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1. 发明申请

US20100099676A1 SULFONYLUREA DERIVATIVE CAPABLE OF SELECTIVELY INHIBITING MMP-13 审中-公开
标题翻译：选择性抑制MMP-13的SULFONYLUREA衍生物
公开(公告)号：US20100099676A1
公开(公告)日：2010-04-22
申请号：US12447743
申请日：2007-10-31
申请人： Takeshi Endoh , Yasuhiko Fujii , Eiichi Kojima , Genta Tadano , Naoko Yamaguchi , Yo Adachi , Sachie Tagashira , Yuki Tachibana , Naohiro Onodera
发明人： Takeshi Endoh , Yasuhiko Fujii , Eiichi Kojima , Genta Tadano , Naoko Yamaguchi , Yo Adachi , Sachie Tagashira , Yuki Tachibana , Naohiro Onodera
IPC分类号： A61K31/5377 , C07D417/10 , A61K31/497 , C07D413/14 , C07D401/02 , C07D413/02 , A61K31/4965 , C07D241/04
CPC分类号： C07D209/86 , C07D211/96 , C07D213/81 , C07D215/20 , C07D241/04 , C07D243/08 , C07D263/32 , C07D277/28 , C07D295/22 , C07D295/26 , C07D307/81 , C07D307/91
摘要： A compound represented by the general formula (I): wherein R1 is wherein R26 and R28 are each independently lower alkyloxy and the like; n1 is an integer of 0 to 3; Z is a optionally substituted C1-C5 alkynylene which may be interrupted with a substituent selected from Substituent group a and the like; A is a group represented by the formula: wherein R6 and R7 are each independently lower alkyl and the like; m and n are each independently 0, 1, or 2; R2 is a hydrogen atom and the like; R3 is optionally substituted lower alkyl and the like; R4 is a hydrogen atom; or R3 and R4 may be taken together with an adjacent carbon atom to from a ring; R5 is hydroxyl and the like, or an optically active isomer, a pharmaceutically acceptable salt or a solvate thereof.
摘要翻译：由通式（I）表示的化合物：其中R 1是其中R 26和R 28各自独立地为低级烷氧基等; n1为0〜3的整数， Z是可以被选自取代基组a等的取代基中断的任选取代的C 1 -C 5亚炔基; A是由下式表示的基团：其中R6和R7各自独立地为低级烷基等; m和n各自独立地为0,1或2; R2是氢原子等; R3是任选取代的低级烷基等; R4是氢原子; 或者R 3和R 4可以与相邻的碳原子一起与环一起取代; R5是羟基等，或光学活性异构体，其药学上可接受的盐或溶剂化物。

2. 发明申请

US20130172317A1 TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION HAVING AN ANALGESIC ACTIVITY COMPRISING THE SAME 有权
标题翻译：具有包括其同源活性的TRIAZINE衍生物和药物组合物
公开(公告)号：US20130172317A1
公开(公告)日：2013-07-04
申请号：US13814346
申请日：2011-08-09
申请人： Hiroyuki Kai , Takayuki Kameyama , Tohru Horiguchi , Kentaro Asahi , Takeshi Endoh , Yasuhiko Fujii , Takuya Shintani , Ken'ichiroh Nakamura , Sae Jikihara , Tsuyoshi Hasegawa , Miho Oohara , Yukio Tada , Toshikatsu Maki , Akira Iida
发明人： Hiroyuki Kai , Takayuki Kameyama , Tohru Horiguchi , Kentaro Asahi , Takeshi Endoh , Yasuhiko Fujii , Takuya Shintani , Ken'ichiroh Nakamura , Sae Jikihara , Tsuyoshi Hasegawa , Miho Oohara , Yukio Tada , Toshikatsu Maki , Akira Iida
IPC分类号： C07D251/46 , C07D417/12 , C07D413/12 , C07D405/06 , C07D401/14 , C07D251/52 , C07D405/14 , C07D401/12 , C07D403/12 , C07D403/04 , C07D413/14
CPC分类号： C07D251/46 , C07D251/52 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The present invention provides novel compounds having a P2X3 and/or P2X2/3 receptor antagonistic effect.A pharmaceutical composition having an analgesic effect or an improving effect of urination disorder comprising a compound of the formula (I): wherein Rh and Rj are taken together to form a bond; Ra and Rb and/or Rd and Re are taken together to form oxo or the like; Rc is hydrogen, substituted or unsubstituted alkyl or the like; Rf is —(CR4aR4b)n—R2; R4a and R4b are hydrogen, substituted or unsubstituted alkyl or the like; R2 is substituted or unsubstituted cycloalkyl or the like; n is an integer of 1 to 4; —Rg is —X—R3; —X— is —O—, —S— or the like; R3 is substituted or unsubstituted cycloalkyl or the like, or its pharmaceutically acceptable salt or a solvate thereof.
摘要翻译：本发明提供具有P2X3和/或P2X2 / 3受体拮抗作用的新化合物。一种具有止痛作用或排尿障碍改善作用的药物组合物，其包含式（I）化合物：其中Rh和Rj一起形成键; Ra和Rb和/或Rd和Re一起形成氧代等; Rc是氢，取代或未取代的烷基等; Rf是 - （CR4aR4b）n-R2; R4a和R4b是氢，取代或未取代的烷基等; R2是取代或未取代的环烷基等; n为1〜4的整数， -Rg为-X-R3; -X-是-O-，-S-等; R3是取代或未取代的环烷基等，或其药学上可接受的盐或溶剂合物。

3. 发明授权

US09212130B2 Heterocyclic derivative and pharmaceutical composition comprising the same 有权
标题翻译：杂环衍生物和包含其的药物组合物
公开(公告)号：US09212130B2
公开(公告)日：2015-12-15
申请号：US13816085
申请日：2011-08-09
申请人： Hiroyuki Kai , Takeshi Endoh , Sae Jikihara , Tohru Horiguchi
发明人： Hiroyuki Kai , Takeshi Endoh , Sae Jikihara , Tohru Horiguchi
IPC分类号： A61K31/505 , A61K31/497 , A61K31/44 , A61K31/135 , A61K31/425 , C07C233/75 , C07C217/84 , C07C217/80 , C07D401/14 , C07D239/84 , C07D211/72 , C07D237/04 , C07C217/92 , C07D213/74 , C07D213/80 , C07D213/82 , C07D215/22 , C07D217/24 , C07D231/38 , C07D233/96 , C07D235/30 , C07D237/32 , C07D239/42 , C07D239/47 , C07D239/54 , C07D239/95 , C07D239/96 , C07D241/20 , C07D255/02 , C07D261/12 , C07D263/32 , C07D263/34 , C07D263/48 , C07D265/10 , C07D265/26 , C07D265/36 , C07D277/20 , C07D277/34 , C07D277/38 , C07D401/12 , C07D405/12 , C07D405/14 , C07D417/12 , C07D417/14 , C07D277/28 , C07D405/06 , C07D409/06 , C07D409/12 , C07D413/12 , C07D407/06 , C07C233/25 , C07D215/56 , C07D217/22 , C07D233/88 , C07D237/20 , C07D239/48 , C07D239/545 , C07D239/557 , C07D239/78 , C07D265/06 , C07D277/42 , C07D213/69
CPC分类号： C07D239/545 , C07C217/80 , C07C217/84 , C07C217/92 , C07C233/25 , C07C233/75 , C07C2601/14 , C07D211/72 , C07D213/64 , C07D213/69 , C07D213/74 , C07D213/79 , C07D213/80 , C07D213/82 , C07D215/22 , C07D215/56 , C07D217/22 , C07D217/24 , C07D231/38 , C07D233/88 , C07D233/96 , C07D235/30 , C07D237/04 , C07D237/20 , C07D237/32 , C07D239/42 , C07D239/47 , C07D239/48 , C07D239/54 , C07D239/557 , C07D239/78 , C07D239/84 , C07D239/95 , C07D239/96 , C07D241/20 , C07D255/02 , C07D261/12 , C07D263/32 , C07D263/34 , C07D263/48 , C07D265/06 , C07D265/10 , C07D265/26 , C07D265/36 , C07D277/20 , C07D277/28 , C07D277/34 , C07D277/38 , C07D277/42 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/06 , C07D409/06 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention provides novel compounds having a P2X3 and/or P2X2/3 receptor antagonistic effect.A pharmaceutical composition having a P2X3 and/or P2X2/3 receptor antagonistic effect comprising a compound of the formula (I): wherein ring A is substituted or unsubstituted 5 to 7-membered cycloalkane, substituted or unsubstituted 5 to 7-membered cycloalkene or the like; C is a carbon atom; —X— is —N(R16)— or the like; R16 is hydrogen, substituted or unsubstituted alkyl or the like; R7 is substituted or unsubstituted 5- or 6-membered heteroaryl, substituted or unsubstituted 6 to 10 membered aryl; Q1 and Q2 are each independently a carbon atom or a nitrogen atom; -L- is —O—, —S— or the like; R6 is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl or the like; R2 is hydrogen, hydroxy or the like, or its pharmaceutically acceptable salt or a solvate thereof.
摘要翻译：本发明提供具有P2X3和/或P2X2 / 3受体拮抗作用的新化合物。一种具有P2X3和/或P2X2 / 3受体拮抗作用的药物组合物，其包含式（I）化合物：其中环A是取代或未取代的5至7元环烷烃，取代或未取代的5至7元环烯烃或喜欢; C是碳原子; -X-是-N（R 16） - 等; R 16是氢，取代或未取代的烷基等; R 7是取代或未取代的5元或6元杂芳基，取代或未取代的6至10元芳基; Q1和Q2各自独立地为碳原子或氮原子; -L-是-O-，-S-等; R6是取代或未取代的环烷基，取代或未取代的环烯基等; R2是氢，羟基等，或其药学上可接受的盐或其溶剂合物。

4. 发明申请

US20070210804A1 Load abnormality detecting system and method 失效
标题翻译：负载异常检测系统及方法
公开(公告)号：US20070210804A1
公开(公告)日：2007-09-13
申请号：US11714448
申请日：2007-03-06
申请人： Takeshi Endoh
发明人： Takeshi Endoh
IPC分类号： G01R31/08
CPC分类号： G01R31/025
摘要： A load abnormality detecting system and method for detecting the burnout and short circuit of a load are provided. A voltage generator (10) generates a specified voltage Vs in accordance with a load current IL. A judging device (4) compares a signal corresponding to this voltage (Vs) with a specified reference value (T1, T2) to judge whether a load (2) has any abnormality. A selector (6) causes the burnout reference value (T1) to be inputted to the judging device (4) and controls the voltage generator (10) to use a first resistance value when checking the burnout of the load (2) while causing the short-circuit reference value (T2) to be inputted to the judging device (4) and controlling the voltage generator (10) to use a second resistance value when checking the short circuit of the load (2).
摘要翻译：提供一种用于检测负载的烧坏和短路的负载异常检测系统和方法。电压发生器（10）根据负载电流IL产生规定的电压Vs。判断装置（4）将与该电压（Vs）对应的信号与规定的基准值（T 1，T 2）进行比较，判断负载（2）是否有异常。选择器（6）使得烧断参考值（T 1）被输入到判断装置（4），并且当检查负载（2）的烧坏时，控制电压发生器（10）使用第一电阻值，同时引起输入到判断装置（4）的短路参考值（T 2），并且在检查负载（2）的短路时控制电压发生器（10）使用第二电阻值。

5. 发明授权

US08575197B2 Pyrolinone derivative and pharmaceutical composition comprising the same 失效
标题翻译：吡罗啉酮衍生物及其组合物
公开(公告)号：US08575197B2
公开(公告)日：2013-11-05
申请号：US13121072
申请日：2009-09-24
申请人： Hiroyuki Kai , Yoshiyuki Taoda , Takeshi Endoh , Kentaro Asahi , Hiroyuki Tobinaga
发明人： Hiroyuki Kai , Yoshiyuki Taoda , Takeshi Endoh , Kentaro Asahi , Hiroyuki Tobinaga
IPC分类号： A61K31/4418 , A61K31/443 , A61K31/4439 , A61K31/422 , A61K31/4245 , A61K31/402 , A61K31/4025 , C07D207/38 , C07D271/06 , C07D261/08 , C07D409/10 , C07D403/14 , C07D413/14 , C07D401/04
CPC分类号： C07D487/04 , C07D207/38 , C07D401/04 , C07D401/10 , C07D403/04 , C07D405/14 , C07D409/10 , C07D409/14 , C07D413/10 , C07D413/14 , C07D417/04
摘要： The present invention provides a novel P2X3 and/or P2X2/3 receptor antagonist.A compound represented by the formula (I): wherein Z1 is optionally protected hydroxy, etc.; Z2 is —C(═O)—, etc.; Z3a and Z3b are taken together ═O or ═S; t is an integer of 0 to 4; R4a and R4b are each independently, hydrogen or substituted or unsubstituted lower alkyl, etc.; m and n are each independently an integer of 0 to 2; k is an integer of 0 or 1; Ring A is an aromatic carbocyclic ring or a heterocyclic ring, etc.; B is aromatic carbocyclic ring-diyl or heterocyclic ring-diyl, etc.; R1a and R1b are each independently halogen, hydroxy, substituted or unsubstituted lower alkyl, etc.; R2 is substituted or unsubstituted alkyl, etc.; R3 is substituted or unsubstituted alkyl, substituted or unsubstituted aryl or a substituted or unsubstituted heterocyclic group, etc.; or its pharmaceutically acceptable salt, or a solvate thereof is provided.
摘要翻译：本发明提供了一种新型的P2X3和/或P2X2 / 3受体拮抗剂。由式（I）表示的化合物：其中Z 1任选被保护的羟基等; Z2是-C（= O） - 等; Z3a和Z3b在一起= O或= S; t为0〜4的整数; R4a和R4b各自独立地为氢或取代或未取代的低级烷基等; m和n各自独立地为0〜2的整数。 k是0或1的整数; 环A是芳族碳环或杂环等; B是芳族碳环环 - 二基或杂环环二基等; R1a和R1b各自独立地为卤素，羟基，取代或未取代的低级烷基等; R2是取代或未取代的烷基等; R3是取代或未取代的烷基，取代或未取代的芳基或取代或未取代的杂环基等; 或其药学上可接受的盐或其溶剂合物。

6. 发明申请

US20130225596A1 NOVEL HETEROCYCLIC DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME (AS AMENDED) 有权
标题翻译：新型杂环衍生物和药物组合物（如修饰）
公开(公告)号：US20130225596A1
公开(公告)日：2013-08-29
申请号：US13816085
申请日：2011-08-09
申请人： Hiroyuki Kai , Takeshi Endoh , Sae Jikihara , Kentaro Asahi , Tohru Horiguchi
发明人： Hiroyuki Kai , Takeshi Endoh , Sae Jikihara , Kentaro Asahi , Tohru Horiguchi
IPC分类号： C07C233/75 , C07D239/84 , C07D213/74 , C07C217/84 , C07D211/72 , C07D405/06 , C07C217/80 , C07D413/12 , C07D409/12 , C07D409/06 , C07D277/28 , C07D401/14 , C07D237/04
CPC分类号： C07D239/545 , C07C217/80 , C07C217/84 , C07C217/92 , C07C233/25 , C07C233/75 , C07C2601/14 , C07D211/72 , C07D213/64 , C07D213/69 , C07D213/74 , C07D213/79 , C07D213/80 , C07D213/82 , C07D215/22 , C07D215/56 , C07D217/22 , C07D217/24 , C07D231/38 , C07D233/88 , C07D233/96 , C07D235/30 , C07D237/04 , C07D237/20 , C07D237/32 , C07D239/42 , C07D239/47 , C07D239/48 , C07D239/54 , C07D239/557 , C07D239/78 , C07D239/84 , C07D239/95 , C07D239/96 , C07D241/20 , C07D255/02 , C07D261/12 , C07D263/32 , C07D263/34 , C07D263/48 , C07D265/06 , C07D265/10 , C07D265/26 , C07D265/36 , C07D277/20 , C07D277/28 , C07D277/34 , C07D277/38 , C07D277/42 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D405/14 , C07D407/06 , C07D409/06 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14
摘要： The present invention provides novel compounds having a P2X3 and/or P2X2/3 receptor antagonistic effect.A pharmaceutical composition having a P2X3 and/or P2X2/3 receptor antagonistic effect comprising a compound of the formula (I): wherein ring A is substituted or unsubstituted 5 to 7-membered cycloalkane, substituted or unsubstituted 5 to 7-membered cycloalkene or the like; C is a carbon atom; —X— is —N(R16)— or the like; R16 is hydrogen, substituted or unsubstituted alkyl or the like; R7 is substituted or unsubstituted 5- or 6-membered heteroaryl, substituted or unsubstituted 6 to 10 membered aryl; Q1 and Q2 are each independently a carbon atom or a nitrogen atom; -L- is —O—, —S— or the like; R6 is substituted or unsubstituted cycloalkyl, substituted or unsubstituted cycloalkenyl or the like; R2 is hydrogen, hydroxy or the like, or its pharmaceutically acceptable salt or a solvate thereof.
摘要翻译：本发明提供具有P2X3和/或P2X2 / 3受体拮抗作用的新化合物。一种具有P2X3和/或P2X2 / 3受体拮抗作用的药物组合物，其包含式（I）化合物：其中环A是取代或未取代的5至7元环烷烃，取代或未取代的5至7元环烯烃或喜欢; C是碳原子; -X-是-N（R 16） - 等; R 16是氢，取代或未取代的烷基等; R 7是取代或未取代的5元或6元杂芳基，取代或未取代的6至10元芳基; Q1和Q2各自独立地为碳原子或氮原子; -L-是-O-，-S-等; R6是取代或未取代的环烷基，取代或未取代的环烯基等; R2是氢，羟基等，或其药学上可接受的盐或其溶剂合物。

7. 发明授权

US07525318B2 Load abnormality detecting system and method 失效
标题翻译：负载异常检测系统及方法
公开(公告)号：US07525318B2
公开(公告)日：2009-04-28
申请号：US11714448
申请日：2007-03-06
申请人： Takeshi Endoh
发明人： Takeshi Endoh
IPC分类号： G01R31/08
CPC分类号： G01R31/025
摘要： A load abnormality detecting system and method for detecting the burnout and short circuit of a load are provided. A voltage generator (10) generates a specified voltage Vs in accordance with a load current IL. A judging device (4) compares a signal corresponding to this voltage (Vs) with a specified reference value (T1, T2) to judge whether a load (2) has any abnormality. A selector (6) causes the burnout reference value (T1) to be inputted to the judging device (4) and controls the voltage generator (10) to use a first resistance value when checking the burnout of the load (2) while causing the short-circuit reference value (T2) to be inputted to the judging device (4) and controlling the voltage generator (10) to use a second resistance value when checking the short circuit of the load (2).
摘要翻译：提供一种用于检测负载的烧坏和短路的负载异常检测系统和方法。电压发生器（10）根据负载电流IL产生规定的电压Vs。判断装置（4）将与该电压（Vs）对应的信号与规定的基准值（T1，T2）进行比较，判断负载（2）是否有异常。选择器（6）使得将烧坏参考值（T1）输入到判断装置（4），并且当检查负载（2）的烧坏同时使电压发生器（10）使用第一电阻值，同时使输入到判断装置（4）的短路基准值（T2），并且在检查负载（2）的短路时，控制电压发生器（10）使用第二电阻值。

8. 发明授权

US5548096A Method and apparatus for assembling motor vehicle body 失效
标题翻译：机动车身组装方法及装置
公开(公告)号：US5548096A
公开(公告)日：1996-08-20
申请号：US327490
申请日：1994-10-21
申请人： Yoshio Akasaka , Kenichi Kakijima , Takeshi Endoh , Goro Uchida , Masaaki Tanaka , Takefumi Fujie , Daiji Sukawa , Satoshi Endoh , Hideo Saitoh , Takashi Kubo
发明人： Yoshio Akasaka , Kenichi Kakijima , Takeshi Endoh , Goro Uchida , Masaaki Tanaka , Takefumi Fujie , Daiji Sukawa , Satoshi Endoh , Hideo Saitoh , Takashi Kubo
IPC分类号： B23K11/31 , B23K37/04 , B23K11/11 , B23K11/24 , B23K37/00
CPC分类号： B23K37/0443 , B23K11/315
摘要： A method for assembling a motor vehicle body by fixing relative positional relationship among a plurality of motor vehicle body constituent parts by means of positioning members provided in a welding jig which is disposed on each side of an assembly station and, in this condition, welding together the plurality of motor vehicle body constituent parts at a plurality of tack-welding locations. First welding guns of indirect feeding type are mounted on the welding jig to weld a part of the tack-welding portions. A welding robot having mounted thereon a second welding gun is disposed outside the welding jig. The above-described part of the tack-welding portions are welded by supplying electric power from the second welding gun to the first welding guns by pinching, by the second welding gun, feeder terminals of the first welding guns in a condition in which the above-described part of the tack-welding portions are being pinched by the first welding guns. The remaining of the tack-welding portions are thereafter welded by the second welding gun.
摘要翻译：通过借助于设置在组装工位的每一侧的焊接夹具中的定位构件固定多个机动车车身构成部件之间的相对位置关系，并且在这种状态下焊接在一起的方式来组装机动车体的方法所述多个机动车体构成部件在多个定位焊接位置。第一个间接进给型焊枪安装在焊接夹具上以焊接部分焊接部分。安装有第二焊枪的焊接机器人设置在焊接夹具的外部。上述部分焊接部分通过从第二焊枪向第一焊枪提供电力，通过第二焊枪将上述第一焊枪的馈线端子夹在上述状态下进行焊接定位焊接部分的描述部分被第一焊枪夹住。其后的焊接部分由第二焊枪焊接。

9. 发明申请

US20200033068A1 WICK, LOOP HEAT PIPE, COOLING DEVICE, ELECTRONIC DEVICE, METHOD OF MANUFACTURING POROUS BODY, AND METHOD OF MANUFACTURING WICK 审中-公开
公开(公告)号：US20200033068A1
公开(公告)日：2020-01-30
申请号：US16521019
申请日：2019-07-24
申请人： Takeshi Endoh , Takashi Tanaka , Akihiko Moki , Atsuo Hirai
发明人： Takeshi Endoh , Takashi Tanaka , Akihiko Moki , Atsuo Hirai
IPC分类号： F28D15/04 , H05K7/20
摘要： A wick includes a porous body. The porous body includes a plurality of bubbles, a plurality of composite cells, and a plurality of communication holes. The plurality of bubbles has sizes in a range from 0.1 μm to 50 μm, both inclusive, in a cross section obtained when the porous body is cut. The plurality of composite cells is formed by spherical bubbles partially overlapping each other. Bubbles of pore sizes from 5 μm to 10 μm, both inclusive, are most present among the plurality of composite cells. The plurality of communication holes of 5 μm or smaller is between the plurality of bubbles.

10. 发明申请

US20190390918A1 LOOP HEAT PIPE, COOLING DEVICE, AND ELECTRONIC DEVICE 审中-公开
公开(公告)号：US20190390918A1
公开(公告)日：2019-12-26
申请号：US16444212
申请日：2019-06-18
申请人： Tomoyasu Hirasawa , Kiyotada Katoh , Takeshi Endoh , Takashi Tanaka , Toshihiko Baba , Keisuke Ikeda , Hiroki Yamasaki
发明人： Tomoyasu Hirasawa , Kiyotada Katoh , Takeshi Endoh , Takashi Tanaka , Toshihiko Baba , Keisuke Ikeda , Hiroki Yamasaki
IPC分类号： F28D15/02 , H05K7/20
摘要： A disclosed loop heat pipe includes an evaporator configured to absorb heat from outside by a wall to evaporate a working fluid from a liquid phase gas phase; a condenser configured to condense a gas phase working fluid introduced from the evaporator into a liquid phase; an elastic wick configured to contact an inner wall of the evaporator by an elastic force from the elastic wick; and a wick deformation member configured to deform the elastic wick increase a contact pressure of the elastic wick against the inner wall of the evaporator.

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