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1. 发明申请

US20050288344A1 Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases 有权
标题翻译：用于治疗或预防肺病毒感染和相关疾病的化合物，组合物和方法
公开(公告)号：US20050288344A1
公开(公告)日：2005-12-29
申请号：US10524162
申请日：2003-08-11
申请人： Theodore Nitz , Janet Gaboury , Christopher Burns , Sylvia Laquerre , Daniel Pevear , Thomas Lessen , David Rys
发明人： Theodore Nitz , Janet Gaboury , Christopher Burns , Sylvia Laquerre , Daniel Pevear , Thomas Lessen , David Rys
IPC分类号： A61K31/41 , A61P25/00 , C07D257/04 , C07D401/14 , C07D417/14 , C07D43/02
CPC分类号： C07D275/02 , A61K31/11 , A61K31/136 , A61K31/18 , A61K31/196 , A61K31/222 , A61K31/357 , A61K31/41 , A61K31/425 , A61K31/427 , A61K31/4453 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K45/06 , C07C47/565 , C07C69/18 , C07C223/06 , C07C235/16 , C07C235/68 , C07C311/29 , C07D211/32 , C07D257/04 , C07D401/14 , C07D407/10 , C07D417/14
摘要： Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infection.
摘要翻译：提供了化合物，组合物和方法用于预防和治疗由副粘病毒肺炎链球菌亚科病毒引起的感染和与此类感染有关的疾病。

2. 发明申请

US20050288345A1 Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases 有权
标题翻译：用于治疗或预防肺病毒感染和相关疾病的化合物，组合物和方法
公开(公告)号：US20050288345A1
公开(公告)日：2005-12-29
申请号：US10524313
申请日：2003-08-11
申请人： David Rys , Theodore Nitz , Janet Gaboury , Christopher Burns , Daniel Pevear , Thomas Lessen , Torsten Herbertz
发明人： David Rys , Theodore Nitz , Janet Gaboury , Christopher Burns , Daniel Pevear , Thomas Lessen , Torsten Herbertz
IPC分类号： A61K31/41 , C07D257/04 , C07D43/02
CPC分类号： C07D257/04 , A61K31/41 , A61K38/21 , A61K39/395
摘要： Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infections.
摘要翻译：提供了化合物，组合物和方法用于预防和治疗由副粘病毒肺炎链球菌亚科病毒引起的感染和与此类感染有关的疾病。

3. 发明申请

US20070231318A1 BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES 失效
标题翻译：苯佐芬化合物，组合物和方法治疗和预防乙型肝炎病毒感染和相关疾病
公开(公告)号：US20070231318A1
公开(公告)日：2007-10-04
申请号：US11753145
申请日：2007-05-24
申请人： Ashis Saha , Christopher Burns , Alfred Del Vecchio , Thomas Bailey , Jason Reinhardt , Bheemashankar Kulkarni , Thomas Faitg , Hao Feng , Susan Rippin , Charles Blackledge , David Rys , Thomas Lessen , John Swestock , Yijum Deng , Theodore Nitz
发明人： Ashis Saha , Christopher Burns , Alfred Del Vecchio , Thomas Bailey , Jason Reinhardt , Bheemashankar Kulkarni , Thomas Faitg , Hao Feng , Susan Rippin , Charles Blackledge , David Rys , Thomas Lessen , John Swestock , Yijum Deng , Theodore Nitz
IPC分类号： A61K31/343 , A61K31/7052 , A61K31/7105 , A61K38/14 , A61K39/395 , C07D307/78
CPC分类号： C07D405/04 , C07D307/84 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention relates to novel benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.
摘要翻译：本发明涉及新的苯并呋喃衍生物和类似物，以及含有该苯并呋喃衍生物和类似物的组合物及其用于治疗或预防与其相关的病毒感染和疾病，特别是由丙型肝炎病毒引起的那些病毒感染和相关疾病的用途。

4. 发明申请

US20070219212A1 Pyranouidole Derivatives and the Use Thereof for the Treatment of Hepatitis C Virus Infection or Disease 审中-公开
标题翻译：吡喃并吡喃衍生物及其用途用于治疗丙型肝炎病毒感染或疾病
公开(公告)号：US20070219212A1
公开(公告)日：2007-09-20
申请号：US10589453
申请日：2005-03-01
申请人： Stephen Condon , Randy Jackson , Matthew Laporte , Christopher Burns , Torsten Herbertz , Janet Gaboury
发明人： Stephen Condon , Randy Jackson , Matthew Laporte , Christopher Burns , Torsten Herbertz , Janet Gaboury
IPC分类号： A61K31/407 , C07D491/02
CPC分类号： C07D491/04
摘要： The invention is directed to novel pyranoindole derivatives and analogs as well as compositions containing the same and to the use thereof for the treatment, prevention or inhibition of viral infections and associated diseases caused by the Hepatitis C virus.
摘要翻译：本发明涉及新颖的吡喃吲哚衍生物和类似物以及含有它们的组合物及其用于治疗，预防或抑制由丙型肝炎病毒引起的病毒感染和相关疾病的用途。

5. 发明申请

US20140156421A1 SPONSORED MESSAGE NETWORK BASED ON COMMUNITY PREFERENCES 有权
标题翻译：基于社区优先权的赞助信息网络
公开(公告)号：US20140156421A1
公开(公告)日：2014-06-05
申请号：US13705838
申请日：2012-12-05
申请人： Christopher Burns , John Woolley
发明人： Christopher Burns , John Woolley
IPC分类号： G06Q30/02
CPC分类号： G06Q30/0277
摘要： The invention described here is a system and method for efficiently presenting sponsored messages to the user of a participating information site or service, based on the level of interest recently expressed in those messages by other visitors to the same site. Presentation of sponsored messages may also be based on the level of interest expressed by other visitors across the network who are in the individual user's geographic region.
摘要翻译：这里描述的发明是基于最近在同一站点的其他访问者在这些消息中表达的兴趣水平来有效地向参与信息站点或服务的用户呈现赞助消息的系统和方法。赞助邮件的呈现也可以基于在个人用户的地理区域中的网络上的其他访问者所表达的兴趣水平。

6. 发明申请

US20070161635A1 Kinase inhibitors 审中-公开
标题翻译：激酶抑制剂
公开(公告)号：US20070161635A1
公开(公告)日：2007-07-12
申请号：US11711957
申请日：2007-02-27
申请人： Christopher Burns , Xianyong Bu , Andrew Wilks
发明人： Christopher Burns , Xianyong Bu , Andrew Wilks
IPC分类号： A61K31/5377 , A61K31/497
CPC分类号： C07D401/14 , A61K31/497 , C07D403/04 , C07D403/14 , C07D413/14 , C07D471/04
摘要： Methods using compounds of the general formula: or pharmaceutically acceptable salts, hydrates, solvates, crystal forms or diastereomers thereof to treat protein kinase-associated disease states is described.
摘要翻译：描述了使用以下通式的化合物或其药学上可接受的盐，水合物，溶剂合物，结晶形式或非对映异构体来治疗蛋白激酶相关疾病状态的方法。

7. 发明授权

US06173344B2 SCSI bus transceiver and method for making the same 失效
标题翻译： SCSI总线收发器及其制作方法
公开(公告)号：US06173344B2
公开(公告)日：2001-01-09
申请号：US09085671
申请日：1998-05-27
申请人： Abdul Waheed Mohammed , Peter K. Cheung , Barry Davis , Christopher Burns
发明人： Abdul Waheed Mohammed , Peter K. Cheung , Barry Davis , Christopher Burns
IPC分类号： G06F1300
CPC分类号： G06F13/4072
摘要： Disclosed is a SCSI host adapter for use in a computer system. The SCSI host adapter is configured to provide the computer system with interconnection with internal and/or external target devices. The SCSI host adapter includes a low voltage differential connector for interconnecting to a low voltage differential bus, and the low voltage differential bus is configured to communicate a first transaction. The SCSI host adapter also includes a single ended connector for interconnecting to a single ended bus, and the single ended bus is configured to communicate a second transaction. Furthermore, the SCSI host adapter includes a transceiver unit that is configured to interface between the low voltage differential bus and the single ended bus and produce a target information signal. The target information signal is configured to indicate whether the first transaction or the second transaction is occurring between the SCSI host adapter and the low voltage differential bus or the single ended bus.
摘要翻译：公开了一种用于计算机系统的SCSI主机适配器。 SCSI主机适配器被配置为向计算机系统提供与内部和/或外部目标设备的互连。 SCSI主机适配器包括用于互连到低电压差分总线的低压差分连接器，并且低电压差分总线被配置为传送第一事务。 SCSI主机适配器还包括用于互连到单端总线的单端连接器，并且单端总线被配置为传送第二事务。此外，SCSI主机适配器包括收发器单元，其被配置为在低电压差分总线和单端总线之间进行接口并产生目标信息信号。目标信息信号被配置为指示在SCSI主机适配器和低电压差分总线或单端总线之间是否发生第一事务或第二事务。

8. 发明授权

US5889053A Farnesyl transferase inhibitors, preparation thereof and pharmaceuticals compositions containing said inhibitors 失效
标题翻译：法呢基转移酶抑制剂，其制备物和含有所述抑制剂的药物组合物
公开(公告)号：US5889053A
公开(公告)日：1999-03-30
申请号：US5154
申请日：1998-01-09
申请人： Bernard Baudoin , Christopher Burns , Alain Commercon , Alain Lebrun
发明人： Bernard Baudoin , Christopher Burns , Alain Commercon , Alain Lebrun
IPC分类号： A61K31/195 , A61K31/215 , A61P35/00 , A61P43/00 , C07C323/59 , A61K31/235
CPC分类号： C07C323/59
摘要： Novel farnesyl transferase inhibitors of general formula (I), ##STR1## the preparation thereof and pharmaceutical compositions containing said inhibitors, are disclosed. In general formula (I), R.sub.1 is Y--S--A.sub.1 (where Y is a hydrogen atom, an amino acid residue, a fatty acid residue, an alkyl or alkoxycarbonyl radical or a radical R.sub.4 --S-- where R.sub.4 is a C.sub.1-4 alkyl radical optionally substituted by a phenyl radical or a radical of general formula (II) ##STR2## wherein A.sub.1, X, X.sub.1, Y.sub.1, R'.sub.1, R.sub.2, R'.sub.2 and R are defined as below, and A.sub.1 is a C.sub.1-4 alkylene radical optionally alpha-substituted in the >C(X.sub.1)(Y.sub.1) grouping by an amino or alkylamino, dialkylamino, alkanoylamino or alkoxycarbonylamino radical); X.sub.1 and Y.sub.1 are each a hydrogen atom or, taken together with the carbon atom to which they are attached, form a >C.dbd.O grouping; R'.sub.1 is hydrogen or a C.sub.1-6 alkyl radical; X is an oxygen or sulphur atom; R.sub.2 is a C.sub.1-6 alkyl, alkenyl or alkynyl radical optionally substituted by hydroxyl, alkoxy, mercapto, alkylthio, alkylsulphinyl or alkylsulphonyl, with the proviso that when R.sub.2 is an alkyl radical substituted by a hydroxy radical, R.sub.2 can form a lactone with the .alpha.-carboxy radical; and R'.sub.2 is hydrogen or a C.sub.1-6 alkyl radical; and R is a hydrogen atom or an optionally substituted alkyl radical or an optionally substituted pheny radical, with the proviso that radical (a) ##STR3## is in the 3 or 4 position of the naphthyl ring. The novel products have anticancer properties.
摘要翻译：公开了通式（I）的新型法呢基转移酶抑制剂，其制备方法和含有所述抑制剂的药物组合物。在通式（I）中，R 1是YS-A1（其中Y是氢原子，氨基酸残基，脂肪酸残基，烷基或烷氧基羰基或基团R 4 -S-，其中R 4是C 1-4烷基任选被苯基或通式（II）的基团取代的基团其中A1，X，X1，Y1，R'1，R2，R'2和R定义如下，而A1是通过氨基或烷基氨基，二烷基氨基，烷酰基氨基或烷氧基羰基氨基，在> C（X1）（Y1）组中任意α-取代的C1-4亚烷基; X1和Y1各自为氢原子，或与它们所连接的碳原子一起形成> C = O基团; R 1是氢或C 1-6烷基; X是氧或硫原子; R2是任选被羟基，烷氧基，巯基，烷硫基，烷基亚磺酰基或烷基磺酰基取代的C 1-6烷基，烯基或炔基，条件是当R 2是被羟基取代的烷基时，R 2可以与 α-羧基; 和R'2是氢或C 1-6烷基; 并且R是氢原子或任选取代的烷基或任选取代的苯基，条件是基团（a）（a）在萘环的3或4位。新产品具有抗癌性能。

9. 发明申请

US20070082894A1 Pyrazine-based tubulin inhibitors 有权
标题翻译：基于吡嗪的微管蛋白抑制剂
公开(公告)号：US20070082894A1
公开(公告)日：2007-04-12
申请号：US10538499
申请日：2003-12-11
申请人： Christopher Burns , Andrew Wilks , Xianyong Bu , Harrison Sikanyika , Michael Harte
发明人： Christopher Burns , Andrew Wilks , Xianyong Bu , Harrison Sikanyika , Michael Harte
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/4965 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D405/12 , C07D241/20 , C07D401/12 , C07D405/04 , C07F9/650952
摘要： A compound of general formula (I) or pharmaceutically acceptable prodrugs, salts, hydrates, solvates, crystal forms or diastereomers thereof is described. A method of treating a hyperproliferation-related disease state or disorder in a subject using a compound of formula (I) is also described.
摘要翻译：描述了通式（I）的化合物或其药学上可接受的前药，盐，水合物，溶剂合物，结晶形式或非对映异构体。还描述了使用式（I）化合物治疗受试者的过度增生相关疾病状态或障碍的方法。

10. 发明申请

US20060148824A1 Protein kinase inhibitors 审中-公开
标题翻译：蛋白激酶抑制剂
公开(公告)号：US20060148824A1
公开(公告)日：2006-07-06
申请号：US11367248
申请日：2006-03-02
申请人： Christopher Burns , Xianyong Bu , Andrew Wilks
发明人： Christopher Burns , Xianyong Bu , Andrew Wilks
IPC分类号： A61K31/4965
CPC分类号： C07D401/12 , C07D241/20 , C07D405/12
摘要： A compound of the general formula: or pharmaceutically acceptable salts, hydrates, solvates, crystal forms of diastereomers thereof is described. Method of inhibiting a protein kinase using compounds of Formula I are also described.
摘要翻译：描述了以下通式的化合物或其药学上可接受的盐，水合物，溶剂合物，其非对映异构体的晶体形式。还描述了使用式I化合物抑制蛋白激酶的方法。

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