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1. 发明授权

US6072474A Document processing device 失效
标题翻译：文件处理装置
公开(公告)号：US6072474A
公开(公告)日：2000-06-06
申请号：US674108
申请日：1996-07-03
申请人： Takeshi Morimura , Tadashi Watanabe , Yuichi Fukui
发明人： Takeshi Morimura , Tadashi Watanabe , Yuichi Fukui
IPC分类号： G06F3/023 , G06F3/0488 , G06F3/0489 , G09G5/00
CPC分类号： G06F3/04892 , G06F3/0488
摘要： When a user touches a tablet with a pen, a coordinate pointed with a nib of a pen and a tool force on this coordinate are detected, and a cursor is displayed at a position corresponding to the coordinate in a display device. Furthermore, the shape, color and size, etc., of the cursor can be varied according to a change in coordinate, tool force. This permits the user to recognize a level of the tool force which he actually applies at a glance. Additionally, an operational mode is switched according to an amount of change in detected coordinate and the tool force. As a result, the user is permitted to control an operational mode of the document processing device with ease only by a pen operation, thereby improving an operability.
摘要翻译：当用户用笔触摸平板电脑时，检测到与笔的笔尖和该坐标上的工具力指向的坐标，并且在与显示装置中的坐标相对应的位置处显示光标。此外，光标的形状，颜色和尺寸等可以根据坐标，刀具力的变化而变化。这使得用户能够一目了然地识别他实际应用的工具力的水平。此外，根据检测到的坐标和工具力的变化量来切换操作模式。结果，允许用户仅通过笔操作容易地控制文档处理设备的操作模式，从而提高可操作性。

2. 发明授权

US4464382A Rhodanine derivatives, process for their preparation, and aldose reductase inhibitor containing the rhodanine derivatives as active ingredient 失效
标题翻译：罗丹宁衍生物，其制备方法和含有绕丹宁衍生物作为活性成分的醛糖还原酶抑制剂
公开(公告)号：US4464382A
公开(公告)日：1984-08-07
申请号：US292076
申请日：1981-08-12
申请人： Tadao Tanouchi , Masanori Kawamura , Akio Ajima , Tetsuya Mohri , Masaki Hayashi , Hiroshi Terashima , Fumio Hirata , Takeshi Morimura
发明人： Tadao Tanouchi , Masanori Kawamura , Akio Ajima , Tetsuya Mohri , Masaki Hayashi , Hiroshi Terashima , Fumio Hirata , Takeshi Morimura
IPC分类号： C12N9/99 , A61K31/425 , A61K31/426 , A61K31/44 , A61P3/08 , A61P27/02 , A61P27/12 , A61P43/00 , C07D277/20 , C07D277/36 , C07D333/00 , C07D417/06 , C07D417/14
CPC分类号： C07D277/20
摘要： The rhodanine derivatives of the general formula: ##STR1## wherein (I) R.sup.1 and R.sup.2 are taken together to represent a tetramethylene or pentamethylene group; (II) R.sup.1 represents a hydrogen atom, and R.sup.2 represents (1) a cycloalkyl or cycloalkenyl group of 4-7 carbon atoms which is unsubstituted or substituted by at least one alkyl group of 1-4 carbon atoms, (2) an anthryl or naphthyl group, (3) a phenyl group which is unsubstituted or substituted, (4) a heterocyclic group containing at least one of nitrogen, oxygen and sulfur atoms which is unsubstituted or substituted (5) a ##STR2## group (wherein R.sup.4 represents a hydrogen atom, a halogen atom, phenyl group or an alkyl group of 1-5 carbon atoms; and R.sup.5 represents a hydrogen atom, a phenyl group or an alkyl group of 1-5 carbon atoms) or ##STR3## group; or (III) R.sup.1 and R.sup.2, which may be the same or different with each other, each represents a phenyl group which is unsubstituted or substituted; and R.sup.3 represents a hydrogen atom, an alkyl group of 1-12 carbon atoms, an aralkyl group of 7-13 carbon atoms, a cycloalkyl or cycloalkenyl group of 4-7 carbon atoms which is unsubstituted or substituted by at least one alkyl group of 1-4 carbon atoms, or a phenyl group which is unsubstituted or substituted, possess a strong inhibitory activity on aldose reductase.
摘要翻译：通式：（I）的绕丹宁衍生物其中（I）R 1和R 2一起表示四亚甲基或五亚甲基; （II）R1表示氢原子，R2表示（1）未被取代或被至少一个1-4个碳原子的烷基取代的4-7个碳原子的环烷基或环烯基，（2）蒽基或萘基，（3）未取代或取代的苯基，（4）含有未取代或取代的氮，氧和硫原子中的至少一个的杂环基（5）基团（其中R 4表示氢原子，卤素原子，苯基或1-5个碳原子的烷基; R5表示氢原子，苯基或1-5个碳原子的烷基）或基团; 或（III）可以相同或不同的R 1和R 2各自表示未取代或取代的苯基; 并且R 3表示氢原子，1-12个碳原子的烷基，7-13个碳原子的芳烷基，4-7个碳原子的环烷基或环烯基，其未被取代或被至少一个烷基 1-4个碳原子或未取代或取代的苯基对醛糖还原酶具有强烈的抑制活性。

3. 发明授权

US4831045A Rhodanine derivatives, process for their preparation, and aldose reductase inhibitor containing the rhodanine derivatives as active ingredient 失效
标题翻译：罗丹宁衍生物，其制备方法和含有绕丹宁衍生物作为活性成分的醛糖还原酶抑制剂
公开(公告)号：US4831045A
公开(公告)日：1989-05-16
申请号：US96091
申请日：1987-09-10
申请人： Tadao Tanouchi , Masanori Kawamura , Akio Ajima , Tetsuya Mohri , Masaki Hayashi , Hiroshi Terashima , Fumio Hirata , Takeshi Morimura
发明人： Tadao Tanouchi , Masanori Kawamura , Akio Ajima , Tetsuya Mohri , Masaki Hayashi , Hiroshi Terashima , Fumio Hirata , Takeshi Morimura
IPC分类号： C12N9/99 , A61K31/425 , A61K31/426 , A61K31/44 , A61P3/08 , A61P27/02 , A61P27/12 , A61P43/00 , C07D277/20 , C07D277/36 , C07D333/00 , C07D417/06 , C07D417/14
CPC分类号： C07D277/20
摘要： The rhodanine derivatives of the general formula: ##STR1## [wherein (I) R.sup.1 and R.sup.2 are taken together to represent a tetramethylene or pentamethylene group; (II) R.sup.1 represents a hydrogen atom, and R.sup.2 represents (1) a cycloalkyl or cycloalkenyl group of 4-7 carbon atoms which is unsubstituted or substituted by at least one alkyl group of 1-4 carbon atoms, (2) an anthryl or naphthyl group, (3) a phenyl group which is unsubstituted or substituted by at least one of (a) halogen atom, (b) trifluoromethyl group, (c) hydroxyl group, (d) nitro group, (e) carboxyl group, (f) amino group which may be substituted by alkyl group(s) of 1-4 carbon atoms, (g) alkyl, alkoxy or alkylthio group of 1-5 carbon atoms, (h) phenyl group, (i) heterocyclic group containing at least one of nitrogen, oxygen and sulfur atoms which is unsubstituted or substituted by at least one of the above-described substituents (a) to (h), and (j) alkyl group of 1-4 carbon atoms which is substituted by at least one of the above-described substituents (c), (h) and (i), (4) a heterocyclic group containing at least one of nitrogen, oxygen and sulfur atoms which is unsubstituted or substituted by at least one of oxo group and the above-described substituents (a) to (h) and (j), or (5) a ##STR2## (wherein R.sup.4 represents a hydrogen atom, a halogen atom, phenyl group or an alkyl group of 1-5 carbon atoms; and R.sup.5 represents a hydrogen atom, a phenyl group or an alkyl group of 1-5 carbon atoms) or ##STR3## or (III) R.sup.1 and R.sup.2, which may be the same or different with each other, each represents a phenyl group which is unsubstituted or substituted by at least one of the above-described substituents (a) to (j); and R.sup.3 represents a hydrogen atom, an alkyl group of 1-12 carbon atoms, an aralkyl group of 7-13 carbon atoms, a cycloalkyl or cycloalkenyl group of 4-7 carbon atoms which is unsubstituted or substituted by at least one alkyl group of 1-4 carbon atoms, or a phenyl group which is unsubstituted or substituted by at least one of the above-described substituents (a) to (j)] and, when R.sup.3 represents a hydrogen atom, non-toxic salts of the acids possess a strong inhibitory activity on aldose reductase, and are useful for the prevention and treatment of nerve disturbances such as neuralgia, retinopathy, diabetic cataract and renal disturbances such as tubular nephropathy.

4. 发明授权

US4791126A Rhodanine derivatives, process for their preparation, and aldose reductase inhibitor containing the rhodanine derivatives as active ingredients 失效
公开(公告)号：US4791126A
公开(公告)日：1988-12-13
申请号：US96808
申请日：1987-09-10
申请人： Tadao Tanouchi , Masanori Kawamura , Akio Ajima , Tetsuya Mohri , Masaki Hayashi , Hiroshi Terashima , Fumio Hirata , Takeshi Morimura
发明人： Tadao Tanouchi , Masanori Kawamura , Akio Ajima , Tetsuya Mohri , Masaki Hayashi , Hiroshi Terashima , Fumio Hirata , Takeshi Morimura
IPC分类号： C07D277/20 , C07D277/36 , A61K31/425
CPC分类号： C07D277/20
摘要： The rhodanine derivatives of the general formula: ##STR1## [wherein (I) R.sup.1 and R.sup.2 are taken together to represent a tetramethylene or pentamethylene group; (II) R.sup.1 represents a hydrogen atom, and R.sup.2 represents (1) a cycloalkyl or cycloalkenyl group of 4-7 carbon atoms which is unsubstituted or substituted by at least one alkyl group of 1-4 carbon atoms, (2) an anthryl or naphthyl group, (3) a phenyl group which is unsubstituted or substituted by at least one of (a) halogen atom, (b) trifluoromethyl group, (c) hydroxyl group, (d) nitro group, (e) carboxyl group, (f) amino group which may be substituted by alkyl group(s) of 1-4 carbon atoms, (g) alkyl, alkoxy or alkylthio group of 1-5 carbon atoms, (h) phenyl group, (i) heterocyclic group containing at least one of nitrogen, oxygen and sulfur atoms which is unsubstituted or substituted by at least one of the above-described substituents (a) to (h), and (j) alkyl group of 1-4 carbon atoms which is substituted by at least one of the above-described substituents (c), (h) and (i), (4) a heterocyclic group containing at least one of nitrogen, oxygen and sulfur atoms which is unsubstituted or substituted by at least one of oxo group and the above-described substituents (a) to (h) and (j), or (5) a ##STR2## group (wherein R.sup.4 represents a hydrogen atom, a halogen atom, phenyl group or an alkyl group of 1-5 carbon atoms; and R.sup.5 represents a hydrogen atom, a phenyl group or an alkyl group of 1-5 carbon atoms) or ##STR3## group; or (III) R.sup.1 and R.sup.2, which may be the same or different with each other, each represents a phenyl group which is unsubstituted or substituted by at least one of the above-described substituents (a) to (j); and R.sup.3 represents a hydrogen atom, an alkyl group of 1-12 carbon atoms, an aralkyl group of 7-13 carbon atoms, a cycloalkyl or cycloalkenyl group of 4-7 carbon atoms which is unsubstituted or substituted by at least one alkyl group of 1-4 carbon atoms, or a phenyl group which is unsubstituted or substituted by at least one of the above-described substituents (a) to (j)] and, when R.sup.3 represents hydrogen atom, non-toxic salts of the acids possess a strong inhibitory activity on aldose reductase, and are useful for the prevention and treatment of nerve disturbances such as neuralgia, retinopathy, diabetic cataract and renal disturbances such as tubular nephropathy.

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