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1. 发明申请

US20070197512A1 Carboxylic Acid Compounds and Use Thereof 审中-公开
标题翻译：羧酸化合物及其用途
公开(公告)号：US20070197512A1
公开(公告)日：2007-08-23
申请号：US11627439
申请日：2007-01-26
申请人： Teruhiko Inoue , Toshihiro Kiguchi , Kazuyuki Hirata , Yuko Shinagawa , Naoki Ogawa , Katsuya Deai
发明人： Teruhiko Inoue , Toshihiro Kiguchi , Kazuyuki Hirata , Yuko Shinagawa , Naoki Ogawa , Katsuya Deai
IPC分类号： A61K31/5415 , A61K31/538 , C07D279/16 , C07D265/36
CPC分类号： C07D265/36 , C07D279/16
摘要： Provision of a superior URAT1 activity inhibitor effective for the treatment and the like of a pathology involving uric acid, such as hyperuricemia, gouty tophus, acute gouty arthritis, chronic gouty arthritis, gouty kidney, urinary lithiasis, renal dysfunction, coronary heart disease, ischemic cardiac diseases and the like. A URAT1 activity inhibitor containing a compound represented by the following formula [1] or a pharmaceutically acceptable salt thereof, or a solvate thereof as an active ingredient: wherein each symbol is as defined in the specification.
摘要翻译：提供一种有效治疗尿酸的病例的高级URAT1活性抑制剂，如高尿酸血症，痛风，急性痛风性关节炎，慢性痛风性关节炎，痛肾，尿结石，肾功能不全，冠心病，缺血性心脏病等。含有下述通式[1]表示的化合物或其药学上可接受的盐或其溶剂合物作为有效成分的URAT1活性抑制剂：其中每个符号如说明书中所定义。

2. 发明申请

US20070010670A1 Nitrogen-containing fused ring compounds and use thereof 审中-公开
标题翻译：含氮稠环化合物及其用途
公开(公告)号：US20070010670A1
公开(公告)日：2007-01-11
申请号：US11288792
申请日：2005-11-29
申请人： Kazuyuki Hirata , Naoki Ogawa , Yuko Shinagawa , Toshihiro Kiguchi , Teruhiko Inoue , Akira Matsuo , Yoshinori Kosugi , Yukihiro Nomura , Iichiro Kawahara , Hideto Uehara
发明人： Kazuyuki Hirata , Naoki Ogawa , Yuko Shinagawa , Toshihiro Kiguchi , Teruhiko Inoue , Akira Matsuo , Yoshinori Kosugi , Yukihiro Nomura , Iichiro Kawahara , Hideto Uehara
IPC分类号： C07D487/02
CPC分类号： A61K45/06 , A61K31/395 , C07D209/08 , C07D223/16 , C07D241/42 , C07D241/44 , C07D243/12 , C07D263/56 , C07D265/36 , C07D265/38 , C07D267/02 , C07D267/14 , C07D279/16 , C07D413/06 , C07D413/12
摘要： A URAT1 activity inhibitor containing a nitrogen-containing fused ring compound represented by the following formula [1]: wherein each symbol is as defined in the description. The present invention is useful for the prophylaxis or treatment of pathology showing involvement of uric acid, such as hyperuricemia, gouty tophus, acute gouty arthritis, chronic gouty arthritis, gouty kidney, urolithiasis, renal function disorder, coronary artery disease, ischemic heart disease and the like.
摘要翻译：含有由下式[1]表示的含氮稠环化合物的URAT1活性抑制剂：其中每个符号如说明书中所定义。本发明可用于预防或治疗显示尿酸例如高尿酸血症，痛风，急性痛风性关节炎，慢性痛风性关节炎，痛肾，尿路结石，肾功能障碍，冠状动脉疾病，缺血性心脏病和类似。

3. 发明申请

US20080064871A1 Production Method of Nitrogen-Containing Fused Ring Compounds 审中-公开
标题翻译：含氮稠合环化合物的制备方法
公开(公告)号：US20080064871A1
公开(公告)日：2008-03-13
申请号：US11753231
申请日：2007-05-24
申请人： Kazuyuki Hirata , Naoki Ogawa , Yuko Shinagawa , Toshihiro Kiguchi , Teruhiko Inoue , Yasuki Komeda , Ichiro Yamashita , Yukihiro Kamiya
发明人： Kazuyuki Hirata , Naoki Ogawa , Yuko Shinagawa , Toshihiro Kiguchi , Teruhiko Inoue , Yasuki Komeda , Ichiro Yamashita , Yukihiro Kamiya
IPC分类号： C07D487/00 , C07D223/16 , C07D241/36 , C07D265/36
CPC分类号： C07D265/36 , C07D209/12 , C07D215/08 , C07D223/16 , C07D241/42 , C07D243/14 , C07D265/34 , C07D265/38 , C07D267/14 , C07D279/16 , C07D498/04
摘要： [Problems] The present invention provides a superior production method and a superior purification method of compounds effective for the treatment or prophylaxis of pathology showing involvement of uric acid, such as hyperuricemia, gouty tophus, acute gouty arthritis, chronic gouty arthritis, gouty kidney, urolithiasis, renal function disorder, coronary artery disease, ischemic heart disease and the like. [Means] A compound represented by the following formula [2] or a pharmaceutically acceptable salt thereof can be produced by reacting a compound represented by the following formula [3] or a salt thereof with a compound represented by the following formula [4], a salt thereof or a reactive derivative thereof. Moreover, crystallization of a compound represented by the formula [2] can be performed with industrially superior workability, and high quality crystals of a compound represented by the formula [2] can be obtained. wherein each symbol is as defined in the description.
摘要翻译：【问题】本发明提供了一种有效治疗或预防尿酸如高尿酸血症，痛风，急性痛风性关节炎，慢性痛风性关节炎，痛风肾，尿路结石，肾功能障碍，冠状动脉疾病，缺血性心脏病等。由下式[2]表示的化合物或其药学上可接受的盐可以通过使由下式[3]表示的化合物或其盐与下式[4]表示的化合物反应来制备，其盐或其反应性衍生物。此外，由式[2]表示的化合物的结晶可以以工业上优异的加工性进行，并且可以获得由式[2]表示的化合物的高质量晶体。其中每个符号如说明书中所定义。

4. 发明授权

US09017506B2 Method for manufacturing core of rotating electrical machine 有权
标题翻译：旋转电机芯的制造方法
公开(公告)号：US09017506B2
公开(公告)日：2015-04-28
申请号：US13616471
申请日：2012-09-14
申请人： Kazuyuki Hirata
发明人： Kazuyuki Hirata
IPC分类号： H02K15/02 , B21D28/12 , B32B38/04 , H02K1/16
CPC分类号： H02K15/024 , B21D28/12 , B32B38/04 , H02K1/16 , H02K15/02 , H02K2201/09 , Y10T156/1056 , Y10T156/1062 , Y10T156/1074 , Y10T156/1077 , Y10T156/1092
摘要： A core of a rotating electrical machine is formed by laminating core plates, which are each formed by a plurality of core pieces. According to the method for manufacturing the core, a belt-like workpiece is first conveyed intermittently in its longitudinal direction. Then, while the workpiece is in a stopped state, side edges of a core piece are punched out. At a downstream position in the conveying direction of the workpiece, the remaining edges of the core piece are cut, so that the core piece is punched out. The punched out core pieces are lined up on a support. The core plate is thus formed, and the core pieces are laminated.
摘要翻译：旋转电机的铁芯是通过层叠由多个芯片形成的芯板而形成的。根据芯的制造方法，首先将带状工件沿其长度方向间歇地传送。然后，当工件处于停止状态时，将芯片的侧边缘冲压出来。在工件的输送方向的下游位置，切断芯片的剩余边缘，使得芯片被冲压。冲出的核心部分排列在支撑上。由此形成芯板，层叠芯片。

5. 发明授权

US4542934A Front body construction for motor vehicle 失效
标题翻译：汽车前身体施工
公开(公告)号：US4542934A
公开(公告)日：1985-09-24
申请号：US465484
申请日：1983-02-10
申请人： Nobuhiro Komatsu , Minoru Fujimoto , Kazuyuki Hirata , Makoto Yamane
发明人： Nobuhiro Komatsu , Minoru Fujimoto , Kazuyuki Hirata , Makoto Yamane
IPC分类号： B62D25/08
CPC分类号： B62D25/084 , B62D25/082 , B62D25/088
摘要： A compact and light front body construction for a motor vehicle, in which a pair of suspension towers are increased in strength. In the construction, each of a pair of wheel aprons is divided into upper and lower wheel-aprons and the lower wheel-apron has a projecting portion such that the suspension tower is formed by the projecting portion and an upper panel attached to an upper face of the projecting portion. Furthermore, the upper wheel-apron has a closed cross section such that the upper panel is secured to an underside of the upper wheel-apron.
摘要翻译：一种用于机动车辆的紧凑且轻的前身体结构，其中一对悬吊塔的强度增加。在该结构中，一对车轮围裙分为上下轮围裙，下轮挡板具有突出部分，使悬吊塔由突出部分形成，上部面板连接到上表面的突出部分。此外，上轮挡板具有闭合的横截面，使得上面板固定在上轮胎围裙的下侧。

6. 发明申请

US20140243458A1 POWDERY HYDROPHILIC POLYMER, METHOD FOR PRODUCING THE SAME, AND FLOCCULATING AGENT USING SAME 审中-公开
标题翻译：粉末水解聚合物，其制造方法和使用其的絮凝剂
公开(公告)号：US20140243458A1
公开(公告)日：2014-08-28
申请号：US14241794
申请日：2012-01-13
申请人： Manabu Tonami , Kiyoshi Aoyama , Kazuyuki Hirata
发明人： Manabu Tonami , Kiyoshi Aoyama , Kazuyuki Hirata
IPC分类号： C08F6/16 , D21H21/18 , D21H17/00
CPC分类号： C08F6/16 , C02F1/56 , C08F2/32 , C08F220/56 , C08J3/16 , C08J2300/12 , C08J2333/14 , C08J2339/00 , C08J2339/04 , C08J2379/02 , D21H17/72 , D21H21/18
摘要： Provided is a powdery hydrophilic polymer by aggregating a hydrophilic polymer comprising a water-in-oil emulsion in a liquid form by emulsion breaking and granulating the aggregate, followed by drying. As an emulsion breaker, ionic surfactants, nonionic surfactants having an HLB value of 11 to 20, or oil-soluble polymer compounds having a hydrophilic group and a hydrophobic group can be used. The powdery hydrophilic polymer obtained by this method exhibits excellent effects as a flocculating agent.
摘要翻译：提供了一种粉末亲水性聚合物，其通过乳液破乳和骨料的粒化将聚合物包含液体形式的包含油包水乳液的亲水性聚合物，然后干燥。作为破乳剂，可以使用离子表面活性剂，HLB值为11〜20的非离子表面活性剂，或具有亲水基团和疏水基团的油溶性高分子化合物。通过该方法获得的粉状亲水性聚合物作为絮凝剂显示出优异的效果。

7. 发明授权

US09440281B2 Device and method for manufacturing work 有权
标题翻译：制造工作的装置和方法
公开(公告)号：US09440281B2
公开(公告)日：2016-09-13
申请号：US12885811
申请日：2010-09-20
申请人： Kazuyuki Hirata
发明人： Kazuyuki Hirata
IPC分类号： B21D45/02 , B21D45/04 , B26D5/16 , B26D7/18 , B21D45/00
CPC分类号： B21D45/003 , B21D45/02 , B21D45/04 , B26D5/16 , B26D7/1818 , Y10T83/0448 , Y10T83/2096
摘要： An upper die unit and a lower die unit are provided. One of the upper and lower die units includes a main punch and the other die unit includes an ejector, a slider and a biasing portion which is connected to the slider and biases the slider in a predetermined sliding direction S. A cam structure is disposed between the slider and the ejector and converts a movement of the ejector to a movement of the slider in a direction opposite to a predetermined sliding direction when the upper and lower die units are closed, and converts a movement of the slider to a movement of the ejector in a work ejecting direction when the upper and lower die units are opened. A position retaining portion is also provided which retains a position of the slider for a period of time.
摘要翻译：提供上模单元和下模单元。上模具单元和下模具单元之一包括主冲头，另一模具单元包括喷射器，滑块和偏置部分，其连接到滑块并沿预定滑动方向S偏压滑块。凸轮结构设置在滑块和喷射器，并且当上模具单元和下模具单元关闭时，将喷射器的运动转换成与预定滑动方向相反的方向的滑块的运动，并且将滑块的运动转换成喷射器的运动在上下模具单元打开时的工作排出方向上。还设置有保持滑块的位置一段时间的位置保持部分。

8. 发明授权

US08915279B2 Rotary lamination apparatus 有权
标题翻译：旋转层压装置
公开(公告)号：US08915279B2
公开(公告)日：2014-12-23
申请号：US13412894
申请日：2012-03-06
申请人： Kazuyuki Hirata
发明人： Kazuyuki Hirata
IPC分类号： B29C65/06 , H02K15/02 , B21D28/22
CPC分类号： H02K15/02 , B21D28/22 , Y10T156/12
摘要： A rotary lamination apparatus includes a die, a punch, a rotation drive source, a mounting table, at least one proximity sensor, and a determining device. The punch punches core pieces from a thin plate material. The rotation drive source drives and rotates the die about the central axis of the die. The mounting table is arranged in the inner space formed by the die. The core pieces are rotated and laminated on the mounting table. The proximity sensor detects whether the die is in the proximity of a predetermined position in a non-contact manner after the die has stopped rotating. The determining device determines whether the die is stopped at the predetermined position based on a detection result from the proximity sensor.
摘要翻译：旋转层压装置包括模具，冲头，旋转驱动源，安装台，至少一个接近传感器和确定装置。该冲头从薄板材料冲压芯片。旋转驱动源围绕模具的中心轴驱动并旋转模具。安装台布置在由模具形成的内部空间中。芯片旋转并层压在安装台上。接近传感器在模具停止旋转之后检测模具是否处于非接触式的预定位置附近。确定装置基于来自接近传感器的检测结果来确定模具是否停在预定位置。

9. 发明授权

US08844600B2 Rotary lamination apparatus 有权
标题翻译：旋转层压装置
公开(公告)号：US08844600B2
公开(公告)日：2014-09-30
申请号：US13401082
申请日：2012-02-21
申请人： Kazuyuki Hirata
发明人： Kazuyuki Hirata
IPC分类号： B29C65/00 , B32B37/00 , B32B38/04 , B32B38/10 , B31F5/00 , B23K37/00 , H02K15/02 , H02K15/10 , B23P19/00 , H02K15/00 , H02K1/06 , B65G13/00 , B21D43/22
CPC分类号： H02K15/02 , B21D43/22 , Y10T29/49012 , Y10T29/53143 , Y10T156/1304 , Y10T156/1322 , Y10T156/17 , Y10T156/1761
摘要： A rotary lamination apparatus has a rotary lamination turntable rotational about a vertical axis. A plurality of workpieces are rotated and laminated on the turntable. The turntable includes a support member that is arranged on an upper surface of the turntable, a plurality of rolling bodies mounted on the upper surface of the turntable, and a plurality of urging members for urging the rolling bodies upward. The support member is formed of material having a high friction coefficient. The rolling bodies are selectively movable between an upper position and a lower position. In the upper position, at least a portion of each of the rolling bodies is located above the upper surface of the support member. In the lower position, each rolling body is located below the upper surface of the support member. In the upper position, the rolling bodies support the workpieces movably in a lateral direction.
摘要翻译：旋转层压装置具有围绕垂直轴旋转的旋转层压转盘。多个工件旋转并层压在转台上。转盘包括设置在转盘上表面上的支撑件，安装在转台上表面上的多个滚动体以及用于向上推动滚动体的多个推压件。支撑构件由具有高摩擦系数的材料形成。滚动体可选择性地在上部位置和下部位置之间移动。在上部位置，每个滚动体的至少一部分位于支撑构件的上表面上方。在下部位置，每个滚动体位于支撑构件的上表面下方。在上部位置，滚动体沿横向方向可移动地支撑工件。

10. 发明授权

US08770077B2 Punch press device 有权
标题翻译：冲压装置
公开(公告)号：US08770077B2
公开(公告)日：2014-07-08
申请号：US13084824
申请日：2011-04-12
申请人： Kazuyuki Hirata
发明人： Kazuyuki Hirata
IPC分类号： B26D5/00 , B21D28/22 , B21D28/00
CPC分类号： B21D28/22 , B21D28/007 , Y10T83/8821 , Y10T83/8828 , Y10T83/883
摘要： A punch press device has a lift that can move up and down with respect to a workpiece and a punch that is supported by the lift and can move up and down with respect to the lift. Further, the punch press device has a switching member that reciprocates between a position where the punch is constrained so that it moves down together with the lift and a position where the punch is released so that it moves up with respect to the lift. The punch press device has two electromagnetic solenoids for reciprocating the switching member. The first electromagnetic solenoid moves the switching member in a first direction, and the second electromagnetic solenoid moves the switching member in a second direction opposite to the first direction.
摘要翻译：冲压装置具有能够相对于工件上下移动的升降机，以及由升降机支撑并可相对于升降机上下移动的冲头。此外，冲压装置具有切换构件，该切换构件在冲头被限制的位置之间往复运动，使得其与提升件一起向下移动，并且其中冲头被释放的位置使得其相对于升降机向上移动。冲压装置具有用于往复切换构件的两个电磁螺线管。第一电磁螺线管沿第一方向移动切换构件，第二电磁螺线管沿与第一方向相反的第二方向移动切换构件。

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