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1. 发明申请

US20100160183A1 INKJET GENE PRINTING 有权
标题翻译： INKJET基因印刷
公开(公告)号：US20100160183A1
公开(公告)日：2010-06-24
申请号：US12663020
申请日：2008-06-06
申请人： Tao Xu , James J. Yoo , Anthony Atala
发明人： Tao Xu , James J. Yoo , Anthony Atala
IPC分类号： C12N15/87 , C12N5/00 , C40B50/14 , C40B60/14
CPC分类号： C12N15/895 , A61K31/713 , C12N15/63 , C12N15/87 , C12N15/89
摘要： Provided herein are methods and apparatuses for transfecting a cell with a compound of interest by stressing the cell, e.g. with shear stress. The compound of interest may be nucleic acids, proteins, molecules, nanoparticles, drugs, etc., or any combination thereof. Methods of printing cells with an inkjet printing device are also provided, wherein at least a portion of viable cells (preferably at least 1%) are transfected with a compound of interest. Preferably, at least 25% of the cells are viable after printing. In addition, methods of forming an array of viable cells are provided wherein at least a portion of the viable printed cells (preferably at least 1%) are transfected with at least one compound of interest.
摘要翻译：本文提供了用于通过施加细胞来转染具有感兴趣的化合物的细胞的方法和装置，例如，具有剪切应力。感兴趣的化合物可以是核酸，蛋白质，分子，纳米颗粒，药物等，或其任何组合。还提供了用喷墨印刷装置印刷细胞的方法，其中至少一部分活细胞（优选至少1％）用感兴趣的化合物转染。优选地，至少25％的细胞在印刷后是活的。此外，提供形成活细胞阵列的方法，其中至少一部分活的印刷细胞（优选至少1％）用至少一种目标化合物转染。

2. 发明申请

US20110172611A1 DELIVERY SYSTEM 审中-公开
标题翻译：输送系统
公开(公告)号：US20110172611A1
公开(公告)日：2011-07-14
申请号：US12986812
申请日：2011-01-07
申请人： James J. Yoo , Anthony Atala , Kyle W. Binder , Weixin Zhao , Dennis Dice , Tao Xu
发明人： James J. Yoo , Anthony Atala , Kyle W. Binder , Weixin Zhao , Dennis Dice , Tao Xu
IPC分类号： A61M35/00 , G06F17/50
CPC分类号： A61M35/00 , A61B5/0064 , A61B5/445 , A61B2017/00747 , A61B2017/00969 , A61B2017/3225 , A61B2034/105 , A61B2034/108 , B41J3/4073
摘要： Provided herein is a delivery system, including: (a) an optical sensor configured to detect data useful to create a map of a bodily surface; and (b) a printer operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the bodily surface based upon the data or map. Methods of forming a tissue on a bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing bodily surface data.
摘要翻译：本文提供了一种传送系统，包括：（a）光学传感器，被配置为检测有用于创建身体表面的地图的数据; 和（b）可操作地与所述光学传感器相关联并且被配置为基于所述数据或地图将组合物（可选地包括细胞）递送到所述身体表面的打印机。还提供了在有需要的患者的身体表面上形成组织的方法，以及可用于处理身体表面数据的方法，系统和计算机程序产品。

3. 发明授权

US10500384B2 Delivery system 有权
公开(公告)号：US10500384B2
公开(公告)日：2019-12-10
申请号：US12986812
申请日：2011-01-07
申请人： James J. Yoo , Anthony Atala , Kyle W. Binder , Weixin Zhao , Dennis Dice , Tao Xu
发明人： James J. Yoo , Anthony Atala , Kyle W. Binder , Weixin Zhao , Dennis Dice , Tao Xu
IPC分类号： A61M35/00
CPC分类号： A61M35/00
摘要： Provided herein is a delivery system, including: (a) an optical sensor configured to detect data useful to create a map of a bodily surface; and (b) a printer operatively associated with the optical sensor and configured to deliver compositions (optionally including cells) to the bodily surface based upon the data or map. Methods of forming a tissue on a bodily surface of a patient in need thereof are also provided, as are methods, systems and computer program products useful for processing bodily surface data.

4. 发明授权

US09045757B2 Inkjet gene printing 有权
标题翻译：喷墨基因印刷
公开(公告)号：US09045757B2
公开(公告)日：2015-06-02
申请号：US12663020
申请日：2008-06-06
申请人： Tao Xu , James J. Yoo , Anthony Atala
发明人： Tao Xu , James J. Yoo , Anthony Atala
IPC分类号： C12N15/87 , C12N5/00 , C40B50/14 , C12N15/63 , C12N15/89
CPC分类号： C12N15/895 , A61K31/713 , C12N15/63 , C12N15/87 , C12N15/89
摘要： Provided herein are methods and apparatuses for transfecting a cell with a compound of interest by stressing the cell, e.g. with shear stress. The compound of interest may be nucleic acids, proteins, molecules, nanoparticles, drugs, etc., or any combination thereof. Methods of printing cells with an inkjet printing device are also provided, wherein at least a portion of viable cells (preferably at least 1%) are transfected with a compound of interest. Preferably, at least 25% of the cells are viable after printing. In addition, methods of forming an array of viable cells are provided wherein at least a portion of the viable printed cells (preferably at least 1%) are transfected with at least one compound of interest.
摘要翻译：本文提供了用于通过施加细胞来转染具有感兴趣的化合物的细胞的方法和装置，例如，具有剪切应力。感兴趣的化合物可以是核酸，蛋白质，分子，纳米颗粒，药物等，或其任何组合。还提供了用喷墨印刷装置印刷细胞的方法，其中至少一部分活细胞（优选至少1％）用感兴趣的化合物转染。优选地，至少25％的细胞在印刷后是活的。此外，提供形成活细胞阵列的方法，其中至少一部分活的印刷细胞（优选至少1％）用至少一种目标化合物转染。

5. 发明申请

US20090208577A1 Inkjet Printing of Tissues and Cells 有权
标题翻译：组织和细胞的喷墨印刷
公开(公告)号：US20090208577A1
公开(公告)日：2009-08-20
申请号：US12370921
申请日：2009-02-13
申请人： Tao Xu , James J. Yoo , Anthony Atala , Dennis Dice
发明人： Tao Xu , James J. Yoo , Anthony Atala , Dennis Dice
IPC分类号： A61K9/00 , C12N11/04 , A61K35/12 , C40B50/06 , B28B1/00 , C12N5/02
CPC分类号： A61K9/5089 , A61F2/062 , A61K35/32 , A61K35/34 , A61K35/36 , A61L27/38 , A61L27/50 , A61L27/58 , B33Y80/00 , B41J3/407 , C12N5/0655 , C12N11/04 , C12N11/08 , C12N2533/54 , C12N2533/56 , D01D5/0007 , D01F6/625
摘要： Provided herein is an apparatus for printing cells which includes an electrospinning device and an inkjet printing device operatively associated therewith. Methods of making a biodegradable scaffold having cells seeded therein are also provided. Methods of forming microparticles containing one or more cells encapsulated by a substrate are also provided, as are methods of forming an array of said microparticles.
摘要翻译：本文提供了一种用于印刷电池的装置，其包括静电纺丝装置和与其可操作地相关联的喷墨打印装置。还提供了制备具有种子细胞的可生物降解的支架的方法。还提供了形成包含一个或多个由基底包封的细胞的微粒的方法，以及形成所述微粒阵列的方法。

6. 发明授权

US08691274B2 Inkjet printing of tissues and cells 有权
标题翻译：喷墨打印组织和细胞
公开(公告)号：US08691274B2
公开(公告)日：2014-04-08
申请号：US12370921
申请日：2009-02-13
申请人： Tao Xu , James J. Yoo , Anthony Atala , Dennis Dice
发明人： Tao Xu , James J. Yoo , Anthony Atala , Dennis Dice
IPC分类号： A61K9/00 , B41M5/52 , B41M99/00 , C12N11/04
CPC分类号： A61K9/5089 , A61F2/062 , A61K35/32 , A61K35/34 , A61K35/36 , A61L27/38 , A61L27/50 , A61L27/58 , B33Y80/00 , B41J3/407 , C12N5/0655 , C12N11/04 , C12N11/08 , C12N2533/54 , C12N2533/56 , D01D5/0007 , D01F6/625
摘要： Provided herein is an apparatus for printing cells which includes an electrospinning device and an inkjet printing device operatively associated therewith. Methods of making a biodegradable scaffold having cells seeded therein are also provided. Methods of forming microparticles containing one or more cells encapsulated by a substrate are also provided, as are methods of forming an array of said microparticles.
摘要翻译：本文提供了一种用于印刷电池的装置，其包括静电纺丝装置和与其可操作地相关联的喷墨打印装置。还提供了制备具有种子细胞的可生物降解的支架的方法。还提供了形成包含一个或多个由基底包封的细胞的微粒的方法，以及形成所述微粒阵列的方法。

7. 发明申请

US20140127308A1 ENCAPSULATED CELLS FOR HORMONE REPLACEMENT THERAPY 审中-公开
标题翻译：用于激素替代治疗的包封细胞
公开(公告)号：US20140127308A1
公开(公告)日：2014-05-08
申请号：US14002504
申请日：2012-02-21
申请人： Emmanuel Opara , James J. Yoo , Justin M. Saul , Sittadjody Sivanandane , Anthony Atala
发明人： Emmanuel Opara , James J. Yoo , Justin M. Saul , Sittadjody Sivanandane , Anthony Atala
IPC分类号： A61K35/54 , A61K9/50
CPC分类号： A61K35/54 , A61K9/167 , A61K9/5036 , A61K9/5073 , A61K31/565 , A61K31/57 , A61K2300/00
摘要： A composition comprising microcapsules, the microcapsules containing both live mammalian ovarian granulosa cells and live mammalian ovarian theca cells, is described. In some embodiments, the granulosa cells and the theca cells are contained in separate microcapsules in the composition; in some embodiments, the granulosa cells and the theca cells are contained together in the same microcapsules in the composition The composition is can be used for estrogen, and optionally also progesterone, delivery, and hence is preferably free or essentially free of oocytes. Methods of using the same and pharmaceutical formulations containing the same are also described.
摘要翻译：描述了包含微胶囊的组合物，包含活哺乳动物卵巢颗粒细胞和活哺乳动物卵巢细胞的微胶囊。在一些实施方案中，颗粒细胞和细胞被包含在组合物中的分离的微胶囊中; 在一些实施方案中，颗粒细胞和细胞在组合物中一起包含在相同的微胶囊中。组合物可用于雌激素，并且任选地也可用于孕酮，递送，因此优选是游离的或基本上不含卵母细胞。还描述了使用它们的方法和含有它们的药物制剂。

8. 发明申请

US20110172683A1 TISSUE EXPANDER 有权
标题翻译：组织膨胀机
公开(公告)号：US20110172683A1
公开(公告)日：2011-07-14
申请号：US12986771
申请日：2011-01-07
申请人： James J. Yoo , Anthony Atala , Paul Scarpinato , Sang Jin Lee , Mitchell Ladd
发明人： James J. Yoo , Anthony Atala , Paul Scarpinato , Sang Jin Lee , Mitchell Ladd
IPC分类号： A61B17/00
CPC分类号： A61B17/322 , A61B90/02 , A61B2017/00969 , A61B2017/3225
摘要： Provided herein is a tissue stretching device including a tissue clamping member defining an area in a Z plane, wherein the tissue clamping member is configured to hold tissue parallel to the Z plane. Methods of use of the tissue stretching device to stretch a tissue as well as for culturing organized tissues are also provided. Stretched and/or cultured tissues produced by these processes are also provided, as well as methods of treatment making use of the same.
摘要翻译：本文提供了一种组织拉伸装置，其包括限定Z平面中的区域的组织夹持构件，其中组织夹持构件被构造成保持平行于Z平面的组织。还提供了使用组织拉伸装置拉伸组织以及培养有组织的组织的方法。还提供了通过这些方法生产的拉伸和/或培养的组织，以及使用它们的治疗方法。

9. 发明授权

US07806937B2 Tissue engineered female reproductive organs 失效
标题翻译：组织工程女性生殖器官
公开(公告)号：US07806937B2
公开(公告)日：2010-10-05
申请号：US10298198
申请日：2002-11-15
申请人： Anthony Atala , James J. Yoo
发明人： Anthony Atala , James J. Yoo
IPC分类号： C12N5/00
CPC分类号： A61L27/3604 , A61K35/12 , A61L27/18 , A61L27/3679 , A61L27/38 , A61L2430/22 , C12N5/0068 , C12N5/0697 , C12N2500/84 , C12N2501/11 , C12N2502/1347 , C12N2502/243 , C12N2533/40 , C08L67/04
摘要： The invention is directed to compositions and methods for reconstructing artificial female reproductive organs. The constructs and methods of the invention can be used for ameliorating congenital malformations and disorders of female reproductive tract using tissue engineered female reproductive organs, such as the uterus, vagina, cervix, and fallopian tubes. These tissue engineered female reproductive organs can be generated by perfusing cultured cell populations derived from cells of the female reproductive tissues, such as uterine, vaginal, cervical, fallopian tube epithelial cells as well as smooth muscle cells.
摘要翻译：本发明涉及用于重建人造女性生殖器官的组合物和方法。本发明的构建和方法可用于使用组织工程化的女性生殖器官如子宫，阴道，子宫颈和输卵管改善先天性畸形和女性生殖道障碍。这些组织工程化的雌性生殖器官可以通过灌注来自雌性生殖组织的细胞的培养细胞群，如子宫，阴道，子宫颈，输卵管上皮细胞以及平滑肌细胞产生。

10. 发明申请

US20100104544A1 SELECTIVE CELL THERAPY FOR THE TREATMENT OF RENAL FAILURE 审中-公开
标题翻译：用于治疗失败的选择性细胞治疗
公开(公告)号：US20100104544A1
公开(公告)日：2010-04-29
申请号：US12618179
申请日：2009-11-13
申请人： Anthony Atala , James J. Yoo
发明人： Anthony Atala , James J. Yoo
IPC分类号： A61K35/12 , C12N5/071 , A61P13/12 , A61P7/06 , C12N5/02
CPC分类号： C12N5/0686 , A61K35/12 , A61K35/22 , C12N2500/02
摘要： Provided herein are isolated populations of kidney cells harvested from differentiated cells of the kidney, wherein the cells have been expanded in vitro. The kidney cells preferably produce erythropoietin (EPO). The kidney cells may also be selected based upon EPO production. Methods of producing an isolated population of EPO producing cells are also provided, and methods of treating a kidney disease resulting in decreased EPO production in a patient in need thereof are provided, including administering the population to the patient, whereby the cells express EPO in vivo in an oxygen tension-dependent manner.
摘要翻译：本文提供了从分化的肾细胞收获的分离的肾细胞群体，其中细胞已经在体外扩增。肾细胞优选产生促红细胞生成素（EPO）。也可以基于EPO生产来选择肾细胞。还提供了产生分离的EPO产生细胞群体的方法，并且提供了治疗有需要的患者中导致EPO产生减少的肾脏疾病的方法，包括向患者施用群体，由此细胞体内表达EPO 以氧依赖于张力的方式。

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