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1. 发明申请

US20070109536A1 Modulated excitation fluorescense analysis 有权
标题翻译：调制激发荧光分析
公开(公告)号：US20070109536A1
公开(公告)日：2007-05-17
申请号：US10561448
申请日：2004-06-17
申请人： Shimon Weiss , Achillefs Kapanidis , Ted Laurence , Nam Lee
发明人： Shimon Weiss , Achillefs Kapanidis , Ted Laurence , Nam Lee
IPC分类号： G01J3/30 , G01N21/64
CPC分类号： G01N21/6458 , G01J3/4338 , G01J3/4406 , G01N21/6408 , G01N21/6428 , G01N21/6445 , G01N21/648 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441
摘要： Fluorescence, spectroscopy is used to analyze small numbers of molecules that are present in a relatively small detection volume or zone. Information regarding physical and chemical properties of these molecules is determined by rapidly modulating the wavelength, intensity and/or polarization of laser energy to excite fluorophores that are attached either to the molecule of interest or a molecule that interacts with the molecule of interest. The emission profile of the fluorophores is used to determine useful information about the labeled and/or non-labeled molecules including molecular interactions between th molecules.
摘要翻译：荧光，光谱法用于分析存在于较小检测体积或区域中的少量分子。通过快速调节激光能量的波长，强度和/或极化以激发连接到感兴趣分子或与感兴趣的分子相互作用的分子的荧光团来确定关于这些分子的物理和化学性质的信息。荧光团的发射谱用于确定有关标记和/或非标记分子的有用信息，包括第th分子之间的分子相互作用。

2. 发明申请

US20060176479A1 Monitoring molecular interactions using photon arrival-time interval distribution analysis 有权
公开(公告)号：US20060176479A1
公开(公告)日：2006-08-10
申请号：US10521632
申请日：2003-07-25
申请人： Ted Laurence , Shimon Weiss
发明人： Ted Laurence , Shimon Weiss
IPC分类号： G01J3/30 , G01N21/64
CPC分类号： G01N21/6428 , G01J1/42 , G01J3/4406 , G01N21/6408 , G01N21/6458 , G01N2021/6419 , G01N2021/6421 , G01N2021/6441
摘要： A method for analyzing/monitoring the properties of species that are labeled with fluorophores. A detector is used to detect photons emitted from species that are labeled with one or more fluorophores and located in a confocal detection volume. The arrival time of each of the photons is determined. The interval of time between various photon pairs is then determined to provide photon pair intervals. The number of photons that have arrival times within the photon pair intervals is also determined. The photon pair intervals are then used in combination with the corresponding counts of intervening photons to analyze properties and interactions of the molecules including brightness, concentration, coincidence and transit time. The method can be used for analyzing single photon streams and multiple photon streams.

3. 发明申请

US20060050268A1 Nanosensors based on functionalized nanoparticles and Surface Enhanced Raman Scattering 有权
标题翻译：基于官能化纳米粒子和表面增强拉曼散射的纳米传感器
公开(公告)号：US20060050268A1
公开(公告)日：2006-03-09
申请号：US10935783
申请日：2004-09-07
申请人： Chad Talley , Thomas Huser , Christopher Hollars , Stephen Lane , Joe Satcher , Bradley Hart , Ted Laurence
发明人： Chad Talley , Thomas Huser , Christopher Hollars , Stephen Lane , Joe Satcher , Bradley Hart , Ted Laurence
IPC分类号： G01J3/44
CPC分类号： G01N21/658 , G01J3/44
摘要： Surface-Enhanced Raman Spectroscopy (SERS) is a vibrational spectroscopic technique that utilizes metal surfaces to provide enhanced signals of several orders of magnitude. When molecules of interest are attached to designed metal nanoparticles, a SERS signal is attainable with single molecule detection limits. This provides an ultrasensitive means of detecting the presence of molecules. By using selective chemistries, metal nanoparticles can be functionalized to provide a unique signal upon analyte binding. Moreover, by using measurement techniques, such as, ratiometric received SERS spectra, such metal nanoparticles can be used to monitor dynamic processes in addition to static binding events. Accordingly, such nanoparticles can be used as nanosensors for a wide range of chemicals in fluid, gaseous and solid form, environmental sensors for pH, ion concentration, temperature, etc., and biological sensors for proteins, DNA, RNA, etc.
摘要翻译：表面增强拉曼光谱（SERS）是一种振动光谱技术，利用金属表面提供几个数量级的增强信号。当感兴趣的分子连接到设计的金属纳米粒子时，可以通过单分子检测限达到SERS信号。这提供了检测分子存在的超灵敏手段。通过使用选择性化学成分，金属纳米粒子可以被功能化，以在分析物结合时提供独特的信号。此外，通过使用诸如比例接收的SERS光谱的测量技术，除了静态结合事件之外，这种金属纳米颗粒可用于监测动态过程。因此，这种纳米颗粒可用作流体，气体和固体形式的广泛化学品的纳米传感器，用于pH，离子浓度，温度等的环境传感器，以及用于蛋白质，DNA，RNA等的生物传感器。

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