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1. 发明授权

US08173633B2 Protein kinase C activity enhancer containing alkyl ether derivative or salt thereof 失效
标题翻译：含有烷基醚衍生物或其盐的蛋白激酶C活性增强剂
公开(公告)号：US08173633B2
公开(公告)日：2012-05-08
申请号：US12376296
申请日：2007-08-02
申请人： Tetsuo Fukushima , Akiko Takagi , Nobuo Terashima
发明人： Tetsuo Fukushima , Akiko Takagi , Nobuo Terashima
IPC分类号： A61K31/4025
CPC分类号： C07D409/12 , A61K31/397
摘要： Disclosed is a protein kinase C enhancer characterized by containing a benzothiophene alkyl ether derivative represented by the general formula below or a salt thereof. (In the formula, R1 and R2 may be the same or different and represent one or more groups selected from a hydrogen atom, a halogen atom, an alkyl group, an aryl group, an aralkyl group, an alkoxy group, an aryloxy group, an alkenyl group, an amino group, a heterocyclic group, an optionally protected amino group, a hydroxyl group, a carboxyl group, an oxo group and the like; R3 represents an alkylamino group, an amino group, a hydroxyl group or the like; and m and n may be the same or different and represent an integer of 1-6.) This protein kinase C enhancer is useful for treatment or prevention of various diseases associated with protein kinase C.
摘要翻译：公开了一种蛋白激酶C增强剂，其特征在于含有下述通式所示的苯并噻吩烷基醚衍生物或其盐。（式中，R 1，R 2可以相同也可以不同，表示选自氢原子，卤原子，烷基，芳基，芳烷基，烷氧基，芳氧基，链烯基，氨基，杂环基，任意保护的氨基，羟基，羧基，氧代基等; R3表示烷基氨基，氨基，羟基等; m和n可以相同或不同，表示1-6的整数。）该蛋白激酶C增强子可用于治疗或预防与蛋白激酶C相关的各种疾病。

2. 发明授权

US5578627A 1,2-benzoisoxazole derivative or its salt and brain-protecting agent comprising the same 失效
标题翻译： 1,2-苯并异恶唑衍生物或其盐和包含其的脑保护剂
公开(公告)号：US5578627A
公开(公告)日：1996-11-26
申请号：US411667
申请日：1995-04-12
申请人： Kenji Takeda , Nobuo Terashima , Joji Nakano , Hisashi Minami , Toyokazu Kobayashi , Kunikazu Furuhata , Tadakazu Takakura , Makoto Takata , Hiroyo Kawafuchi , Toru Hiraiwa
发明人： Kenji Takeda , Nobuo Terashima , Joji Nakano , Hisashi Minami , Toyokazu Kobayashi , Kunikazu Furuhata , Tadakazu Takakura , Makoto Takata , Hiroyo Kawafuchi , Toru Hiraiwa
IPC分类号： C07D261/20 , C07D413/04 , C07D413/12 , C07D413/14 , C07D417/12 , A61K31/405 , C07D209/10
CPC分类号： C07D413/04 , C07D261/20 , C07D413/12 , C07D413/14 , C07D417/12
摘要： This invention relates to a 1,2-benzoisoxazole derivative represented by the following general formula (I) or its salt: ##STR1##
摘要翻译： PCT No.PCT / JP93 / 01549 Sec。 371日期：1995年4月12日 102（e）日期1995年4月12日PCT 1993年10月27日PCT公布。出版物WO94 / 10158 日期：1994年5月11日本发明涉及由以下通式（I）表示的1,2-苯并异恶唑衍生物或其盐：

3. 发明授权

US4472386A 5-Fluoro-(.beta.-uridine or 2'-deoxy-.beta.-uridine) derivatives, a process for producing the same and a carcinostatic agent containing the same 失效
标题翻译： 5-氟 - （β-尿苷或2'-脱氧-β-尿苷）衍生物，其制备方法和含有它们的制癌剂
公开(公告)号：US4472386A
公开(公告)日：1984-09-18
申请号：US46109
申请日：1979-06-06
申请人： Tsutomu Kodama , Masaakira Senoura , Hajime Aoyama , Tomonobu Yamaguchi , Isao Kitayama , Minako Yotsuji , Toru Hiraiwa , Masaharu Omori , Nobuo Terashima , Yutaka Kodama
发明人： Tsutomu Kodama , Masaakira Senoura , Hajime Aoyama , Tomonobu Yamaguchi , Isao Kitayama , Minako Yotsuji , Toru Hiraiwa , Masaharu Omori , Nobuo Terashima , Yutaka Kodama
IPC分类号： A61K31/70 , A61K31/7042 , A61K31/7052 , A61K31/7064 , A61K31/7072 , A61P35/00 , C07H19/06 , C07H19/073 , C07H19/08
CPC分类号： C07H19/06
摘要： 5-Fluoro-(.beta.-uridine or 2'-deoxy-.beta.-uridine) derivatives having an acyl group at the 3-position of the molecule. These compounds are useful as carcinostatic agent. This disclosure relates to such compounds, a process for producing the same and a carcinostatic agent comprising such a compound.
摘要翻译：在分子的3位具有酰基的5-氟 - （β-尿苷或2'-脱氧-β-尿苷）衍生物。这些化合物可用作制癌剂。本公开涉及这样的化合物，其制备方法和包含这种化合物的制癌剂。

4. 发明申请

US20110245228A1 PROTEIN KINASE C ACTIVITY ENHANCER CONTAINING ALKYL ETHER DERIVATIVE OR SALT THEREOF 审中-公开
标题翻译：蛋白激酶C活性增强剂含有其它衍生物或其盐
公开(公告)号：US20110245228A1
公开(公告)日：2011-10-06
申请号：US13163105
申请日：2011-06-17
申请人： Tetsuo FUKUSHIMA , Akiko Takagi , Nobuo Terashima
发明人： Tetsuo FUKUSHIMA , Akiko Takagi , Nobuo Terashima
IPC分类号： A61K31/397 , A61P35/00 , A61P3/08
CPC分类号： C07D409/12 , A61K31/397
摘要： Disclosed is a protein kinase C enhancer characterized by containing a benzothiophene alkyl ether derivative represented by the general formula below or a salt thereof. (In the formula, R1 and R2 may be the same or different and represent one or more groups selected from a hydrogen atom, a halogen atom, an alkyl group, an aryl group, an aralkyl group, an alkoxy group, an aryloxy group, an alkenyl group, an amino group, a heterocyclic group, an optionally protected amino group, a hydroxyl group, a carboxyl group, an oxo group and the like; R3 represents an alkylamino group, an amino group, a hydroxyl group or the like; and m and n may be the same or different and represent an integer of 1-6.) This protein kinase C enhancer is useful for treatment or prevention of various diseases associated with protein kinase C.
摘要翻译：公开了一种蛋白激酶C增强剂，其特征在于含有下述通式所示的苯并噻吩烷基醚衍生物或其盐。（式中，R 1，R 2可以相同或不同，表示选自氢原子，卤素原子，烷基，芳基，芳烷基，烷氧基，芳氧基，链烯基，氨基，杂环基，任意保护的氨基，羟基，羧基，氧代基等; R3表示烷基氨基，氨基，羟基等; m和n可以相同或不同，表示1-6的整数。）该蛋白激酶C增强子可用于治疗或预防与蛋白激酶C相关的各种疾病。

5. 发明申请

US20100184997A1 PROTEIN KINASE C ACTIVITY ENHANCER CONTAINING ALKYL ETHER DERIVATIVE OR SALT THEREOF 失效
标题翻译：蛋白激酶C活性增强剂含有其它衍生物或其盐
公开(公告)号：US20100184997A1
公开(公告)日：2010-07-22
申请号：US12376296
申请日：2007-08-02
申请人： Tetsuo Fukushima , Akiko Takagi , Nobuo Terashima
发明人： Tetsuo Fukushima , Akiko Takagi , Nobuo Terashima
IPC分类号： C07D205/04
CPC分类号： C07D409/12 , A61K31/397
摘要： Disclosed is a protein kinase C enhancer characterized by containing a benzothiophene alkyl ether derivative represented by the general formula below or a salt thereof. (In the formula, R1 and R2 may be the same or different and represent one or more groups selected from a hydrogen atom, a halogen atom, an alkyl group, an aryl group, an aralkyl group, an alkoxy group, an aryloxy group, an alkenyl group, an amino group, a heterocyclic group, an optionally protected amino group, a hydroxyl group, a carboxyl group, an oxo group and the like; R3 represents an alkylamino group, an amino group, a hydroxyl group or the like; and m and n may be the same or different and represent an integer of 1-6.) This protein kinase C enhancer is useful for treatment or prevention of various diseases associated with protein kinase C.
摘要翻译：公开了一种蛋白激酶C增强剂，其特征在于含有下述通式所示的苯并噻吩烷基醚衍生物或其盐。（式中，R 1，R 2可以相同也可以不同，表示选自氢原子，卤原子，烷基，芳基，芳烷基，烷氧基，芳氧基，链烯基，氨基，杂环基，任意保护的氨基，羟基，羧基，氧代基等; R3表示烷基氨基，氨基，羟基等; m和n可以相同或不同，表示1-6的整数。）该蛋白激酶C增强子可用于治疗或预防与蛋白激酶C相关的各种疾病。

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