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1. 发明申请

US20060176479A1 Monitoring molecular interactions using photon arrival-time interval distribution analysis 有权
公开(公告)号：US20060176479A1
公开(公告)日：2006-08-10
申请号：US10521632
申请日：2003-07-25
申请人： Ted Laurence , Shimon Weiss
发明人： Ted Laurence , Shimon Weiss
IPC分类号： G01J3/30 , G01N21/64
CPC分类号： G01N21/6428 , G01J1/42 , G01J3/4406 , G01N21/6408 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441
摘要： A method for analyzing/monitoring the properties of species that are labeled with fluorophores. A detector is used to detect photons emitted from species that are labeled with one or more fluorophores and located in a confocal detection volume. The arrival time of each of the photons is determined. The interval of time between various photon pairs is then determined to provide photon pair intervals. The number of photons that have arrival times within the photon pair intervals is also determined. The photon pair intervals are then used in combination with the corresponding counts of intervening photons to analyze properties and interactions of the molecules including brightness, concentration, coincidence and transit time. The method can be used for analyzing single photon streams and multiple photon streams.

2. 发明申请

US20070109536A1 Modulated excitation fluorescense analysis 有权
标题翻译：调制激发荧光分析
公开(公告)号：US20070109536A1
公开(公告)日：2007-05-17
申请号：US10561448
申请日：2004-06-17
申请人： Shimon Weiss , Achillefs Kapanidis , Ted Laurence , Nam Lee
发明人： Shimon Weiss , Achillefs Kapanidis , Ted Laurence , Nam Lee
IPC分类号： G01J3/30 , G01N21/64
CPC分类号： G01N21/6458 , G01J3/4338 , G01J3/4406 , G01N21/6408 , G01N21/6428 , G01N21/6445 , G01N21/648 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441
摘要： Fluorescence, spectroscopy is used to analyze small numbers of molecules that are present in a relatively small detection volume or zone. Information regarding physical and chemical properties of these molecules is determined by rapidly modulating the wavelength, intensity and/or polarization of laser energy to excite fluorophores that are attached either to the molecule of interest or a molecule that interacts with the molecule of interest. The emission profile of the fluorophores is used to determine useful information about the labeled and/or non-labeled molecules including molecular interactions between th molecules.
摘要翻译：荧光，光谱法用于分析存在于较小检测体积或区域中的少量分子。通过快速调节激光能量的波长，强度和/或极化以激发连接到感兴趣分子或与感兴趣的分子相互作用的分子的荧光团来确定关于这些分子的物理和化学性质的信息。荧光团的发射谱用于确定有关标记和/或非标记分子的有用信息，包括第th分子之间的分子相互作用。

3. 发明授权

US08080405B2 Semiconductor nanocrystal probes for biological applications and process for making and using such probes 有权
公开(公告)号：US08080405B2
公开(公告)日：2011-12-20
申请号：US12406651
申请日：2009-03-18
申请人： Shimon Weiss , Marcel Bruchez , Paul Alivisatos
发明人： Shimon Weiss , Marcel Bruchez , Paul Alivisatos
IPC分类号： C12M1/00 , C12Q1/68
摘要： A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a second energy, and (2) one or more linking agents, having a first portion linked to the one or more semiconductor nanocrystals and a second portion capable of linking to one or more affinity molecules. One or more semiconductor nanocrystal compounds are linked to one or more affinity molecules to form a semiconductor nanocrystal probe capable of bonding with one or more detectable substances in a material being analyzed, and capable of, in response to exposure to a first energy, providing a second energy. Also described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and treating materials with the probe.

4. 发明授权

US08071359B2 Semiconductor nanocrystal probes for biological applications and process for making and using such probes 有权
公开(公告)号：US08071359B2
公开(公告)日：2011-12-06
申请号：US11566998
申请日：2006-12-05
申请人： Shimon Weiss , Marcel Bruchez , Paul Alivisatos
发明人： Shimon Weiss , Marcel Bruchez , Paul Alivisatos
IPC分类号： C12M1/00 , C12Q1/68
CPC分类号： H01L33/0062 , B82Y15/00 , C09K11/025 , C09K11/565 , C09K11/883 , C09K11/89 , C09K11/892 , C12Q1/6816 , C12Q2563/107 , G01N33/533 , G01N33/542 , G01N33/54373 , G01N33/588 , H01L33/0083 , Y10T436/141111 , Y10T436/142222
摘要： A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a second energy, and (2) one or more linking agents, having a first portion linked to the one or more semiconductor nanocrystals and a second portion capable of linking to one or more affinity molecules. One or more semiconductor nanocrystal compounds are linked to one or more affinity molecules to form a semiconductor nanocrystal probe capable of bonding with one or more detectable substances in a material being analyzed, and capable of, in response to exposure to a first energy, providing a second energy. Also described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and treating materials with the probe.

5. 发明授权

US08026661B2 Electronic displays using optically pumped luminescent semiconductor nanocrystals 有权
标题翻译：使用光泵浦发光半导体纳米晶体的电子显示器
公开(公告)号：US08026661B2
公开(公告)日：2011-09-27
申请号：US12471889
申请日：2009-05-26
申请人： Shimon Weiss , Michael C. Schlamp , A. Paul Alivisatos
发明人： Shimon Weiss , Michael C. Schlamp , A. Paul Alivisatos
IPC分类号： H01J1/62 , H01J63/04
CPC分类号： G02B5/207 , B82Y20/00 , B82Y30/00 , G02F1/1333 , G02F1/133362 , G02F1/133509 , G02F1/133528 , G02F1/133617 , G02F2202/36 , H01L27/3211 , H01L51/5012 , H01L2251/5369
摘要： A multicolor electronic display is based on an array of luminescent semiconductor nanocrystals. Nanocrystals which emit light of different colors are grouped into pixels. The nanocrystals are optically pumped to produce a multicolor display. Different sized nanocrystals are used to produce the different colors. A variety of pixel addressing systems can be used.
摘要翻译：多色电子显示器基于发光半导体纳米晶体阵列。发射不同颜色的光的纳米晶体被分组成像素。将纳米晶体进行光泵浦以产生多色显示器。不同大小的纳米晶体用于生产不同的颜色。可以使用各种像素寻址系统。

6. 发明申请

US20090253211A1 SEMICONDUCTOR NANOCRYSTAL PROBES FOR BIOLOGICAL APPLICATIONS AND PROCESS FOR MAKING AND USING SUCH PROBES 有权
公开(公告)号：US20090253211A1
公开(公告)日：2009-10-08
申请号：US12408466
申请日：2009-03-20
申请人： Shimon Weiss , Marcel Bruchez , Paul Alivisatos
发明人： Shimon Weiss , Marcel Bruchez , Paul Alivisatos
IPC分类号： G01N33/50
CPC分类号： H01L33/0062 , B82Y15/00 , C09K11/025 , C09K11/565 , C09K11/883 , C09K11/89 , C09K11/892 , C12Q1/6816 , C12Q2563/107 , G01N33/533 , G01N33/542 , G01N33/54373 , G01N33/588 , H01L33/0083 , Y10T436/141111 , Y10T436/142222
摘要： A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a second energy, and (2) one or more linking agents, having a first portion linked to the one or more semiconductor nanocrystals and a second portion capable of linking to one or more affinity molecules. One or more semiconductor nanocrystal compounds are linked to one or more affinity molecules to form a semiconductor nanocrystal probe capable of bonding with one or more detectable substances in a material being analyzed, and capable of, in response to exposure to a first energy, providing a second energy. Also described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and treating materials with the probe.

7. 发明授权

US07599059B2 Monitoring molecular interactions using photon arrival-time interval distribution analysis 有权
标题翻译：使用光子到达时间间隔分布分析监测分子相互作用
公开(公告)号：US07599059B2
公开(公告)日：2009-10-06
申请号：US10521632
申请日：2003-07-25
申请人： Ted A. Laurence , Shimon Weiss
发明人： Ted A. Laurence , Shimon Weiss
IPC分类号： G01J3/30
CPC分类号： G01N21/6428 , G01J1/42 , G01J3/4406 , G01N21/6408 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441
摘要： A method for analyzing/monitoring the properties of species that are labeled with fluorophores. A detector is used to detect photons emitted from species that are labeled with one or more fluorophores and located in a confocal detection volume. The arrival time of each of the photons is determined. The interval of time between various photon pairs is then determined to provide photon pair intervals. The number of photons that have arrival times within the photon pair intervals is also determined. The photon pair intervals are then used in combination with the corresponding counts of intervening photons to analyze properties and interactions of the molecules including brightness, concentration, coincidence and transit time. The method can be used for analyzing single photon streams and multiple photon streams.
摘要翻译：用于分析/监测用荧光团标记的物种的性质的方法。检测器用于检测由一个或多个荧光团标记并位于共聚焦检测体积中的物质发射的光子。确定每个光子的到达时间。然后确定各种光子对之间的时间间隔以提供光子对间隔。还确定了在光子对间隔内具有到达时间的光子的数量。然后将光子对间隔与相应的中间光子计数结合使用，以分析包括亮度，浓度，重合和传播时间在内的分子的性质和相互作用。该方法可用于分析单光子流和多光子流。

8. 发明授权

US07101718B2 Organo luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes 有权
公开(公告)号：US07101718B2
公开(公告)日：2006-09-05
申请号：US10918622
申请日：2004-08-12
申请人： Shimon Weiss , Marcel Bruchez, Jr. , Paul Alivisatos
发明人： Shimon Weiss , Marcel Bruchez, Jr. , Paul Alivisatos
IPC分类号： G01N33/551
CPC分类号： C12Q1/6816 , B82Y15/00 , G01N33/533 , G01N33/542 , G01N33/54373 , G01N33/588 , Y10T428/2982 , Y10T428/2989 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T428/2996 , Y10T436/24 , C12Q2563/107
摘要： A semiconductor nanocrystal compound is described capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation and/or absorbing energy, and/or scattering or diffracting electromagnetic radiation—when excited by an electromagnetic radiation source or a particle beam; and (2) at least one linking agent, having a first portion linked to the semiconductor nanocrystal and a second portion capable of linking to an affinity molecule. The compound is linked to an affinity molecule to form a semiconductor nanocrystal probe capable of bonding with a detectable substance. subsequent exposure to excitation energy will excite the semiconductor nanocrystal in the probe causing the emission of electromagnetic radiation. Further described are processes for respectively: making the luminescent semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and using the probe to determine the presence of a detectable substance in a material.

9. 发明授权

US5990479A Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes 失效
标题翻译：用于生物应用的有机发光半导体纳米晶体探针和用于制造和使用这种探针的方法
公开(公告)号：US5990479A
公开(公告)日：1999-11-23
申请号：US978450
申请日：1997-11-25
申请人： Shimon Weiss , Marcel Bruchez, Jr. , Paul Alivisatos
发明人： Shimon Weiss , Marcel Bruchez, Jr. , Paul Alivisatos
IPC分类号： C12Q1/68 , G01N33/533 , G01N33/542 , G01N33/543 , G01N33/58 , G01Q70/08 , G01Q70/18 , G01N1/30 , G01N21/63
CPC分类号： C12Q1/6816 , B82Y15/00 , G01N33/533 , G01N33/542 , G01N33/54373 , G01N33/588 , Y10T428/2982 , Y10T428/2989 , Y10T428/2991 , Y10T428/2993 , Y10T428/2995 , Y10T428/2996 , Y10T436/24
摘要： A luminescent semiconductor nanocrystal compound is described which is capable of linking to an affinity molecule. The compound comprises (1) a semiconductor nanocrystal capable of emitting electromagnetic radiation (luminescing) in a narrow wavelength band and/or absorbing energy, and/or scattering or diffracting electromagnetic radiation--when excited by an electromagnetic radiation source (of narrow or broad bandwidth) or a particle beam; and (2) at least one linking agent, having a first portion linked to the semiconductor nanocrystal and a second portion capable of linking to an affinity molecule. The luminescent semiconductor nanocrystal compound is linked to an affinity molecule to form an organo luminescent semiconductor nanocrystal probe capable of bonding with a detectable substance in a material being analyzed, and capable of emitting electromagnetic radiation in a narrow wavelength band and/or absorbing, scattering, or diffracting energy when excited by an electromagnetic radiation source (of narrow or broad bandwidth) or a particle beam. The probe is stable to repeated exposure to light in the presence of oxygen and/or other radicals.Further described is a process for making the luminescent semiconductor nanocrystal compound and for making the organo luminescent semiconductor nanocrystal probe comprising the luminescent semiconductor nanocrystal compound linked to an affinity molecule capable of bonding to a detectable substance. A process is also described for using the probe to determine the presence of a detectable substance in a material.
摘要翻译：描述了能够连接到亲和分子的发光半导体纳米晶体化合物。该化合物包括（1）当被电磁辐射源（窄或宽带宽）激发时，能够发射在窄波段和/或吸收能量的电磁辐射（发光）和/或散射或衍射电磁辐射的半导体纳米晶体）或粒子束; 和（2）至少一种连接剂，其具有连接到半导体纳米晶体的第一部分和能够连接到亲和分子的第二部分。发光半导体纳米晶体化合物与亲和分子连接以形成能够与正在分析的材料中的可检测物质结合的有机发光半导体纳米晶体探针，并且能够发射窄波段的电磁辐射和/或吸收，散射，或者当被电磁辐射源（窄带或宽带宽）或粒子束激发时被激发的能量。探针在氧和/或其他自由基存在下重复暴露于光下是稳定的。进一步描述了制造发光半导体纳米晶体化合物和制备包含与能够与可检测物质结合的亲和分子连接的发光半导体纳米晶体化合物的有机发光半导体纳米晶体探针的方法。还描述了使用探针来确定材料中可检测物质的存在的方法。

10. 发明授权

US08639449B2 Semiconductor nanocrystal probes for biological applications and process for making and using such probes 有权
标题翻译：用于生物应用的半导体纳米晶体探针和用于制造和使用这种探针的方法
公开(公告)号：US08639449B2
公开(公告)日：2014-01-28
申请号：US13097430
申请日：2011-04-29
申请人： Shimon Weiss , Marcel Bruchez , Paul Alivisatos
发明人： Shimon Weiss , Marcel Bruchez , Paul Alivisatos
IPC分类号： G01N33/48 , G01N33/50
CPC分类号： H01L33/0062 , B82Y15/00 , C09K11/025 , C09K11/565 , C09K11/883 , C09K11/89 , C09K11/892 , C12Q1/6816 , C12Q2563/107 , G01N33/533 , G01N33/542 , G01N33/54373 , G01N33/588 , H01L33/0083 , Y10T436/141111 , Y10T436/142222
摘要： A semiconductor nanocrystal compound and probe are described. The compound is capable of linking to one or more affinity molecules. The compound comprises (1) one or more semiconductor nanocrystals capable of, in response to exposure to a first energy, providing a second energy, and (2) one or more linking agents, having a first portion linked to the one or more semiconductor nanocrystals and a second portion capable of linking to one or more affinity molecules. One or more semiconductor nanocrystal compounds are linked to one or more affinity molecules to form a semiconductor nanocrystal probe capable of bonding with one or more detectable substances in a material being analyzed, and capable of, in response to exposure to a first energy, providing a second energy. Also described are processes for respectively: making the semiconductor nanocrystal compound; making the semiconductor nanocrystal probe; and treating materials with the probe.
摘要翻译：描述了半导体纳米晶体化合物和探针。该化合物能够连接至一个或多个亲和分子。化合物包括（1）能够响应于暴露于第一能量提供第二能量的一种或多种半导体纳米晶体，和（2）一种或多种连接剂，其具有连接到所述一种或多种半导体纳米晶体的第一部分和能够连接到一个或多个亲和分子的第二部分。一个或多个半导体纳米晶体化合物与一个或多个亲和分子连接以形成半导体纳米晶体探针，该半导体纳米晶体探针能够与正在分析的材料中的一种或多种可检测物质结合，并且能够响应于暴露于第一能量而提供第二节能量。还描述了分别制造半导体纳米晶体化合物的方法; 制造半导体纳米晶体探针; 并用探针处理材料。

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