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1. 发明授权

US09568575B2 Conduit-containing devices and methods for analyte processing and detection 有权
标题翻译：用于分析物处理和检测的含导管的装置和方法
公开(公告)号：US09568575B2
公开(公告)日：2017-02-14
申请号：US13878935
申请日：2011-10-19
申请人： Thomas Jay Lowery, Jr. , Parris S. Wellman , John J. McDonough , James Franklin Chepin , Charles William Rittershaus , Vasiliki Demas , Alison Skelley
发明人： Thomas Jay Lowery, Jr. , Parris S. Wellman , John J. McDonough , James Franklin Chepin , Charles William Rittershaus , Vasiliki Demas , Alison Skelley
IPC分类号： G01V3/00 , G01R33/465 , G01R33/28 , G01R33/30 , G01R33/44
CPC分类号： G01R33/465 , G01R33/281 , G01R33/30 , G01R33/302 , G01R33/448
摘要： This invention features devices and methods for analyte processing and detection, and use of such methods, e.g., in the treatment and diagnosis of disease or determining the presence of a pathogen.
摘要翻译：本发明的特征在于用于分析物处理和检测的装置和方法，以及使用这些方法，例如在疾病的治疗和诊断中或确定病原体的存在。

2. 发明申请

US20130265054A1 CONDUIT-CONTAINING DEVICES AND METHODS FOR ANALYTE PROCESSING AND DETECTION 有权
标题翻译：用于分析处理和检测的包含装置和方法
公开(公告)号：US20130265054A1
公开(公告)日：2013-10-10
申请号：US13878935
申请日：2011-10-19
申请人： Thomas Jay Lowery, JR. , Parris S. Wellman , John J. McDonough , James Franklin Chepin , Charles William Rittershaus , Vasiliki Demas , Alison Skelley
发明人： Thomas Jay Lowery, JR. , Parris S. Wellman , John J. McDonough , James Franklin Chepin , Charles William Rittershaus , Vasiliki Demas , Alison Skelley
IPC分类号： G01R33/465
CPC分类号： G01R33/465 , G01R33/281 , G01R33/30 , G01R33/302 , G01R33/448
摘要： This invention features devices and methods for analyte processing and detection, and use of such methods, e.g., in the treatment and diagnosis of disease or determining the presence of a pathogen.
摘要翻译：本发明的特征在于用于分析物处理和检测的装置和方法，以及使用这些方法，例如在疾病的治疗和诊断中或确定病原体的存在。

3. 发明授权

US08518705B2 Methods and apparatuses for stretching polymers 失效
标题翻译：聚合物拉伸的方法和装置
公开(公告)号：US08518705B2
公开(公告)日：2013-08-27
申请号：US10775599
申请日：2004-02-10
申请人： Eugene Y. Chan , Lance C. Gleich , Parris S. Wellman
发明人： Eugene Y. Chan , Lance C. Gleich , Parris S. Wellman
IPC分类号： B01L3/00
CPC分类号： G01N15/1456 , B01F5/061 , B01F5/064 , B01F5/0646 , B01F13/0059 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L2200/0647 , B01L2200/0663 , B01L2300/0816 , B01L2300/0883 , B01L2400/086 , C12Q1/6869 , G01N1/286 , G01N15/1459 , G01N33/442 , G01N2015/1493 , G01N2015/1495 , Y10T436/143333
摘要： The present invention provides structures and methods that allow polymers of any length, including nucleic acids containing entire genomes, to be stretched into a long, linear conformation for further analysis. The present invention also provides structures and methods for selecting and stretching polymers based on their lengths. Polymers are loaded into a device and run through the structures. Stretching is achieved by, e.g., applying shear forces as the polymer passes through the structures, placing obstacles in the path of the polymer, or a combination thereof. Since multiple molecules may be stretched in succession, extremely high throughput screening, e.g., screening of more than one molecule per second, is achieved.
摘要翻译：本发明提供允许任何长度的聚合物（包括含有全部基因组的核酸）拉伸成长的线性构象用于进一步分析的结构和方法。本发明还提供了基于其长度来选择和拉伸聚合物的结构和方法。聚合物装载到设备中并穿过结构。通过例如当聚合物通过结构时施加剪切力，在聚合物的路径中放置障碍物或其组合来实现拉伸。由于可以连续拉伸多个分子，因此实现极高通量筛选，例如每秒筛选多于一个分子。

4. 发明授权

US06696022B1 Methods and apparatuses for stretching polymers 有权
标题翻译：聚合物拉伸的方法和装置
公开(公告)号：US06696022B1
公开(公告)日：2004-02-24
申请号：US09636793
申请日：2000-08-11
申请人： Eugene Y. Chan , Lance C. Gleich , Parris S. Wellman
发明人： Eugene Y. Chan , Lance C. Gleich , Parris S. Wellman
IPC分类号： B01L300
CPC分类号： G01N15/1456 , B01F5/061 , B01F5/064 , B01F5/0646 , B01F13/0059 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L2200/0647 , B01L2200/0663 , B01L2300/0816 , B01L2300/0883 , B01L2400/086 , C12Q1/6869 , G01N1/286 , G01N15/1459 , G01N33/442 , G01N2015/1493 , G01N2015/1495 , Y10T436/143333
摘要： The present invention provides structures and methods that allow polymers of any length, including nucleic acids containing entire genomes, to be stretched into a long, linear conformation for further analysis. The present invention also provides structures and methods for selecting and stretching polymers based on their lengths. Polymers are loaded into a device and run through the structures. Stretching is achieved by, e.g., applying shear forces as the polymer passes through the structures, placing obstacles in the path of the polymer, or a combination thereof. Since multiple molecules may be stretched in succession, extremely high throughput screening, e.g., screening of more than one molecule per second, is achieved.
摘要翻译：本发明提供允许任何长度的聚合物（包括含有全部基因组的核酸）拉伸成长的线性构象用于进一步分析的结构和方法。本发明还提供了基于其长度来选择和拉伸聚合物的结构和方法。聚合物装载到设备中并穿过结构。通过例如当聚合物通过结构时施加剪切力，在聚合物的路径中放置障碍物或其组合来实现拉伸。由于可以连续拉伸多个分子，因此实现极高通量筛选，例如每秒筛选多于一个分子。

5. 发明授权

US06695838B2 System and method for performing cardiac tissue ablation 有权
标题翻译：用于进行心脏组织消融的系统和方法
公开(公告)号：US06695838B2
公开(公告)日：2004-02-24
申请号：US09966765
申请日：2001-09-28
申请人： Parris S. Wellman , Rajesh Pendekanti
发明人： Parris S. Wellman , Rajesh Pendekanti
IPC分类号： A61B1818
CPC分类号： A61B18/1482 , A61B18/16 , A61B2018/00363 , A61B2018/00577
摘要： A method of forming a lesion at a predetermined heart location is provided. An energy-delivering electrode is positioned proximal to the predetermined heart location; a return electrode is positioned in contact with cardiac tissue. An electrosurgical current, capable of delivering energy through the energy-delivering electrode to the predetermined heart location at a magnitude and for a duration effective to form a lesion is established. A system for treating atrial fibrillation by forming transmural lesions and a heart-positioning device including a return electrode are also provided.
摘要翻译：提供了在预定心脏位置处形成病变的方法。能量输送电极位于预定的心脏位置附近; 定位回返电极与心脏组织接触。建立了一种电外科电流，其能够以有效形成损伤的量级和持续时间将能量通过能量输送电极输送到预定的心脏位置。还提供了一种通过形成透壁病变治疗房颤的系统和包括返回电极的心脏定位装置。

6. 发明授权

US06585733B2 Surgical treatment for atrial fibrillation using radiofrequency technology 有权
公开(公告)号：US06585733B2
公开(公告)日：2003-07-01
申请号：US09966756
申请日：2001-09-28
申请人： Parris S. Wellman
发明人： Parris S. Wellman
IPC分类号： A61B1818
CPC分类号： A61B18/1477 , A61B18/1492 , A61B18/16 , A61B2018/00083 , A61B2018/00357 , A61B2018/00363 , A61B2018/1425
摘要： Ablation systems and methods for treating atrial fibrillation utilizing RF energy are provided. The system generally includes a first conductive member having a shape which defines a desired lesion pattern or a portion of a desired lesion pattern, and a second conductive member effective to transmit ablative radiation to the first conductive member. The first conductive member is adapted to be positioned on a first tissue surface, and the second conductive member is adapted to be positioned on a second, opposed tissue surface. In use, ablative radiation is transmitted from the second conductive member through the tissue to the first conductive member to form a lesion having the desired lesion pattern.

7. 发明申请

US20090024119A1 SURGICAL TREATMENT FOR ATRIAL FIBRILLATION USING RADIOFREQUENCY TECHNOLOGY 有权
标题翻译：使用无线电技术进行ATRIAL FIBRILLATION的外科治疗
公开(公告)号：US20090024119A1
公开(公告)日：2009-01-22
申请号：US12183144
申请日：2008-07-31
申请人： Parris S. Wellman
发明人： Parris S. Wellman
IPC分类号： A61B18/18
CPC分类号： A61B18/1477 , A61B18/1492 , A61B18/16 , A61B2018/00083 , A61B2018/00357 , A61B2018/00363 , A61B2018/1425
摘要： Ablation systems and methods for treating atrial fibrillation utilizing RF energy are provided. The system generally includes a first conductive member having a shape which defines a desired lesion pattern or a portion of a desired lesion pattern, and a second conductive member effective to transmit ablative radiation to the first conductive member. The first conductive member is adapted to be positioned on a first tissue surface, and the second conductive member is adapted to be positioned on a second, opposed tissue surface. In use, ablative radiation is transmitted from the second conductive member through the tissue to the first conductive member to form a lesion having the desired lesion pattern.
摘要翻译：提供了利用RF能量治疗房颤的消融系统和方法。该系统通常包括具有限定期望的病变图案或期望损伤图案的一部分的形状的第一导电构件和有效将消融辐射传送到第一导电构件的第二导电构件。第一导电构件适于定位在第一组织表面上，并且第二导电构件适于定位在第二相对的组织表面上。在使用中，烧蚀辐射从第二导电构件通过组织传递到第一导电构件以形成具有期望损伤图案的损伤。

8. 发明授权

US06997719B2 Training model for endoscopic vessel harvesting 失效
标题翻译：内窥镜血管收获训练模型
公开(公告)号：US06997719B2
公开(公告)日：2006-02-14
申请号：US10183270
申请日：2002-06-27
申请人： Parris S. Wellman , William McJames , Daniel Gordon
发明人： Parris S. Wellman , William McJames , Daniel Gordon
IPC分类号： G09B23/28
CPC分类号： G09B23/285
摘要： A leg model, designed to teach endoscopic saphenous vein harvesting, is provided that accurately models the anatomy of the saphenous vein in the human thigh, and closely approximates the subcutaneous tissues in a human. The subcutaneous tissue is formulated and manufactured such that the saphenous vein adheres to the subcutaneous tissue to simulate the adhesion in a human leg. The model includes a reusable base and a replaceable single use insert. The base is size and configured to receive the insert. The tray can include a slit located at a point along its length that permits the ends of the tray to rotate about the slit so that the ends can be bent with respect to one another.
摘要翻译：提供旨在教导内窥镜隐静脉收获的腿模型，其精确地模拟人大腿隐静脉的解剖结构，并且紧密接近人体的皮下组织。配制和制造皮下组织，使得隐静脉粘附到皮下组织以模拟人腿中的粘附。该模型包括可重复使用的基座和可更换的单用插入件。基座是大小并配置为接收插入。托盘可以包括位于沿其长度的点处的狭缝，其允许托盘的端部围绕狭缝旋转，使得端部可以相对于彼此弯曲。

9. 发明授权

US06927065B2 Methods and apparatus for characterization of single polymers 失效
标题翻译：用于表征单一聚合物的方法和装置
公开(公告)号：US06927065B2
公开(公告)日：2005-08-09
申请号：US09875779
申请日：2001-06-06
申请人： Eugene Y. Chan , Lance C. Gleich , Parris S. Wellman
发明人： Eugene Y. Chan , Lance C. Gleich , Parris S. Wellman
IPC分类号： B01F5/06 , B01F13/00 , B01L3/00 , C12N15/09 , C12Q1/68 , G01N1/28 , G01N15/14 , G01N21/64 , G01N21/78 , G01N27/447 , G01N33/44 , G01N33/483
CPC分类号： B01L3/502761 , B01L3/5027 , B01L2200/0647 , B01L2200/0663 , B01L2300/0816 , B01L2400/086 , C12Q1/6869 , G01N1/286 , G01N15/1456 , G01N15/1459 , G01N15/1463 , G01N33/442 , G01N2015/1075 , G01N2015/1493 , G01N2015/1495 , Y10T436/13 , Y10T436/143333
摘要： A method for determining the length and velocity of single elongated macromolecules is disclosed. In particular, the present invention relates to methods and apparatus for determining the velocity of elongated polymeric molecules moving relative to one or more detection stations, as well as to methods and apparatus for determining the length of such molecules and the distance between landmarks that may be present on such molecules. The invention makes use of time correlated measurements of signal amplitude profiles that result from interactions between each detection station and portions of each macromolecule.
摘要翻译：公开了一种用于确定单个细长大分子的长度和速度的方法。特别地，本发明涉及用于确定相对于一个或多个检测站移动的细长聚合物分子的速度的方法和装置，以及用于确定这种分子的长度的方法和装置以及标记之间的距离存在于这样的分子上。本发明利用由每个检测站与每个大分子的部分之间的相互作用产生的信号幅度分布的时间相关测量。

10. 发明授权

US06907297B2 Expandable intracardiac return electrode and method of use 有权
标题翻译：可扩展心内返回电极及其使用方法
公开(公告)号：US06907297B2
公开(公告)日：2005-06-14
申请号：US10032296
申请日：2001-12-21
申请人： Parris S. Wellman , Rajesh Pendekanti , Jia Hua Xiao
发明人： Parris S. Wellman , Rajesh Pendekanti , Jia Hua Xiao
IPC分类号： A61B18/14 , A61B18/16 , A61N1/06 , A61N1/00
CPC分类号： A61B18/1482 , A61B18/16 , A61B2018/00363 , A61B2018/00577 , A61N1/06
摘要： A method of forming a lesion at a predetermined heart location is provided. An energy-delivering electrode is positioned proximal to the predetermined heart location; a return electrode is positioned in contact with cardiac tissue. An electrosurgical current, capable of delivering energy through the energy-delivering electrode to the predetermined heart location at a magnitude and for a duration effective to form a lesion is established. A system for treating atrial fibrillation by forming transmural lesions and a heart-positioning device including a return electrode are also provided. In one embodiment, one of the electrodes includes at least a portion that is selectively movable between a first, retracted position in which the electrode is adapted to be deployed through tissue, and a second, expanded position in which the electrode is adapted to be placed within a chamber of a heart.
摘要翻译：提供了在预定心脏位置处形成病变的方法。能量输送电极位于预定的心脏位置附近; 定位回返电极与心脏组织接触。建立了一种电外科电流，其能够以有效形成损伤的量级和持续时间将能量通过能量输送电极输送到预定的心脏位置。还提供了一种通过形成透壁病变治疗房颤的系统和包括返回电极的心脏定位装置。在一个实施例中，电极中的一个包括至少一部分，其可选择性地在电极适于通过组织展开的第一缩回位置和第二扩展位置之间移动，其中电极适于放置在其中在心脏的一个房间内

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