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1. 发明专利

JP2006306757A Remedy for corneal disease 有权
标题翻译：治疗脊髓损害
公开(公告)号：JP2006306757A
公开(公告)日：2006-11-09
申请号：JP2005129450
申请日：2005-04-27
申请人： Teika Seiyaku Kk , テイカ製薬株式会社
发明人： KIMURA TAKAHITO , FUJISHITA SHIGETO , KAWADA HIROYOSHI
IPC分类号： A61K31/53 , A61K9/08 , A61P27/02 , C07D251/18
CPC分类号： A61K9/0048 , A61K31/53 , C07D251/18
摘要： PROBLEM TO BE SOLVED: To discover a medicine capable of effectively treating and improving corneal disease which increases in recent years, and to provide a remedy for the corneal disease containing the medicine as an active ingredient.
SOLUTION: This remedy for the corneal disease contains irsogladine or a salt thereof as the active ingredient. A dosage form of the remedy for the corneal disease comprises an eye lotion.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：发现能够有效治疗和改善近年来增加的角膜疾病的药物，并且为含有该药物作为活性成分的角膜疾病提供补救。解决方案：角膜疾病的这种治疗方法含有作为活性成分的irsogladine或其盐。用于角膜疾病的补救剂的剂型包括眼液。版权所有（C）2007，JPO＆INPIT

2. 发明专利

JP2013133327A Method of producing antifungal retainer, antifungal retainer, and use of the same 有权
标题翻译：生产抗真菌保留剂，抗真菌保留剂及其使用的方法
公开(公告)号：JP2013133327A
公开(公告)日：2013-07-08
申请号：JP2011286619
申请日：2011-12-27
申请人： Teika Seiyaku Kk , テイカ製薬株式会社 , Univ Of Fukui , 国立大学法人福井大学
发明人： KIMURA TAKAHITO , FUJISHITA SHIGETO , SHIODA SATOSHI , TAKAHATA KOICHI , ITO HIROKO , HORI TERUO , MORI YASUMITSU
IPC分类号： A01N25/10 , A01N43/50 , A01N43/60 , A01N43/653 , A01P3/00 , B01J3/00 , D06M23/00
CPC分类号： Y02P20/544
摘要： PROBLEM TO BE SOLVED: To provide an antifungal retainer and a method of producing the antifungal retainer, which can develop a therapeutically effective antifungal activity (beneficial effect) and has cleaning durability, and thereby, can continuously demonstrate sufficient antifungal activity even after cleaning or washing, and to provide antifungal raw materials, articles for infection prevention or treatment of fungus diseases, external preparations for infection prevention or treatment of fungus diseases, and others, using the above antifungal retainer.SOLUTION: The method of producing the antifungal retainer includes an injection step of dissolving an antifungal in a medium selected from a supercritical fluid, a subcritical fluid or water in a liquid state at a temperature over 100°C, and bringing the medium with the antifungal dissolved into contact with a carrier to inject the antifungal together with the medium into the carrier.
摘要翻译：要解决的问题：提供抗真菌保持器和抗真菌保持器的制造方法，其可以产生治疗有效的抗真菌活性（有益效果）并具有清洁耐久性，从而即使在清洁或洗涤后也可以连续显示足够的抗真菌活性，并提供抗真菌原料，用于感染预防或治疗真菌疾病的物品，用于感染预防或真菌疾病治疗的外用制剂等。使用上述抗真菌保持剂。解决方案：制备抗真菌保持剂的方法包括注射在超过100℃的温度下将抗真菌剂溶解在选自超临界流体，亚临界流体或液体状态的介质中的步骤，以及使抗真菌剂溶解的载体与载体接触以将抗真菌剂与介质进入载体。

3. 发明专利

JP2013189451A Medicinal composition storing unit 审中-公开
标题翻译：药物成分储存单位
公开(公告)号：JP2013189451A
公开(公告)日：2013-09-26
申请号：JP2013104834
申请日：2013-05-17
申请人： Teika Seiyaku Kk , テイカ製薬株式会社
发明人： KIMURA TAKAHITO , ORIHASHI MASAHIRO , FUJISHITA SHIGETO , TAKAHATA KOICHI , KATO TATSUHISA , SHIODA SATOSHI , SHIMA YUICHIRO
IPC分类号： A61K31/485 , A61K9/70 , A61K47/06 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/16 , A61K47/28 , A61K47/32 , A61K47/34 , A61K47/38 , A61P25/04
CPC分类号： A61K31/485 , A61K9/0014 , A61K9/10 , A61K9/7084 , A61K47/10 , A61K47/12 , A61K47/28
摘要： PROBLEM TO BE SOLVED: To provide a medicinal composition storing unit capable of sustaining a blood morphine concentration at an effective level over at least 48 hours.SOLUTION: A medicinal composition storing unit includes a medicinal composition for transdermal absorption in which an active ingredient selected from morphine or salts thereof is blended in such an amount as corresponding to the saturation solubility or more with an active ingredient-holding vehicle having fluidity at a temperature around the human skin surface temperature and at least a portion of the active ingredient is held in a crystalline form, supported on a carrier with voids. The active ingredient-holding vehicle is preferably one or two or more substances selected from liquid paraffin, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polyvinylpyrrolidone, a silicone oil, ceramide, cholesterol, isopropyl palmitate, lauric acid, palmitic acid, oleic acid, oleyl alcohol, polyoxyethylene lauryl ether, crotamiton, lactic acid, and water.
摘要翻译：要解决的问题：提供能够在至少48小时内维持有效水平的血液吗啡浓度的药物组合物储存单元。解决方案：药物组合物储存单元包括用于经皮吸收的药物组合物，其中选自吗啡或其盐以与饱和溶解度相当的量与具有在人皮肤表面温度附近的温度下具有流动性的活性成分保持载体混合，并且至少一部分活性成分保持在结晶形式，支撑在有空隙的承运人身上。活性成分载体优选为选自液体石蜡，丙二醇，1,3-丁二醇，聚乙二醇，聚乙烯吡咯烷酮，硅油，神经酰胺，胆固醇，棕榈酸异丙酯，月桂酸，棕榈酸的一种或两种以上的物质油酸，油醇，聚氧乙烯月桂基醚，克罗他米通，乳酸和水。

4. 发明专利

JP2009196988A Ophthalmic agent 有权
标题翻译： OPHTHALMIC代理
公开(公告)号：JP2009196988A
公开(公告)日：2009-09-03
申请号：JP2009013505
申请日：2009-01-23
申请人： Teika Seiyaku Kk , テイカ製薬株式会社
发明人： SHIBUYA FUMINORI , SUGIYAMA KIYOSHI , ITO KIYOMI , FUJISHITA SHIGETO , KOBAYASHI MINORU
IPC分类号： A61K31/365 , A61K31/245 , A61K47/02 , A61K47/10 , A61K47/12 , A61K47/18 , A61K47/32 , A61K47/34 , A61P27/02
摘要： PROBLEM TO BE SOLVED: To provide a stable and transparent ophthalmic agent containing fluorescein or its salt and oxybuprocaine or its salt and an ophthalmic agent which allows a long term storage at room temperature and under an unshaded environment.
SOLUTION: The ophthalmic agent is for storage in plastic containers and contains one or not less than two kinds of preservatives selected from the group consisting of (A)-(E): (A) fluorescein or its salt, (B) oxybuprocaine or its salt, (C) a compound having buffer action, (D) a povidone and/or a nonionic surfactant, (E) sorbic acid and its salt, and paraben. Further the agent satisfies any one of the conditions (d1), (d2), and (d3): (d1) the amount of the povidone mixed is not less than 15 w/v% of the total amount of the ophthalmic agent, (d2) the amount of a povidone mixed is less than 15 w/v% of the total amount of the ophthalmic agent and including a nonionic surfactant, and (d3) free of a povidone and including a nonionic surfactant.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种含有荧光素或其盐的稳定且透明的眼用药剂和奥布对卡因或其盐和允许在室温和无阴影环境下长期储存的眼科剂。（A） - （E）：（A）荧光素或其盐，（B）和（B）中的一种或不少于两种防腐剂，（C）具有缓冲作用的化合物，（D）聚维酮和/或非离子表面活性剂，（E）山梨酸及其盐和对羟基苯甲酸酯。此外，该试剂满足条件（d1），（d2）和（d3）中的任一条件：（d1）聚维酮的混合量不小于眼用试剂总量的15w / v％（ d2）混合的聚维酮的量小于眼用试剂总量的15w / v％，并且包括非离子表面活性剂，和（d3）不含聚维酮并包括非离子表面活性剂。版权所有（C）2009，JPO＆INPIT

5. 发明专利

JP2007063218A Agent for treatment of corneal disease 审中-公开
标题翻译：治疗角膜疾病的药剂
公开(公告)号：JP2007063218A
公开(公告)日：2007-03-15
申请号：JP2005253620
申请日：2005-09-01
申请人： Teika Seiyaku Kk , テイカ製薬株式会社
发明人： KIMURA TAKAHITO , FUJISHITA SHIGETO , KAWADA HIROYOSHI
IPC分类号： A61K31/7076 , A61P27/02 , C07H19/213
摘要： PROBLEM TO BE SOLVED: To find a medicine effectively curing or ameliorating recently increasing corneal diseases and provide a corneal disease treating agent containing the medicine as an active component.
SOLUTION: The invention provides an agent for the treatment of corneal diseases by using bucladesine or its salt as an active component, the above agent wherein the dosage form is eye drop, and the above agent applied to the corneal epithelium disorder.
COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：找到有效治愈或改善最近增加的角膜疾病的药物，并提供含有药物作为活性成分的角膜疾病治疗剂。解决方案：本发明提供了一种通过使用水杨酸或其盐作为活性成分治疗角膜疾病的药剂，上述剂型，其中剂型为滴眼剂，上述药剂用于角膜上皮细胞病变。版权所有（C）2007，JPO＆INPIT

6. 发明专利

JP2006124339A Preparation for percutaneous absorption 有权
标题翻译：精油吸收制备
公开(公告)号：JP2006124339A
公开(公告)日：2006-05-18
申请号：JP2004315760
申请日：2004-10-29
申请人： Teika Seiyaku Kk , テイカ製薬株式会社
发明人： KIMURA TAKAHITO , SHIMATANI TAKAO , FUJISHITA SHIGETO , IWAI TAKEHIKO , HOSHIDA MANABU
IPC分类号： A61K31/137 , A61K9/70 , A61K47/14 , A61K47/22 , A61K47/32
摘要： PROBLEM TO BE SOLVED: To provide a preparation for percutaneous absorption, very low in skin irritation in and after use and having sufficient percutaneous absorption and effective persistency of the medicine.
SOLUTION: The preparation for percutaneous absorption comprises a homopolymer of vinyl acetate keeping the medicine in a crystal state as a medicinal vehicle.
COPYRIGHT: (C)2006,JPO&NCIPI
摘要翻译：要解决的问题：为了提供经皮吸收制剂，在使用中和使用后皮肤刺激非常低，并且具有足够的经皮吸收和药物的有效持续性。解决方案：用于经皮吸收的制剂包括乙酸乙烯酯的均聚物，其将药物保持为晶体状态，作为药用载体。版权所有（C）2006，JPO＆NCIPI

7. 发明专利

JP2010053078A Percutaneously absorbable pharmaceutical composition of oxycodone, pharmaceutical composition storage unit and percutaneously absorbable preparation by utilizing the same 有权
标题翻译：氧化钙，药物组合物储存单元的可吸收药物组合物及其可吸收性的制备方法
公开(公告)号：JP2010053078A
公开(公告)日：2010-03-11
申请号：JP2008219877
申请日：2008-08-28
申请人： Teika Seiyaku Kk , テイカ製薬株式会社
发明人： KIMURA TAKAHITO , ORIHASHI MASAHIRO , FUJISHITA SHIGETO , TAKAHATA KOICHI , KATO TATSUHISA , SHIODA SATOSHI , SHIMA YUICHIRO
IPC分类号： A61K31/485 , A61K9/70 , A61K47/06 , A61K47/10 , A61K47/34 , A61P25/04
摘要： PROBLEM TO BE SOLVED: To provide a percutaneously absorbable pharmaceutical composition maintaining the blood concentration of oxycodone in an effective level over at least 48 hr on applying to a human. SOLUTION: The percutaneously absorbable pharmaceutical composition prepared by blending an active ingredient selected from the oxycodone or its salts in an active ingredient-holding medium having fluidity at a temperature in the vicinity of a human skin surface temperature by a blending amount higher than its saturation solubility and holding at least a part of the active ingredient as a crystal form is characterized by making the preparation so that the percutaneously absorbable pharmaceutical composition has 31.1 mg content of the active ingredient based on the oxycodone base per one sheet and an effective percutaneous absorption range becomes as a square having 1.5 cm side, and showing at least ≥150 μg/hr/cm 2 mean permeation rate of the active ingredient based on the oxycodone base on applying it on the abdominal flawless skin of a hairless rat for 48 h. COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：待解决的问题：提供一种经皮可吸收的药物组合物，其在施用于人时至少48小时内将氧可酮的血液浓度保持在有效水平。解决方案：通过将选自羟考酮或其盐的活性成分在具有流动性的活性成分保持介质中，在人皮肤表面温度附近的混合量混合而制备的经皮吸收药物组合物，其饱和溶解度和保持至少一部分作为结晶形式的活性成分的特征在于制备该制剂使得经皮吸收的药物组合物具有31.1mg的活性成分含量，基于每片片的羟考酮碱和有效的经皮吸收范围变为1.5cm侧的正方形，并且当将其施用于腹部无瑕疵的皮肤时，基于羟考酮基的活性成分的平均渗透速率至少≥150μg/ hr / cm 2 的无毛大鼠48小时。版权所有（C）2010，JPO＆INPIT

8. 发明专利

JP2008274151A Wound-covering composition and wound-covering material 有权
标题翻译：覆盖组合物和覆盖材料
公开(公告)号：JP2008274151A
公开(公告)日：2008-11-13
申请号：JP2007120641
申请日：2007-05-01
申请人： Osaka Organic Chem Ind Ltd , Teika Seiyaku Kk , テイカ製薬株式会社 , 大阪有機化学工業株式会社
发明人： KITANO HIROMI , GENMYO MAKOTO , FUJISHITA SHIGETO , SARUWATARI YOSHIYUKI
IPC分类号： C08L33/14 , A61F13/02 , A61L15/16 , C08F220/36
摘要： PROBLEM TO BE SOLVED: To provide a wound-covering material excellent in wound healing rate. SOLUTION: A wound-covering composition contains a vinyl polymer having a monomer unit represented by formula (5) [wherein R 1 is H or -CH 3 ; R 2 is 1-6C alkylene; R 3 and R 4 are each a 1-4C alkyl; R 5 is a 1-4C alkylene; and Z is -O- or -NH-]. The wound-covering material is obtained using the same. COPYRIGHT: (C)2009,JPO&INPIT

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