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1. 发明授权

US08691274B2 Inkjet printing of tissues and cells 有权
标题翻译：喷墨打印组织和细胞
公开(公告)号：US08691274B2
公开(公告)日：2014-04-08
申请号：US12370921
申请日：2009-02-13
申请人： Tao Xu , James J. Yoo , Anthony Atala , Dennis Dice
发明人： Tao Xu , James J. Yoo , Anthony Atala , Dennis Dice
IPC分类号： A61K9/00 , B41M5/52 , B41M99/00 , C12N11/04
CPC分类号： A61K9/5089 , A61F2/062 , A61K35/32 , A61K35/34 , A61K35/36 , A61L27/38 , A61L27/50 , A61L27/58 , B33Y80/00 , B41J3/407 , C12N5/0655 , C12N11/04 , C12N11/08 , C12N2533/54 , C12N2533/56 , D01D5/0007 , D01F6/625
摘要： Provided herein is an apparatus for printing cells which includes an electrospinning device and an inkjet printing device operatively associated therewith. Methods of making a biodegradable scaffold having cells seeded therein are also provided. Methods of forming microparticles containing one or more cells encapsulated by a substrate are also provided, as are methods of forming an array of said microparticles.
摘要翻译：本文提供了一种用于印刷电池的装置，其包括静电纺丝装置和与其可操作地相关联的喷墨打印装置。还提供了制备具有种子细胞的可生物降解的支架的方法。还提供了形成包含一个或多个由基底包封的细胞的微粒的方法，以及形成所述微粒阵列的方法。

2. 发明申请

US20090208577A1 Inkjet Printing of Tissues and Cells 有权
标题翻译：组织和细胞的喷墨印刷
公开(公告)号：US20090208577A1
公开(公告)日：2009-08-20
申请号：US12370921
申请日：2009-02-13
申请人： Tao Xu , James J. Yoo , Anthony Atala , Dennis Dice
发明人： Tao Xu , James J. Yoo , Anthony Atala , Dennis Dice
IPC分类号： A61K9/00 , C12N11/04 , A61K35/12 , C40B50/06 , B28B1/00 , C12N5/02
CPC分类号： A61K9/5089 , A61F2/062 , A61K35/32 , A61K35/34 , A61K35/36 , A61L27/38 , A61L27/50 , A61L27/58 , B33Y80/00 , B41J3/407 , C12N5/0655 , C12N11/04 , C12N11/08 , C12N2533/54 , C12N2533/56 , D01D5/0007 , D01F6/625
摘要： Provided herein is an apparatus for printing cells which includes an electrospinning device and an inkjet printing device operatively associated therewith. Methods of making a biodegradable scaffold having cells seeded therein are also provided. Methods of forming microparticles containing one or more cells encapsulated by a substrate are also provided, as are methods of forming an array of said microparticles.
摘要翻译：本文提供了一种用于印刷电池的装置，其包括静电纺丝装置和与其可操作地相关联的喷墨打印装置。还提供了制备具有种子细胞的可生物降解的支架的方法。还提供了形成包含一个或多个由基底包封的细胞的微粒的方法，以及形成所述微粒阵列的方法。

3. 发明授权

US10500384B2 Delivery system 有权
公开(公告)号：US10500384B2
公开(公告)日：2019-12-10
申请号：US12986812
申请日：2011-01-07
申请人： James J. Yoo , Anthony Atala , Kyle W. Binder , Weixin Zhao , Dennis Dice , Tao Xu
发明人： James J. Yoo , Anthony Atala , Kyle W. Binder , Weixin Zhao , Dennis Dice , Tao Xu
IPC分类号： A61M35/00
CPC分类号： A61M35/00
摘要： Provided herein is a delivery system, including: (a) an optical sensor configured to detect data useful to create a map of a bodily surface; and (b) a printer operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the bodily surface based upon the data or map. Methods of forming a tissue on a bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing bodily surface data.

4. 发明申请

US20110172611A1 DELIVERY SYSTEM 审中-公开
标题翻译：输送系统
公开(公告)号：US20110172611A1
公开(公告)日：2011-07-14
申请号：US12986812
申请日：2011-01-07
申请人： James J. Yoo , Anthony Atala , Kyle W. Binder , Weixin Zhao , Dennis Dice , Tao Xu
发明人： James J. Yoo , Anthony Atala , Kyle W. Binder , Weixin Zhao , Dennis Dice , Tao Xu
IPC分类号： A61M35/00 , G06F17/50
CPC分类号： A61M35/00 , A61B5/0064 , A61B5/445 , A61B2017/00747 , A61B2017/00969 , A61B2017/3225 , A61B2034/105 , A61B2034/108 , B41J3/4073
摘要： Provided herein is a delivery system, including: (a) an optical sensor configured to detect data useful to create a map of a bodily surface; and (b) a printer operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the bodily surface based upon the data or map. Methods of forming a tissue on a bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing bodily surface data.
摘要翻译：本文提供了一种传送系统，包括：（a）光学传感器，被配置为检测有用于创建身体表面的地图的数据; 和（b）可操作地与所述光学传感器相关联并且被配置为基于所述数据或地图将组合物（可选地包括细胞）递送到所述身体表面的打印机。还提供了在有需要的患者的身体表面上形成组织的方法，以及可用于处理身体表面数据的方法，系统和计算机程序产品。

5. 发明申请

US20100160183A1 INKJET GENE PRINTING 有权
标题翻译： INKJET基因印刷
公开(公告)号：US20100160183A1
公开(公告)日：2010-06-24
申请号：US12663020
申请日：2008-06-06
申请人： Tao Xu , James J. Yoo , Anthony Atala
发明人： Tao Xu , James J. Yoo , Anthony Atala
IPC分类号： C12N15/87 , C12N5/00 , C40B50/14 , C40B60/14
CPC分类号： C12N15/895 , A61K31/713 , C12N15/63 , C12N15/87 , C12N15/89
摘要： Provided herein are methods and apparatuses for transfecting a cell with a compound of interest by stressing the cell, e.g. with shear stress. The compound of interest may be nucleic acids, proteins, molecules, nanoparticles, drugs, etc., or any combination thereof. Methods of printing cells with an inkjet printing device are also provided, wherein at least a portion of viable cells (preferably at least 1%) are transfected with a compound of interest. Preferably, at least 25% of the cells are viable after printing. In addition, methods of forming an array of viable cells are provided wherein at least a portion of the viable printed cells (preferably at least 1%) are transfected with at least one compound of interest.
摘要翻译：本文提供了用于通过施加细胞来转染具有感兴趣的化合物的细胞的方法和装置，例如，具有剪切应力。感兴趣的化合物可以是核酸，蛋白质，分子，纳米颗粒，药物等，或其任何组合。还提供了用喷墨印刷装置印刷细胞的方法，其中至少一部分活细胞（优选至少1％）用感兴趣的化合物转染。优选地，至少25％的细胞在印刷后是活的。此外，提供形成活细胞阵列的方法，其中至少一部分活的印刷细胞（优选至少1％）用至少一种目标化合物转染。

6. 发明授权

US09045757B2 Inkjet gene printing 有权
标题翻译：喷墨基因印刷
公开(公告)号：US09045757B2
公开(公告)日：2015-06-02
申请号：US12663020
申请日：2008-06-06
申请人： Tao Xu , James J. Yoo , Anthony Atala
发明人： Tao Xu , James J. Yoo , Anthony Atala
IPC分类号： C12N15/87 , C12N5/00 , C40B50/14 , C12N15/63 , C12N15/89
CPC分类号： C12N15/895 , A61K31/713 , C12N15/63 , C12N15/87 , C12N15/89
摘要： Provided herein are methods and apparatuses for transfecting a cell with a compound of interest by stressing the cell, e.g. with shear stress. The compound of interest may be nucleic acids, proteins, molecules, nanoparticles, drugs, etc., or any combination thereof. Methods of printing cells with an inkjet printing device are also provided, wherein at least a portion of viable cells (preferably at least 1%) are transfected with a compound of interest. Preferably, at least 25% of the cells are viable after printing. In addition, methods of forming an array of viable cells are provided wherein at least a portion of the viable printed cells (preferably at least 1%) are transfected with at least one compound of interest.
摘要翻译：本文提供了用于通过施加细胞来转染具有感兴趣的化合物的细胞的方法和装置，例如，具有剪切应力。感兴趣的化合物可以是核酸，蛋白质，分子，纳米颗粒，药物等，或其任何组合。还提供了用喷墨印刷装置印刷细胞的方法，其中至少一部分活细胞（优选至少1％）用感兴趣的化合物转染。优选地，至少25％的细胞在印刷后是活的。此外，提供形成活细胞阵列的方法，其中至少一部分活的印刷细胞（优选至少1％）用至少一种目标化合物转染。

7. 发明申请

US20090208466A1 INK-JET PRINTING OF TISSUES 审中-公开
标题翻译： INK-JET打印组织
公开(公告)号：US20090208466A1
公开(公告)日：2009-08-20
申请号：US12293490
申请日：2007-04-20
申请人： James Yoo , Tao Xu , Anthony Atala
发明人： James Yoo , Tao Xu , Anthony Atala
IPC分类号： A61K35/12 , C40B50/12 , A61P35/00
CPC分类号： C12N5/0062 , B01L3/0268 , B29C70/76 , B33Y10/00 , B33Y80/00 , C12N2533/54 , C12N2533/74
摘要： A method of forming an array of viable cells is carried out by ink-jet printing a cellular composition containing said cells on a substrate. At least two different types of viable mammalian cells are printed on the substrate, the at least two different types of viable mammalian cells selected to together form a tissue. In some embodiments at least three or four different viable mammalian cells are printed on the substrate, the cells selected to together form a tissue. In some embodiments one of the viable mammalian cell types is a stem cell. In some embodiments the method further comprises printing at least one support compound on the substrate, the support compound selected to form a tissue together with said cells. In some embodiments the method further comprises printing at least one growth factor on the substrate, the growth factor selected to cause the cells to form a tissue.
摘要翻译：形成活细胞阵列的方法是通过在基片上喷墨印刷含有所述细胞的细胞组合物进行的。将至少两种不同类型的活的哺乳动物细胞印刷在底物上，所选择的至少两种不同类型的活的哺乳动物细胞一起形成组织。在一些实施方案中，至少三个或四个不同的可行的哺乳动物细胞印刷在底物上，所选择的细胞一起形成组织。在一些实施方案中，活的哺乳动物细胞类型之一是干细胞。在一些实施方案中，所述方法还包括在所述底物上印刷至少一种载体化合物，所述载体化合物选择为与所述细胞一起形成组织。在一些实施方案中，该方法还包括在底物上印刷至少一种生长因子，选择该生长因子以使细胞形成组织。

8. 发明申请

US20200251289A1 PEROVSKITE PHOTOVOLTAIC DEVICE 审中-公开
公开(公告)号：US20200251289A1
公开(公告)日：2020-08-06
申请号：US16779421
申请日：2020-01-31
申请人： Tao Xu
发明人： Tao Xu
IPC分类号： H01G9/20 , H01G9/00 , H01L51/00 , H01L51/42
摘要： A photovoltaic device, comprises (1) a first conductive layer, (2) an optional blocking layer, on the first conductive layer, (3) a semiconductor layer, on the first conductive layer, (4) n light-harvesting material, on the semiconductor layer, (5) a hole transport material, on the light-harvesting material, and (6) a second conductive layer, on the hole transport material. The light harvesting material comprises, a pervoskite absorber, and the second conductive layer comprises nickel. The semiconductor layer tray comprise TiO2 nanowires. The light-harvesting material may comprise a pervoskite absorber containing a psuedohalogen.

9. 发明授权

US10625115B2 Lower back exercise apparatus 有权
公开(公告)号：US10625115B2
公开(公告)日：2020-04-21
申请号：US16110189
申请日：2018-08-23
申请人： Tao Xu
发明人： Tao Xu
IPC分类号： A63B23/02 , A61H1/02 , A63B22/16 , A63B21/16 , A61H1/00 , A63B22/00 , A63B22/20 , A63B24/00
CPC分类号： A63B23/0238 , A61H1/005 , A61H1/0292 , A63B21/1609 , A63B22/0087 , A63B22/16 , A63B22/201 , A63B24/0087 , A61H2201/1223 , A61H2201/1269 , A61H2201/1284 , A61H2201/149 , A63B2022/206 , A63B2208/0233
摘要： A lower back exercise apparatus exercises or imparts laterally and upwardly directed movements into a user's lower back when seated thereupon. The lower back exercise apparatus includes a lower base assembly, an upper seat assembly, and a motor assembly. The lower base assembly includes an upper, laterally concave base surface. The upper seat assembly includes a lower, laterally convex seat surface and an upper seat surface. The upper seat assembly is laterally ridable upon and movable relative to the lower base assembly. The motor assembly is drives a laterally directed, cylindrical arc length trajectory of the upper seat assembly relative to the lower base assembly. The concave and convex surfacing have a common radius of curvature with a common fulcrum point spatially located adjacent an upper portion of a user's lumbar spinal region. Lateral flexion is thus imparted into a user's lower back when a user is seated thereupon.

10. 发明授权

US10586659B2 Perovskite photovoltaic device 有权
公开(公告)号：US10586659B2
公开(公告)日：2020-03-10
申请号：US15564950
申请日：2015-04-06
申请人： Tao Xu
发明人： Tao Xu
IPC分类号： H01G9/20 , H01G9/00 , H01L51/42 , H01L51/00
摘要： A photovoltaic device, comprises (1) a first conductive layer, (2) an optional blocking layer, on the first conductive layer, (3) a semiconductor layer, on the first conductive layer, (4) a light-harvesting material, on the semiconductor layer, (5) a hole transport material, on the light-harvesting material, and (6) a second conductive layer, on the hole transport material. The light-harvesting material comprises a perovskite absorber, and the second conductive layer comprises nickel. The semiconductor layer may comprise TiO2 nanowires. The light-harvesting material may comprise a perovskite absorber containing a pseudohalogen.

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