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1. 发明授权

US08173633B2 Protein kinase C activity enhancer containing alkyl ether derivative or salt thereof 失效
标题翻译：含有烷基醚衍生物或其盐的蛋白激酶C活性增强剂
公开(公告)号：US08173633B2
公开(公告)日：2012-05-08
申请号：US12376296
申请日：2007-08-02
申请人： Tetsuo Fukushima , Akiko Takagi , Nobuo Terashima
发明人： Tetsuo Fukushima , Akiko Takagi , Nobuo Terashima
IPC分类号： A61K31/4025
CPC分类号： C07D409/12 , A61K31/397
摘要： Disclosed is a protein kinase C enhancer characterized by containing a benzothiophene alkyl ether derivative represented by the general formula below or a salt thereof. (In the formula, R1 and R2 may be the same or different and represent one or more groups selected from a hydrogen atom, a halogen atom, an alkyl group, an aryl group, an aralkyl group, an alkoxy group, an aryloxy group, an alkenyl group, an amino group, a heterocyclic group, an optionally protected amino group, a hydroxyl group, a carboxyl group, an oxo group and the like; R3 represents an alkylamino group, an amino group, a hydroxyl group or the like; and m and n may be the same or different and represent an integer of 1-6.) This protein kinase C enhancer is useful for treatment or prevention of various diseases associated with protein kinase C.
摘要翻译：公开了一种蛋白激酶C增强剂，其特征在于含有下述通式所示的苯并噻吩烷基醚衍生物或其盐。（式中，R 1，R 2可以相同也可以不同，表示选自氢原子，卤原子，烷基，芳基，芳烷基，烷氧基，芳氧基，链烯基，氨基，杂环基，任意保护的氨基，羟基，羧基，氧代基等; R3表示烷基氨基，氨基，羟基等; m和n可以相同或不同，表示1-6的整数。）该蛋白激酶C增强子可用于治疗或预防与蛋白激酶C相关的各种疾病。

2. 发明申请

US20110245228A1 PROTEIN KINASE C ACTIVITY ENHANCER CONTAINING ALKYL ETHER DERIVATIVE OR SALT THEREOF 审中-公开
标题翻译：蛋白激酶C活性增强剂含有其它衍生物或其盐
公开(公告)号：US20110245228A1
公开(公告)日：2011-10-06
申请号：US13163105
申请日：2011-06-17
申请人： Tetsuo FUKUSHIMA , Akiko Takagi , Nobuo Terashima
发明人： Tetsuo FUKUSHIMA , Akiko Takagi , Nobuo Terashima
IPC分类号： A61K31/397 , A61P35/00 , A61P3/08
CPC分类号： C07D409/12 , A61K31/397
摘要： Disclosed is a protein kinase C enhancer characterized by containing a benzothiophene alkyl ether derivative represented by the general formula below or a salt thereof. (In the formula, R1 and R2 may be the same or different and represent one or more groups selected from a hydrogen atom, a halogen atom, an alkyl group, an aryl group, an aralkyl group, an alkoxy group, an aryloxy group, an alkenyl group, an amino group, a heterocyclic group, an optionally protected amino group, a hydroxyl group, a carboxyl group, an oxo group and the like; R3 represents an alkylamino group, an amino group, a hydroxyl group or the like; and m and n may be the same or different and represent an integer of 1-6.) This protein kinase C enhancer is useful for treatment or prevention of various diseases associated with protein kinase C.
摘要翻译：公开了一种蛋白激酶C增强剂，其特征在于含有下述通式所示的苯并噻吩烷基醚衍生物或其盐。（式中，R 1，R 2可以相同或不同，表示选自氢原子，卤素原子，烷基，芳基，芳烷基，烷氧基，芳氧基，链烯基，氨基，杂环基，任意保护的氨基，羟基，羧基，氧代基等; R3表示烷基氨基，氨基，羟基等; m和n可以相同或不同，表示1-6的整数。）该蛋白激酶C增强子可用于治疗或预防与蛋白激酶C相关的各种疾病。

3. 发明申请

US20100184997A1 PROTEIN KINASE C ACTIVITY ENHANCER CONTAINING ALKYL ETHER DERIVATIVE OR SALT THEREOF 失效
标题翻译：蛋白激酶C活性增强剂含有其它衍生物或其盐
公开(公告)号：US20100184997A1
公开(公告)日：2010-07-22
申请号：US12376296
申请日：2007-08-02
申请人： Tetsuo Fukushima , Akiko Takagi , Nobuo Terashima
发明人： Tetsuo Fukushima , Akiko Takagi , Nobuo Terashima
IPC分类号： C07D205/04
CPC分类号： C07D409/12 , A61K31/397
摘要： Disclosed is a protein kinase C enhancer characterized by containing a benzothiophene alkyl ether derivative represented by the general formula below or a salt thereof. (In the formula, R1 and R2 may be the same or different and represent one or more groups selected from a hydrogen atom, a halogen atom, an alkyl group, an aryl group, an aralkyl group, an alkoxy group, an aryloxy group, an alkenyl group, an amino group, a heterocyclic group, an optionally protected amino group, a hydroxyl group, a carboxyl group, an oxo group and the like; R3 represents an alkylamino group, an amino group, a hydroxyl group or the like; and m and n may be the same or different and represent an integer of 1-6.) This protein kinase C enhancer is useful for treatment or prevention of various diseases associated with protein kinase C.
摘要翻译：公开了一种蛋白激酶C增强剂，其特征在于含有下述通式所示的苯并噻吩烷基醚衍生物或其盐。（式中，R 1，R 2可以相同也可以不同，表示选自氢原子，卤原子，烷基，芳基，芳烷基，烷氧基，芳氧基，链烯基，氨基，杂环基，任意保护的氨基，羟基，羧基，氧代基等; R3表示烷基氨基，氨基，羟基等; m和n可以相同或不同，表示1-6的整数。）该蛋白激酶C增强子可用于治疗或预防与蛋白激酶C相关的各种疾病。

4. 发明授权

US5011973A Novel process for producing bischoline-disulfonate derivatives 失效
标题翻译：制备二萜二磺酸衍生物的新方法
公开(公告)号：US5011973A
公开(公告)日：1991-04-30
申请号：US352610
申请日：1989-05-15
申请人： Yasuyuki Suzuki , Noboru Takagawa , Mikio Kawabata , Mariko Hayashi , Akiko Takagi , Takako Wakamiya , Isamu Saikawa
发明人： Yasuyuki Suzuki , Noboru Takagawa , Mikio Kawabata , Mariko Hayashi , Akiko Takagi , Takako Wakamiya , Isamu Saikawa
IPC分类号： A61K31/14 , A61K31/185 , A61K31/225 , A61P1/00 , C07C20060101 , C07C67/00 , C07C69/66 , C07C213/02 , C07C217/08 , C07C219/06 , C07C301/00 , C07C303/22 , C07C303/32 , C07C309/35
CPC分类号： C07C213/10
摘要： The process for producing bischoline-disulfonate derivatives of Formula (I) ##STR1## useful for enhancing the digestive function comprising reacting, in the presence of an organic solvent, a trimethylammonium salt derivative of Formula (II) ##STR2## wherein R.sup.1 and R.sup.2 are individually lower alkyl and X is a group removable by a disulfonic acid of Formula (III)R(SO.sub.3 H).sub.2 (III)wherein R is a naphthylene, or an organic base salt of said acid.
摘要翻译：用于生产用于增强消化功能的式（I）的二萜类 - 二磺酸衍生物的方法，其包括在有机溶剂存在下使式（II）的三甲基铵盐衍生物（II））其中R 1和R 2各自为低级烷基，X为可由式（III）的二磺酸R（SO 3 H）2（III）除去的基团，其中R为亚萘基或所述酸的有机碱盐。

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