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1. 发明授权

US10450590B2 Process for preparing an alpha, omega-alkanediol 有权
公开(公告)号：US10450590B2
公开(公告)日：2019-10-22
申请号：US14763378
申请日：2014-01-10
申请人： Thomas Haas , Philip Engel , Jan Christoph Pfeffer , Oliver Thum , Christian Gehring
发明人： Thomas Haas , Philip Engel , Jan Christoph Pfeffer , Oliver Thum , Christian Gehring
IPC分类号： C12P7/18 , C07C67/08 , C07C29/136 , C12P7/62
摘要： The invention relates to a process for preparing an α,ω-alkanediol comprising the steps of a) reacting an alkanoic acid with an alkanol to give an ester, b) oxidizing at least one terminal carbon atom of the ester by contacting with a whole-cell catalyst, which expresses an alkane hydroxylase, in aqueous solution and in the presence of molecular oxygen, to give an oxidized ester, c) hydrogenating the oxidized ester to form the alkanediol and alkanol, and d) removing the alkanol by distillation, forming a reaction mixture depleted with respect to the alkanol, and recycling the alkanol in step b).

2. 发明申请

US20150275245A1 BIOTECHNOLOGICAL PRODUCTION OF ALCOHOLS AND DERIVATIVES THEREOF 审中-公开
标题翻译：酒精及其衍生物的生物技术生产
公开(公告)号：US20150275245A1
公开(公告)日：2015-10-01
申请号：US14367610
申请日：2012-12-14
申请人： Thomas Haas , Oliver Thum , Jan Christoph Pfeffer , Philip Engel , Christian Gehring , Markus Poetter
发明人： Thomas Haas , Oliver Thum , Jan Christoph Pfeffer , Philip Engel , Christian Gehring , Markus Poetter
IPC分类号： C12P13/00 , C12N9/02 , C12N9/10
CPC分类号： C12P13/005 , C12N9/001 , C12N9/0071 , C12N9/0077 , C12N9/1096 , C12P7/04 , C12P7/24 , C12P7/6409 , C12P7/6436 , C12P7/649 , C12P13/001 , C12Y114/11 , C12Y114/15003 , Y02E50/13
摘要： The present invention relates to a microorganism having a reduced fatty acid degradation capacity and expressing a recombinant alkane oxidase, a method for oxidizing an alkyl, comprising a contacting the alkyl with an aqueous solution comprising the inventive cell.
摘要翻译：本发明涉及具有降低的脂肪酸降解能力并表达重组烷烃氧化酶的微生物，一种氧化烷基的方法，包括使烷基与包含本发明细胞的水溶液接触。

3. 发明申请

US20150010968A1 BIOLOGICAL ALKENE OXIDATION 审中-公开
标题翻译：生物碱性氧化
公开(公告)号：US20150010968A1
公开(公告)日：2015-01-08
申请号：US14373089
申请日：2013-01-18
申请人： Philip Engel , Thomas Haas , Jan Christoph Pfeffer , Oliver Thum , Christian Gehring
发明人： Philip Engel , Thomas Haas , Jan Christoph Pfeffer , Oliver Thum , Christian Gehring
IPC分类号： C12P7/40 , C12P7/04
CPC分类号： C12P7/40 , C12P7/04 , C12P7/24
摘要： The present invention relates to method for oxidising an alkene comprising contacting said alkene with an AlkB-type oxidoreductase in the presence of oxygen, and a use of an AlkB-type oxidoreductase, preferably AlkB from Pseudomonas putida GPO1 or a variant thereof, for oxidising an alkene to an alcohol and/or acid.
摘要翻译：本发明涉及氧化烯烃的方法，包括在氧气存在下使所述烯烃与AlkB型氧化还原酶接触，以及使用AlkB型氧化还原酶，优选来自恶臭假单胞菌GPO1的AlkB或其变体，用于氧化烯烃与醇和/或酸反应。

4. 发明申请

US20150044744A1 BIOLOGICAL ALKANE OXIDATION 审中-公开
标题翻译：生物碱性氧化
公开(公告)号：US20150044744A1
公开(公告)日：2015-02-12
申请号：US14363165
申请日：2012-11-22
申请人： Jan Christoph Pfeffer , Thomas Haas , Oliver Thum , Frank Erhardt , Eva Maria Wittmann , Christian Gehring , Sabine Hafkemeyer , Thomas Hueller
发明人： Jan Christoph Pfeffer , Thomas Haas , Oliver Thum , Frank Erhardt , Eva Maria Wittmann , Christian Gehring , Sabine Hafkemeyer , Thomas Hueller
IPC分类号： C12P7/52
CPC分类号： C12P7/52 , C12P7/02 , C12P7/16 , C12P7/24 , C12P7/40 , Y02E50/10
摘要： The invention relates to a method for oxidizing an alkane, comprising contacting the alkane with a type alkB oxidoreductase and using a type alkB oxidoreductase to prepare a mixture of oxidation products of an alkane, wherein the ratio of carboxylic acid to alcohol in the oxidation products is preferably greater than 1:1.
摘要翻译：本发明涉及一种氧化烷烃的方法，包括使烷烃与alkB氧化还原酶接触，并使用alkB型氧化还原酶制备烷烃氧化产物的混合物，其中氧化产物中羧酸与醇的比例为优选大于1:1。

5. 发明申请

US20150218600A1 BIOTECHNOLOGICAL PREPARATION OF 3-HYDROXYISOBUTYRIC ACID 审中-公开
标题翻译： 3-羟基丁酸的生物技术制备
公开(公告)号：US20150218600A1
公开(公告)日：2015-08-06
申请号：US14363178
申请日：2012-11-14
申请人： Thomas Haas , Steffen Schaffer , Markus Poetter , Mirja Wessel , Jan Christoph Pfeffer , Christian Gehring , Nicole Kirchner , Eva Maria Wittmann
发明人： Thomas Haas , Steffen Schaffer , Markus Poetter , Mirja Wessel , Jan Christoph Pfeffer , Christian Gehring , Nicole Kirchner , Eva Maria Wittmann
IPC分类号： C12P7/42 , C12N9/88 , C12N9/12 , C12N9/02 , C12N9/00 , C12N9/10
CPC分类号： C12P7/42 , C12N9/0004 , C12N9/001 , C12N9/1217 , C12N9/13 , C12N9/88 , C12N9/93 , C12N15/52 , C12Y103/99002 , C12Y207/02007 , C12Y402/01017 , C12Y602/01002
摘要： The invention relates to a method comprising the steps a) providing isobutyric acid, b) bringing isobutyric acid into contact with the combination of isobutyrate kinase and phosphotransisobutyrylase and/or isobutyryl-coenzyme A synthetase/ligase and/or isobutyrate-coenzyme A transferase, c) bringing the product from step a) into contact with isobutyryl-coenzyme A dehydrogenase, d) bringing the product from step b) into contact with methacrylyl-coenzyme A hydratase, and e) hydrolyzing the product from step d) to form 3-hydroxyisobutyric acid, where at least one of the enzymes is used in the form of a cell which, compared to its wildtype, comprises a reduced activity of a 3-hydroxyisobutyric acid dehydrogenase or a variant thereof, a cell which has at least one enzyme from the group comprising isobutyryl-coenzyme A synthetase/ligase, isobutyrate-coenzyme A transferase, isobutyrate kinase, phosphotransisobutyrylase, isobutyryl-coenzyme A dehydrogenase, methacrylyl-coenzyme A hydratase and 3-hydroxyisobutyryl-coenzyme A hydrolase and, compared to its wildtype, a reduced activity of a 3-hydroxyisobutyric acid dehydrogenase or a variant thereof, wherein the cell preferably has, in addition, a monooxygenase, more preferably a monooxygenase of the alkBGT type or a variant thereof and the use of such a cell for preparing 3-hydroxyisobutyric acid.
摘要翻译：本发明涉及包括以下步骤的方法：a）提供异丁酸，b）使异丁酸与异丁酸酯激酶和磷酸转移异丁酰基酶和/或异丁酰辅酶A合成酶/连接酶和/或异丁酸酯辅酶A转移酶c的组合接触）使来自步骤a）的产物与异丁酰辅酶A脱氢酶接触，d）将来自步骤b）的产物与甲基丙烯酰辅酶A水合酶接触，和e）水解步骤d）中的产物以形成3-羟基异丁酸酸，其中至少一种酶以细胞形式使用，与其野生型相比，其包含3-羟基异丁酸脱氢酶或其变体的降低的活性，具有至少一种酶的细胞异丁酰辅酶A合成酶/连接酶，异丁酸酯辅酶A转移酶，异丁酸酯激酶，磷酸转移异丁酰基酶，异丁酰辅酶A脱氢酶，甲基丙烯酰辅酶A水合酶和 3-羟基异丁酰辅酶A水解酶，与其野生型相比，3-羟基异丁酸脱氢酶或其变体的活性降低，其中细胞优选还具有单加氧酶，更优选alkBGT型的单加氧酶或其变体以及这种细胞用于制备3-羟基异丁酸的用途。

6. 发明申请

US20150111253A1 ENZYMATIC OMEGA-OXIDATION AND OMEGA-AMINATION OF FATTY ACIDS 有权
标题翻译：脂肪酸的氧化欧米茄氧化和欧米加氨基酸
公开(公告)号：US20150111253A1
公开(公告)日：2015-04-23
申请号：US14384301
申请日：2013-03-12
申请人： Steffen Schaffer , Michaela Hauberg , Mirja Wessel , Hans-Georg Hennemann , Jan Christoph Pfeffer , Thomas Haas , Harald Haeger
发明人： Steffen Schaffer , Michaela Hauberg , Mirja Wessel , Hans-Georg Hennemann , Jan Christoph Pfeffer , Thomas Haas , Harald Haeger
IPC分类号： C12P7/64 , C07K14/21
CPC分类号： C12P7/6436 , C07K14/21 , C07K14/79 , C12N9/0006 , C12N9/0016 , C12N9/0077 , C12N9/0095 , C12N9/1096 , C12P7/42 , C12P7/62 , C12P7/6409 , C12P13/005 , C12Y114/14001
摘要： The invention relates to a method for oxidizing a fatty acid or an ester thereof of formula (I) H3C—(CH2)n-COOR, wherein R is selected from the group that comprises H, methyl, ethyl, propyl, and butyl, wherein n is 0 to 30, preferably 6 to 24, comprising the step of oxidizing the fatty acid or the ester thereof by contacting the fatty acid or the ester thereof with a cytochrome P450 monooxygenase of the CYP153 family in the presence of molecular oxygen and NAD(P)H and a whole-cell catalyst that expresses a recombinant cytochrome P450 monooxygenase of the CYP153 family, a recombinant alcohol dehydrogenase, a recombinant transaminase, and optionally one or more than one recombinant enzyme from the group comprising alanine dehydrogenase, ferredoxin, and ferredoxin reductase, and the use of said whole-cell catalyst to oxidize a fatty acid or an ester thereof.
摘要翻译：本发明涉及一种氧化式（I）的H3C-（CH2）n-COOR的脂肪酸或其酯的方法，其中R选自H，甲基，乙基，丙基和丁基，其中 n为0至30，优选6至24，包括通过在分子氧和NAD存在下使脂肪酸或其酯与CYP153家族的细胞色素P450单加氧酶接触来氧化脂肪酸或其酯的步骤 P）H和表达CYP153家族的重组细胞色素P450单加氧酶，重组醇脱氢酶，重组转氨酶以及任选的一种或多于一种重组酶的全细胞催化剂，其包含丙氨酸脱氢酶，铁氧还蛋白和铁氧还蛋白还原酶，以及所述全细胞催化剂用于氧化脂肪酸或其酯的用途。

7. 发明申请

US20140120587A1 ENZYMATIC AMINATION 审中-公开
标题翻译：酶联系
公开(公告)号：US20140120587A1
公开(公告)日：2014-05-01
申请号：US14126607
申请日：2012-01-10
申请人： Thomas Haas , Jan Christoph Pfeffer , Kurt Faber , Michael Fuchs
发明人： Thomas Haas , Jan Christoph Pfeffer , Kurt Faber , Michael Fuchs
IPC分类号： C12P17/12 , C12P13/00 , C12P17/04
CPC分类号： C12P13/001 , C12P7/22 , C12P17/04 , C12P17/12
摘要： A method comprising the steps (a) contacting a hydrocarbon comprising a hydroxyl group with a biological agent having oxygen-dependent and cofactor-dependent carbohydrate oxidase activity in the presence of oxygen and carbohydrate oxidase cofactor, and (b) contacting the hydrocarbon produced in step a) with a biological agent having transaminase activity and a biological agent having cofactor-dependent amino acid dehydrogenase activity in the presence of amino acid dehydrogenase cofactor and the substrate amino acid of the amino acid dehydrogenase.
摘要翻译：一种方法，包括以下步骤：（a）在氧和碳水化合物氧化酶辅因子的存在下使包含羟基的烃与具有氧依赖性和辅因子依赖性碳水化合物氧化酶活性的生物试剂接触，和（b）使步骤 a）具有转氨酶活性的生物制剂和在氨基酸脱氢酶辅因子和氨基酸脱氢酶的底物氨基酸存在下具有辅因子依赖性氨基酸脱氢酶活性的生物试剂。

8. 发明申请

US20140039223A1 CONTINUOUSLY OPERABLE METHOD FOR PRODUCING CARBONYL COMPOUNDS BY MEANS OF A CATALYST CONTAINING A NITROXYL RADICAL 有权
标题翻译：通过含有硝基吡咯的催化剂生产碳化合物的连续可操作方法
公开(公告)号：US20140039223A1
公开(公告)日：2014-02-06
申请号：US14110450
申请日：2011-12-06
申请人： Florian Klasovsky , Thomas Haas , Thomas Tacke , Jan Christoph Pfeffer , Michael Rimbach , Michael Volland , Michiel Janssen , Roger Sheldon , Juergen Haberland
发明人： Florian Klasovsky , Thomas Haas , Thomas Tacke , Jan Christoph Pfeffer , Michael Rimbach , Michael Volland , Michiel Janssen , Roger Sheldon , Juergen Haberland
IPC分类号： C07C45/59
CPC分类号： C07C45/59 , C07D493/04
摘要： The invention relates to a method for the oxidation of a primary or secondary alcohol, preferably to form an aldehyde or ketone, comprising the following steps: a) providing a catalyst composition comprising at least one compound containing a nitroxyl radical, at least one NO source, at least one carbon or mineral acid or an anhydride of a carbon or mineral acid; b) producing a reaction mixture by adding at least one primary or secondary alcohol and a gas comprising oxygen and optionally one or more than one solvent to the catalyst composition from step a) or step e); c) incubating the reaction mixture from step b) at a temperature of between 0 and 100° C. or at the boiling point of the solvent; d) simultaneously with or subsequent to step c): crystallizing the reaction product; and e) recovering the catalyst composition by removing the crystallized reaction product from the reaction mixture obtained in step d).
摘要翻译：本发明涉及氧化伯醇或仲醇，优选形成醛或酮的方法，包括以下步骤：a）提供包含至少一种含有硝酰基的化合物的催化剂组合物，至少一种NO源，至少一种碳或无机酸或碳或无机酸的酸酐; b）通过从步骤a）或步骤e）向催化剂组合物中加入至少一种伯醇或仲醇和包含氧气和任选的一种或多种溶剂的气体产生反应混合物; c）在0-100℃的温度或溶剂的沸点下温育来自步骤b）的反应混合物; d）与步骤c）同时或之后步骤：使反应产物结晶; 和e）通过从步骤d）中获得的反应混合物中除去结晶的反应产物来回收催化剂组合物。

9. 发明授权

US10071951B2 Liquid cation exchanger 有权
公开(公告)号：US10071951B2
公开(公告)日：2018-09-11
申请号：US14000028
申请日：2011-12-01
申请人： Frank Erhardt , Thomas Haas , Martin Roos , Daniel Demicoli , Markus Pötter , Anja Schubert , Jan Christoph Pfeffer , Thomas Tacke , Harald Häger , Andreas Pfennig , Marie-Dominique Przybylski-Freund
发明人： Frank Erhardt , Thomas Haas , Martin Roos , Daniel Demicoli , Markus Pötter , Anja Schubert , Jan Christoph Pfeffer , Thomas Tacke , Harald Häger , Andreas Pfennig , Marie-Dominique Przybylski-Freund
IPC分类号： B01D11/00 , B01J39/04 , C07C67/62 , B01D11/04 , B01J39/16 , C07C227/40 , C07C229/08 , C02F1/26 , C02F1/42 , C02F101/34
CPC分类号： C07C67/62 , B01D11/0492 , B01J39/04 , B01J39/16 , C02F1/26 , C02F2001/425 , C02F2101/34 , C07C227/40 , C07C229/08
摘要： The present application relates to a process for removing an organic compound having one or more positive charges from an aqueous solution, comprising the steps a) provision of the aqueous solution comprising the organic compound and of a hydrophobic organic solution which comprises a liquid cation exchanger, where the liquid cation exchanger is hydrophobic, and where the liquid cation exchanger has one or more negative charges and an overall negative charge, b) contacting the aqueous solution and the organic solution, and c) separating off the organic solution from the aqueous solution.

10. 发明授权

US09315443B2 Liquid cation exchanger 有权
标题翻译：液体阳离子交换剂
公开(公告)号：US09315443B2
公开(公告)日：2016-04-19
申请号：US14000067
申请日：2011-12-01
申请人： Frank Erhardt , Thomas Haas , Martin Roos , Daniel Demicoli , Markus Poetter , Anja Schubert , Jan Christoph Pfeffer , Thomas Tacke , Harald Haeger , Andreas Pfennig , Marie-Dominique Przybylski-Freund
发明人： Frank Erhardt , Thomas Haas , Martin Roos , Daniel Demicoli , Markus Poetter , Anja Schubert , Jan Christoph Pfeffer , Thomas Tacke , Harald Haeger , Andreas Pfennig , Marie-Dominique Przybylski-Freund
IPC分类号： C07C227/00 , C07C67/62 , B01D11/04 , B01J39/04 , B01J39/16 , C07C227/40 , C07C229/08 , C02F1/26 , C02F1/42 , C02F101/34
CPC分类号： C07C67/62 , B01D11/0492 , B01J39/04 , B01J39/16 , C02F1/26 , C02F2001/425 , C02F2101/34 , C07C227/40 , C07C229/08
摘要： The invention relates to a method for removing an organic compound having one or more positive charges from an aqueous solution. Said method consists of the following steps a) the aqueous solution containing the organic compound, and a hydrophobic organic solution which contains a hydrophobic liquid cation exchanger having one or more negative charges and a negative total charge, are provided, b) the aqueous solution and the organic solution are brought into contact with each other and c) the organic solution is separated from the aqueous solution.
摘要翻译：本发明涉及从水溶液中除去具有一个或多个正电荷的有机化合物的方法。所述方法包括以下步骤a）含有有机化合物的水溶液和含有具有一个或多个负电荷和负总电荷的疏水液体阳离子交换剂的疏水性有机溶液，b）水溶液和使有机溶液彼此接触并且c）将有机溶液与水溶液分离。

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