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1. 发明专利

JP2010053078A Percutaneously absorbable pharmaceutical composition of oxycodone, pharmaceutical composition storage unit and percutaneously absorbable preparation by utilizing the same 有权
标题翻译：氧化钙，药物组合物储存单元的可吸收药物组合物及其可吸收性的制备方法
公开(公告)号：JP2010053078A
公开(公告)日：2010-03-11
申请号：JP2008219877
申请日：2008-08-28
申请人： Teika Seiyaku Kk , テイカ製薬株式会社
发明人： KIMURA TAKAHITO , ORIHASHI MASAHIRO , FUJISHITA SHIGETO , TAKAHATA KOICHI , KATO TATSUHISA , SHIODA SATOSHI , SHIMA YUICHIRO
IPC分类号： A61K31/485 , A61K9/70 , A61K47/06 , A61K47/10 , A61K47/34 , A61P25/04
摘要： PROBLEM TO BE SOLVED: To provide a percutaneously absorbable pharmaceutical composition maintaining the blood concentration of oxycodone in an effective level over at least 48 hr on applying to a human. SOLUTION: The percutaneously absorbable pharmaceutical composition prepared by blending an active ingredient selected from the oxycodone or its salts in an active ingredient-holding medium having fluidity at a temperature in the vicinity of a human skin surface temperature by a blending amount higher than its saturation solubility and holding at least a part of the active ingredient as a crystal form is characterized by making the preparation so that the percutaneously absorbable pharmaceutical composition has 31.1 mg content of the active ingredient based on the oxycodone base per one sheet and an effective percutaneous absorption range becomes as a square having 1.5 cm side, and showing at least ≥150 μg/hr/cm 2 mean permeation rate of the active ingredient based on the oxycodone base on applying it on the abdominal flawless skin of a hairless rat for 48 h. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供一种经皮可吸收的药物组合物，其在施用于人时至少48小时内将氧可酮的血液浓度保持在有效水平。解决方案：通过将选自羟考酮或其盐的活性成分在具有流动性的活性成分保持介质中，在人皮肤表面温度附近的混合量混合而制备的经皮吸收药物组合物，其饱和溶解度和保持至少一部分作为结晶形式的活性成分的特征在于制备该制剂使得经皮吸收的药物组合物具有31.1mg的活性成分含量，基于每片片的羟考酮碱和有效的经皮吸收范围变为1.5cm侧的正方形，并且当将其施用于腹部无瑕疵的皮肤时，基于羟考酮基的活性成分的平均渗透速率至少≥150μg/ hr / cm 2 的无毛大鼠48小时。版权所有（C）2010，JPO＆INPIT

2. 发明专利

JP2013189451A Medicinal composition storing unit 审中-公开
标题翻译：药物成分储存单位
公开(公告)号：JP2013189451A
公开(公告)日：2013-09-26
申请号：JP2013104834
申请日：2013-05-17
申请人： Teika Seiyaku Kk , テイカ製薬株式会社
发明人： KIMURA TAKAHITO , ORIHASHI MASAHIRO , FUJISHITA SHIGETO , TAKAHATA KOICHI , KATO TATSUHISA , SHIODA SATOSHI , SHIMA YUICHIRO
IPC分类号： A61K31/485 , A61K9/70 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/16 , A61K47/28 , A61K47/32 , A61K47/34 , A61K47/38 , A61P25/04
CPC分类号： A61K31/485 , A61K9/0014 , A61K9/10 , A61K9/7084 , A61K47/10 , A61K47/12 , A61K47/28
摘要： PROBLEM TO BE SOLVED: To provide a medicinal composition storing unit capable of sustaining a blood morphine concentration at an effective level over at least 48 hours.SOLUTION: A medicinal composition storing unit includes a medicinal composition for transdermal absorption in which an active ingredient selected from morphine or salts thereof is blended in such an amount as corresponding to the saturation solubility or more with an active ingredient-holding vehicle having fluidity at a temperature around the human skin surface temperature and at least a portion of the active ingredient is held in a crystalline form, supported on a carrier with voids. The active ingredient-holding vehicle is preferably one or two or more substances selected from liquid paraffin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polyvinylpyrrolidone, a silicone oil, ceramide, cholesterol, isopropyl palmitate, lauric acid, palmitic acid, oleic acid, oleyl alcohol, polyoxyethylene lauryl ether, crotamiton, lactic acid, and water.
摘要翻译：要解决的问题：提供能够在至少48小时内维持有效水平的血液吗啡浓度的药物组合物储存单元。解决方案：药物组合物储存单元包括用于经皮吸收的药物组合物，其中选自吗啡或其盐以与饱和溶解度相当的量与具有在人皮肤表面温度附近的温度下具有流动性的活性成分保持载体混合，并且至少一部分活性成分保持在结晶形式，支撑在有空隙的承运人身上。活性成分载体优选为选自液体石蜡，丙二醇，1,3-丁二醇，聚乙二醇，聚乙烯吡咯烷酮，硅油，神经酰胺，胆固醇，棕榈酸异丙酯，月桂酸，棕榈酸的一种或两种以上的物质油酸，油醇，聚氧乙烯月桂基醚，克罗他米通，乳酸和水。

3. 发明专利

JP2013133327A Method of producing antifungal retainer, antifungal retainer, and use of the same 有权
标题翻译：生产抗真菌保留剂，抗真菌保留剂及其使用的方法
公开(公告)号：JP2013133327A
公开(公告)日：2013-07-08
申请号：JP2011286619
申请日：2011-12-27
申请人： Teika Seiyaku Kk , テイカ製薬株式会社 , Univ Of Fukui , 国立大学法人福井大学
发明人： KIMURA TAKAHITO , FUJISHITA SHIGETO , SHIODA SATOSHI , TAKAHATA KOICHI , ITO HIROKO , HORI TERUO , MORI YASUMITSU
IPC分类号： A01N25/10 , A01N43/50 , A01N43/60 , A01N43/653 , A01P3/00 , B01J3/00 , D06M23/00
CPC分类号： Y02P20/544
摘要： PROBLEM TO BE SOLVED: To provide an antifungal retainer and a method of producing the antifungal retainer, which can develop a therapeutically effective antifungal activity (beneficial effect) and has cleaning durability, and thereby, can continuously demonstrate sufficient antifungal activity even after cleaning or washing, and to provide antifungal raw materials, articles for infection prevention or treatment of fungus diseases, external preparations for infection prevention or treatment of fungus diseases, and others, using the above antifungal retainer.SOLUTION: The method of producing the antifungal retainer includes an injection step of dissolving an antifungal in a medium selected from a supercritical fluid, a subcritical fluid or water in a liquid state at a temperature over 100°C, and bringing the medium with the antifungal dissolved into contact with a carrier to inject the antifungal together with the medium into the carrier.
摘要翻译：要解决的问题：提供抗真菌保持器和抗真菌保持器的制造方法，其可以产生治疗有效的抗真菌活性（有益效果）并具有清洁耐久性，从而即使在清洁或洗涤后也可以连续显示足够的抗真菌活性，并提供抗真菌原料，用于感染预防或治疗真菌疾病的物品，用于感染预防或真菌疾病治疗的外用制剂等。使用上述抗真菌保持剂。解决方案：制备抗真菌保持剂的方法包括注射在超过100℃的温度下将抗真菌剂溶解在选自超临界流体，亚临界流体或液体状态的介质中的步骤，以及使抗真菌剂溶解的载体与载体接触以将抗真菌剂与介质进入载体。

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