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1. 发明授权

US5224939A Self locking guide catheter 失效
标题翻译：自锁导向导管
公开(公告)号：US5224939A
公开(公告)日：1993-07-06
申请号：US888748
申请日：1992-05-22
申请人： Thomas J. Holman , Henry J. Pepin , William H. Penny
发明人： Thomas J. Holman , Henry J. Pepin , William H. Penny
IPC分类号： A61M5/158 , A61M25/00 , A61M25/088
CPC分类号： A61M5/158 , A61M25/0014 , A61M2025/0098 , A61M25/0097
摘要： A guide catheter in which the components of the hub include a ratchet mechanism that is operative to lock the hub components together and compress an integral flange of the catheter shaft therebetween to form a seal between the hub and catheter shaft without the use of bonding agents that will not become loosened accidently or inadvertently.
摘要翻译：一种引导导管，其中所述轮毂的部件包括棘轮机构，所述棘轮机构可操作以将所述轮毂部件锁定在一起并将所述导管轴的整体凸缘压缩在其间，以在所述轮毂和导管轴之间形成密封，而不使用粘结剂不会意外或不经意地松动。

2. 发明授权

US5160559A Method for forming a guide catheter tip bond 失效
标题翻译：形成导向器提示胶的方法
公开(公告)号：US5160559A
公开(公告)日：1992-11-03
申请号：US606090
申请日：1990-10-31
申请人： Brian J. Scovil , Henry J. Pepin
发明人： Brian J. Scovil , Henry J. Pepin
IPC分类号： A61M25/00 , B29C35/16 , B29C65/00 , B29C65/06 , B29C65/14 , B29C65/78
CPC分类号： A61M25/001 , B29C65/0618 , B29C65/14 , B29C65/7802 , B29C66/0342 , B29C66/1122 , B29C66/1142 , B29C66/324 , B29C66/3242 , B29C66/522 , B29C66/5221 , B29C66/5344 , B29C66/63 , B29C66/7392 , B29C66/91411 , B29C66/919 , A61M2025/0081 , A61M25/0054 , B29C2035/1616 , B29C65/1435 , B29C65/1477 , B29C66/73921 , B29C66/949 , B29L2023/005 , B29L2031/7542
摘要： A method for forming a guide catheter with a deformable tip includes setting a mating distal end of a tubular member against a mating proximal end of a soft, deformable tip to form a butt joint. The butt joint is then softened to render the mating proximal and distal ends of the deformable tip and tubular member flowable. The tubular member and the deformable tip are then oscillated along a longitudinal axis such that the materials of the mating proximal and distal ends flow into one another creating a connection zone. The connection zone then solidifies to form a lap joint tip bond that securely fastens the deformable tip to the tubular member.
摘要翻译：用于形成具有可变形尖端的引导导管的方法包括将管状构件的配合远端抵靠软的可变形尖端的配合近端设置以形成对接接头。然后对接接头软化，使得可变形顶端和管状构件的配合近端和远端可流动。然后，管状构件和可变形尖端沿着纵向轴线振荡，使得配合的近端和远端的材料彼此流动，形成连接区域。连接区然后固化以形成搭接接头尖端接合，其将可变形尖端牢固地固定到管状构件。

3. 发明授权

US07354430B2 Catheter incorporating a curable polymer layer to control flexibility 有权
标题翻译：引入可固化聚合物层以控制灵活性的导管
公开(公告)号：US07354430B2
公开(公告)日：2008-04-08
申请号：US11211800
申请日：2005-08-25
申请人： Henry J. Pepin
发明人： Henry J. Pepin
IPC分类号： A61M25/00
CPC分类号： A61M25/0045 , A61L29/085 , A61L29/106 , A61M25/005 , A61M25/0053 , A61M25/0054 , Y10T428/139
摘要： The present invention relates generally to catheters for performing medical procedures including percutaneous transluminal coronary angioplasty. More particularly, the present invention relates to guide catheters, diagnostic catheters and balloon catheters with an improved shaft design. In a preferred embodiment, the present invention includes a catheter shaft comprising an elongate support member having an outer surface, the elongate support member preferably defining a lubricious liner; a first layer disposed over the lubricious liner, a second layer disposed over the first layer, a third layer disposed over the second layer, a fourth layer disposed over the third layer, and a fifth layer disposed over the fourth layer. In preferred embodiments, the first and third layers comprise an ultraviolet-curable epoxy which is cured to desired degrees at select axial locations on the shaft to provide desired stiffness.
摘要翻译：本发明一般涉及用于执行包括经皮腔内冠状动脉血管成形术在内的医疗程序的导管。更具体地，本发明涉及具有改进的轴设计的引导导管，诊断导管和球囊导管。在优选实施例中，本发明包括导管轴，其包括具有外表面的细长支撑构件，细长支撑构件优选地限定润滑衬垫; 布置在光滑衬里上的第一层，设置在第一层上的第二层，设置在第二层上的第三层，设置在第三层上的第四层，以及设置在第四层上的第五层。在优选的实施方案中，第一层和第三层包含可紫外固化的环氧树脂，其在轴的选定轴向位置处被固化至所需的程度以提供所需的刚性。

4. 发明授权

US5908413A Radiopaque catheter and method of manufacture thereof 失效
标题翻译：不透射线导管及其制造方法
公开(公告)号：US5908413A
公开(公告)日：1999-06-01
申请号：US943450
申请日：1997-10-03
申请人： Michael R. Lange , Henry J. Pepin , Alan R. Dombrowski
发明人： Michael R. Lange , Henry J. Pepin , Alan R. Dombrowski
IPC分类号： A61B19/00 , A61M25/00 , A61M25/01 , A61M25/095 , A61M25/098
CPC分类号： A61M25/0108 , A61B90/39 , A61M2025/0098 , A61M25/0009 , A61M25/0045
摘要： Radiopaque catheter and method of manufacture thereof having a first layer and a second layer in a coaxial arrangement wherein each of the layers has a radiopaque filler material intermixed therewith. The radiopaque filler materials and/or the concentrations thereof may be the same or different for each of the layers. Further, the plastic binder material used for each of the layers may be the same or different. By selecting a high concentration of a highly radiopaque filler material for an inner layer and a lower concentration of a radiopaque filler that is selected to provide a relatively smooth surface, the X-ray visibility of the catheter may be maximized while still maintaining a relative smooth outer surface.
摘要翻译：不透射线导管及其制造方法，其具有同轴布置中的第一层和第二层，其中每个层具有与其混合的不透射线填充材料。不透射线填料材料和/或其浓度可以对于每个层相同或不同。此外，用于每个层的塑料粘合剂材料可以相同或不同。通过选择高浓度的用于内层的高度不透射线的填充材料和用于提供相对光滑表面的不透射线填料的较低浓度，导管的X射线可视性可以最大化，同时仍然保持相对平滑外表面。

5. 发明授权

US6077258A Braided angiography catheter having full length radiopacity and controlled flexibility 失效
标题翻译：编织血管造影导管具有全长的射线不透性和受控的灵活性
公开(公告)号：US6077258A
公开(公告)日：2000-06-20
申请号：US943628
申请日：1997-10-03
申请人： Michael R. Lange , Henry J. Pepin
发明人： Michael R. Lange , Henry J. Pepin
IPC分类号： A61M25/00 , A61M25/088 , A61M25/095 , A61M25/098
CPC分类号： A61M25/0054 , A61M25/0045 , A61M25/0053 , A61M2025/0081
摘要： A guiding catheter or angiographic catheter for use in cardiovascular interventions which incorporates a low-flexibility multi-layer proximal zone wherein a transition zone separates the proximal zone and a high flexibility distal zone. A mid-region zone transitions the high stiffness of the proximal zone to the higher flexibility of the distal zone to eliminate buckling and kinking. All zones of the catheter have a sufficiently large and substantially similar radiopacity, which allows the entirety of the catheter to be visible in a fluoroscope or other form of x-ray so that the positioning of the catheter can be precisely determined.
摘要翻译：用于心血管干预的引导导管或血管造影导管，其包括低柔性多层近区，其中过渡区分离近端区和高柔性远端区。中间区域将近端区域的高刚度转移到远端区域的较高柔性，以消除屈曲和扭结。导管的所有区域具有足够大且基本上相似的放射不透性，其允许整个导管以荧光镜或其他形式的x射线可见，使得能够精确地确定导管的定位。

6. 发明授权

US5868718A Process to form dimensionally variable tubular members for use in catheter procedures 失效
标题翻译：用于形成用于导管过程的尺寸可变的管状构件的方法
公开(公告)号：US5868718A
公开(公告)日：1999-02-09
申请号：US736409
申请日：1996-10-24
申请人： Henry J. Pepin , Michael S. Ferrandino , Andrew G. Richardson
发明人： Henry J. Pepin , Michael S. Ferrandino , Andrew G. Richardson
IPC分类号： A61M25/00 , B29C47/00 , B29C47/34 , B29C47/92 , B29C55/22 , A61M5/00
CPC分类号： A61M25/001 , B29C47/34 , B29C55/22 , B29C2793/0063 , B29C2947/92514 , B29C2947/9258 , B29C2947/926 , B29C2947/92619 , B29C2947/92638 , B29C2947/92809 , B29C2947/92923 , B29C2947/92933 , B29C47/0023 , B29C47/0026 , B29C47/0033 , B29C47/0066 , B29C47/92 , B29L2031/7542
摘要： Process for forming a dimensionally variable tubular member for use in catheterization procedures. The process includes a mechanism for extruding a tubular member. A variable speed puller pulls the tubular member through or from the extrusion means at a selectively variable speed. A variable air or gas pressure supply supplies pressurized air or gas to the extrusion mechanism at a selectively variable rate. The dimensionally varying tubular member may be cut to desired lengths for use as catheter shafts or catheter soft tips. The process may include forming a tubular member having a dimensionally varying first layer and a dimensionally varying second layer, wherein a portion of the first layer at a distal end of the tubular member is removed.
摘要翻译：用于形成用于导管术程序的尺寸可变的管状构件的方法。该方法包括用于挤压管状构件的机构。变速牵引器以可选择的速度将管状构件拉过挤压装置或从挤压装置拉出。可变空气或气体压力供应以可选择的速率向压缩机构供应加压空气或气体。尺寸可变的管状构件可以被切割成期望的长度，用作导管轴或导管软尖端。该方法可以包括形成具有尺寸变化的第一层和尺寸上可变的第二层的管状构件，其中在管状构件的远端处的第一层的一部分被去除。

7. 发明授权

US5531721A Multiple member intravascular guide catheter 失效
标题翻译：多成员血管内引导导管
公开(公告)号：US5531721A
公开(公告)日：1996-07-02
申请号：US353142
申请日：1994-12-09
申请人： Henry J. Pepin , Brian J. Scovil , Jeffrey M. Welch
发明人： Henry J. Pepin , Brian J. Scovil , Jeffrey M. Welch
IPC分类号： A61M25/00 , A61M25/06 , A61M29/02
CPC分类号： A61M25/104 , A61M25/005 , A61M25/0662 , A61M25/0053
摘要： An intravascular guide catheter includes a main shaft member, a bond member, an intermediate shaft member and a terminal shaft member. The main shaft has a proximal end and a mating distal end. The bond ring includes a mating proximal end, which is joined to the mating distal end of the main shaft member, and a mating distal end. The intermediate shaft member includes a mating proximal end, which is joined to the mating distal end of the bond member, and a mating distal end. The terminal shaft member includes a mating proximal end, which is joined to the mating distal end of the intermediate member, and a distal end. The main and intermediate shaft members have wire braiding reinforcing layers. The material of the intermediate shaft member has a greater hardness than the material of the terminal shaft member and a lower hardness than the material of the main shaft member.
摘要翻译：血管内引导导管包括主轴构件，接合构件，中间轴构件和端子轴构件。主轴具有近端和配合的远端。接合环包括配合的近端，其接合到主轴构件的配合远端以及配合的远端。中间轴构件包括接合到接合构件的配合远端的配合近端和配合远端。端子轴构件包括接合到中间构件的配合远端的配合近端和远端。主轴和中间轴构件具有线编织增强层。中间轴构件的材料具有比端子轴构件的材料更大的硬度和比主轴构件的材料更低的硬度。

8. 发明授权

US07322988B2 Methods of forming catheters with soft distal tips 有权
标题翻译：用软远端尖端形成导管的方法
公开(公告)号：US07322988B2
公开(公告)日：2008-01-29
申请号：US10346979
申请日：2003-01-17
申请人： Michael W. Sterud , Brandon J. Worcester , George N. Omae , Michael Kuhn , Henry J. Pepin
发明人： Michael W. Sterud , Brandon J. Worcester , George N. Omae , Michael Kuhn , Henry J. Pepin
IPC分类号： A61F11/00
CPC分类号： B29C65/18 , A61M25/001 , A61M25/0045 , A61M25/0068 , A61M25/0069 , A61M25/008 , A61M2025/0081 , B29C57/00 , B29C65/68 , B29C66/0222 , B29C66/1122 , B29C66/1142 , B29C66/1222 , B29C66/1224 , B29C66/5221 , B29C66/5344 , B29C66/63 , B29C66/71 , B29C66/7212 , B29C66/7392 , B29C66/82 , B29K2995/007 , B29L2031/7542 , B29K2309/08 , B29K2277/10 , B29K2021/003 , B29K2067/00
摘要： A catheter can be formed from an elongate shaft and a distal tip. The catheter can be formed by flaring a proximal end of the distal tip to form a flared proximal end and positioning the distal tip such that the flared proximal end of the distal tip overlaps a distal end of the outer layer. Heat and pressure are applied to melt and flow together a portion of the outer layer proximate the distal end of the shaft and the overlapped portion of the flared proximal end of the distal tip, thereby forming a joint between the elongate shaft and the distal tip.
摘要翻译：导管可以由细长轴和远端构成。导管可以通过使远侧末端的近端扩张以形成扩张的近端并定位远侧末端，使得远侧末端的扩张近端与外层的远端重叠。施加热量和压力以使靠近轴的远端的外层的一部分和远侧末端的扩张近端的重叠部分一起熔化和流动，从而在细长轴和远侧末端之间形成接合。

9. 发明授权

US06945970B2 Catheter incorporating a curable polymer layer to control flexibility and method of manufacture 有权
标题翻译：引入可固化聚合物层以控制柔韧性和制造方法的导管
公开(公告)号：US06945970B2
公开(公告)日：2005-09-20
申请号：US10034697
申请日：2001-12-27
申请人： Henry J. Pepin
发明人： Henry J. Pepin
IPC分类号： A61L29/08 , A61L29/10 , A61M25/00 , B32B1/08 , F16L11/12 , G20B6/04
CPC分类号： A61M25/0045 , A61L29/085 , A61L29/106 , A61M25/005 , A61M25/0053 , A61M25/0054 , Y10T428/139
摘要： The present invention relates generally to catheters for performing medical procedures including percutaneous transluminal coronary angioplasty. More particularly, the present invention relates to guide catheters, diagnostic catheters and balloon catheters with an improved shaft design. In a preferred embodiment, the present invention includes a catheter shaft comprising an elongate support member having an outer surface, the elongate support member preferably defining a lubricious liner; a first layer disposed over the lubricious liner, a second layer disposed over the first layer, a third layer disposed over the second layer, a fourth layer disposed over the third layer, and a fifth layer disposed over the fourth layer. In preferred embodiments, the first and third layers comprise an ultraviolet-curable epoxy which is cured to desired degrees at select axial locations on the shaft to provide desired stiffness.
摘要翻译：本发明一般涉及用于执行包括经皮腔内冠状动脉血管成形术在内的医疗程序的导管。更具体地，本发明涉及具有改进的轴设计的引导导管，诊断导管和球囊导管。在优选实施例中，本发明包括导管轴，其包括具有外表面的细长支撑构件，细长支撑构件优选地限定润滑衬垫; 布置在光滑衬里上的第一层，设置在第一层上的第二层，设置在第二层上的第三层，设置在第三层上的第四层，以及设置在第四层上的第五层。在优选的实施方案中，第一层和第三层包含可紫外固化的环氧树脂，其在轴的选定轴向位置处被固化至所需的程度以提供所需的刚性。

10. 发明授权

US06652507B2 Intravascular catheter having multi-layered tip 有权
标题翻译：血管内导管具有多层尖端
公开(公告)号：US06652507B2
公开(公告)日：2003-11-25
申请号：US09898742
申请日：2001-07-03
申请人： Henry J. Pepin
发明人： Henry J. Pepin
IPC分类号： A61M2500
CPC分类号： A61M25/0069 , A61M25/0045 , A61M25/0108
摘要： An intravascular catheter having a multi-layered distal tip including an inner layer, an intermediate layer and an outer layer wherein the intermediate layer is formed of a polymeric material loaded with a high percentage of radiopaque agent, and the inner and outer layers are formed of readily bondable materials which substantially cover the intermediate layer to thereby increase surface area contact and bond strength therebetween.
摘要翻译：一种具有包括内层，中间层和外层的多层远侧末端的血管内导管，其中中间层由装载有高百分比的不透射线剂的聚合物材料形成，并且内层和外层由易于粘合的材料，其基本上覆盖中间层，从而增加其间的表面积接触和粘结强度。

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