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1. 发明授权

US09205224B2 Infusion mechanism and method 有权
标题翻译：输液机制及方法
公开(公告)号：US09205224B2
公开(公告)日：2015-12-08
申请号：US12756400
申请日：2010-04-08
申请人： Therese O'Day , Frank J. Fischer, Jr. , Lindsay Koren , Mark Allen Magnuson , Richard Earl Luedemann , Shyam Kuppurathanam , Keith R. Milner
发明人： Therese O'Day , Frank J. Fischer, Jr. , Lindsay Koren , Mark Allen Magnuson , Richard Earl Luedemann , Shyam Kuppurathanam , Keith R. Milner
IPC分类号： A61M25/00 , A61M25/01 , A61M25/09
CPC分类号： A61M25/003 , A61M25/002 , A61M25/007 , A61M25/0108 , A61M2025/004 , A61M2025/0073 , A61M2025/0079 , A61M2025/0183 , A61M2025/09175
摘要： An infusion mechanism for treating an intraluminal site in a patient includes an infusion catheter having an elongate body with a proximal body end defining at least one fluid supply orifice, and a distal body end. The elongate body defines a high head loss lumen in fluid communication with a first set of side ports defining a proximal infusion zone. The elongate body further defines a low head loss lumen in fluid communication with a second set of side ports defining a distal infusion zone.
摘要翻译：用于治疗患者的管腔内部位的输注机构包括具有细长体的输注导管，其具有限定至少一个流体供应孔的近端体端和远端本体端。细长体限定了与限定近端输注区的第一组侧端口流体连通的高头损失腔。细长体进一步限定与限定远端输注区的第二组侧端口流体连通的低头损失腔。

2. 发明申请

US20110251588A1 Infusion Mechanism And Method 有权
标题翻译：输液机制与方法
公开(公告)号：US20110251588A1
公开(公告)日：2011-10-13
申请号：US12756400
申请日：2010-04-08
申请人： Therese O'Day , Frank J. Fischer, JR. , Lindsay Koren , Mark Allen Magnuson , Richard Earl Luedemann , Shyam Kuppurathanam , Keith R. Milner
发明人： Therese O'Day , Frank J. Fischer, JR. , Lindsay Koren , Mark Allen Magnuson , Richard Earl Luedemann , Shyam Kuppurathanam , Keith R. Milner
IPC分类号： A61M25/00 , A61M25/09
CPC分类号： A61M25/003 , A61M25/002 , A61M25/007 , A61M25/0108 , A61M2025/004 , A61M2025/0073 , A61M2025/0079 , A61M2025/0183 , A61M2025/09175
摘要： An infusion mechanism for treating an intraluminal site in a patient includes an infusion catheter having an elongate body with a proximal body end defining at least one fluid supply orifice, and a distal body end. The elongate body defines a high head loss lumen in fluid communication with a first set of side ports defining a proximal infusion zone. The elongate body further defines a low head loss lumen in fluid communication with a second set of side ports defining a distal infusion zone.
摘要翻译：用于治疗患者的管腔内部位的输注机构包括具有细长体的输注导管，其具有限定至少一个流体供应孔的近端体端和远端本体端。细长体限定了与限定近端输注区的第一组侧端口流体连通的高头损失腔。细长体进一步限定与限定远端输注区的第二组侧端口流体连通的低头损失腔。

3. 发明申请

US20130046282A1 Method Of Treating An Intravascular Site In A Patient, And Thrombolysis Catheter Therefor 有权
标题翻译：治疗患者血管内位置的方法及其溶栓导管
公开(公告)号：US20130046282A1
公开(公告)日：2013-02-21
申请号：US13695915
申请日：2011-05-03
申请人： Therese O'Day , Frank J. Fisher , Lindsay Koren , Mark Allen Magnuson , Richard Earl Luedemann , Shyam Kuppurathanam , Keith R. Milner
发明人： Therese O'Day , Frank J. Fisher , Lindsay Koren , Mark Allen Magnuson , Richard Earl Luedemann , Shyam Kuppurathanam , Keith R. Milner
IPC分类号： A61M11/00 , A61M25/14
CPC分类号： A61M25/007
摘要： A method of treating an intravascular site in a patient includes spraying jets of treatment fluid out of spray orifices formed in an elongate catheter body, and changing an impingement pattern of the treatment fluid on material within the intravascular site in response to a torque induced by a back pressure of the jets. A thrombolysis catheter includes an elongate catheter body having a plurality of spray orifices formed in a body wall, and communicating with a fluid lumen longitudinally extending in the elongate catheter body. The plurality of spray orifices define a torque inducing spray jet pattern, whereby a back pressure of spray jets exiting the spray orifices induces a torque on the elongate catheter body.
摘要翻译：一种治疗患者血管内部位的方法包括从形成于细长导管体内的喷孔喷射治疗液的喷射，并且响应于由所述血管内位置引起的扭矩，改变治疗流体在血管内部位内的材料的冲击模式喷气机的背压。溶栓导管包括细长导管主体，其具有形成在体壁中的多个喷孔，并且与在细长导管主体中纵向延伸的流体腔连通。多个喷射孔限定了转矩诱导喷射喷射图案，由此离开喷嘴的喷射射流的背压在细长导管主体上引起扭矩。

4. 发明授权

US09314589B2 Method of treating an intravascular site in a patient, and thrombolysis catheter therefor 有权
标题翻译：治疗患者血管内部位的方法及其溶栓导管
公开(公告)号：US09314589B2
公开(公告)日：2016-04-19
申请号：US13695915
申请日：2011-05-03
申请人： Therese O'Day , Frank J. Fisher , Lindsay Koren , Mark Allen Magnuson , Richard Earl Luedemann , Shyam Kuppurathanam , Keith R. Milner
发明人： Therese O'Day , Frank J. Fisher , Lindsay Koren , Mark Allen Magnuson , Richard Earl Luedemann , Shyam Kuppurathanam , Keith R. Milner
IPC分类号： A61M25/00
CPC分类号： A61M25/007
摘要： A method of treating an intravascular site in a patient includes spraying jets of treatment fluid out of spray orifices formed in an elongate catheter body, and changing an impingement pattern of the treatment fluid on material within the intravascular site in response to a torque induced by a back pressure of the jets. A thrombolysis catheter includes an elongate catheter body having a plurality of spray orifices formed in a body wall, and communicating with a fluid lumen longitudinally extending in the elongate catheter body. The plurality of spray orifices define a torque inducing spray jet pattern, whereby a back pressure of spray jets exiting the spray orifices induces a torque on the elongate catheter body.
摘要翻译：一种治疗患者血管内部位的方法包括从形成于细长导管体内的喷孔喷射治疗液的喷射，并且响应于由所述血管内位置引起的扭矩，改变治疗流体在血管内部位内的材料的冲击模式喷气机的背压。溶栓导管包括细长导管主体，其具有形成在体壁中的多个喷孔，并且与在细长导管主体中纵向延伸的流体腔连通。多个喷射孔限定了转矩诱导喷射喷射图案，由此离开喷嘴的喷射射流的背压在细长导管主体上引起扭矩。

5. 发明申请

US20130122248A1 ELECTROSPUN PATTERNED STENT GRAFT COVERING 有权
标题翻译：电极图案STET GRAFT COVERING
公开(公告)号：US20130122248A1
公开(公告)日：2013-05-16
申请号：US13295589
申请日：2011-11-14
申请人： Kenneth A. Haselby , Keith R. Milner , Sara M. Sherman , Seoggwan Kim , Richard A. Swift
发明人： Kenneth A. Haselby , Keith R. Milner , Sara M. Sherman , Seoggwan Kim , Richard A. Swift
IPC分类号： B32B3/10 , B29C35/08 , B29C47/08
CPC分类号： D04H1/728 , A61F2/07 , A61F2250/0001 , D01D5/0076 , Y10T428/24273
摘要： An endoluminal prosthesis and systems and methods for making the prosthesis are provided. In one example, a patterned graft material for a prosthesis includes a network of electrospun fibers. The network of electrospun fibers may include a plurality of continuous electrospun fibers. The fibers may be collected on a collector plate using an electrospinning process to form the network of fibers. The patterned graft material also may include a plurality of openings in the network of electrospun fibers. The plurality of openings may be arranged in a pattern. The network of electrospun fibers may include a plurality of edges, each surrounding a corresponding one of the plurality of openings. Each of the plurality of edges may include at least one electrospun fiber of the network of electrospun fibers. A majority of the electrospun fibers of the plurality of edges may be continuous at the edges.
摘要翻译：提供了一种用于制造假体的腔内假体和系统和方法。在一个实例中，用于假体的图案化移植材料包括电纺纤维网络。电纺纤维的网络可以包括多个连续的电纺丝纤维。可以使用电纺丝方法将纤维收集在收集板上以形成纤维网。图案化的移植材料还可以包括电纺纤维网络中的多个开口。多个开口可以以图案布置。电纺纤维的网络可以包括多个边缘，每个边缘围绕多个开口中的对应的一个开口。多个边缘中的每一个可以包括电纺纤维网络的至少一个电纺纤维。多个边缘中的大多数电纺丝纤维可以在边缘处是连续的。

6. 发明申请

US20120259170A1 METHOD FOR MAKING A FLEXIBLE STENT-GRAFT 有权
标题翻译：制造柔性钢筋混凝土的方法
公开(公告)号：US20120259170A1
公开(公告)日：2012-10-11
申请号：US13438549
申请日：2012-04-03
申请人： David G. Grewe , Keith R. Milner , Blayne A. Roeder , Steven J. Charlebois
发明人： David G. Grewe , Keith R. Milner , Blayne A. Roeder , Steven J. Charlebois
IPC分类号： A61F2/06
CPC分类号： A61F2/82 , A61F2/07 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/072 , A61F2002/075 , A61F2002/91566 , A61F2220/005 , A61F2240/001 , A61L31/022 , A61L31/10 , A61L2420/02
摘要： A method of making a stent-graft is provided. The method includes mounting a stent on a mandrel so that the stent is stretched when it is on the mandrel. A graft layer is then adhered to the stent while it is mounted on the mandrel. When the stent-graft is removed from the mandrel, the stent contracts and the graft layer becomes partially wrinkled when the stent is in its expanded relaxed state.
摘要翻译：提供一种制造支架移植物的方法。该方法包括将支架安装在心轴上，使得支架在心轴上时被拉伸。接枝层然后在其被安装在心轴上时粘附到支架上。当支架移植物从心轴移除时，当支架处于其膨胀的松弛状态时，支架收缩并且移植层变得部分起皱。

7. 发明授权

US09175427B2 Electrospun patterned stent graft covering 有权
标题翻译：电纺图案支架移植覆盖物
公开(公告)号：US09175427B2
公开(公告)日：2015-11-03
申请号：US13295589
申请日：2011-11-14
申请人： Kenneth A. Haselby , Keith R. Milner , Sara M. Sherman , Seoggwan Kim , Richard A. Swift
发明人： Kenneth A. Haselby , Keith R. Milner , Sara M. Sherman , Seoggwan Kim , Richard A. Swift
IPC分类号： B32B3/24 , D04H1/728 , D01D5/00 , A61F2/07
CPC分类号： D04H1/728 , A61F2/07 , A61F2250/0001 , D01D5/0076 , Y10T428/24273
摘要： An endoluminal prosthesis and systems and methods for making the prosthesis are provided. In one example, a patterned graft material for a prosthesis includes a network of electrospun fibers. The network of electrospun fibers may include a plurality of continuous electrospun fibers. The fibers may be collected on a collector plate using an electrospinning process to form the network of fibers. The patterned graft material also may include a plurality of openings in the network of electrospun fibers. The plurality of openings may be arranged in a pattern. The network of electrospun fibers may include a plurality of edges, each surrounding a corresponding one of the plurality of openings. Each of the plurality of edges may include at least one electrospun fiber of the network of electrospun fibers. A majority of the electrospun fibers of the plurality of edges may be continuous at the edges.
摘要翻译：提供了一种用于制造假体的腔内假体和系统和方法。在一个实例中，用于假体的图案化移植材料包括电纺纤维网络。电纺纤维的网络可以包括多个连续的电纺丝纤维。可以使用电纺丝方法将纤维收集在收集板上以形成纤维网。图案化的移植材料还可以包括电纺纤维网络中的多个开口。多个开口可以以图案布置。电纺纤维的网络可以包括多个边缘，每个边缘围绕多个开口中的对应的一个开口。多个边缘中的每一个可以包括电纺纤维网络的至少一个电纺纤维。多个边缘中的大多数电纺丝纤维可以在边缘处是连续的。

8. 发明授权

US09060852B2 Method for making a flexible stent-graft 有权
标题翻译：制造柔性支架移植物的方法
公开(公告)号：US09060852B2
公开(公告)日：2015-06-23
申请号：US13438549
申请日：2012-04-03
申请人： David G. Grewe , Keith R. Milner , Blayne A. Roeder , Steven J. Charlebois
发明人： David G. Grewe , Keith R. Milner , Blayne A. Roeder , Steven J. Charlebois
IPC分类号： A61F2/07 , A61F2/91 , A61F2/915 , A61F2/89
CPC分类号： A61F2/82 , A61F2/07 , A61F2/89 , A61F2/91 , A61F2/915 , A61F2002/072 , A61F2002/075 , A61F2002/91566 , A61F2220/005 , A61F2240/001 , A61L31/022 , A61L31/10 , A61L2420/02
摘要： A method of making a stent-graft is provided. The method includes mounting a stent on a mandrel so that the stent is stretched when it is on the mandrel. A graft layer is then adhered to the stent while it is mounted on the mandrel. When the stent-graft is removed from the mandrel, the stent contracts and the graft layer becomes partially wrinkled when the stent is in its expanded relaxed state.
摘要翻译：提供一种制造支架移植物的方法。该方法包括将支架安装在心轴上，使得支架在心轴上时被拉伸。接枝层然后在其被安装在心轴上时粘附到支架上。当支架移植物从心轴移除时，当支架处于其膨胀的松弛状态时，支架收缩并且移植层变得部分起皱。

9. 发明授权

US08535590B2 Spray system and method of making phase separated polymer membrane structures 有权
标题翻译：制备相分离聚合物膜结构的喷雾系统和方法
公开(公告)号：US08535590B2
公开(公告)日：2013-09-17
申请号：US13005090
申请日：2011-01-12
申请人： Keith R. Milner , Matthew S. Huser
发明人： Keith R. Milner , Matthew S. Huser
IPC分类号： A61F2/82 , B05B5/025 , B05C5/00 , B05D1/02
CPC分类号： B29C41/003 , B05B13/0214 , B05B13/0442 , B29C41/085 , B29C41/365 , B29C41/52 , B29L2031/7532 , B29L2031/755
摘要： A spray system and method of using such spray system to fabricate a polymer membrane structure for use as a vascular graft or tissue engineered scaffold is provided. Generally, this spray system includes the use of at least two spray apparatus to apply different polymer and solvent mixtures to the outer surface of a mandrel to form a blended layer. Upon curing of the blended layer, phase separation occurs leading to the formation of a polymer membrane structure having variable properties along at least a portion of its longitudinal axis.
摘要翻译：提供了一种使用这种喷雾系统制造用作血管移植物或组织工程支架的聚合物膜结构的喷雾系统和方法。通常，该喷雾系统包括使用至少两个喷雾装置以将不同的聚合物和溶剂混合物施加到心轴的外表面以形成混合层。在混合层固化后，发生相分离，导致在其纵轴的至少一部分上形成具有可变性质的聚合物膜结构。

10. 发明申请

US20130138202A1 BLOOD PERFUSION DEVICE 审中-公开
标题翻译：血液灌注装置
公开(公告)号：US20130138202A1
公开(公告)日：2013-05-30
申请号：US13761391
申请日：2013-02-07
申请人： Ram H. Paul , Richard A. Swift , Oliver Bach , Ralf Steiner , Angela R. Barnett , Keith R. Milner
发明人： Ram H. Paul , Richard A. Swift , Oliver Bach , Ralf Steiner , Angela R. Barnett , Keith R. Milner
IPC分类号： A61F2/82
CPC分类号： A61F2/82 , A61F2/07 , A61F2/848 , A61F2/915 , A61F2002/075 , A61F2002/8483 , A61F2002/91558 , A61F2002/91575 , A61F2210/0076 , A61F2220/0016 , A61F2220/0075 , A61F2250/0023 , A61F2250/0036 , A61F2250/0037
摘要： A perfusion device and a delivery system for repair of a damaged portion of a body vessel. Perfusion device can include a tubular body that is self-expandable, having a proximal portion, a distal portion, and an intermediate portion. One or more series of barbs can be disposed circumferentially along the intermediate portion. Barbs are capable of penetrating into the tunica intima and tunica media of said vessel wall upon insertion of said device into said body vessel, and not into said tunica adventitia. A graft can be associated with the tubular body. Graft has a proximal end and a distal end, and preferably extends entirely along a luminal wall of the tubular body. Graft may also extend along an exterior surface of the tubular body at the proximal and distal portions. A remodelable covering can be applied along the intermediate portion. Delivery devices for the perfusion implant and methods of delivering the perfusion implant are also provided.
摘要翻译：灌注装置和用于修复身体血管损伤部分的输送系统。灌注装置可以包括可自膨胀的管状体，其具有近端部分，远端部分和中间部分。一个或多个串联的倒钩可以沿着中间部分周向设置。倒钩在将所述装置插入所述身体容器中时能够渗入所述血管壁的中膜和中膜，并且不会进入所述外膜。移植物可以与管状体相关联。移植物具有近端和远端，优选地沿管状体的腔壁完全延伸。移植物也可以在近端部分和远端部分沿管状体的外表面延伸。可以沿着中间部分施加可重塑的覆盖物。还提供用于灌注植入物的递送装置和递送灌注植入物的方法。

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