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1. 发明申请

US20070010670A1 Nitrogen-containing fused ring compounds and use thereof 审中-公开
标题翻译：含氮稠环化合物及其用途
公开(公告)号：US20070010670A1
公开(公告)日：2007-01-11
申请号：US11288792
申请日：2005-11-29
申请人： Kazuyuki Hirata , Naoki Ogawa , Yuko Shinagawa , Toshihiro Kiguchi , Teruhiko Inoue , Akira Matsuo , Yoshinori Kosugi , Yukihiro Nomura , Iichiro Kawahara , Hideto Uehara
发明人： Kazuyuki Hirata , Naoki Ogawa , Yuko Shinagawa , Toshihiro Kiguchi , Teruhiko Inoue , Akira Matsuo , Yoshinori Kosugi , Yukihiro Nomura , Iichiro Kawahara , Hideto Uehara
IPC分类号： C07D487/02
CPC分类号： A61K45/06 , A61K31/395 , C07D209/08 , C07D223/16 , C07D241/42 , C07D241/44 , C07D243/12 , C07D263/56 , C07D265/36 , C07D265/38 , C07D267/02 , C07D267/14 , C07D279/16 , C07D413/06 , C07D413/12
摘要： A URAT1 activity inhibitor containing a nitrogen-containing fused ring compound represented by the following formula [1]: wherein each symbol is as defined in the description. The present invention is useful for the prophylaxis or treatment of pathology showing involvement of uric acid, such as hyperuricemia, gouty tophus, acute gouty arthritis, chronic gouty arthritis, gouty kidney, urolithiasis, renal function disorder, coronary artery disease, ischemic heart disease and the like.
摘要翻译：含有由下式[1]表示的含氮稠环化合物的URAT1活性抑制剂：其中每个符号如说明书中所定义。本发明可用于预防或治疗显示尿酸例如高尿酸血症，痛风，急性痛风性关节炎，慢性痛风性关节炎，痛肾，尿路结石，肾功能障碍，冠状动脉疾病，缺血性心脏病和类似。

2. 发明授权

US07977331B1 Tetracyclic fused heterocyclic compound and use thereof as HCV polymerase inhibitor 有权
标题翻译：四环稠合杂环化合物及其作为HCV聚合酶抑制剂的用途
公开(公告)号：US07977331B1
公开(公告)日：2011-07-12
申请号：US11962622
申请日：2007-12-21
申请人： Takahiro Oka , Kazutaka Ikegashira , Shintaro Hirashima , Hiroshi Yamanaka , Satoru Noji , Yasushi Niwa , Yoko Matsumoto , Toshihiro Sato , Izuru Ando , Yukihiro Nomura
发明人： Takahiro Oka , Kazutaka Ikegashira , Shintaro Hirashima , Hiroshi Yamanaka , Satoru Noji , Yasushi Niwa , Yoko Matsumoto , Toshihiro Sato , Izuru Ando , Yukihiro Nomura
IPC分类号： A61K31/53 , A61K31/495 , A61K31/519 , A61K31/44 , A61K31/415 , A61K31/40 , C07D253/00 , C07D487/00 , C07D239/02 , C07D471/02 , C07D209/80
CPC分类号： C07D513/04 , C07D487/04 , C07D487/14 , C07D498/04 , C07D498/14
摘要： The present invention relates to a tetracyclic fused heterocyclic compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable a salt thereof, and a hepatitis C virus (HCV) polymerase inhibitor and a therapeutic agent for hepatitis C containing this compound. The compound of the present invention shows an anti-HCV activity based on the HCV polymerase inhibitory activity, and useful as an agent for the prophylaxis or treatment of hepatitis C.
摘要翻译：本发明涉及由下式[I]表示的四环稠合杂环化合物，其中各符号如说明书中所定义，或其药学上可接受的盐，丙型肝炎病毒（HCV）聚合酶抑制剂和治疗剂含有该化合物的丙型肝炎。本发明化合物基于HCV聚合酶抑制活性显示抗HCV活性，可用作预防或治疗丙型肝炎的药剂。

3. 发明申请

US20090264602A1 Curable Resin Composition and Cold Setting Adhesive 有权
标题翻译：可固化树脂组合物和冷定型粘合剂
公开(公告)号：US20090264602A1
公开(公告)日：2009-10-22
申请号：US12494540
申请日：2009-06-30
申请人： Shigeki Mori , Yukihiro Nomura , Kazuhiro Iyo , Shinichi Sato
发明人： Shigeki Mori , Yukihiro Nomura , Kazuhiro Iyo , Shinichi Sato
IPC分类号： C08L77/00 , C08L83/00 , C08L75/04 , C08L61/00 , C08L83/05
CPC分类号： C08L101/10 , C08G18/10 , C08G18/4825 , C08G18/4837 , C08G18/755 , C09J175/08 , C08G18/289
摘要： Disclosed is a moisture-curing type curable resin composition containing: a curable resin intramolecularly having a silicon-containing functional group; and a Lewis acid or a complex of the Lewis acid as a curing catalyst, the Lewis acid being selected from the group consisting of metal halides and boron halides, which is rapidly cured at room temperature. The silicon-containing functional group is represented by general formula: —SiX1X2X3 or —SiR1X1 X2 (wherein, X1, X2 and X3 respectively represent a hydrolytic group and may be the same as or different from each other, and R1 represents a substituted or unsubstituted organic group having 1 to 20 carbons). If the silicon-containing functional group is —SiR1X1 X2, the curable resin further contains intramolecularly a polar component that is one of urethane, thiourethane, urea, thiourea, substituted urea, substituted thiourea, amide, and sulfide bonds, and hydroxyl, secondary amino and tertiary amino groups. Two-part type adhesive is constitutible with separating the curable resin from the curing catalyst.
摘要翻译：公开了一种湿固化型固化性树脂组合物，其含有：分子内具有含硅官能团的固化性树脂; 路易斯酸或作为固化催化剂的路易斯酸的络合物，所述路易斯酸选自金属卤化物和卤化硼，其在室温下快速固化。含硅官能团由以下通式表示：-SiX1X2X3或-SiR1X1 X2（其中，X1，X2和X3分别表示水解基团，可以相同或不同，R1表示取代或未取代的碳原子数为1〜20的有机基团）。如果含硅官能团为-SiR1X1 X2，则固化性树脂还分子内含有氨基甲酸酯，硫代氨基甲酸酯，脲，硫脲，取代的脲，取代的硫脲，酰胺和硫键之一的极性成分，羟基，仲氨基和叔氨基。两部分型粘合剂是可固化树脂与固化催化剂分离的组成成分。

4. 发明申请

US20090053308A1 Release-Control Composition 有权
标题翻译：释放控制组成
公开(公告)号：US20090053308A1
公开(公告)日：2009-02-26
申请号：US11885467
申请日：2006-03-03
申请人： Hajime Ishida , Yukihiro Nomura
发明人： Hajime Ishida , Yukihiro Nomura
IPC分类号： A61K9/62 , A61K9/56 , A61K9/58 , A61P35/00 , A61K9/14 , A61K31/4188
CPC分类号： A61K9/5078 , A61K9/4816 , A61K9/4866 , A61K9/5026 , A61K9/5042 , A61K9/5047 , A61K31/4164 , A61K31/4188
摘要： The present invention relates to a controlled release capsule preparation for oral administration, which contains (i) a granule containing a physiologically active substance which is a compound represented by the formula: wherein n is an integer of 1 to 3, and Ar is an aromatic ring optionally having substituent(s), or a salt thereof, and a hydrophilic polymer, and coated with an enteric coating agent and the like, and (ii) a fluidizer. According to the present invention, a controlled release composition for oral administration of an imidazole derivative, which has steroid C17,20-lyase inhibiting activity and which has remarkably improved sustainability of the blood concentration, is provided.
摘要翻译：本发明涉及口服给药的控释胶囊制剂，其包含（i）含有下式表示的化合物的生理活性物质的颗粒：其中n为1〜3的整数，Ar为芳香族任选具有取代基的环或其盐和亲水性聚合物，并用肠溶衣剂等涂布，和（ii）流化剂。根据本发明，提供了具有类固醇C17,20-裂解酶抑制活性并显着改善血液浓度可持续性的咪唑衍生物的口服给药组合物。

5. 发明申请

US20060189736A1 Curable resin composition and cold-setting adhesive 失效
标题翻译：可固化树脂组合物和冷固粘合剂
公开(公告)号：US20060189736A1
公开(公告)日：2006-08-24
申请号：US10564843
申请日：2004-07-16
申请人： Shigeki Mori , Yukihiro Nomura , Kazuhiro Iyo , Shinichi Sato
发明人： Shigeki Mori , Yukihiro Nomura , Kazuhiro Iyo , Shinichi Sato
IPC分类号： C08K3/38
CPC分类号： C08L101/10 , C08G18/10 , C08G18/4825 , C08G18/4837 , C08G18/755 , C09J175/08 , C08G18/289
摘要： Disclosed is a moisture-curing type curable resin composition containing: a curable resin intramolecularly having a silicon-containing functional group; and a Lewis acid or a complex of the Lewis acid as a curing catalyst, the Lewis acid being selected from the group consisting of metal halides and boron halides, which is rapidly cured at room temperature. The silicon-containing functional group is represented by general formula: —SiX1X2X3 or —SiR1X1X2 (wherein, X1, X2 and X3 respectively represent a hydrolytic group and may be the same as or different from each other, and R1 represents a substituted or unsubstituted organic group having 1 to 20 carbons). If the silicon-containing functional group is —SiR1X1X2, the curable resin further contains intramolecularly a polar component that is one of urethane, thiourethane, urea, thiourea, substituted urea, substituted thiourea, amide, and sulfide bonds, and hydroxyl, secondary amino and tertiary amino groups. Two-part type adhesive is constitutible with separating the curable resin from the curing catalyst.
摘要翻译：公开了一种湿固化型固化性树脂组合物，其含有：分子内具有含硅官能团的固化性树脂; 路易斯酸或作为固化催化剂的路易斯酸的络合物，所述路易斯酸选自金属卤化物和卤化硼，其在室温下快速固化。含硅官能团由以下通式表示：-SiX 1 X 2 X 3或-SiR 1 O / X 1 2 X 2（其中，X 1，X 2，X 3和X 3） >分别表示水解基团，可以相同也可以不同，R 1表示取代或未取代的碳原子数1〜20的有机基团）。如果含硅官能团是-SiR 1 X 1 X 2 O 2，那么可固化树脂还分子内含有极性组分，其为氨基甲酸酯，硫代氨基甲酸酯，脲，硫脲，取代的脲，取代的硫脲，酰胺和硫键，以及羟基，仲氨基和叔氨基。两部分型粘合剂是可固化树脂与固化催化剂分离的组成成分。

6. 发明授权

US4765927A Antioxidizing composition 失效
标题翻译：抗氧化组合物
公开(公告)号：US4765927A
公开(公告)日：1988-08-23
申请号：US893887
申请日：1986-08-06
申请人： Yukihiro Nomura , Yoko Okuda
发明人： Yukihiro Nomura , Yoko Okuda
IPC分类号： A23D7/06 , A23D9/06 , C09K15/06 , C09K15/08 , C09K15/32 , C11B5/00
CPC分类号： C11B5/0007 , C11B5/0092
摘要： This invention relates to an antioxidizing composition which comprises an antioxidant such as tocopherol, BHT or BHA; condensed phosphate such as pentapolyphosphate; and citric acid. The antioxidizing composition has antioxidant action superior to conventional compositions and has good compatibility with fat, oil and food containing fat or oil. The antioxidizing composition preferably comprises tocopherol, lecithin, pentapolyphosphate and citric acid.
摘要翻译：本发明涉及抗氧化组合物，其包含抗氧化剂如生育酚，BHT或BHA; 缩聚磷酸盐如五聚磷酸盐; 和柠檬酸。抗氧化组合物具有优于常规组合物的抗氧化作用，并且与脂肪，油和含有脂肪或油的食品具有良好的相容性。抗氧化组合物优选包含生育酚，卵磷脂，五聚磷酸盐和柠檬酸。

7. 发明授权

US08541024B2 Film-coated scored tablet 有权
标题翻译：薄膜包衣片剂
公开(公告)号：US08541024B2
公开(公告)日：2013-09-24
申请号：US13063515
申请日：2009-09-15
申请人： Akihiko Ono , Naomi Nagaoka , Shigeyuki Marunaka , Yukihiro Nomura
发明人： Akihiko Ono , Naomi Nagaoka , Shigeyuki Marunaka , Yukihiro Nomura
IPC分类号： A61K9/20
CPC分类号： A61K9/282 , A61J3/005 , A61K9/2072 , A61K31/4245 , A61K31/513 , A61K31/553
摘要： A film-coated scored tablet in which the forms of respective parts associated with a score line are optimized so as to more preferably divide the film along the score line is provided.
摘要翻译：提供了一种薄膜涂抹的刻痕片，其中优化与刻痕线相关联的各部分的形式，以便更优选地沿着刻痕线划分膜。

8. 发明申请

US20100016382A1 PHARMACEUTICAL COMPOSITION 审中-公开
标题翻译：药物组合物
公开(公告)号：US20100016382A1
公开(公告)日：2010-01-21
申请号：US12310075
申请日：2007-08-09
申请人： Yukihiro Nomura , Muneo Nonomura
发明人： Yukihiro Nomura , Muneo Nonomura
IPC分类号： A61K31/4245 , A61P9/12
CPC分类号： A61K31/4245 , A61K9/2018 , A61K9/2054
摘要： The present invention provides a solid pharmaceutical composition superior in the stability and dissolution property, wherein the drug dissolution property of a solid dosage form containing a fat and oil-like substance having a low melting point is improved.The present invention provides a solid pharmaceutical composition containing an active ingredient, a fat and oil-like substance having a low melting point and a low viscosity binder, and a method of improving dissolution of an active ingredient from a solid pharmaceutical composition containing the active ingredient and a fat and oil-like substance having a low melting point, which includes using a low viscosity binder.
摘要翻译：本发明提供了稳定性和溶解性优异的固体药物组合物，其中含有具有低熔点的脂肪和油状物质的固体剂型的药物溶解性提高。本发明提供一种固体药物组合物，其含有活性成分，具有低熔点和低粘度粘合剂的脂肪和油状物质，以及改善活性成分从含有活性成分的固体药物组合物溶解的方法和具有低熔点的脂肪和油状物质，其包括使用低粘度粘合剂。

9. 发明授权

US07357982B2 Polybenzazole fiber and use thereof 失效
标题翻译：聚吲唑纤维及其用途
公开(公告)号：US07357982B2
公开(公告)日：2008-04-15
申请号：US10517832
申请日：2003-06-26
申请人： Yukihiro Abe , Go Matsuoka , Kohei Kiriyama , Hiroki Murase , Muneatsu Nakamura , Yukihiro Nomura , Hironori Eguchi , Yukinari Okuyama , Tadao Kuroki , Takaharu Ichiryu , Hiroshi Tachimori
发明人： Yukihiro Abe , Go Matsuoka , Kohei Kiriyama , Hiroki Murase , Muneatsu Nakamura , Yukihiro Nomura , Hironori Eguchi , Yukinari Okuyama , Tadao Kuroki , Takaharu Ichiryu , Hiroshi Tachimori
IPC分类号： D02G3/00
CPC分类号： E04C5/07 , B63H9/0657 , B63H2009/0678 , D01F6/74 , D07B1/025 , D07B2205/2096 , E04C5/073 , Y10T428/2913 , Y10T428/2967 , Y10T428/2969 , D07B2801/10
摘要： The present invention relates to polybenzazole fibers or filaments, staple fibers, spun yarns, and woven or knitted fabrics containing in themselves an organic pigment having heat resistance as high as a thermal decomposition temperature of 200° C. or higher, and soluble in a mineral acid and having group(s) of —N═ and/or NH— in the molecule, such as any of perinones and/or perylenes, any of phthalocyanines, any of quinacridones, and any of dioxazines, wherein they have a strength retention of 50% or higher when exposed to light from a xenon lamp for 100 hours and having a tensile strength retention of 85% or higher after exposed to an atmosphere of a temperature of 80° C. and a relative humidity of 80% for 700 hours.The polybenzazole fibers or filaments, staple fibers, spun yarns, and woven or knitted fabrics can be used for cords for reinforcing rubber, sheets and rods for reinforcing cement/concrete, composite materials, sail clothes, ropes, knife proof vests and bullet proof vests.
摘要翻译：本发明涉及聚吲哚纤维或长丝，短纤维，短纤纱，以及其本身含有耐热性高达200℃或更高的热分解温度的有机颜料并可溶于矿物的机织或针织织物酸和在分子中具有-N和/或NH-的基团，例如百里香酮和/或苝中的任何一种，酞菁，任何喹吖啶酮和任何二恶嗪，其中它们的强度保留为当暴露于来自氙灯的光100小时并且在暴露于80℃的温度和80％的相对湿度的气氛中700小时之后的拉伸强度保持率为85％或更高时，为50％或更高。聚吲哚纤维或长丝，短纤维，短纤纱和机织或针织织物可用于增强橡胶，用于增强水泥/混凝土，复合材料，帆衣，绳索，防刀背心和防弹背心的橡胶，片材和棒材的帘线。

10. 发明授权

US07251171B2 Semiconductor memory and system apparatus 有权
标题翻译：半导体存储器和系统装置
公开(公告)号：US07251171B2
公开(公告)日：2007-07-31
申请号：US11167318
申请日：2005-06-28
申请人： Koichi Nishimura , Shinichi Yamada , Yukihiro Nomura
发明人： Koichi Nishimura , Shinichi Yamada , Yukihiro Nomura
IPC分类号： G11C7/00 , G11C7/10 , G11C8/00
CPC分类号： G11C7/1045 , G11C11/4072 , G11C2029/0407
摘要： A register part of a mode register has a plurality of operation setting parts in which plural types of operating specifications are respectively set to operate the semiconductor memory. The mode register outputs a soft reset signal when at least a value of one-bit of the register part represents a reset state. A reset signal generator outputs a reset signal for resetting an internal circuit in response to the soft reset signal. In the present invention, a system that controls the semiconductor memory is required to necessarily assign a predetermined bit with a setting command of the mode register in order to generate the soft reset signal. Accordingly, it is possible to reliably reset the internal circuit by external control.
摘要翻译：模式寄存器的寄存器部分具有多个操作设置部分，其中分别设置多种类型的操作规范以操作半导体存储器。当至少寄存器部分的1位的值表示复位状态时，模式寄存器输出软复位信号。复位信号发生器响应于软复位信号输出用于复位内部电路的复位信号。在本发明中，控制半导体存储器的系统需要用模式寄存器的设定命令来分配预定的位，以产生软复位信号。因此，可以通过外部控制可靠地复位内部电路。

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