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1. 发明授权

US07235045B2 Fluorescence imaging endoscope 失效
标题翻译：荧光成像内窥镜
公开(公告)号：US07235045B2
公开(公告)日：2007-06-26
申请号：US10393028
申请日：2003-03-20
申请人： Thomas D. Wang , Michael S. Feld , Yang Wang , Jacques Van Dam , Stephen F. Fulghum
发明人： Thomas D. Wang , Michael S. Feld , Yang Wang , Jacques Van Dam , Stephen F. Fulghum
IPC分类号： A61B1/04 , A61B1/06
CPC分类号： G01J3/4406 , A61B1/00009 , A61B1/0005 , A61B1/043 , A61B1/05 , A61B1/07 , A61B5/0071 , A61B5/0084 , A61B5/415 , A61B5/418 , G01J3/02 , G01J3/0232 , G01J3/10 , G01N21/6456 , G01N2021/6417 , G01N2021/6421 , G01N2021/6484
摘要： An endoscope having an optical guide that is optically coupled to a first broadband light source and a second laser light source that emits light at a wavelength in a range of 350 nm to 420 nm. The endoscope has an image sensor at a distal end and collects a reflectance image including red, green and blue components with the image sensor in response to illumination by said broadband light source. The image sensor also collects an autofluorescence image having a blue component, a green component and a red component. A processor processes the fluorescence image by determining a ratio of the fluorescence image and the reflectance image to provide a processed fluorescence image.
摘要翻译：一种具有与第一宽带光源光学耦合的光导的内窥镜和发射在350nm至420nm范围内的波长的光的第二激光光源。内窥镜在远端具有图像传感器，并响应于所述宽带光源的照明，利用图像传感器收集包括红色，绿色和蓝色分量的反射图像。图像传感器还收集具有蓝色分量，绿色分量和红色分量的自发荧光图像。处理器通过确定荧光图像和反射率图像的比例来处理荧光图像以提供经处理的荧光图像。

2. 发明授权

US06537211B1 Flourescence imaging endoscope 失效
标题翻译：荧光成像内窥镜
公开(公告)号：US06537211B1
公开(公告)日：2003-03-25
申请号：US09238664
申请日：1999-01-26
申请人： Thomas D. Wang , Michael S. Feld , Yang Wang , Jacques Van Dam , Stephen F. Fulghum
发明人： Thomas D. Wang , Michael S. Feld , Yang Wang , Jacques Van Dam , Stephen F. Fulghum
IPC分类号： A61B106
CPC分类号： G01J3/4406 , A61B1/00009 , A61B1/0005 , A61B1/043 , A61B1/05 , A61B1/07 , A61B5/0071 , A61B5/0084 , A61B5/415 , A61B5/418 , G01J3/02 , G01J3/0232 , G01J3/10 , G01N21/6456 , G01N2021/6417 , G01N2021/6421 , G01N2021/6484
摘要： The present invention relates to a fluorescence endoscope imaging system. The system uses first and second light sources to provide fluorescence and reflectance images of tissue being examined. The imaging system also includes an electronic controller that actuates the illumination of the system by switching current through the first light source between a first illumination level and a second illumination level such that the tissue is illuminated at the first or second illumination level. An imaging device mounted at the distal end of the device is used to collect both images.
摘要翻译：本发明涉及一种荧光内窥镜成像系统。该系统使用第一和第二光源来提供正在检查的组织的荧光和反射图像。成像系统还包括电子控制器，其通过在第一照明水平和第二照明水平之间切换通过第一光源的电流来致动系统的照明，使得组织以第一或第二照明水平照亮。安装在设备远端的成像装置用于收集两个图像。

3. 发明授权

US6070583A Optical imaging of tissue using inelastically scattered light 失效
标题翻译：使用非弹性散射光进行组织的光学成像
公开(公告)号：US6070583A
公开(公告)日：2000-06-06
申请号：US391209
申请日：1995-02-21
申请人： Lev T. Perelman , Jun Wu , Yang Wang , Ramachandra Roa Dasari , Irving Itzkan , Michael S. Feld
发明人： Lev T. Perelman , Jun Wu , Yang Wang , Ramachandra Roa Dasari , Irving Itzkan , Michael S. Feld
IPC分类号： A61B5/00 , G01N21/47 , A61B6/00
CPC分类号： A61B5/0073 , G01N21/4795
摘要： The present invention relates to the use of inelastically scattered light, particularly fluorescent and Raman scattered light, for determining the location and composition of material within various organs of the human body. The systems and methods of the present invention provide for medical imaging in three dimensions as well as histological information that can be used for diagnosing disease and various medical conditions.
摘要翻译：本发明涉及非弹性散射光，特别是荧光和拉曼散射光的用途，用于确定人体各种器官内材料的位置和组成。本发明的系统和方法提供三维医学成像以及可用于诊断疾病和各种医疗状况的组织学信息。

4. 发明授权

US5615673A Apparatus and methods of raman spectroscopy for analysis of blood gases and analytes 失效
标题翻译：用于分析血气和分析物的拉曼光谱仪的装置和方法
公开(公告)号：US5615673A
公开(公告)日：1997-04-01
申请号：US410927
申请日：1995-03-27
申请人： Andrew J. Berger , James F. Brennan, III , Ramanchandra R. Dasari , Michael S. Feld , Irving Itzkan , Kaz Tanaka , Yang Wang
发明人： Andrew J. Berger , James F. Brennan, III , Ramanchandra R. Dasari , Michael S. Feld , Irving Itzkan , Kaz Tanaka , Yang Wang
IPC分类号： A61B5/00 , A61B5/145 , A61B5/1455 , A61B5/1459 , G01N21/65
CPC分类号： G01J3/02 , A61B5/14532 , A61B5/14546 , A61B5/1455 , A61B5/14551 , G01J3/021 , G01J3/0221 , G01N21/65 , A61B2562/12 , G01N2021/656
摘要： The present invention relates to systems of methods of measuring selected analytes in blood and tissue using Raman spectroscopy to aid in diagnosis. More particularly, Raman spectra are collected and analyzed to measure the concentration of dissolved gases and other analytes of interest in blood. Methods include in vivo transdermal and continuous monitoring as well as in vitro blood analysis.
摘要翻译：本发明涉及使用拉曼光谱法测量血液和组织中选定分析物以辅助诊断的方法的系统。更具体地，收集和分析拉曼光谱，以测量溶解气体和其他有关血液中分析物的浓度。方法包括体内透皮和连续监测以及体外血液分析。

5. 发明授权

US5919140A Optical imaging using time gated scattered light 失效
标题翻译：光学成像使用时间门控散射光
公开(公告)号：US5919140A
公开(公告)日：1999-07-06
申请号：US549623
申请日：1995-10-27
申请人： Lev T. Perelman , Jun Wu , Yang Wang , Ramachandra Rao Dasari , Irving Itzkan , Michael S. Feld
发明人： Lev T. Perelman , Jun Wu , Yang Wang , Ramachandra Rao Dasari , Irving Itzkan , Michael S. Feld
IPC分类号： A61B5/00 , G01N21/47 , A61B6/00
CPC分类号： G01N21/4795 , A61B5/0073
摘要： The present invention relates to the use of time gated scattered light, for determining the location and composition of material within various organs of the human body. The systems and methods of the present invention provide for medical imaging in three dimensions of internal body structures for diagnostic purposes.
摘要翻译：本发明涉及时间门控散射光的使用，用于确定人体各种器官内材料的位置和组成。本发明的系统和方法提供用于诊断目的的内部身体结构的三维的医学成像。

6. 发明授权

US06321111B1 Optical imaging using time gated scattered light 失效
标题翻译：光学成像使用时间门控散射光
公开(公告)号：US06321111B1
公开(公告)日：2001-11-20
申请号：US09347050
申请日：1999-07-02
申请人： Lev T. Perelman , Jun Wu , Yang Wang , Ramachandra Rac Dasari , Irving Itzkan , Michael S. Feld
发明人： Lev T. Perelman , Jun Wu , Yang Wang , Ramachandra Rac Dasari , Irving Itzkan , Michael S. Feld
IPC分类号： A61B600
CPC分类号： G01N21/4795 , A61B5/0073
摘要： The present invention relates to the use of time gated scattered light, for determining the location and composition of material within various organs of the human body. The systems and methods of the present invention provide for medical imaging in three dimensions of internal body structures for diagnostic purposes.
摘要翻译：本发明涉及时间门控散射光的使用，用于确定人体各种器官内材料的位置和组成。本发明的系统和方法提供用于诊断目的的内部身体结构的三维的医学成像。

7. 发明授权

US08380268B2 System and methods of fluorescence, reflectance and light scattering spectroscopy for measuring tissue characteristics 有权
公开(公告)号：US08380268B2
公开(公告)日：2013-02-19
申请号：US11166798
申请日：2005-06-24
申请人： Irene Georgakoudi , Michael S. Feld , Qingguo Zhang , Markus G. Mueller
发明人： Irene Georgakoudi , Michael S. Feld , Qingguo Zhang , Markus G. Mueller
IPC分类号： A61B5/00
CPC分类号： G01N21/6486 , A61B5/0059 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/1459 , A61B5/4331 , G01N21/47 , G01N21/64
摘要： The present invention utilizes a plurality of spectroscopic systems and methods to measure characteristics of tissue useful in the diagnosis of disease. In a preferred embodiment, a combination of fluorescence, reflectance and light scattered spectra can be measured and processed to provide biochemical, architectural and morphological state of tissue. The methods and systems can be used particularly in the early detection of carcinoma within tissue in vivo and in vitro.

8. 发明授权

US07365858B2 Systems and methods for phase measurements 有权
标题翻译：相位测量的系统和方法
公开(公告)号：US07365858B2
公开(公告)日：2008-04-29
申请号：US10823389
申请日：2004-04-13
申请人： Christopher M. Fang-Yen , Gabriel Popescu , Changhuei Yang , Adam Wax , Ramachandra R. Dasari , Michael S. Feld
发明人： Christopher M. Fang-Yen , Gabriel Popescu , Changhuei Yang , Adam Wax , Ramachandra R. Dasari , Michael S. Feld
IPC分类号： G01B9/02 , G01B11/02
CPC分类号： G01B9/02091 , A61B5/14532 , A61B5/1455 , A61B5/7232 , G01B9/02002 , G01B9/02007 , G01B9/02011 , G01B9/02057 , G01B9/02063 , G01B9/02067 , G01B9/02069 , G01B9/02071 , G01B9/02072 , G01B9/02078 , G01B9/02083 , G01B9/0209 , G01B2290/45 , G01B2290/60 , G01B2290/70 , G01J9/04 , G01N21/45
摘要： Preferred embodiments of the present invention are directed to systems for phase measurement which address the problem of phase noise using combinations of a number of strategies including, but not limited to, common-path interferometry, phase referencing, active stabilization and differential measurement. Embodiment are directed to optical devices for imaging small biological objects with light. These embodiments can be applied to the fields of, for example, cellular physiology and neuroscience. These preferred embodiments are based on principles of phase measurements and imaging technologies. The scientific motivation for using phase measurements and imaging technologies is derived from, for example, cellular biology at the sub-micron level which can include, without limitation, imaging origins of dysplasia, cellular communication, neuronal transmission and implementation of the genetic code. The structure and dynamics of sub-cellular constituents cannot be currently studied in their native state using the existing methods and technologies including, for example, x-ray and neutron scattering. In contrast, light based techniques with nanometer resolution enable the cellular machinery to be studied in its native state. Thus, preferred embodiments of the present invention include systems based on principles of interferometry and/or phase measurements and are used to study cellular physiology. These systems include principles of low coherence interferometry (LCI) using optical interferometers to measure phase, or light scattering spectroscopy (LSS) wherein interference within the cellular components themselves is used, or in the alternative the principles of LCI and LSS can be combined to result in systems of the present invention.
摘要翻译：本发明的优选实施例涉及用于相位测量的系统，其使用多种策略的组合来解决相位噪声问题，包括但不限于公共路径干涉测量，相位参考，主动稳定和差分测量。实施例涉及用于用光成像小生物物体的光学装置。这些实施方案可以应用于例如细胞生理学和神经科学领域。这些优选实施例基于相位测量和成像技术的原理。使用相位测量和成像技术的科学动机源于例如亚微米级别的细胞生物学，其可以包括但不限于成像发育异常起源，细胞通讯，神经元传播和遗传密码的实现。亚细胞组分的结构和动力学目前不能使用现有的方法和技术（例如x射线和中子散射）在其天然状态下研究。相比之下，具有纳米分辨率的基于光的技术使得能够以其天然状态研究细胞机械。因此，本发明的优选实施例包括基于干涉测量和/或相位测量的原理的系统，并且用于研究细胞生理学。这些系统包括使用光学干涉仪来测量相位的低相干干涉测量（LCI）原理，或使用其中使用细胞部件本身内部的干扰的光散射光谱（LSS），或者替代地，LCI和LSS的原理可以组合以产生在本发明的系统中。

9. 发明授权

US06611339B1 Phase dispersive tomography 失效
标题翻译：相分散层析成像
公开(公告)号：US06611339B1
公开(公告)日：2003-08-26
申请号：US09591297
申请日：2000-06-09
申请人： Changhuei Yang , Adam Wax , Michael S. Feld
发明人： Changhuei Yang , Adam Wax , Michael S. Feld
IPC分类号： G01B902
CPC分类号： A61B5/0073 , A61B5/0066 , G01N15/0205 , G01N21/4795
摘要： Radiation that propagates undeflected through a turbid medium, undergoes a small change in phase velocity due to its wave nature. This change can be measured using a differential phase optical interferometer. Ballistic propagation can be classified into three regimes: For scatterers small compared to the wavelength, the turbid medium acts as a bulk medium; for large scatterers, phase velocity is independent of turbidity; and in the intermediate regime the phase velocity is strongly dependent on scatterer radius. In particular, for scatterers having intermediate size a phase velocity increase and negative dispersion is observed by adding positive dispersion scatterers of higher refractive index. These measurements are made using the phase difference between fundamental and harmonic light and can be used to provide diagnostic information and images of tissue or biological fluids.
摘要翻译：通过混浊介质传播未偏转的辐射由于其波浪性质而在相位速度上发生小的变化。可以使用差分相位光学干涉仪测量该变化。弹道传播可以分为三种方式：对于与波长相比较小的散射体，混浊介质作为大量介质; 对于大散射体，相速度与浊度无关; 并且在中间状态下，相速度很大程度上取决于散射体半径。特别地，对于具有中等尺寸的散射体，通过添加较高折射率的正离散散射体观察到相速度增加和负色散。这些测量使用基波和谐波光之间的相位差进行，可用于提供组织或生物流体的诊断信息和图像。

10. 发明授权

US5290275A Catheter for laser angiosurgery 失效
标题翻译：导管用于激光照射
公开(公告)号：US5290275A
公开(公告)日：1994-03-01
申请号：US731010
申请日：1991-07-16
申请人： Carter Kittrell , Robert M. Cothren, Jr. , Michael S. Feld , Barry Sachs
发明人： Carter Kittrell , Robert M. Cothren, Jr. , Michael S. Feld , Barry Sachs
IPC分类号： A61B5/00 , A61B18/20 , A61B18/22 , A61B18/24 , B23K26/03 , B23K26/067 , G02B6/04 , G02B6/14 , G02B6/24 , G02B6/35 , G02B6/42 , A61B17/32
CPC分类号： B23K26/032 , A61B1/00096 , A61B18/20 , A61B18/245 , A61B5/0071 , A61B5/0075 , A61B5/0084 , B23K26/067 , G02B6/04 , G02B6/241 , G02B6/4296 , A61B2018/00636 , A61B2018/2238 , G01N2021/4747 , G02B6/14 , G02B6/3504 , G02B6/3508 , G02B6/3512 , G02B6/3516 , G02B6/3548 , G02B6/3598
摘要： A laser catheter is disclosed wherein optical fibers carrying laser light are mounted in a catheter for insertion into an artery to provide controlled delivery of a laser beam for percutaneous intravascular laser treatment of atherosclerotic disease. A transparent protective shield is provided at the distal end of the catheter for mechanically diplacing intravascular blood and protecting the fibers from the intravascular contents, as well as protecting the patient in the event of failure of the fiber optics. Multiple optical fibers allow the selection of tissue that is to be removed. A computer controlled system automatically aligns fibers with the laser and controls exposure time. Spectroscopic diagnostics determine what tissue is to be removed.
摘要翻译：公开了一种激光导管，其中携带激光的光纤被安装在用于插入动脉的导管中以提供用于经皮血管内激光治疗动脉粥样硬化疾病的激光束的受控输送。在导管的远端处提供透明保护屏蔽，用于机械地置换血管内血液并保护纤维免受血管内内容物的影响，并且在光纤故障的情况下保护患者。多个光纤允许选择要去除的组织。计算机控制系统自动将光纤与激光对准并控制曝光时间。光谱诊断确定要去除什么组织。

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