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1. 发明专利

JP2008263957A Molecular diagnosis system for human lung cancer 审中-公开
标题翻译：人肺癌分子诊断系统
公开(公告)号：JP2008263957A
公开(公告)日：2008-11-06
申请号：JP2008060269
申请日：2008-03-10
申请人： Tama Tlo Kk , タマティーエルオー株式会社
发明人： FURUHATA CHIE , WATANABE TAKASHI
IPC分类号： C12M1/00 , C12N15/09 , C12Q1/68 , G01N33/53 , G01N33/543 , G01N33/574
摘要： PROBLEM TO BE SOLVED: To provide a molecular diagnosis system for human lung cancer which can be used in common for four pathologic conditions of the human lung cancer and by which the four pathologic conditions can be automatically identified.
SOLUTION: A fluorescence value of specimen cells and a fluorescence value of normal lung-derived cells are obtained from a DNA microarray on which a DNA probe set including oligonucleotide consisting of a DNA sequence expressed in sequence numbers 1-80 is mounted. Four evaluations concerning the fluorescence value are outputted for each spot. The result of estimation of each spot is cross-checked with an evaluation table of each pathologic condition which is previously prepared and the result of diagnosis of lung cancer is automatically determined.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供一种人肺癌分子诊断系统，可以在人类肺癌的四种病理状况下共同使用，可以自动识别四种病理状态。解决方案：从其中安装包含由序列号1-80表示的DNA序列组成的寡核苷酸的DNA探针组的DNA微阵列获得标本细胞的荧光值和正常肺衍生细胞的荧光值。对于每个点输出关于荧光值的四个评估。每个斑点的估计结果与预先准备的每个病理状况的评估表交叉检查，并且自动确定肺癌的诊断结果。版权所有（C）2009，JPO＆INPIT

2. 发明专利

JP2008268171A Dna probe set for classifying four pathologica conditions of human lung cancer 审中-公开
标题翻译：用于分类人肺癌四种病理学的DNA探针
公开(公告)号：JP2008268171A
公开(公告)日：2008-11-06
申请号：JP2007234363
申请日：2007-09-10
申请人： Tama Tlo Kk , タマティーエルオー株式会社
发明人： FURUHATA CHIE , WATANABE TAKASHI
IPC分类号： G01N33/574 , C12M1/00 , C12N15/09 , C12Q1/02 , C12Q1/68 , G01N21/78 , G01N33/53 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a DNA probe set and a DNA micro-array mounted with this DNA probe set, usable in common for four pathological conditions of human lung cancer, and capable of specifying a morbid state by identifying four pathological conditions.
SOLUTION: The morbid state can be specified by identifying the four pathological conditions, in addition to sepecifying the human lung cancer by using the DNA micro-array mounted with the DNA probe set, including oligonucleotide composed of a DNA array expressed by array numbers 1-80. This DNA probe set can construct an inexpensive and high performance diagnostic system for human lung cancer molecule by manufacturing the DNA micro-array which is miniaturized further than a conventional DNA micro-array.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：为了提供安装有该DNA探针组的DNA探针组和DNA微阵列，其可用于人肺癌的四种病理状况的共同之处，并且能够通过鉴定四种病理学来指定病态条件。解决方案：除了通过使用安装有DNA探针组的DNA微阵列（包括由阵列表示的DNA阵列组成的寡核苷酸）来分辨人肺癌，可以通过鉴定四种病理状况来指定病态数字1-80。该DNA探针组可以通过制造比常规DNA微阵列进一步小型化的DNA微阵列，为人肺癌分子构建廉价且高性能的诊断系统。版权所有（C）2009，JPO＆INPIT

3. 发明专利

JP2006275981A PROBE PLATE INCLUDING DNA PROBE FOR SCREENING CARCINOGENIC SUBSTANCE, MANUFACTURING METHOD THEREOF, AND cDNA SCREENING METHOD WITH USAGE OF THE PROBE PLATE 审中-公开
标题翻译：探针板包括用于筛选致癌物质的DNA探针，其制备方法和使用探针板的cDNA筛选方法
公开(公告)号：JP2006275981A
公开(公告)日：2006-10-12
申请号：JP2005099843
申请日：2005-03-30
申请人： Institute Of Physical & Chemical Research , Tama Tlo Kk , タマティーエルオー株式会社 , 独立行政法人理化学研究所
发明人： FURUHATA CHIE , TOBE KAORI , TASHIRO HIDEO , KONDO YASUMITSU , SUZUKI TAKAMASA
IPC分类号： G01N33/53 , C12N15/09 , C12Q1/68 , G01N33/574 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To generate a probe plate capable of selecting only oligonucleotide giving high selection to a carcinogenic substance, capable of conducting a test at the low cost in a short time as a DNA microarray, and capable of making high selective hybridization with a marked cDNA; and to achieve high selectivity, high efficiency and low cost of screening. SOLUTION: This DNA probe plate 10 is provided with a substrate 12, and a spot 14 including oligonucleotide adhered to the substrate; and the oligonucleotide is a base structure wherein 5'-end and 3'-end are G (guanine), C (cytosine), or two base sequences including the 5'-end and the 3'-end are GG, GC, CG, CC. Further, the manufacturing method of the DNA probe plate and the cDNA screening method with the usage of the probe plate are also provided. COPYRIGHT: (C)2007,JPO&INPIT
摘要翻译：要解决的问题：为了产生能够仅选择对致癌物质进行高选择的寡核苷酸的探针板，能够在短时间内作为DNA微阵列以低成本进行测试，并能够制备高选择性与标记的cDNA杂交; 并实现高选择性，高效率和低成本筛选。解决方案：该DNA探针板10具有底物12和包含寡核苷酸的斑点14，粘附于基底上; 并且寡核苷酸是其中5'端和3'末端是G（鸟嘌呤），C（胞嘧啶）或包括5'末端和3'末端的两个碱基序列是GG，GC，CG ，CC。此外，还提供了DNA探针板的制造方法和使用探针板的cDNA筛选方法。版权所有（C）2007，JPO＆INPIT

4. 发明专利

JP2009244017A Dna chip holder 审中-公开
标题翻译： DNA芯片支架
公开(公告)号：JP2009244017A
公开(公告)日：2009-10-22
申请号：JP2008089497
申请日：2008-03-31
申请人： Tama Tlo Ltd , タマティーエルオー株式会社
发明人： FURUHATA CHIE , WATANABE TAKASHI , OMIYA HIROMICHI
IPC分类号： G01N35/02 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a DNA chip holder for improving the handleability of a quadrangular mini DNA chip having a side of a few millimeters when the mini DNA chip is introduced to an existing gene analysis automation system.
SOLUTION: A pressing member in which a notch part is formed is fitted in a recession part of a plate-shaped holder body provided with the recession part to be in contact with at least two sides of the mini DNA chip having a quadrangular shape having a side of a few millimeters. After the mini DNA chip is housed in a housing space defined by the recession part of the holder body and the notch part of the pressing member, the pressing member is fastened by a screw. At this time, side surfaces of the mini DNA chip are pressed by wall surfaces of the notch part of the pressing member by the slight rotation of the pressing member in the same direction as the rotation direction of the screw to reliably hold the mini DNA chip in the housing space.
COPYRIGHT: (C)2010,JPO&INPIT
摘要翻译：要解决的问题：当将微型DNA芯片引入现有的基因分析自动化系统时，提供一种用于提高具有几毫米的一边的四边形小型DNA芯片的可操作性的DNA芯片保持器。解决方案：其中形成有切口部分的按压构件装配在设置有凹陷部分的板状保持器主体的凹部中，以与具有四边形的小型DNA芯片的至少两侧接触形状有几毫米的一边。在迷你DNA芯片被容纳在由保持器本体的凹陷部分和按压构件的切口部分限定的容纳空间中之后，按压构件通过螺钉紧固。此时，通过按压部件的旋转方向与螺杆的旋转方向相同的方向，微型DNA芯片的侧面被按压部件的切口部的壁面按压，以可靠地保持微型DNA芯片在住房空间。版权所有（C）2010，JPO＆INPIT

5. 发明专利

JP2009213391A Dna probe set for identifying differentiated type or undifferentiated type of human stomach cancer cell, dna microarray loaded with the dna probe set, and molecular diagnostic system for human stomach cancer, using the dna microarray 审中-公开
标题翻译：用于识别差异型或不同类型的人淋巴癌细胞的DNA探针，用DNA探针组装载的DNA微阵列，以及使用DNA微阵列的人类肿瘤癌的分子诊断系统
公开(公告)号：JP2009213391A
公开(公告)日：2009-09-24
申请号：JP2008059994
申请日：2008-03-10
申请人： Tama Tlo Ltd , タマティーエルオー株式会社
发明人： FURUHATA CHIE , WATANABE TAKASHI , WATANABE KEITA
IPC分类号： C12Q1/68 , C12M1/00 , C12N15/09 , C12Q1/02 , G01N33/53 , G01N37/00
摘要： PROBLEM TO BE SOLVED: To provide a DNA probe set commonly usable for both of the differentiated type and the undifferentiated type of human stomach cancer, and capable of differentiating and specifying the two types; to provide a DNA microarray loaded with the DNA probe set; and to provide a molecular diagnostic system for the human stomach cancer, using the DNA microarray.
SOLUTION: The differentiated type or the undifferentiated type of the human stomach cancer cell is identified and specified by using the DNA microarray loaded with the DNA probe set including an oligonucleotide comprising a specific DNA sequence. The DNA probe set enables the production of the DNA microarray miniaturized than the conventional one.
COPYRIGHT: (C)2009,JPO&INPIT
摘要翻译：要解决的问题：提供通常可用于分化型和未分化型的人类胃癌的DNA探针组，并且能够区分和指定两种类型; 提供负载有DNA探针组的DNA微阵列; 并使用DNA微阵列提供人胃癌的分子诊断系统。解决方案：通过使用装载有包含特定DNA序列的寡核苷酸的DNA探针组的DNA微阵列来鉴定和指定人胃癌细胞的分化型或未分化型。 DNA探针组使得能够生产小于现有技术的DNA微阵列。版权所有（C）2009，JPO＆INPIT

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