内燃机控制的特性图的方法，其中内燃机的型号首先通过在内燃机上的测量形成。在此过程中，说明内燃机输出变量对特征图的依赖性。在优化中，内燃机的输出变量对特征图的依赖性和特征图的平滑同时优化。

3. 发明申请

US20130110749A1 CONTROL DEVICE AND METHOD FOR CALCULATING AN OUTPUT PARAMETER FOR A CONTROLLER 有权
标题翻译：用于计算控制器的输出参数的控制装置和方法
公开(公告)号：US20130110749A1
公开(公告)日：2013-05-02
申请号：US13643464
申请日：2011-04-06
申请人： Felix Streichert , Tobias Lang , Heiner Markert , Axel Aue , Thomas Kruse , Volker Imhof , Thomas Richardsen , Ulrich Schulmeister , Nico Bannow , Rene Diener , Ernst Kloppenburg , Michael Saetzler , Holger Ulmer
发明人： Felix Streichert , Tobias Lang , Heiner Markert , Axel Aue , Thomas Kruse , Volker Imhof , Thomas Richardsen , Ulrich Schulmeister , Nico Bannow , Rene Diener , Ernst Kloppenburg , Michael Saetzler , Holger Ulmer
IPC分类号： G06N99/00
CPC分类号： G06N99/005 , F02D41/1401 , F02D2041/1433 , G05B17/02 , G06N7/005
摘要： A control device in a vehicle includes a unit for calculating, during operation of the vehicle, on the basis of at least one input variable ascertained during operation, at least one output variable for a control system of functions of the vehicle. The control device performs the calculation of the output variables using a Bayesian regression of training values ascertained, before operation, for the output variable and the input variable.
摘要翻译：车辆中的控制装置包括：用于在车辆的操作期间，基于在操作期间确定的至少一个输入变量来计算用于车辆的功能的控制系统的至少一个输出变量的单元。控制装置使用在操作之前为输出变量和输入变量确定的训练值的贝叶斯回归来执行输出变量的计算。

4. 发明授权

US10013658B2 Control device and method for calculating an output parameter for a controller 有权
公开(公告)号：US10013658B2
公开(公告)日：2018-07-03
申请号：US13643464
申请日：2011-04-06
申请人： Felix Streichert , Tobias Lang , Heiner Markert , Axel Aue , Thomas Kruse , Volker Imhof , Thomas Richardsen , Ulrich Schulmeister , Nico Bannow , Rene Diener , Ernst Kloppenburg , Michael Saetzler , Holger Ulmer
发明人： Felix Streichert , Tobias Lang , Heiner Markert , Axel Aue , Thomas Kruse , Volker Imhof , Thomas Richardsen , Ulrich Schulmeister , Nico Bannow , Rene Diener , Ernst Kloppenburg , Michael Saetzler , Holger Ulmer
IPC分类号： G06N99/00 , F02D41/14 , G05B17/02 , G06N7/00
CPC分类号： G06N20/00 , F02D41/1401 , F02D2041/1433 , G05B17/02 , G06N7/005
摘要： A control device in a vehicle includes a unit for calculating, during operation of the vehicle, on the basis of at least one input variable ascertained during operation, at least one output variable for a control system of functions of the vehicle. The control device performs the calculation of the output variables using a Bayesian regression of training values ascertained, before operation, for the output variable and the input variable.

5. 发明申请

US20140330400A1 METHOD FOR SETTING UP A FUNCTIONALITY FOR A CONTROL UNIT 有权
标题翻译：用于设置控制单元的功能的方法
公开(公告)号：US20140330400A1
公开(公告)日：2014-11-06
申请号：US14240312
申请日：2012-07-19
申请人： Heiner Markert , Thomas Kruse , Volker Imhof , Thorsten Huber , Rene Diener , Ernst Kloppenburg , Felix Streichert , Holger Ulmer , Stefan Angermaier
发明人： Heiner Markert , Thomas Kruse , Volker Imhof , Thorsten Huber , Rene Diener , Ernst Kloppenburg , Felix Streichert , Holger Ulmer , Stefan Angermaier
IPC分类号： G05B13/04
CPC分类号： G05B13/04 , G06F17/5009 , G06F17/5045 , G06N7/005
摘要： A method is provided for populating a function for a control unit with data, in which method measurements are performed on a system at different measuring points on a test stand, and a global data-based model is set up based on the obtained measured values, and virtual measurements which simulate real measurements on the test stand are carried out on the global data-based model, and uncertainties for virtual measured values of the virtual measurements are determined from the global data-based model, the uncertainties of the virtual measured values being taken into account when populating the function for the control unit with data.
摘要翻译：提供了一种用于为控制单元填充具有数据的功能的方法，其中在测试台上的不同测量点处对系统执行方法测量，并且基于获得的测量值建立全局数据模型，并且在全局数据模型上进行模拟测试台上的实际测量的虚拟测量，并且从全局基于数据的模型确定虚拟测量的虚拟测量值的不确定性，虚拟测量值的不确定性为在使用数据填充控制单元的功能时考虑。

6. 发明授权

US09952567B2 Method for setting up a functionality for a control unit 有权
公开(公告)号：US09952567B2
公开(公告)日：2018-04-24
申请号：US14240312
申请日：2012-07-19
申请人： Heiner Markert , Thomas Kruse , Volker Imhof , Thorsten Huber , Rene Diener , Ernst Kloppenburg , Felix Streichert , Holger Ulmer , Stefan Angermaier
发明人： Heiner Markert , Thomas Kruse , Volker Imhof , Thorsten Huber , Rene Diener , Ernst Kloppenburg , Felix Streichert , Holger Ulmer , Stefan Angermaier
IPC分类号： G06F7/60 , G06F17/10 , G06F17/50 , G05B13/04 , G06N7/00
CPC分类号： G05B13/04 , G06F17/5009 , G06F17/5045 , G06N7/005
摘要： A method is provided for populating a function for a control unit with data, in which method measurements are performed on a system at different measuring points on a test stand, and a global data-based model is set up based on the obtained measured values, and virtual measurements which simulate real measurements on the test stand are carried out on the global data-based model, and uncertainties for virtual measured values of the virtual measurements are determined from the global data-based model, the uncertainties of the virtual measured values being taken into account when populating the function for the control unit with data.

7. 发明授权

US09708383B2 Double-acylated GLP-1 derivatives 有权
公开(公告)号：US09708383B2
公开(公告)日：2017-07-18
申请号：US13882947
申请日：2011-11-09
申请人： Alice Ravn Madsen , Birgit Wieczorek , Jacob Kofoed , Jesper Lau , Jane Spetzler , Janos Tibor Kodra , Lars Linderoth , Patrick William Garibay , Per Sauerberg , Thomas Kruse
发明人： Alice Ravn Madsen , Birgit Wieczorek , Jacob Kofoed , Jesper Lau , Jane Spetzler , Janos Tibor Kodra , Lars Linderoth , Patrick William Garibay , Per Sauerberg , Thomas Kruse
IPC分类号： A61K38/00 , C07K14/605 , A61K47/48
CPC分类号： C07K14/605 , A61K47/542
摘要： The invention relates to a derivative of a GLP-1 analog, which analog comprises a first K residue at a position corresponding to position 18 of GLP-1(7-37) (SEQ ID NO: 1), a second K residue at another position, and a maximum of twelve amino acid changes as compared to GLP-1(7-37); which derivative comprises two protracting moieties attached to said first and second K residue, respectively, via a linker, wherein the protracting moiety is selected from Chem. 1, Chem. 2, and Chem. 3: HOOC—(CH2)x—CO—* Chem. 1: HOOC—C6H4—O—(CH2)y—CO—* Chem. 2: R2—C6H4—(CH2)z—CO—*, Chem. 3: in which x is an integer in the range of 6-18, y is an integer in the range of 3-17, z is an integer in the range of 1-5, and R2 is a group having a molar mass not higher than 150 Da; and the linker comprises *—NH—(CH2)2—(O—(CH2)2)k—O—(CH2)n—CO—*. Chem. 4: wherein k is an integer in the range of 1-5, and n is an integer in the range of 1-5; or a pharmaceutically acceptable salt, amide, or ester thereof. The invention also relates to the pharmaceutical use thereof, for example in the treatment and/or prevention of all forms of diabetes and related diseases, as well as to corresponding novel peptides and side chain intermediates. The derivatives are suitable for oral administration.

8. 发明授权

US09358733B2 Method and a device for the manufacture of a fibre composite component, and a fibre composite component 有权
标题翻译：用于制造纤维复合材料部件的方法和装置以及纤维复合材料部件
公开(公告)号：US09358733B2
公开(公告)日：2016-06-07
申请号：US14111662
申请日：2012-02-29
申请人： Marc Schimmler , Bernd Raeckers , Thomas Kruse , Wolfgang Schulze
发明人： Marc Schimmler , Bernd Raeckers , Thomas Kruse , Wolfgang Schulze
IPC分类号： B29C70/54 , B29C70/48 , B29C70/30 , B29C53/58 , B29K105/08 , B29L31/30
CPC分类号： B29C70/545 , B29C53/585 , B29C53/587 , B29C70/30 , B29C70/48 , B29C2793/0018 , B29K2105/0872 , B29L2031/3076 , Y02T50/43 , Y10T428/24273
摘要： A method for the manufacture of a fiber composite component with at least one opening, which is edged by an integral collar, a device for the execution of a method of this type with a mold core, which has at least one convexity for the formation of a component section in the form of a bulge, also a fiber composite component with a multiplicity of openings, each of which is edged by an integral collar.
摘要翻译：一种用于制造纤维复合材料部件的方法，所述纤维复合材料部件具有至少一个开口，所述至少一个开口由整体的轴环边缘，用于执行具有模芯的这种类型的方法的装置，所述模具具有至少一个用于形成凸起形式的部件，也是具有多个开口的纤维复合部件，每个开口由整体的凸缘边缘。

9. 发明授权

US09006178B2 Double-acylated GLP-1 derivatives with a linker 有权
标题翻译：具有接头的双酰化GLP-1衍生物
公开(公告)号：US09006178B2
公开(公告)日：2015-04-14
申请号：US13883946
申请日：2011-11-09
申请人： Jacob Kofoed , Jesper Lau , Lars Linderoth , Patrick William Garibay , Thomas Kruse
发明人： Jacob Kofoed , Jesper Lau , Lars Linderoth , Patrick William Garibay , Thomas Kruse
IPC分类号： A61K38/26 , A61P3/10 , A61P7/12 , C07K14/605 , A61K38/28 , C07K5/00 , C07K7/00 , C07K16/00 , C07K17/00 , A61K47/48
CPC分类号： C07K14/605 , A61K47/542
摘要： The invention relates to a derivative of a GLP-1 analog, which analog comprises a first K residue at a position corresponding to position 18 of GLP-1(7-37) (SEQ ID NO: 1), a second K residue at another position, and a maximum of twelve amino acid changes as compared to GLP-1(7-37); which derivative comprises two protracting moieties attached to said first and second K residue, respectively, via a linker, wherein the protracting moiety is selected from Chem. 1: HOOC—(CH2)x—CO—*, and Chem. 2: HOOC—C6H4-0-(CH2)y—CO—*, in which x is an integer in the range of 6-18, and y is an integer in the range of 3-17; and the linker comprises Chem. 3: *—NH—(CH2)q—CH[(CH2)w—NH2]—CO—*, wherein q is an integer in the range of 0-5, and w is an integer in the range of 0-5; or a pharmaceutically acceptable salt, amide, or ester thereof. The invention also relates to the pharmaceutical use thereof, for example in the treatment and/or prevention of all forms of diabetes and related diseases, as well as to corresponding novel peptides and side chain intermediates. The derivatives are potent, protracted, and suitable for oral administration.
摘要翻译：本发明涉及GLP-1类似物的衍生物，其类似物包含在对应于GLP-1（7-37）（SEQ ID NO：1）的第18位的位置处的第一个K残基，另一个的第二个K残基位置和与GLP-1（7-37）相比最多12个氨基酸变化; 该衍生物分别包含通过接头分别连接到所述第一和第二K残基的两个伸长部分，其中伸长部分选自Chem。 1：HOOC-（CH 2）x-CO- *，和Chem。 2：HOOC-C6H4-0-（CH2）y-CO- *，其中x是6-18的整数，y是3-17的整数; 连接体包括Chem。 3：* -NH-（CH 2）q-CH [（CH 2）w -NH 2] -CO- *，其中q是0-5的整数，w是0-5的整数 ; 或其药学上可接受的盐，酰胺或酯。本发明还涉及其药物用途，例如用于治疗和/或预防所有形式的糖尿病和相关疾病，以及相应的新型肽和侧链中间体。衍生物有效，延长，适合口服。

10. 发明授权

US08895694B2 Glucagon-Like Peptide-1 derivatives and their pharmaceutical use 有权
标题翻译：胰高血糖素样肽-1衍生物及其药物用途
公开(公告)号：US08895694B2
公开(公告)日：2014-11-25
申请号：US12676451
申请日：2008-09-05
申请人： Jane Spetzler , Lauge Schäffer , Jesper Lau , Thomas Kruse , Patrick William Garibay , Steffen Reedtz-Runge , Henning Thøgersen , Ingrid Pettersson
发明人： Jane Spetzler , Lauge Schäffer , Jesper Lau , Thomas Kruse , Patrick William Garibay , Steffen Reedtz-Runge , Henning Thøgersen , Ingrid Pettersson
IPC分类号： A61K38/00 , A61K39/00 , C07K14/605
CPC分类号： C07K14/605 , A61K38/26
摘要： The invention relates to protracted Glucagon-Like Peptide-1 (GLP-1) derivatives and therapeutic uses thereof. The GLP-1 derivative of the invention comprises a modified GLP-1(7-37) sequence having a total of 2-12 amino acid modifications, including Glu22 and Arg26, and being derivatised with an albumin binding residue or pegylated in position 18, 20, 23, 30, 31, 34, 36, 37, or 39. These compounds are useful in the treatment or prevention of diabetes type 2 and related diseases. The compounds are potent, stable, have long half-lives, a high affinity of binding to albumin, and/or a high affinity of binding to the extracellular domain of the GLP-1 receptor (GLP-1R), all of which is of potential relevance for the overall aim of achieving long-acting, stable and active GLP-1 derivatives with a potential for once weekly administration.
摘要翻译：本发明涉及长效的胰高血糖素样肽-1（GLP-1）衍生物及其治疗用途。本发明的GLP-1衍生物包含具有总共2-12个氨基酸修饰的修饰的GLP-1（7-37）序列，包括Glu22和Arg26，并用白蛋白结合残基衍生或在18位聚乙二醇化， 20,23,30,31,34,36,37或39.这些化合物可用于治疗或预防2型糖尿病和相关疾病。该化合物是有效的，稳定的，具有长的半衰期，与白蛋白结合的高亲和力，和/或与GLP-1受体（GLP-1R）细胞外结构域结合的高亲和力，所有这些都是对于实现长效，稳定和活性的GLP-1衍生物的总体目标的潜在相关性，具有每周一次行政的潜力。

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