专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5466593A Hepatocyte growth factor activating protease and gene encoding the protease 失效
标题翻译：肝细胞生长因子激活蛋白酶和编码蛋白酶的基因
公开(公告)号：US5466593A
公开(公告)日：1995-11-14
申请号：US148910
申请日：1993-11-05
申请人： Takeshi Shimomura , Kazunori Yamada , Yuuki Morimoto , Naomi Kitamura , Keiji Miyazawa
发明人： Takeshi Shimomura , Kazunori Yamada , Yuuki Morimoto , Naomi Kitamura , Keiji Miyazawa
IPC分类号： C07K14/475 , C12N9/64 , C12N15/12 , C12N15/57 , C12N5/10 , C12N15/63
CPC分类号： C12N9/64 , C07K14/475 , C07K14/4753 , C12N9/6421
摘要： A gene encoding a protease derived from human serum and having an activity to convert single-chain hepatocyte growth factor (HGF) into active two-chain HGF and a method of producing the protease by the use of said gene are provided. A method of producing a precursor protein of said protease is also provided.
摘要翻译：提供了编码来自人血清并具有将单链肝细胞生长因子（HGF）转化为活性双链HGF的活性的基因的编码基因和使用所述基因产生蛋白酶的方法。还提供了产生所述蛋白酶的前体蛋白质的方法。

2. 发明授权

US5677164A Hepatocyte growth factor activating protease and gene encoding the protease 失效
标题翻译：肝细胞生长因子激活蛋白酶和编码蛋白酶的基因
公开(公告)号：US5677164A
公开(公告)日：1997-10-14
申请号：US448937
申请日：1995-05-24
申请人： Takeshi Shimomura , Kazunori Yamada , Yuuki Morimoto , Naomi Kitamura , Keiji Miyazawa
发明人： Takeshi Shimomura , Kazunori Yamada , Yuuki Morimoto , Naomi Kitamura , Keiji Miyazawa
IPC分类号： C07K14/475 , C12N9/64 , C12N15/12 , C12N15/57
CPC分类号： C12N9/64 , C07K14/475 , C07K14/4753 , C12N9/6421
摘要： A gene encoding a protease derived from human serum and having an activity to convert single-chain hepatocyte growth factor (HGF) into active two-chain HGF and a method of producing the protease by the use of said gene are provided. A method of producing a precursor protein of said protease is also provided.
摘要翻译：提供了编码来自人血清并具有将单链肝细胞生长因子（HGF）转化为活性双链HGF的活性的基因的编码基因和使用所述基因产生蛋白酶的方法。还提供了产生所述蛋白酶的前体蛋白质的方法。

3. 发明授权

US06465622B2 Protein, DNA coding for same and method of producing the protein 失效
标题翻译：蛋白质，编码相同的DNA和产生蛋白质的方法
公开(公告)号：US06465622B2
公开(公告)日：2002-10-15
申请号：US09765449
申请日：2001-01-22
申请人： Takeshi Shimomura , Toshiya Kawaguchi , Naomi Kitamura , Keiji Miyazawa
发明人： Takeshi Shimomura , Toshiya Kawaguchi , Naomi Kitamura , Keiji Miyazawa
IPC分类号： C07K14453
CPC分类号： C07K14/8114
摘要： A novel protein having inhibitory activity on the protease activity of hepatocyte growth factor (HGF) activator was purified and isolated, and its molecular weight (ca. 40,000 daltons) and its N-terminal and partial amino acid sequences were determined. A gene coding for the protein was cloned, and the gene DNA was incorporated into a vector, for transforming host cells. Cultivation of the transformant gave the desired protein. The protein can be used as an in vivo or in vitro control factor for HGF or HGF activator. It is also useful as an antigen to be used in producing an antibody to be used as means for kinetic studies of the protein, or as a standard in assay systems therefor.
摘要翻译：纯化并分离出具有对肝细胞生长因子（HGF）活化剂的蛋白酶活性的抑制活性的新型蛋白质，测定其分子量（约40,000道尔顿）及其N-末端部分氨基酸序列。克隆编码该蛋白的基因，并将基因DNA并入载体中，用于转化宿主细胞。转化体的培养给出了所需的蛋白质。该蛋白质可用作HGF或HGF活化剂的体内或体外控制因子。它也可用作生产用作蛋白质动力学研究手段的抗体或作为其测定系统中的标准物的抗原。

4. 发明授权

US06225081B1 Protein, DNA coding for same and method of producing the protein 失效
标题翻译：蛋白质，编码相同的DNA和产生蛋白质的方法
公开(公告)号：US06225081B1
公开(公告)日：2001-05-01
申请号：US08685558
申请日：1996-07-24
申请人： Takeshi Shimomura , Toshiya Kawaguchi , Naomi Kitamura , Keiji Miyazawa
发明人： Takeshi Shimomura , Toshiya Kawaguchi , Naomi Kitamura , Keiji Miyazawa
IPC分类号： C12N1515
CPC分类号： C07K14/8114
摘要： A novel protein having inhibitory activity on the protease activity of hepatocyte growth factor (HGF) activator was purified and isolated, and its molecular weight (ca. 40,000 daltons) and its N-terminal and partial amino acid sequences were determined. A gene coding for the protein was cloned, and the gene DNA was incorporated into a vector, for transforming host cells. Cultivation of the transformant gave the desired protein. The protein can be used as an in vivo or in vitro control factor for HGF or HGF activator. It is also useful as an antigen to be used in producing an antibody to be used as means for kinetic studies of the protein, or as a standard in assay systems therefor.
摘要翻译：纯化并分离出具有对肝细胞生长因子（HGF）活化剂的蛋白酶活性的抑制活性的新型蛋白质，测定其分子量（约40,000道尔顿）及其N-末端部分氨基酸序列。克隆编码该蛋白的基因，并将基因DNA并入载体中，用于转化宿主细胞。转化体的培养给出了所需的蛋白质。该蛋白质可用作HGF或HGF活化剂的体内或体外控制因子。它也可用作生产用作蛋白质动力学研究手段的抗体或作为其测定系统中的标准物的抗原。

5. 发明授权

US5500354A Hepatic parenchymal cell growth factor gene encoding the same, process for producing the factor and transformants producing the factor 失效
标题翻译：肝实质细胞生长因子基因编码相同，产生因子的过程和产生因子的转化体
公开(公告)号：US5500354A
公开(公告)日：1996-03-19
申请号：US89417
申请日：1993-07-09
申请人： Naomi Kitamura , Keiji Miyazawa , Yasushi Daikuhara , Hirohito Tsubouchi , Daiji Naka , Kazuhiro Takahashi , Rie Matsui , Yoshiko Yoshiyama , Takehisa Ishii
发明人： Naomi Kitamura , Keiji Miyazawa , Yasushi Daikuhara , Hirohito Tsubouchi , Daiji Naka , Kazuhiro Takahashi , Rie Matsui , Yoshiko Yoshiyama , Takehisa Ishii
IPC分类号： A61K38/00 , C07K14/475 , C12N15/16 , C07H21/04 , C12N5/16 , C12N15/79
CPC分类号： C07K14/4753 , A61K38/00
摘要： According to the present invention, there are provided hepatic parenchymal cell growth factor obtained by recombinant DNA technology, a gene coding for the factor, an expression vector capable of expressing the gene, a cell, in particular animal cell, transformed with the expression vector, and a process for producing the hepatic parenchymal cell growth factor.
摘要翻译：根据本发明，提供了通过重组DNA技术获得的肝实质细胞生长因子，编码该因子的基因，能够表达该基因的表达载体，用表达载体转化的细胞，特别是动物细胞，以及肝实质细胞生长因子的制造方法。

6. 发明申请

US20120039808A1 Brain Tumor Stem Cell Differentiation Promoter, and Therapeutic Agent for Brain Tumor 审中-公开
标题翻译：脑肿瘤干细胞分化启动子和脑肿瘤治疗剂
公开(公告)号：US20120039808A1
公开(公告)日：2012-02-16
申请号：US13207846
申请日：2011-08-11
申请人： Kohei Miyazono , Hiroaki Ikushima , Keiji Miyazawa , Tomoki Todo , Yasushi Ino
发明人： Kohei Miyazono , Hiroaki Ikushima , Keiji Miyazawa , Tomoki Todo , Yasushi Ino
IPC分类号： A61K49/00 , A61K31/7088 , A61K31/711 , A61K31/713 , A61P35/00 , C12Q1/02 , C12Q1/68 , C40B30/02 , C07H21/00 , C07H21/02 , G01N33/53
CPC分类号： A61K31/713 , A61K31/4439 , A61K45/06 , C12N15/113 , C12N2310/11 , C12N2310/14
摘要： A promoter for differentiation of brain tumor initiating cells is provided.
摘要翻译：提供了用于脑肿瘤起始细胞分化的启动子。

7. 发明授权

US07013735B2 Pressure sensor 有权
标题翻译：压力传感器
公开(公告)号：US07013735B2
公开(公告)日：2006-03-21
申请号：US10485450
申请日：2002-07-31
申请人： Keiji Miyazawa
发明人： Keiji Miyazawa
IPC分类号： G01L9/00
CPC分类号： G01L13/025 , G01L15/00
摘要： A differential pressure sensor chip (4) comprises a diaphragm for measuring a differential pressure and converts a pressure received by the diaphragm for measuring the differential pressure into an electrical signal. A static pressure sensor chip (5) comprises a diaphragm for measuring a static pressure and converts a pressure received by the diaphragm for measuring the static pressure into an electrical signal. The differential pressure sensor chip (4) and static pressure sensor chip (5) are mounted on a header (1) so that one surface of the differential pressure sensor chip (4) and one surface of the static pressure sensor chip (5) are exposed to the interior of a common pressure introducing chamber (17).
摘要翻译：差压传感器芯片（4）包括用于测量差压的膜片，并将用于测量差压的膜片接收的压力转换成电信号。静压传感器芯片（5）包括用于测量静压力的膜片，并将由膜片接收的压力转换成用于测量静态压力的电信号。差压传感器芯片（4）和静压传感器芯片（5）安装在集管（1）上，使差压传感器芯片（4）的一个表面和静压传感器芯片（5）的一个表面暴露于公共压力引入室（17）的内部。

8. 发明授权

US07280220B2 Physical quantity measuring method and device therefor 失效
标题翻译：物理量测量方法及其装置
公开(公告)号：US07280220B2
公开(公告)日：2007-10-09
申请号：US10489782
申请日：2002-09-18
申请人： Seiichiro Kinugasa , Keiji Miyazawa , Takaaki Kuroiwa
发明人： Seiichiro Kinugasa , Keiji Miyazawa , Takaaki Kuroiwa
IPC分类号： G01B9/02
CPC分类号： G01D5/35303 , G01L9/0077 , G01L13/025
摘要： Light emitted by a light source is inputted to a sensor to generate an optical path difference on input light according to a physical parameter to be measured, light outputted with an optical path difference generated in response to the input is inputted to another sensor to generate an optical path difference on input light according to a physical parameter to be measured, and light outputted with an optical path difference generated in response to the input is split into two to generate an interference fringe. Due to the presence of light which is changed in optical path length in the first sensor, is inputted to the sensor of the subsequent stage, and is transmitted without being changed in optical path length, and light which is not changed in optical path length in the first sensor, is inputted to the sensor of the subsequent stage, and is transmitted after being changed in optical path length, an interference fringe is generated with an fringe located on a position corresponding to a difference value between physical parameters to be measured. Thus, a difference value between physical parameters is measured by detecting the position.
摘要翻译：由光源发出的光被输入到传感器，根据待测物理参数产生输入光的光路差，将输入的光路差产生的光输入到另一传感器，生成根据要测量的物理参数的输入光的光程差，以及响应于输入而产生的光路差输出的光被分成两个，以产生干涉条纹。由于在第一传感器中光路长度改变的光的存在被输入到后级的传感器，并且在不改变光路长度的情况下被传输，并且在光路长度上没有改变的光第一传感器被输入到后级的传感器，并且在光路长度改变之后被传输，产生干涉条纹，其边缘位于与待测物理参数之间的差值相对应的位置上。因此，通过检测位置来测量物理参数之间的差值。

9. 发明授权

US4841296A Two-wire transmitter 失效
标题翻译：双线变送器
公开(公告)号：US4841296A
公开(公告)日：1989-06-20
申请号：US3896
申请日：1987-01-16
申请人： Norio Kadoya , Jun Kawachi , Keiji Miyazawa
发明人： Norio Kadoya , Jun Kawachi , Keiji Miyazawa
IPC分类号： G01F15/02 , G01F15/06 , G01L19/08 , G08C19/02 , G08C19/16
CPC分类号： G01L19/083 , G08C19/02 , G08C19/16
摘要： A two-wire transmitter having a detecting section for detecting a physical variable to be measured to produce a detection output, first and second constant voltage devices connected in series with a two-wire transmission path, a signal processor driven by a voltage supplied by the first constant voltage device for converting the detection output into representative serial pulse signals and a switching circuit which is connected in parallel with the second constant voltage device and is turned on and off by the serial pulse signals to produce corresponding output signals from the transmitter on the two-wire transmission path by utilizing a current flowing in the two-wire transmission path while enabling the transmitter to connect in a single loop with another two-wire transmitter.
摘要翻译：一种具有用于检测要测量的物理变量以产生检测输出的检测部分的两线制发送器，与两线传输路径串联连接的第一和第二恒定电压装置，由所述两线传输路径提供的电压驱动的信号处理器第一恒压装置，用于将检测输出转换成代表性的串行脉冲信号;以及开关电路，其与第二恒压装置并联连接，并通过串行脉冲信号导通和截止，以在发生器上产生相应的输出信号通过利用在双线传输路径中流动的电流，同时使得发射机能够在单个环路中与另一个双线发射机连接，从而实现两线传输路径。

10. 发明申请

US20090239860A1 NOVEL BENZOFURAN DERIVATIVE, MEDICINAL COMPOSITION CONTAINING THE SAME, AND USES OF THESE 审中-公开
标题翻译：新的苯唑嘌呤衍生物，含有它们的药物组合物及其用途
公开(公告)号：US20090239860A1
公开(公告)日：2009-09-24
申请号：US10597443
申请日：2005-01-21
申请人： Tetsuya Nakamura , Hiroaki Shiohara , Yoshihiro Terao , Satoko Nakayama , Keiji Miyazawa , Hideki Ohnota
发明人： Tetsuya Nakamura , Hiroaki Shiohara , Yoshihiro Terao , Satoko Nakayama , Keiji Miyazawa , Hideki Ohnota
IPC分类号： A61K31/5377 , C07D413/00 , A61P35/00
CPC分类号： C07D405/12
摘要： The present invention provides compounds represented by general formula (I): or pharmaceutical acceptable salts thereof, wherein R1 is hydrogen or lower alkyl; R2 is lower alkyl, halo-lower alkyl, cycloalkyl, heterocycloalkyl, aryl, aralkyl, arylalkenyl, aryloxy-lower alkyl, heteroaryl, heteroaryl-lower alkyl, etc; R3, R4, R5 and R6 are each hydrogen, halogen, cyano, lower alkyl, halo-lower alkyl, lower alkoxy, hydroxy, aryl, etc; provided that at least one of R3, R4, R5 and R6 is other than hydrogen. Compound (I) of the present invention shows a potent adenosine A2A receptor antagonistic activity, and are useful for treating or preventing a disease mediated by adenosine A2A receptors such as motor function disorders, depression, anxiety disorders, cognitive function disorders, cerebral ischemia disorders, restless legs syndrome and the like.
摘要翻译：本发明提供由通式（I）表示的化合物或其药学上可接受的盐，其中R 1是氢或低级烷基; R2是低级烷基，卤代低级烷基，环烷基，杂环烷基，芳基，芳烷基，芳基烯基，芳氧基 - 低级烷基，杂芳基，杂芳基 - 低级烷基等; R3，R4，R5和R6各自为氢，卤素，氰基，低级烷基，卤代低级烷基，低级烷氧基，羟基，芳基等; 条件是R3，R4，R5和R6中的至少一个不是氢。本发明的化合物（I）显示有效的腺苷A 2A受体拮抗活性，可用于治疗或预防由腺苷A2A受体介导的疾病，例如运动功能障碍，抑郁症，焦虑症，认知功能障碍，脑缺血障碍，不安腿综合征等。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式