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1. 发明授权

US06700121B1 Methods of sampling specimens for microanalysis 失效
标题翻译：微量分析样品取样方法
公开(公告)号：US06700121B1
公开(公告)日：2004-03-02
申请号：US10428372
申请日：2003-05-01
申请人： Thomas F. Kelly , Richard L. Martens , Steven L. Goodman
发明人： Thomas F. Kelly , Richard L. Martens , Steven L. Goodman
IPC分类号： G01N132
CPC分类号： G01N1/32 , Y10T436/25
摘要： Methods of sampling specimens for microanalysis, particularly microanalysis by atom probe microscopy, include steps of forming a study specimen in a first study object (as by use of focused ion beam milling); removing the study specimen from the study object; situating the study specimen on a second study object; and microanalyzing the study specimen. Where the first study object is of particular interest for study, the study specimen may be taken from a functional portion of the first study object so that microanalysis will provide information regarding this functional portion. Where the second study object is of particular interest for study, the second study object may be subjected to manufacturing processes (e.g., deposition of layers of materials) after the study specimen is situated thereon so that the study specimen will provide information regarding the results of the manufacturing process. The study specimen may have study regions formed thereon which are particularly suitable for study by atom probes, e.g., regions bearing raised protrusions, at virtually any point during the process, thereby greatly enhancing the speed and efficiency of specimen preparation.
摘要翻译：用于微量分析的样品取样方法，特别是通过原子探针显微镜进行微量分析的方法包括在第一研究对象中（如通过使用聚焦离子束研磨）形成研究样品的步骤; 从研究对象中取出研究标本; 将研究样本置于第二个研究对象上; 并微观分析研究样本。如果第一研究对象对于研究特别感兴趣，则研究样本可以从第一研究对象的功能部分获取，使得微量分析将提供关于该功能部分的信息。在第二研究对象特别感兴趣的研究中，第二研究对象可以在研究样本位于其上之后进行制造过程（例如，材料层的沉积），使得研究样本将提供关于制造过程。研究样本可以具有在其上形成的研究区域，其特别适合于在原子探针（例如，具有凸起突起的区域）的研究中，在该过程中的几乎任何点，从而大大提高了样品制备的速度和效率。

2. 发明授权

US06576900B2 Methods of sampling specimens for microanalysis 有权
标题翻译：微量分析样品取样方法
公开(公告)号：US06576900B2
公开(公告)日：2003-06-10
申请号：US09861405
申请日：2001-05-18
申请人： Thomas F. Kelly , Richard L. Martens , Steven L. Goodman
发明人： Thomas F. Kelly , Richard L. Martens , Steven L. Goodman
IPC分类号： G01N132
CPC分类号： G01N1/32 , Y10T436/25
摘要： Methods of sampling specimens for microanalysis, particularly microanalysis by atom probe microscopy, include steps of forming a study specimen in a first study object (as by use of focused ion beam milling); removing the study specimen from the study object; situating the study specimen on a second study object; and microanalyzing the study specimen. Where the first study object is of particular interest for study, the study specimen may be taken from a functional portion of the first study object so that microanalysis will provide information regarding this functional portion. Where the second study object is of particular interest for study, the second study object may be subjected to manufacturing processes (e.g., deposition of layers of materials) after the study specimen is situated thereon so that the study specimen will provide information regarding the results of the manufacturing process. The study specimen may have study regions formed thereon which are particularly suitable for study by atom probes, e.g., regions bearing raised protrusions, at virtually any point during the process, thereby greatly enhancing the speed and efficiency of specimen preparation.
摘要翻译：用于微量分析的样品取样方法，特别是通过原子探针显微镜进行微量分析的方法包括在第一研究对象中（如通过使用聚焦离子束研磨）形成研究样品的步骤; 从研究对象中取出研究标本; 将研究样本置于第二个研究对象上; 并微观分析研究样本。如果第一研究对象对于研究特别感兴趣，则研究样本可以从第一研究对象的功能部分获取，使得微量分析将提供关于该功能部分的信息。在第二研究对象特别感兴趣的研究中，第二研究对象可以在研究样本位于其上之后进行制造过程（例如，材料层的沉积），使得研究样本将提供关于制造过程。研究样本可以具有在其上形成的研究区域，其特别适合于在原子探针（例如，具有凸起突起的区域）的研究中，在该过程中的几乎任何点，从而大大提高了样品制备的速度和效率。

3. 发明申请

US20100152052A1 SPECIMENS FOR MICROANALYSIS PROCESSES 审中-公开
标题翻译：微观分析方法样本
公开(公告)号：US20100152052A1
公开(公告)日：2010-06-17
申请号：US11997141
申请日：2006-07-28
申请人： Steven L. Goodman , Thomas F. Kelly , Terri J. Tomicki
发明人： Steven L. Goodman , Thomas F. Kelly , Terri J. Tomicki
IPC分类号： C40B30/00 , C12Q1/70 , C12Q1/02 , G01N1/00 , C40B50/14
CPC分类号： G01N1/36 , Y10T436/2525
摘要： The present invention relates to specimens for use in microanalysis processes. One aspect of the invention is directed toward using a mold to form specimens for a microanalysis process (e.g., including an atom probe and/or transmission electron microscope processes). Other aspects of the invention are directed towards embedding specimen material (e.g., including nanoparticles) in an embedment material to produce a specimen suitable for use in a microanalysis process. Still other aspects include combining specimen material with an embedment material to enhance a microanalysis process. Yet other embodiments of the invention are directed toward combining a specimen material with multiple embedment materials to produce specimens suitable for a microanalysis process. Further aspects of the invention are directed toward analyzing at least a portion of a specimen produced by one or more of the processes discussed above.
摘要翻译：本发明涉及用于微量分析方法的试样。本发明的一个方面涉及使用模具来形成用于微量分析方法的样品（例如，包括原子探针和/或透射电子显微镜方法）。本发明的其它方面涉及将样品材料（例如，包括纳米颗粒）嵌入到嵌入材料中以产生适合用于微量分析过程的试样。还有一些方面包括将样品材料与嵌入材料组合以增强微量分析过程。本发明的其它实施方案涉及将样品材料与多种嵌入材料组合以产生适于微量分析工艺的试样。本发明的另外方面涉及分析由上述一个或多个过程产生的样本的至少一部分。

4. 发明授权

US07285363B2 Photoactivators, methods of use, and the articles derived therefrom 失效
标题翻译：光活化剂，使用方法及其衍生物
公开(公告)号：US07285363B2
公开(公告)日：2007-10-23
申请号：US10705254
申请日：2003-11-10
申请人： Paul J. Campagnola , Amy R. Howell , Jun Wang , Steven L. Goodman
发明人： Paul J. Campagnola , Amy R. Howell , Jun Wang , Steven L. Goodman
IPC分类号： G03F7/012 , G03C9/08 , G03C1/76
CPC分类号： A61K6/083 , A61K6/0052 , G03F7/038 , G03F7/2053
摘要： A method for crosslinking one or more molecules comprises crosslinking the one or more molecules with a photactivatable crosslinker by one-photon or multi-photon excitation, wherein the crosslinker comprises at least two photoactive groups linked by a bridging moiety, and further wherein the point volume of the activation has at least one dimension of less than about 1 micron. The method is of particular utility for water-soluble molecules, particularly biologically active water-soluble molecules.
摘要翻译：交联一个或多个分子的方法包括通过单光子或多光子激发与可光活化的交联剂交联一个或多个分子，其中交联剂包含至少两个由桥连部分连接的光活性基团，并且其中所述点体积的活化具有小于约1微米的至少一个维度。该方法特别适用于水溶性分子，特别是生物活性水溶性分子。

5. 发明授权

US5551326A Adhesive-less microtome boat 失效
标题翻译：无粘合剂切片机小船
公开(公告)号：US5551326A
公开(公告)日：1996-09-03
申请号：US356422
申请日：1994-12-15
申请人： Steven L. Goodman
发明人： Steven L. Goodman
IPC分类号： G01N1/06
CPC分类号： G01N1/06 , Y10T83/222 , Y10T83/293
摘要： A boat for use with microtomes eliminates the needs for adhesives and provides reusability by use of an elastomeric gasket compressed between contacting surfaces of the knife and boat. The compression is provided by a clamping action of components of the boat for ultramicrotome applications or in the case of histological knives, where the knife base is much broader, by means of a separate leaf spring encircling the unobstructed lower edge of the knife.
摘要翻译：与切片机一起使用的船只消除了对粘合剂的需求，并通过使用在刀和船的接触表面之间压缩的弹性垫片来提供可重用性。通过用于超薄切片机应用的船的部件的夹紧动作或在刀基座宽得多的组织刀的情况下，通过围绕刀的无障碍下边缘的单独的片簧来提供压缩。

6. 发明申请

US20120006711A1 DEVICE FOR HOLDING ELECTRON MICROSCOPE GRIDS AND OTHER MATERIALS 有权
标题翻译：用于保持电子显微镜网格和其他材料的装置
公开(公告)号：US20120006711A1
公开(公告)日：2012-01-12
申请号：US13043220
申请日：2011-03-08
申请人： Steven L. Goodman , Jack LaSee , Mark T. Nelson
发明人： Steven L. Goodman , Jack LaSee , Mark T. Nelson
IPC分类号： B65D85/48
CPC分类号： H01J37/20 , H01J2237/2007 , H01J2237/201
摘要： A device for holding a specimen holder, the device including a body with a slot formed therein. The slot includes an interior for receiving the specimen holder which may be a flat disk with edges and a pair of opposing sides. The disk may be made of a resilient deformable material. The slot may be sized to receive the specimen holder through an open top end and may taper from top bottom, such that the bottom end of the slot is smaller than the specimen holder. The slot further configured to contact the specimen holder along edges of the specimen holder and to allow some sideways deformation of the specimen holder without either side of the specimen holder distant from the edges coming into contact with the interior of the slot.
摘要翻译：一种用于保持试样保持器的装置，该装置包括其中形成有槽的主体。狭槽包括用于容纳样品架的内部，其可以是具有边缘的平板和一对相对的侧面。盘可以由弹性可变形材料制成。狭槽的尺寸可以通过敞开的顶端容纳样品架，并且可以从顶部底部逐渐变细，使得狭槽的底端小于样品架。所述槽进一步构造成沿着所述试样保持器的边缘接触所述试样保持器，并且允许所述试样保持器的一些侧向变形，而所述试样保持器的任何一侧远离所述边缘与所述槽的内部接触。

7. 发明申请

US20080068707A1 DEVICE FOR PREPARING MICROSCOPY SAMPLES 有权
标题翻译：制备微观样品的装置
公开(公告)号：US20080068707A1
公开(公告)日：2008-03-20
申请号：US11752570
申请日：2007-05-23
申请人： Steven L. Goodman
发明人： Steven L. Goodman
IPC分类号： G02B21/00
CPC分类号： G01N1/31 , B01L3/0275 , B01L3/502 , B01L2300/042 , B01L2300/0609 , B01L2300/0681 , G01N1/36 , G01N2035/0427 , G01N2035/1048 , G02B21/34 , H01J2237/20 , H01J2237/2007 , H01J2237/201
摘要： A device, method and system for preparing and storing samples for microscopic analysis is disclosed. The device provides a reservoir that can be attached to a displacement pipette thereby filling the reservoir with reagents desired for preparing the samples for microscopic analysis. In some embodiments, the specimen may be contained on a transmission electron microscope (TEM) grid. In other embodiments, the sample may be a light microscope (LM) specimen or a scanning electron microscope (SEM) specimen. In yet another embodiment, the invention provides a method of preparing samples for microscopic examination including a device for preparing TEM grids with, a device for preparing TEM, SEM or LM specimens with and a device for storing both grids and specimens in. In yet another embodiment, the invention provides a system for tracking the preparation, analysis and histological evaluation of multiple samples while also providing for their long term storage.
摘要翻译：公开了用于制备和存储用于显微镜分析的样品的装置，方法和系统。该装置提供一个可以连接到移液移液管的储液器，从而用准备用于显微镜分析的样品所需的试剂填充储存器。在一些实施例中，样品可以包含在透射电子显微镜（TEM）网格上。在其他实施方案中，样品可以是光学显微镜（LM）样品或扫描电子显微镜（SEM）样品。在另一个实施方案中，本发明提供了一种制备用于显微镜检查的样品的方法，包括用于制备TEM格栅的装置，用于制备TEM，SEM或LM样品的装置以及用于储存两个栅格和标本的装置。另外本发明提供了一种用于跟踪多个样品的制备，分析和组织学评估的系统，同时还提供其长期储存。

8. 发明授权

US5591298A Machine for ultrasonic bonding 失效
标题翻译：超声波接合机
公开(公告)号：US5591298A
公开(公告)日：1997-01-07
申请号：US990824
申请日：1992-12-11
申请人： Steven L. Goodman , Robert E. Vogt
发明人： Steven L. Goodman , Robert E. Vogt
IPC分类号： B29C65/02 , B29C65/08 , B29C65/78 , D04H13/00 , B32B31/16
CPC分类号： B29C66/83511 , B29C65/086 , B29C65/7847 , B29C66/1122 , B29C66/21 , B29C66/24249 , B29C66/43 , B29C66/45 , B29C66/7294 , B29C66/81241 , B29C66/81422 , B29C66/81429 , B29C66/81433 , B29C66/83411 , B29C66/438 , B29C66/73921 , B29C66/73941 , B29K2313/00 , B29L2031/4878
摘要： An apparatus (10) of the type for laminating two elastomeric fibrous web materials (14,16) together by ultrasonic bonding includes a continuously moving web transport support (12) for transporting at least two overlaid webs (14,16) through the apparatus (10). An ultrasonic horn (18) transmits ultrasonic energy to bond the webs (14,16) together into a laminate. An anvil underlies the ultrasonic horn (18). A vacuum mechanism (24) draws the webs (14,16) against the web transport support (12) for perfecting bonding and to prevent rippling and tearing of the webs (14,16) against the horn (18) and the web transport support (12) during the ultrasonic bonding.
摘要翻译：用于通过超声波接合将两个弹性体纤维网材料（14,16）层合在一起的类型的装置（10）包括连续移动的纤维网传送支撑件（12），用于将至少两个重叠的织物（14,16）输送通过设备 10）。超声波喇叭（18）发射超声能量以将幅材（14,16）结合在一起成为层叠体。砧座位于超声波喇叭（18）的下方。真空机构（24）将腹板（14,16）拉紧靠在纸幅传送支架（12）上，以完成粘结并防止卷筒纸（14,16）相对于喇叭（18）的波纹和撕裂以及纸幅传送支架（12）。

9. 发明授权

US08507876B2 Device for holding electron microscope grids and other materials 有权
标题翻译：用于保存电子显微镜网格和其他材料的装置
公开(公告)号：US08507876B2
公开(公告)日：2013-08-13
申请号：US13043220
申请日：2011-03-08
申请人： Steven L. Goodman , Jack LaSee , Mark T. Nelson
发明人： Steven L. Goodman , Jack LaSee , Mark T. Nelson
IPC分类号： B65D85/48 , G21K5/08 , G21K5/10
CPC分类号： H01J37/20 , H01J2237/2007 , H01J2237/201
摘要： A device for holding a specimen holder, the device including a body with a slot formed therein. The slot includes an interior for receiving the specimen holder which may be a flat disk with edges and a pair of opposing sides. The disk may be made of a resilient deformable material. The slot may be sized to receive the specimen holder through an open top end and may taper from top bottom, such that the bottom end of the slot is smaller than the specimen holder. The slot further configured to contact the specimen holder along edges of the specimen holder and to allow some sideways deformation of the specimen holder without either side of the specimen holder distant from the edges coming into contact with the interior of the slot.
摘要翻译：一种用于保持试样保持器的装置，该装置包括其中形成有槽的主体。狭槽包括用于容纳样品架的内部，其可以是具有边缘的平板和一对相对的侧面。盘可以由弹性可变形材料制成。狭槽的尺寸可以通过敞开的顶端容纳样品架，并且可以从顶部底部逐渐变细，使得狭槽的底端小于样品架。所述槽进一步构造成沿着所述试样保持器的边缘接触所述试样保持器，并且允许所述试样保持器的一些侧向变形，而所述试样保持器的任何一侧远离所述边缘与所述槽的内部接触。

10. 发明授权

US5380589A Biotextured surfaces 失效
标题翻译： Biotextured表面
公开(公告)号：US5380589A
公开(公告)日：1995-01-10
申请号：US49209
申请日：1993-04-19
申请人： Steven L. Goodman , Ralph M. Albrecht
发明人： Steven L. Goodman , Ralph M. Albrecht
IPC分类号： A61F2/00 , A61F2/06 , B29D23/22 , B32B1/08
CPC分类号： A61F2/062 , A61F2/0077 , Y10T428/1352 , Y10T428/1397 , Y10T428/24041
摘要： Synthetic biotextured surfaces and methods to produce the surface are disclosed. The surfaces mimic the topography of a surface of a naturally occurring sub-endothelial or sub-epithelial extracellular matrix. This is achieved by removing a cell layer from the naturally occurring extracellular matrix substrate, covering the extracellular matrix with a casting material, and allowing the casting material to harden. One then removes extracellular matrix from the casting material to uncover a negative core, and then uses the negative core to cast the replica material. By removing the negative core from the replica material one then creates the synthetic surface.
摘要翻译：公开了合成的生物表面和产生表面的方法。表面模拟天然存在的亚内皮或亚上皮细胞外基质的表面的形貌。这是通过从天然存在的细胞外基质底物去除细胞层，用浇铸材料覆盖细胞外基质，并允许浇铸材料硬化来实现的。然后从浇铸材料中除去细胞外基质以露出负芯，然后使用负芯浇铸复制材料。通过从复制材料中去除负芯，则产生合成表面。

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