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1. 发明授权

US08518705B2 Methods and apparatuses for stretching polymers 失效
标题翻译：聚合物拉伸的方法和装置
公开(公告)号：US08518705B2
公开(公告)日：2013-08-27
申请号：US10775599
申请日：2004-02-10
申请人： Eugene Y. Chan , Lance C. Gleich , Parris S. Wellman
发明人： Eugene Y. Chan , Lance C. Gleich , Parris S. Wellman
IPC分类号： B01L3/00
CPC分类号： G01N15/1456 , B01F5/061 , B01F5/064 , B01F5/0646 , B01F13/0059 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L2200/0647 , B01L2200/0663 , B01L2300/0816 , B01L2300/0883 , B01L2400/086 , C12Q1/6869 , G01N1/286 , G01N15/1459 , G01N33/442 , G01N2015/1493 , G01N2015/1495 , Y10T436/143333
摘要： The present invention provides structures and methods that allow polymers of any length, including nucleic acids containing entire genomes, to be stretched into a long, linear conformation for further analysis. The present invention also provides structures and methods for selecting and stretching polymers based on their lengths. Polymers are loaded into a device and run through the structures. Stretching is achieved by, e.g., applying shear forces as the polymer passes through the structures, placing obstacles in the path of the polymer, or a combination thereof. Since multiple molecules may be stretched in succession, extremely high throughput screening, e.g., screening of more than one molecule per second, is achieved.
摘要翻译：本发明提供允许任何长度的聚合物（包括含有全部基因组的核酸）拉伸成长的线性构象用于进一步分析的结构和方法。本发明还提供了基于其长度来选择和拉伸聚合物的结构和方法。聚合物装载到设备中并穿过结构。通过例如当聚合物通过结构时施加剪切力，在聚合物的路径中放置障碍物或其组合来实现拉伸。由于可以连续拉伸多个分子，因此实现极高通量筛选，例如每秒筛选多于一个分子。

2. 发明授权

US06696022B1 Methods and apparatuses for stretching polymers 有权
标题翻译：聚合物拉伸的方法和装置
公开(公告)号：US06696022B1
公开(公告)日：2004-02-24
申请号：US09636793
申请日：2000-08-11
申请人： Eugene Y. Chan , Lance C. Gleich , Parris S. Wellman
发明人： Eugene Y. Chan , Lance C. Gleich , Parris S. Wellman
IPC分类号： B01L300
CPC分类号： G01N15/1456 , B01F5/061 , B01F5/064 , B01F5/0646 , B01F13/0059 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L2200/0647 , B01L2200/0663 , B01L2300/0816 , B01L2300/0883 , B01L2400/086 , C12Q1/6869 , G01N1/286 , G01N15/1459 , G01N33/442 , G01N2015/1493 , G01N2015/1495 , Y10T436/143333
摘要： The present invention provides structures and methods that allow polymers of any length, including nucleic acids containing entire genomes, to be stretched into a long, linear conformation for further analysis. The present invention also provides structures and methods for selecting and stretching polymers based on their lengths. Polymers are loaded into a device and run through the structures. Stretching is achieved by, e.g., applying shear forces as the polymer passes through the structures, placing obstacles in the path of the polymer, or a combination thereof. Since multiple molecules may be stretched in succession, extremely high throughput screening, e.g., screening of more than one molecule per second, is achieved.
摘要翻译：本发明提供允许任何长度的聚合物（包括含有全部基因组的核酸）拉伸成长的线性构象用于进一步分析的结构和方法。本发明还提供了基于其长度来选择和拉伸聚合物的结构和方法。聚合物装载到设备中并穿过结构。通过例如当聚合物通过结构时施加剪切力，在聚合物的路径中放置障碍物或其组合来实现拉伸。由于可以连续拉伸多个分子，因此实现极高通量筛选，例如每秒筛选多于一个分子。

3. 发明授权

US06927065B2 Methods and apparatus for characterization of single polymers 失效
标题翻译：用于表征单一聚合物的方法和装置
公开(公告)号：US06927065B2
公开(公告)日：2005-08-09
申请号：US09875779
申请日：2001-06-06
申请人： Eugene Y. Chan , Lance C. Gleich , Parris S. Wellman
发明人： Eugene Y. Chan , Lance C. Gleich , Parris S. Wellman
IPC分类号： B01F5/06 , B01F13/00 , B01L3/00 , C12N15/09 , C12Q1/68 , G01N1/28 , G01N15/14 , G01N21/64 , G01N21/78 , G01N27/447 , G01N33/44 , G01N33/483
CPC分类号： B01L3/502761 , B01L3/5027 , B01L2200/0647 , B01L2200/0663 , B01L2300/0816 , B01L2400/086 , C12Q1/6869 , G01N1/286 , G01N15/1456 , G01N15/1459 , G01N15/1463 , G01N33/442 , G01N2015/1075 , G01N2015/1493 , G01N2015/1495 , Y10T436/13 , Y10T436/143333
摘要： A method for determining the length and velocity of single elongated macromolecules is disclosed. In particular, the present invention relates to methods and apparatus for determining the velocity of elongated polymeric molecules moving relative to one or more detection stations, as well as to methods and apparatus for determining the length of such molecules and the distance between landmarks that may be present on such molecules. The invention makes use of time correlated measurements of signal amplitude profiles that result from interactions between each detection station and portions of each macromolecule.
摘要翻译：公开了一种用于确定单个细长大分子的长度和速度的方法。特别地，本发明涉及用于确定相对于一个或多个检测站移动的细长聚合物分子的速度的方法和装置，以及用于确定这种分子的长度的方法和装置以及标记之间的距离存在于这样的分子上。本发明利用由每个检测站与每个大分子的部分之间的相互作用产生的信号幅度分布的时间相关测量。

4. 发明授权

US06762059B2 Methods and apparatuses for characterization of single polymers 失效
标题翻译：用于表征单一聚合物的方法和装置
公开(公告)号：US06762059B2
公开(公告)日：2004-07-13
申请号：US09783472
申请日：2001-02-14
申请人： Eugene Y. Chan , Lance C. Gleich , Parris S. Wellman
发明人： Eugene Y. Chan , Lance C. Gleich , Parris S. Wellman
IPC分类号： G01N2101
CPC分类号： B01F5/061 , B01F5/064 , B01F5/0646 , B01F13/0059 , B01L3/50273 , B01L3/502746 , B01L3/502761 , B01L2200/0647 , B01L2200/0663 , B01L2300/0816 , B01L2400/086 , C12Q1/6869 , G01N1/286 , G01N15/1456 , G01N15/1459 , G01N33/442 , G01N2015/1493 , G01N2015/1495 , Y10T436/143333
摘要： The present invention relates to methods and apparatuses for characterization of single polymers. In particular, the invention relates to methods and apparatuses for determination of the velocities of single elongated polymers. Center-of-mass velocity, center-to-center velocity, end-to-end velocity and rise-time velocity are determined using time-correlated measurements of single elongated polymers in two or more detection zones. The invention also relates to methods of determinating lengths and molecular masses of single polymers and to methods of determining the distance between landmarks on a single polymers based on their velocities. The invention further relates to methods of single-molecule DNA restriction fragment analysis.
摘要翻译：本发明涉及用于表征单一聚合物的方法和装置。特别地，本发明涉及用于确定单个细长聚合物的速度的方法和装置。质心速度，中心到中心速度，端对端速度和上升时间速度是使用两个或多个检测区域中的单个细长聚合物的时间相关测量来确定的。本发明还涉及确定单个聚合物的长度和分子量的方法以及基于它们的速度确定单个聚合物上的界标之间的距离的方法。本发明还涉及单分子DNA限制性片段分析方法。

5. 发明授权

US09568425B2 Multicoded analytical nanostrips 有权
标题翻译：多编分析纳米带
公开(公告)号：US09568425B2
公开(公告)日：2017-02-14
申请号：US13361914
申请日：2012-01-30
申请人： Eugene Y. Chan , Moon Z. Chan
发明人： Eugene Y. Chan , Moon Z. Chan
IPC分类号： B82Y15/00 , G01N21/64 , G01N33/58 , G01N33/543 , B01L3/00 , G01N21/21
CPC分类号： G01N21/6428 , B01L3/502761 , B01L2200/0647 , B01L2200/0663 , B82Y15/00 , G01N21/21 , G01N33/54313 , G01N33/54346 , G01N33/582 , G01N33/587 , G01N2021/6441
摘要： Analytical nanostrips for clinical analysis are improved by using multifunctional coding (“multicoding”) to allow simultaneous identification of the particular assay, the value of the assayed analyte, and a calibration of the analyte. The multicoding layout on the nanostrip minimizes the number of zones that are required for a given assay. Moreover, the nanostrip can be scanned in real time during flow of the nanostrip through a detection beam. This both simplifies the assay and allows for alternative means of coding.
摘要翻译：通过使用多功能编码（“多编码”）来改进用于临床分析的分析纳米带，以允许特定测定的同时鉴定，测定的分析物的值和分析物的校准。纳米线上的多编码布局使给定测定所需的区域数量最小化。此外，纳米线可以在纳米片通过检测光束的过程中实时扫描。这两者都简化了测定，并允许替代的编码方式。

6. 发明授权

US08423294B2 High resolution linear analysis of polymers 失效
标题翻译：聚合物的高分辨率线性分析
公开(公告)号：US08423294B2
公开(公告)日：2013-04-16
申请号：US10762207
申请日：2004-01-21
申请人： Mark Nadel , Eugene Y. Chan , Martin Fuchs , Rudolf Gilmanshin
发明人： Mark Nadel , Eugene Y. Chan , Martin Fuchs , Rudolf Gilmanshin
IPC分类号： G01N33/50
CPC分类号： B82Y5/00 , B82Y10/00 , C12Q1/6869 , C12Q2565/629 , C12Q2565/102 , C12Q2563/107
摘要： The invention provides methods and systems for improved spatial resolution of signal detection, particularly as applied to the analysis of polymers such as biological polymers. Some of the methods and systems comprise differentially tagging polymers in order to increase resolution. Some of the methods and systems comprise techniques for improving the precision of separation distance measurements, without necessarily requiring improvements in the known detection resolution of prior art systems.
摘要翻译：本发明提供用于改善信号检测的空间分辨率的方法和系统，特别是应用于聚合物如生物聚合物的分析。一些方法和系统包括差异化标记聚合物以提高分辨率。一些方法和系统包括用于提高分离距离测量的精度的技术，而不一定需要改进现有技术系统的已知检测分辨率。

7. 外观设计

USD785781S1 Sample consumable 有权
公开(公告)号：USD785781S1
公开(公告)日：2017-05-02
申请号：US29484774
申请日：2014-03-12
申请人： Eugene Y. Chan
设计人： Eugene Y. Chan

8. 发明授权

US09194780B2 Microfluidic passive mixing chip 有权
标题翻译：微流控无源混频芯片
公开(公告)号：US09194780B2
公开(公告)日：2015-11-24
申请号：US13374157
申请日：2011-12-14
申请人： Eugene Y. Chan , Moon Z Chan
发明人： Eugene Y. Chan , Moon Z Chan
IPC分类号： G01N1/38 , B01F5/00 , B01F5/06 , B01F13/00 , B01F13/10
CPC分类号： G01N1/38 , B01F5/0071 , B01F5/0647 , B01F13/0059 , B01F13/0093 , B01F13/1027 , Y10T436/25
摘要： An improved device and method for passive mixing of fluids is described, and the use of the device in clinical diagnostic procedures. The mixer provides thorough mixing of a sample of blood or other fluid with an assay material, such as a diluent or a component of an assay system, in a closed system with a low and limited pressure drop. Sample size is small, typically 5 to 300 microliters. Mixing is accomplished by a combination of rotational vortex mixing due to a fluid stream coming tangent to a drain, and either or both of a second vortex mixer of opposite handedness, and a Dean mixer. Combinations of these techniques reliably provide complete mixing at low pressure drop. In a preferred usage, the microfluidic system can run a diluent continuously and inject samples at intervals, to facilitate automatic data processing of optical or other signatures of the well-mixed stream.
摘要翻译：描述了用于流体被动混合的改进的装置和方法，以及该装置在临床诊断程序中的使用。混合器在具有低和有限压降的封闭系统中提供血液或其它流体样品与测定材料（例如测定系统的稀释剂或组分）的充分混合。样品尺寸小，通常为5至300微升。混合通过由于与排水管相切的流体流的旋转涡流混合以及具有相反方向性的第二涡旋混合器中的任一者或两者与Dean混合器组合而实现。这些技术的组合可靠地在低压降下提供完全混合。在优选的用途中，微流体系统可连续运行稀释剂并间隔地注入样品，以便于对混合良好的流的光学或其它特征进行自动数据处理。

9. 发明申请

US20140165711A1 Capillary Manipulation of Clinical Samples 审中-公开
标题翻译：临床样品的毛细管理
公开(公告)号：US20140165711A1
公开(公告)日：2014-06-19
申请号：US13694575
申请日：2012-12-13
申请人： Julia Z. Sharpe , Eugene Y. Chan
发明人： Julia Z. Sharpe , Eugene Y. Chan
IPC分类号： G01N1/10
CPC分类号： B01L3/502715 , A61B10/0051 , A61B10/007 , B01L3/502723 , B01L2200/027 , B01L2200/0684 , B01L2300/0838 , G01N1/02 , G01N2001/002
摘要： A system for collection and delivery of sub-milliliter liquid samples is described that provides a dramatic simplification for the measurement of clinical values. The system produces high dilutions of capillary size samples, such as bodily fluids or blood, by a factor of 1000 or more. Multiple assays can be conducted on a sample of 0.1 cc or less. A small lancet can create a drop of blood on a fingertip or other location, which can be collected into a self-priming capillary blood collector. The sample is then loaded into a consumable loader. Then a fluid, such as saline, is flowed into the consumable loader, and passes through the capillary collector, washing out the fluid. Downstream, the blood in the capillary is reliably diluted by mixing with appropriate reagents to allow analysis of selected blood properties. One or more individual bubbles can be inserted into the stream during loading. The capillary loading system can be used for one or several assays on a single blood sample. It can be very compact and lightweight and is suitable for use in remote environments, such as outer space, in which it is difficult to access diagnostic assays.
摘要翻译：描述了用于收集和递送亚毫升液体样品的系统，其为测量临床值提供了显着的简化。该系统产生毛细管尺寸样品（例如体液或血液）的高稀释倍数为1000或更高。可以对0.1cc或更少的样品进行多次测定。小刺血针可以在指尖或其他位置产生一滴血液，可以将其收集到自吸毛细管血液收集器中。然后将样品装入消耗装载机。然后，诸如盐水的流体流入消耗装载器，并且通过毛细收集器，洗涤流体。在下游，通过与适当的试剂混合可靠地稀释毛细血管中的血液，以便分析选定的血液性质。一个或多个单独的气泡可以在装载过程中插入流中。毛细管装载系统可用于单次血液样品上的一次或多次测定。它可以非常紧凑和轻便，适用于远程环境，如外部空间，难以进行诊断测定。

10. 发明申请

US20080103296A1 Methods and apparati using single polymer analysis 审中-公开
标题翻译：使用单一聚合物分析的方法和设备
公开(公告)号：US20080103296A1
公开(公告)日：2008-05-01
申请号：US11725596
申请日：2007-03-19
申请人： Xiaojian David Zhao , Jeffrey D. Randall , Bijit Kundu , Jessica Kesty , Steven R. Gullans , Eugene Y. Chan , Martin Fuchs , Jenny E. Rooke
发明人： Xiaojian David Zhao , Jeffrey D. Randall , Bijit Kundu , Jessica Kesty , Steven R. Gullans , Eugene Y. Chan , Martin Fuchs , Jenny E. Rooke
IPC分类号： C07H21/04
CPC分类号： C12Q1/6827 , B82Y5/00 , B82Y10/00 , C07H21/02 , C07H21/04 , C12Q1/6818 , C12Q1/6825 , C12Q1/6834 , C12Q2565/101 , C12Q2565/601 , C12Q2521/301 , C12Q2563/107 , C12Q2565/619 , C12Q2565/629 , C12Q2535/125 , C12Q2537/143
摘要： The invention relates to methods for analyzing and characterizing single polymers such as nucleic acid molecules. In preferred embodiments, the single molecules are analyzed using single molecule detection and analysis systems.
摘要翻译：本发明涉及用于分析和表征单一聚合物如核酸分子的方法。在优选的实施方案中，使用单分子检测和分析系统分析单分子。

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