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1. 发明申请

US20070231318A1 BENZOFURAN COMPOUNDS, COMPOSITIONS AND METHODS FOR TREATMENT AND PROPHYLAXIS OF HEPATITIS C VIRAL INFECTIONS AND ASSOCIATED DISEASES 失效
标题翻译：苯佐芬化合物，组合物和方法治疗和预防乙型肝炎病毒感染和相关疾病
公开(公告)号：US20070231318A1
公开(公告)日：2007-10-04
申请号：US11753145
申请日：2007-05-24
申请人： Ashis Saha , Christopher Burns , Alfred Del Vecchio , Thomas Bailey , Jason Reinhardt , Bheemashankar Kulkarni , Thomas Faitg , Hao Feng , Susan Rippin , Charles Blackledge , David Rys , Thomas Lessen , John Swestock , Yijum Deng , Theodore Nitz
发明人： Ashis Saha , Christopher Burns , Alfred Del Vecchio , Thomas Bailey , Jason Reinhardt , Bheemashankar Kulkarni , Thomas Faitg , Hao Feng , Susan Rippin , Charles Blackledge , David Rys , Thomas Lessen , John Swestock , Yijum Deng , Theodore Nitz
IPC分类号： A61K31/343 , A61K31/7052 , A61K31/7105 , A61K38/14 , A61K39/395 , C07D307/78
CPC分类号： C07D405/04 , C07D307/84 , C07D405/06 , C07D405/12 , C07D407/04 , C07D407/12 , C07D409/04 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/12 , C07D417/14
摘要： The present invention relates to novel benzofuran derivatives and analogs, as well as compositions containing the same and to the use thereof for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus.
摘要翻译：本发明涉及新的苯并呋喃衍生物和类似物，以及含有该苯并呋喃衍生物和类似物的组合物及其用于治疗或预防与其相关的病毒感染和疾病，特别是由丙型肝炎病毒引起的那些病毒感染和相关疾病的用途。

2. 发明申请

US20060205697A1 Novel betulin derivatives, preparation thereof and use thereof 审中-公开
标题翻译：新颖的桦木醇衍生物，其制备及其用途
公开(公告)号：US20060205697A1
公开(公告)日：2006-09-14
申请号：US11272019
申请日：2005-11-14
申请人： Gary Robinson , Carl Wild , Mark Ashton , Russell Thomas , Christian Montalbetti , Thomas Coulter , Filippo Magaraci , Robert Townsend , Theodore Nitz
发明人： Gary Robinson , Carl Wild , Mark Ashton , Russell Thomas , Christian Montalbetti , Thomas Coulter , Filippo Magaraci , Robert Townsend , Theodore Nitz
IPC分类号： A61K31/66 , C07J51/00 , C07J53/00 , A61K31/58
CPC分类号： C07J51/00 , C07J53/00
摘要： The present invention relates to novel synthetic derivatives of betulin and the use of such derivatives as pharmaceuticals. The present invention is directed to novel compounds of Formula I: or a pharmaceutically acceptable salt or prodrug thereof.
摘要翻译：本发明涉及新颖的桦木素合成衍生物和药物衍生物的用途。本发明涉及新的式I化合物：或其药学上可接受的盐或前药。

3. 发明申请

US20050288344A1 Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases 有权
标题翻译：用于治疗或预防肺病毒感染和相关疾病的化合物，组合物和方法
公开(公告)号：US20050288344A1
公开(公告)日：2005-12-29
申请号：US10524162
申请日：2003-08-11
申请人： Theodore Nitz , Janet Gaboury , Christopher Burns , Sylvia Laquerre , Daniel Pevear , Thomas Lessen , David Rys
发明人： Theodore Nitz , Janet Gaboury , Christopher Burns , Sylvia Laquerre , Daniel Pevear , Thomas Lessen , David Rys
IPC分类号： A61K31/41 , A61P25/00 , C07D257/04 , C07D401/14 , C07D417/14 , C07D43/02
CPC分类号： C07D275/02 , A61K31/11 , A61K31/136 , A61K31/18 , A61K31/196 , A61K31/222 , A61K31/357 , A61K31/41 , A61K31/425 , A61K31/427 , A61K31/4453 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/5377 , A61K45/06 , C07C47/565 , C07C69/18 , C07C223/06 , C07C235/16 , C07C235/68 , C07C311/29 , C07D211/32 , C07D257/04 , C07D401/14 , C07D407/10 , C07D417/14
摘要： Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infection.
摘要翻译：提供了化合物，组合物和方法用于预防和治疗由副粘病毒肺炎链球菌亚科病毒引起的感染和与此类感染有关的疾病。

4. 发明申请

US20050288345A1 Compounds, compositions and methods for treating or preventing pneumovirus infection and associated diseases 有权
标题翻译：用于治疗或预防肺病毒感染和相关疾病的化合物，组合物和方法
公开(公告)号：US20050288345A1
公开(公告)日：2005-12-29
申请号：US10524313
申请日：2003-08-11
申请人： David Rys , Theodore Nitz , Janet Gaboury , Christopher Burns , Daniel Pevear , Thomas Lessen , Torsten Herbertz
发明人： David Rys , Theodore Nitz , Janet Gaboury , Christopher Burns , Daniel Pevear , Thomas Lessen , Torsten Herbertz
IPC分类号： A61K31/41 , C07D257/04 , C07D43/02
CPC分类号： C07D257/04 , A61K31/41 , A61K38/21 , A61K39/395
摘要： Compounds, compositions and methods are provided for the prophylaxis and treatment of infections caused by viruses of the Pneumovirinae subfamily of Paramyxoviridae and diseases associated with such infections.
摘要翻译：提供了化合物，组合物和方法用于预防和治疗由副粘病毒肺炎链球菌亚科病毒引起的感染和与此类感染有关的疾病。

5. 发明授权

US06364811B1 Model-based transmission upshift control with engine torque management 有权
标题翻译：基于型号的变速箱升档控制与发动机转矩管理
公开(公告)号：US06364811B1
公开(公告)日：2002-04-02
申请号：US09598283
申请日：2000-06-22
申请人： Gregory A Hubbard , Jeffrey Kurt Runde , Larry Theodore Nitz , Timothy Alan Robinson , Todd M Steinmetz
发明人： Gregory A Hubbard , Jeffrey Kurt Runde , Larry Theodore Nitz , Timothy Alan Robinson , Todd M Steinmetz
IPC分类号： F16H6104
CPC分类号： F16H61/061 , B60W10/06 , B60W10/115 , B60W2710/1016 , Y02T10/56 , Y10T477/675 , Y10T477/6937 , Y10T477/6939
摘要： An improved control for an automatic transmission upshift, wherein the engine output torque and on-coming clutch pressure are coordinated during the shift based on an inverse dynamic model of the transmission to achieve a desired output torque trajectory. The desired output torque trajectory is influenced by operator demand, and an initial value of the desired output torque trajectory is used along with the engine output torque to develop an input acceleration trajectory. The inverse dynamic model of the transmission is used (1) to determine an engine torque command that will achieve both the input acceleration trajectory and the desired output torque trajectory, and (2) to determine a feed-forward pressure command for the on-coming clutch that will produce the input acceleration trajectory, given the engine torque command. The desired output torque trajectory and the engine output torque are used to determine the expected input speed, and a feed-back control term based on the deviation of the measured input speed from the expected input speed is used to adjust the on-coming clutch pressure command to account for model errors. Finally, the closed-loop feedback error is used to enable adaptive correction of the feed-forward control so that the feed-forward clutch pressure more nearly produces the commanded input shaft acceleration.
摘要翻译：用于自动变速器升档的改进的控制，其中基于变速器的逆动力学模型，在换档期间协调发动机输出扭矩和接通离合器压力，以实现期望的输出转矩轨迹。期望的输出转矩轨迹受操作者需求的影响，并且使用期望的输出转矩轨迹的初始值以及发动机输出转矩来产生输入加速轨迹。使用变速器的逆动力学模型（1）来确定将实现输入加速度轨迹和期望输出转矩轨迹的发动机扭矩指令，以及（2）确定用于接下来的前馈压力指令给定发动机扭矩指令的离合器将产生输入加速度轨迹。使用期望的输出转矩轨迹和发动机输出转矩来确定预期的输入速度，并且使用基于测量的输入速度与预期输入速度的偏差的反馈控制项来调整接通离合器压力命令来解释模型错误。最后，使用闭环反馈误差来实现前馈控制的自适应校正，使得前馈离合器压力更接近地产生指令的输入轴加速度。

6. 发明申请

US20050043542A1 Oxadiazolyl-phenoxyalkylisoxazoles, compositions thereof and methods for their use as anti-picornaviral agents 失效
标题翻译：恶二唑基 - 苯氧基烷基异恶唑，其组合物及其用作抗小刀毒病毒剂的方法
公开(公告)号：US20050043542A1
公开(公告)日：2005-02-24
申请号：US10487852
申请日：2002-08-29
申请人： Gerald Rhodes , Theodore Nitz
发明人： Gerald Rhodes , Theodore Nitz
IPC分类号： C07D413/12 , A61K31/4245 , C07D413/02
CPC分类号： C07D413/12
摘要： Oxadiazolyl-phenoxyalkylisoxazoles and pharmaceutically acceptable salts thereof, compositions comprising oxadiazolyl-phenoxyalkylisoxazole compounds or pharmaceutically acceptable salts thereof and methods for using oxadiazolyl-phenoxyalkylisoxazole compounds or pharmaceutically acceptable salts thereof as anti-picornaviral agents are described herein. The methods include using pleconaril as a prodrug for conversion to anti-picornaviral compounds in vivo.
摘要翻译：本文描述了恶二唑基 - 苯氧基烷基异恶唑及其药学上可接受的盐，其包含恶二唑基 - 苯氧基烷基异恶唑化合物或其药学上可接受的盐和使用恶二唑基 - 苯氧基烷基异恶唑化合物或其药学上可接受的盐作为抗小RNA病毒剂的方法。所述方法包括使用pleconaril作为在体内转化成抗小刀毒蛋白病毒化合物的前药。

7. 发明申请

US20070269420A1 Compounds, Compositions and Methods for Treatment and Prophylaxis of Hepatitis C Viral Infections and Associated Diseases 审中-公开
标题翻译：用于治疗和预防丙型肝炎病毒感染和相关疾病的化合物，组合物和方法
公开(公告)号：US20070269420A1
公开(公告)日：2007-11-22
申请号：US10579813
申请日：2004-11-24
申请人： Srinivas Chunduru , Christopher Benatatos , Theodore Nitz , Thomas Bailey
发明人： Srinivas Chunduru , Christopher Benatatos , Theodore Nitz , Thomas Bailey
IPC分类号： A61K31/164 , A61K31/135 , A61K31/165 , A61K31/38 , A61K31/415 , A61K31/505 , A61K31/52 , A61K31/53 , A61K31/7105 , A61K31/711 , A61K39/395 , A61P31/12 , C12N5/00 , C12Q1/02 , C12Q1/68 , C12Q1/70 , G01N33/00 , G01N33/53
CPC分类号： A61K31/435 , A61K45/06 , G01N2333/18 , G01N2510/00 , A61K2300/00
摘要： The present invention is directed to compounds, compositions and methods for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by the hepatitis C virus. Also within the scope of this invention are assay methods for identifying agents that modulate NS4B activity, as well as kits for performing such methods.
摘要翻译：本发明涉及用于治疗或预防病毒感染和与之相关疾病的化合物，组合物和方法，特别是由丙型肝炎病毒引起的那些病毒感染和相关疾病。也在本发明范围内的是用于鉴定调节NS4B活性的试剂的测定方法，以及用于进行这些方法的试剂盒。

8. 发明申请

US20060167109A1 Methods of reducing rhinovirus contagion and related compositions 审中-公开
标题翻译：减少鼻病毒感染和相关成分的方法
公开(公告)号：US20060167109A1
公开(公告)日：2006-07-27
申请号：US10504206
申请日：2003-02-14
申请人： Daniel Pevear , Gerald Rhodes , Theodore Nitz , Mark McKinlay , Marc Collett
发明人： Daniel Pevear , Gerald Rhodes , Theodore Nitz , Mark McKinlay , Marc Collett
IPC分类号： A61K31/137
CPC分类号： A61K31/137 , A61K31/4245
摘要： The present invention relates to the use of pleconaril to reduce the contagion of rhinovirus virions shed from a host infected with a rhinovirus and thereby reduce disease transmission or re-infection.
摘要翻译：本发明涉及pleconaril用于减少从感染鼻病毒的宿主流出的鼻病毒病毒粒子的传染性，从而减少疾病传播或再感染的用途。

9. 发明申请

US20070203103A1 Preparation of pharmaceutical salts of 3-O-(3',3'-dimethylsuccinyl)betulinic acid 审中-公开
标题翻译： 3-O-（3'，3'-二甲基琥珀酰基）桦木酸的药物盐的制备
公开(公告)号：US20070203103A1
公开(公告)日：2007-08-30
申请号：US11640488
申请日：2006-12-18
申请人： Christian Hemp , Arndt Hausherr , Theodore Nitz , Roy Swaringen
发明人： Christian Hemp , Arndt Hausherr , Theodore Nitz , Roy Swaringen
IPC分类号： A61K31/56 , C07J53/00
CPC分类号： C07J63/008 , C07J53/00
摘要： This invention relates to a novel process for making 3-O-(3′,3′-dimethylsuccinyl)betulinic acid (“DSB”). This invention also relates to methods of treating HIV and related diseases using pharmaceutical compositions comprising salt forms of DSB prepared according to the process of the present invention. The invention further relates to dosage forms of pharmaceutical compositions comprising salts of DSB made using the process of this invention.
摘要翻译：本发明涉及一种制备3-O-（3'，3'-二甲基琥珀酰基）桦木酸（“DSB”）的新方法。本发明还涉及使用包含根据本发明方法制备的DSB盐形式的药物组合物来治疗HIV和相关疾病的方法。本发明还涉及包含使用本发明方法制备的DSB盐的药物组合物的剂型。

10. 发明申请

US20050027127A1 Oxadiazolyl-phenoxyalkylisoxazoles compositions thereof and methods for their use as anti-picornaviral agents 审中-公开
标题翻译：恶二唑基 - 苯氧基烷基异恶唑组合物及其作为抗小刀毒病毒剂的方法
公开(公告)号：US20050027127A1
公开(公告)日：2005-02-03
申请号：US10487851
申请日：2002-08-29
申请人： Guy Diana , Theodore Nitz
发明人： Guy Diana , Theodore Nitz
IPC分类号： C07D413/12 , C07D413/02
CPC分类号： C07D413/12
摘要： Oxadiazolyl-phenoxyalkylisoxazoles and pharmaceutically acceptable salts thereof, compositions comprising oxadiazolyl-phenoxyalkylisoxazole compounds or pharmaceutically acceptable salts thereof and methods for using oxadiazolyl-phenoxyalkylisoxazole compounds or pharmaceutically acceptable salts thereof as anti-picornaviral agents are described herein.
摘要翻译：本文描述了恶二唑基 - 苯氧基烷基异恶唑及其药学上可接受的盐，其包含恶二唑基 - 苯氧基烷基异恶唑化合物或其药学上可接受的盐和使用恶二唑基 - 苯氧基烷基异恶唑化合物或其药学上可接受的盐作为抗小RNA病毒剂的方法。

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