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1. 发明授权

US06307037B1 Fungal target genes and methods 有权
公开(公告)号：US06307037B1
公开(公告)日：2001-10-23
申请号：US09625188
申请日：2000-07-21
申请人： Thomas Deane Gaffney , Albert Flavier , Michelle M. Cloyd Kirksey , Peter Phillippsen , Frederick Dietrich , Jurgen Wendland , Paul Bernasconi , Kimberly White , Witold Filipowicz
发明人： Thomas Deane Gaffney , Albert Flavier , Michelle M. Cloyd Kirksey , Peter Phillippsen , Frederick Dietrich , Jurgen Wendland , Paul Bernasconi , Kimberly White , Witold Filipowicz
IPC分类号： C07H2104
CPC分类号： C07K14/37
摘要： The invention relates to genes isolated from Ashbya gossypii that code for proteins essential for normal fungal growth and development. The invention also includes the methods of using these proteins to discover new fungicides, based on the essentiality of the gene for normal growth and development. The invention can also be used in a screening assay to identify inhibitors that are potential fungicides.

2. 发明授权

US06291665B1 Fungal target genes and methods 失效
标题翻译：真菌靶基因和方法
公开(公告)号：US06291665B1
公开(公告)日：2001-09-18
申请号：US09588256
申请日：2000-06-06
申请人： Thomas Deane Gaffney , Albert Flavier , Krista Gates , Jürgen Wendland , Yasmina Ayad-Durieux , Fred Dietrich , Peter Philippsen
发明人： Thomas Deane Gaffney , Albert Flavier , Krista Gates , Jürgen Wendland , Yasmina Ayad-Durieux , Fred Dietrich , Peter Philippsen
IPC分类号： C07H2104
CPC分类号： C07K14/37
摘要： The invention relates to genes isolated from Ashbya gossypii that code for proteins essential for normal fungal growth and development. The invention also includes the methods of using these proteins to discover new fungicides, based on the essentiality of the gene for normal growth and development. The invention can also be used in a screening assay to identify inhibitors that are potential fungicides.
摘要翻译：本发明涉及从正常真菌生长和发育所必需的蛋白质编码的Ashbya gossypii分离的基因。本发明还包括基于正常生长和发育的基因的本质使用这些蛋白质发现新的杀真菌剂的方法。本发明还可用于筛选试验以鉴定作为潜在杀真菌剂的抑制剂。

3. 发明授权

US5643774A Genes for the synthesis of antipathogenic substance 失效
标题翻译：用于合成抗病原物质的基因
公开(公告)号：US5643774A
公开(公告)日：1997-07-01
申请号：US456837
申请日：1995-06-01
申请人： James M. Ligon , Thomas Schupp , James Joseph Beck , Dwight Steven Hill , John Andrew Ryals , Thomas Deane Gaffney , Stephen Ting Lam , Philip E. Hammer , Scott Joseph Uknes
发明人： James M. Ligon , Thomas Schupp , James Joseph Beck , Dwight Steven Hill , John Andrew Ryals , Thomas Deane Gaffney , Stephen Ting Lam , Philip E. Hammer , Scott Joseph Uknes
IPC分类号： A01H5/00 , A01N37/44 , A01N63/00 , C07K14/195 , C07K14/21 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/09 , C12N15/31 , C12N15/52 , C12N15/78 , C12N15/82 , C12P17/08 , C12P17/10 , C12P21/02 , C12R1/91 , C12N9/00 , C12P21/06
CPC分类号： C07K14/195 , C07K14/21 , C12N15/52 , C12N15/78 , C12N15/8282 , C12P17/08 , C12P17/10
摘要： The present invention is directed to the production of an antipathogenic substance (APS) in a host via recombinant expression of the polypeptides needed to biologically synthesize the APS. Genes encoding polypeptides necessary to produce particular antipathogenic substances are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize any desired APS. The cloned genes may be transformed and expressed in a desired host organisms to produce the APS according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of the APS.
摘要翻译：本发明涉及通过重组表达生物合成APS所需的多肽来在宿主中产生抗病原体物质（APS）。提供编码产生特定抗病原体物质所必需的多肽的基因，以及用于鉴定和分离重组生物合成任何所需APS所需的基因的方法。克隆的基因可以在所需宿主生物体中转化和表达，以产生本发明的APS用于各种目的，包括保护宿主免受病原体的侵袭，将宿主作为生物防治剂开发，并产生大量均匀的 APS。

4. 发明授权

US5955348A Genetically modified pseudomonas strains with enhanced biocontrol activity 失效
标题翻译：具有增强的生物防治活性的转基因假单胞菌菌株
公开(公告)号：US5955348A
公开(公告)日：1999-09-21
申请号：US977306
申请日：1997-11-25
申请人： James Madison Ligon , Nancy R. Torkewitz , Dwight Steven Hill , Thomas Deane Gaffney , Jill Michelle Stafford
发明人： James Madison Ligon , Nancy R. Torkewitz , Dwight Steven Hill , Thomas Deane Gaffney , Jill Michelle Stafford
IPC分类号： A01N63/00 , C12N1/20 , C12N15/00 , C12P21/06
CPC分类号： C12R1/38 , A01N63/00
摘要： Strains of Pseudomonas have been genetically engineered to have enhanced biocontrol properties. The strains of the invention are particularly effective against plant pathogenic fungi such as species of Rhizoctonia and Pythium, because the strains produce enhanced amounts of antifungal metabolites such as pyrrolnitrin that are active against these fungal pathogens. Both the genetically modified biocontrol strains and the antifungal metabolites can be used as active agents for biocontrol compositions.
摘要翻译：已将基因工程改造为具有增强的生物防治性质的假单胞菌菌株。本发明的菌株对于植物致病真菌如丝核菌属和腐霉属物种特别有效，因为菌株产生增加量的抗真菌代谢物，例如对这些真菌病原体具有活性的吡咯烷酮。遗传修饰的生物防治菌株和抗真菌代谢物均可用作生物防治组合物的活性剂。

5. 发明授权

US5662898A Genes for the synthesis of antipathogenic substances 失效
公开(公告)号：US5662898A
公开(公告)日：1997-09-02
申请号：US457342
申请日：1995-06-01
申请人： James M. Ligon , Thomas Schupp , James Joseph Beck , Dwight Steven Hill , John Andrew Ryals , Thomas Deane Gaffney , Stephen Ting Lam , Philip E. Hammer , Scott Joseph Uknes
发明人： James M. Ligon , Thomas Schupp , James Joseph Beck , Dwight Steven Hill , John Andrew Ryals , Thomas Deane Gaffney , Stephen Ting Lam , Philip E. Hammer , Scott Joseph Uknes
IPC分类号： C07K14/195 , C07K14/21 , C12N15/52 , C12N15/78 , C12N15/82 , A01N63/00 , C12N1/20
CPC分类号： C07K14/21 , C07K14/195 , C12N15/52 , C12N15/78 , C12N15/8282
摘要： The present invention is directed to the production of an antipathogenic substance (APS) in a host via recombinant expression of the polypeptides needed to biologically synthesize the APS. Genes encoding polypeptides necessary to produce particular antipathogenic substances are provided, along with methods for identifying and isolating genes needed to recombinantly biosynthesize any desired APS. The cloned genes may be transformed and expressed in a desired host organisms to produce the APS according to the invention for a variety of purposes, including protecting the host from a pathogen, developing the host as a biocontrol agent, and producing large, uniform amounts of the APS.

6. 发明授权

US06291660B1 Fungal genes required for normal growth and development 失效
标题翻译：正常生长发育所需的真菌基因
公开(公告)号：US06291660B1
公开(公告)日：2001-09-18
申请号：US09415522
申请日：1999-10-08
申请人： Thomas Deane Gaffney , Juergen Wendland , Fred Dietrich , Peter Philippsen , Stephen Arthur Goff
发明人： Thomas Deane Gaffney , Juergen Wendland , Fred Dietrich , Peter Philippsen , Stephen Arthur Goff
IPC分类号： C07H2104
CPC分类号： C07K14/37
摘要： The present invention relates to genomic DNA sequences obtained from terminal sequencing of random genomic fragments of the filamentous fungus Ashbya gossypii, to the sequences obtained therewith and the use of the sequences for forensic identification, to characterize genes and gene organization or this ascomycete by inter-genomic comparison, to identify biosynthetic genes that can be used as selection markers, to isolate promoters and terminators for application in a homologous as well as heterologous context, to find putative centromere containing clones, chromosome mapping, chromosome identifying, general information about chromosome organization and in addition to identify ORF containing SRS sequences with no homology to S. cervisiae or any other organism which allows the identification of A. gossypii specific genes.
摘要翻译：本发明涉及从丝状真菌灰白僵菌的随机基因组片段的末端测序获得的基因组DNA序列，其获得的序列以及用于法医鉴定的序列用于表征基因和基因组织或这种子囊菌，基因组比较，以鉴定可用作选择标记的生物合成基因，分离启动子和终止子以应用于同源和异源上下文中，以发现推定的着丝粒含有克隆，染色体定位，染色体鉴定，关于染色体组织的一般信息和除了鉴定含有SRS序列的ORF之外，还没有与S.sarvisiae或任何其他允许鉴别羊链球菌特异性基因的生物体的同源性。

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