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1. 发明授权

US07846091B2 Autofluorescence imaging system for endoscopy 有权
标题翻译：自体荧光成像系统内窥镜检查
公开(公告)号：US07846091B2
公开(公告)日：2010-12-07
申请号：US10092033
申请日：2002-03-05
申请人： Stephen F. Fulghum
发明人： Stephen F. Fulghum
IPC分类号： A61B1/06 , A61B6/00
CPC分类号： A61B1/0638 , A61B1/00009 , A61B1/00126 , A61B1/043 , A61B1/0646 , A61B1/0669 , A61B1/07 , A61B5/0071 , A61B5/0084
摘要： A system and method for imaging tissue autofluorescence through a video endoscope is described, comprising a light source capable of providing both ultraviolet light capable of inducing tissue autofluorescence and visible light which induces little or no autofluorescence, an optical system to deliver both wavelength bands to the tissue with the same apparent spatial and angular intensity distribution, a means for digitally acquiring the resulting, visible fluorescence and visible reflectance images using a single imaging detector at the distal tip of the endoscope and a means for digitally processing said images to generate a final, false-color image for display which indicates regions of tissue dysplasia. This system can either be added on to an existing video endoscope or integrated into its structure. The combined system can be electronically switched between normal white light imaging and fluorescence imaging.
摘要翻译：描述了一种用于通过视频内窥镜成像组织自体荧光的系统和方法，包括能够提供能够诱导组织自发荧光的紫外光和诱发很少或没有自发荧光的可见光的光源，将两个波长带传送到具有相同表观空间和角度强度分布的组织，用于使用在内窥镜的远侧末端处的单个成像检测器数字获取所得到的可见荧光和可见反射图像的装置，以及用于数字处理所述图像以产生最终，用于显示的伪彩色图像，其指示组织发育不良的区域。该系统可以添加到现有的视频内窥镜上或集成到其结构中。组合系统可以在正常白光成像和荧光成像之间进行电子切换。

2. 发明申请

US20090075391A1 Spectroscopic diagnostic method and system based on scattering of polarized light 审中-公开
标题翻译：基于偏振光散射的光谱诊断方法和系统
公开(公告)号：US20090075391A1
公开(公告)日：2009-03-19
申请号：US12215902
申请日：2008-06-30
申请人： Stephen F. Fulghum, JR.
发明人： Stephen F. Fulghum, JR.
IPC分类号： G01N21/84 , G01N21/49 , G02F1/01
CPC分类号： A61B1/0646 , A61B1/00165 , A61B1/043 , A61B1/0669 , A61B1/2736 , A61B5/0075 , A61B5/0084 , A61B5/7257 , G01N21/255 , G01N21/474 , G01N21/645 , G01N2021/6419 , G01N2021/6421
摘要： The present invention provides systems and methods for the determination of the physical characteristics of a structured superficial layer of material using light scattering spectroscopy. The light scattering spectroscopy system comprises optical probes that can be used with existing endoscopes without modification to the endoscope itself. The system uses a combination of optical and computational methods to detect physical characteristics such as the size distribution of cell nuclei in epithelial layers of organs. The light scattering spectroscopy system can be used alone, or in conjunction with other techniques, such as fluorescence spectroscopy and reflected light spectroscopy.
摘要翻译：本发明提供了使用光散射光谱法确定结构化表层材料的物理特性的系统和方法。光散射光谱系统包括可以与现有内窥镜一起使用而不改变内窥镜本身的光学探针。该系统使用光学和计算方法的组合来检测身体特征，例如器官上皮层中细胞核的大小分布。光散射光谱系统可以单独使用，也可以与其他技术结合使用，如荧光光谱和反射光谱。

3. 发明授权

US06364829B1 Autofluorescence imaging system for endoscopy 有权
标题翻译：自体荧光成像系统内窥镜检查
公开(公告)号：US06364829B1
公开(公告)日：2002-04-02
申请号：US09362806
申请日：1999-07-28
申请人： Stephen F. Fulghum
发明人： Stephen F. Fulghum
IPC分类号： A61B106
CPC分类号： A61B5/0084 , A61B1/00009 , A61B1/00126 , A61B1/043 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B1/07 , A61B5/0071 , A61B5/0075
摘要： A system and method for imaging tissue autofluorescence through a video endoscope is described, comprising a light source capable of providing both ultraviolet light capable of inducing tissue autofluorescence and visible light which induces little or no autofluorescence, an optical system to deliver both wavelength bands to the tissue with the same apparent spatial and angular intensity distribution, a means for digitally acquiring the resulting, visible fluorescence and visible reflectance images using a single imaging detector at the distal tip of the endoscope and a means for digitally processing said images to generate a final, false-color image for display which indicates regions of tissue dysplasia. This system can either be added on to an existing video endoscope or integrated into its structure. The combined system can be electronically switched between normal white light imaging and fluorescence imaging.
摘要翻译：描述了一种用于通过视频内窥镜成像组织自体荧光的系统和方法，包括能够提供能够诱导组织自发荧光的紫外光和诱发很少或没有自发荧光的可见光的光源，将两个波长带传送到具有相同表观空间和角度强度分布的组织，用于使用在内窥镜的远侧末端处的单个成像检测器数字获取所得到的可见荧光和可见反射图像的装置，以及用于数字处理所述图像以产生最终，用于显示的伪彩色图像，其指示组织发育不良的区域。该系统可以添加到现有的视频内窥镜上或集成到其结构中。组合系统可以在正常白光成像和荧光成像之间进行电子切换。

4. 发明授权

US07333189B2 Spectroscopic diagnostic methods and system 失效
标题翻译：光谱诊断方法及系统
公开(公告)号：US07333189B2
公开(公告)日：2008-02-19
申请号：US10346711
申请日：2003-01-17
申请人： Stephen F. Fulghum, Jr. , Koichi Furusawa , Kohei Iketani
发明人： Stephen F. Fulghum, Jr. , Koichi Furusawa , Kohei Iketani
IPC分类号： G01N21/00
CPC分类号： G01N21/645 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/0086 , A61B5/7257 , G01N15/0205 , G01N15/0227 , G01N21/31 , G01N21/49 , G01N2021/6417 , G01N2021/6471
摘要： The present invention provides systems and methods for the determination of the physical characteristics of a structured superficial layer of material using light scattering spectroscopy. The light scattering spectroscopy system comprises optical probes that can be used with existing endoscopes without modification to the endoscope itself. The system uses a combination of optical and computational methods to detect physical characteristics such as the size distribution of cell nuclei in epithelial layers of organs. The light scattering spectroscopy system can be used alone, or in conjunction with other techniques, such as fluorescence spectroscopy and reflected light spectroscopy.
摘要翻译：本发明提供了使用光散射光谱法确定结构化表层材料的物理特性的系统和方法。光散射光谱系统包括可以与现有内窥镜一起使用而不改变内窥镜本身的光学探针。该系统使用光学和计算方法的组合来检测身体特征，例如器官上皮层中细胞核的大小分布。光散射光谱系统可以单独使用，也可以与其他技术结合使用，如荧光光谱和反射光谱。

5. 发明授权

US08764643B2 Autofluorescence imaging system for endoscopy 有权
标题翻译：自体荧光成像系统内窥镜检查
公开(公告)号：US08764643B2
公开(公告)日：2014-07-01
申请号：US12955327
申请日：2010-11-29
申请人： Stephen F. Fulghum
发明人： Stephen F. Fulghum
IPC分类号： A61B1/06 , A61B6/00 , A61B1/04
CPC分类号： A61B1/0638 , A61B1/00009 , A61B1/00126 , A61B1/043 , A61B1/0646 , A61B1/0669 , A61B1/07 , A61B5/0071 , A61B5/0084
摘要： A system and method for imaging tissue autofluorescence through a video endoscope is described, comprising a light source capable of providing both ultraviolet light capable of inducing tissue autofluorescence and visible light which induces little or no autofluorescence, an optical system to deliver both wavelength bands to the tissue with the same apparent spatial and angular intensity distribution, a means for digitally acquiring the resulting, visible fluorescence and visible reflectance images using a single imaging detector at the distal tip of the endoscope and a means for digitally processing said images to generate a final, false-color image for display which indicates regions of tissue dysplasia. This system can either be added on to an existing video endoscope or integrated into its structure. The combined system can be electronically switched between normal white light imaging and fluorescence imaging.
摘要翻译：描述了一种用于通过视频内窥镜成像组织自体荧光的系统和方法，包括能够提供能够诱导组织自发荧光的紫外光和诱发很少或没有自发荧光的可见光的光源，将两个波长带传送到具有相同表观空间和角度强度分布的组织，用于使用在内窥镜的远侧末端处的单个成像检测器数字获取所得到的可见荧光和可见反射图像的装置，以及用于数字处理所述图像以产生最终，用于显示的伪彩色图像，其指示组织发育不良的区域。该系统可以添加到现有的视频内窥镜上或集成到其结构中。组合系统可以在正常白光成像和荧光成像之间进行电子切换。

6. 发明申请

US20110213252A1 AUTOFLUORESCENCE IMAGING SYSTEM FOR ENDOSCOPY 有权
标题翻译：内窥镜自动成像系统
公开(公告)号：US20110213252A1
公开(公告)日：2011-09-01
申请号：US12955327
申请日：2010-11-29
申请人： Stephen F. Fulghum
发明人： Stephen F. Fulghum
IPC分类号： A61B6/00
CPC分类号： A61B1/0638 , A61B1/00009 , A61B1/00126 , A61B1/043 , A61B1/0646 , A61B1/0669 , A61B1/07 , A61B5/0071 , A61B5/0084
摘要： A system and method for imaging tissue autofluorescence through a video endoscope is described, comprising a light source capable of providing both ultraviolet light capable of inducing tissue autofluorescence and visible light which induces little or no autofluorescence, an optical system to deliver both wavelength bands to the tissue with the same apparent spatial and angular intensity distribution, a means for digitally acquiring the resulting, visible fluorescence and visible reflectance images using a single imaging detector at the distal tip of the endoscope and a means for digitally processing said images to generate a final, false-color image for display which indicates regions of tissue dysplasia. This system can either be added on to an existing video endoscope or integrated into its structure. The combined system can be electronically switched between normal white light imaging and fluorescence imaging.
摘要翻译：描述了一种用于通过视频内窥镜成像组织自体荧光的系统和方法，包括能够提供能够诱导组织自发荧光的紫外光和诱发很少或没有自发荧光的可见光的光源，将两个波长带传送到具有相同表观空间和角度强度分布的组织，用于使用在内窥镜的远侧末端处的单个成像检测器数字获取所得到的可见荧光和可见反射图像的装置，以及用于数字处理所述图像以产生最终，用于显示的伪彩色图像，其指示组织发育不良的区域。该系统可以添加到现有的视频内窥镜上或集成到其结构中。组合系统可以在正常白光成像和荧光成像之间进行电子切换。

7. 发明授权

US07404929B2 Spectroscopic diagnostic methods and system based on scattering of polarized light 失效
标题翻译：基于偏振光散射的光谱诊断方法和系统
公开(公告)号：US07404929B2
公开(公告)日：2008-07-29
申请号：US10347134
申请日：2003-01-17
申请人： Stephen F. Fulghum, Jr.
发明人： Stephen F. Fulghum, Jr.
IPC分类号： G01N21/00
CPC分类号： G01N21/6486 , A61B5/0071 , A61B5/0075 , A61B5/0084 , A61B5/7257 , G01N21/255 , G01N21/47 , G01N21/474 , G01N21/49 , G01N21/645 , G01N2021/6419 , G01N2021/6421
摘要： The present invention provides systems and methods for the determination of the physical characteristics of a structured superficial layer of material using light scattering spectroscopy. The light scattering spectroscopy system comprises optical probes that can be used with existing endoscopes without modification to the endoscope itself. The system uses a combination of optical and computational methods to detect physical characteristics such as the size distribution of cell nuclei in epithelial layers of organs. The light scattering spectroscopy system can be used alone, or in conjunction with other techniques, such as fluorescence spectroscopy and reflected light spectroscopy.
摘要翻译：本发明提供了使用光散射光谱法确定结构化表层材料的物理特性的系统和方法。光散射光谱系统包括可以与现有内窥镜一起使用而不改变内窥镜本身的光学探针。该系统使用光学和计算方法的组合来检测身体特征，例如器官上皮层中细胞核的大小分布。光散射光谱系统可以单独使用，也可以与其他技术结合使用，如荧光光谱和反射光谱。

8. 发明授权

US07235045B2 Fluorescence imaging endoscope 失效
标题翻译：荧光成像内窥镜
公开(公告)号：US07235045B2
公开(公告)日：2007-06-26
申请号：US10393028
申请日：2003-03-20
申请人： Thomas D. Wang , Michael S. Feld , Yang Wang , Jacques Van Dam , Stephen F. Fulghum
发明人： Thomas D. Wang , Michael S. Feld , Yang Wang , Jacques Van Dam , Stephen F. Fulghum
IPC分类号： A61B1/04 , A61B1/06
CPC分类号： G01J3/4406 , A61B1/00009 , A61B1/0005 , A61B1/043 , A61B1/05 , A61B1/07 , A61B5/0071 , A61B5/0084 , A61B5/415 , A61B5/418 , G01J3/02 , G01J3/0232 , G01J3/10 , G01N21/6456 , G01N2021/6417 , G01N2021/6421 , G01N2021/6484
摘要： An endoscope having an optical guide that is optically coupled to a first broadband light source and a second laser light source that emits light at a wavelength in a range of 350 nm to 420 nm. The endoscope has an image sensor at a distal end and collects a reflectance image including red, green and blue components with the image sensor in response to illumination by said broadband light source. The image sensor also collects an autofluorescence image having a blue component, a green component and a red component. A processor processes the fluorescence image by determining a ratio of the fluorescence image and the reflectance image to provide a processed fluorescence image.
摘要翻译：一种具有与第一宽带光源光学耦合的光导的内窥镜和发射在350nm至420nm范围内的波长的光的第二激光光源。内窥镜在远端具有图像传感器，并响应于所述宽带光源的照明，利用图像传感器收集包括红色，绿色和蓝色分量的反射图像。图像传感器还收集具有蓝色分量，绿色分量和红色分量的自发荧光图像。处理器通过确定荧光图像和反射率图像的比例来处理荧光图像以提供经处理的荧光图像。

9. 发明授权

US06749562B2 Video endoscope and system incorporating the same 失效
标题翻译：视频内窥镜及其结合的系统
公开(公告)号：US06749562B2
公开(公告)日：2004-06-15
申请号：US09988239
申请日：2001-11-19
申请人： Tetsuya Nakamura , Hirohisa Ueda , Rensuke Adachi , Stephen F. Fulghum, Jr.
发明人： Tetsuya Nakamura , Hirohisa Ueda , Rensuke Adachi , Stephen F. Fulghum, Jr.
IPC分类号： A61B105
CPC分类号： A61B1/05
摘要： An objective lens is substantially telecentric toward the image side, and provided with an ultraviolet cut coating on its rearmost surface. An imaging plane of a CCD is arranged near a position where an image of an object is formed through the objective lens. An ultraviolet and infrared cut filter is interposed between the objective lens and the CCD. The cut coating and the cut filter have a total transmittance of 0.1% or lower for ultraviolet light.
摘要翻译：物镜基本上朝向图像侧为远心，并且在其最后表面上设置紫外线切割涂层。 CCD的成像平面配置在通过物镜形成物体的图像的位置附近。在物镜和CCD之间插入紫外线和红外截止滤光片。切割涂层和切割过滤器对于紫外线具有0.1％或更低的总透射率。

10. 发明授权

US06537211B1 Flourescence imaging endoscope 失效
标题翻译：荧光成像内窥镜
公开(公告)号：US06537211B1
公开(公告)日：2003-03-25
申请号：US09238664
申请日：1999-01-26
申请人： Thomas D. Wang , Michael S. Feld , Yang Wang , Jacques Van Dam , Stephen F. Fulghum
发明人： Thomas D. Wang , Michael S. Feld , Yang Wang , Jacques Van Dam , Stephen F. Fulghum
IPC分类号： A61B106
CPC分类号： G01J3/4406 , A61B1/00009 , A61B1/0005 , A61B1/043 , A61B1/05 , A61B1/07 , A61B5/0071 , A61B5/0084 , A61B5/415 , A61B5/418 , G01J3/02 , G01J3/0232 , G01J3/10 , G01N21/6456 , G01N2021/6417 , G01N2021/6421 , G01N2021/6484
摘要： The present invention relates to a fluorescence endoscope imaging system. The system uses first and second light sources to provide fluorescence and reflectance images of tissue being examined. The imaging system also includes an electronic controller that actuates the illumination of the system by switching current through the first light source between a first illumination level and a second illumination level such that the tissue is illuminated at the first or second illumination level. An imaging device mounted at the distal end of the device is used to collect both images.
摘要翻译：本发明涉及一种荧光内窥镜成像系统。该系统使用第一和第二光源来提供正在检查的组织的荧光和反射图像。成像系统还包括电子控制器，其通过在第一照明水平和第二照明水平之间切换通过第一光源的电流来致动系统的照明，使得组织以第一或第二照明水平照亮。安装在设备远端的成像装置用于收集两个图像。

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