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1. 发明申请

US20130172317A1 TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION HAVING AN ANALGESIC ACTIVITY COMPRISING THE SAME 有权
标题翻译：具有包括其同源活性的TRIAZINE衍生物和药物组合物
公开(公告)号：US20130172317A1
公开(公告)日：2013-07-04
申请号：US13814346
申请日：2011-08-09
申请人： Hiroyuki Kai , Takayuki Kameyama , Tohru Horiguchi , Kentaro Asahi , Takeshi Endoh , Yasuhiko Fujii , Takuya Shintani , Ken'ichiroh Nakamura , Sae Jikihara , Tsuyoshi Hasegawa , Miho Oohara , Yukio Tada , Toshikatsu Maki , Akira Iida
发明人： Hiroyuki Kai , Takayuki Kameyama , Tohru Horiguchi , Kentaro Asahi , Takeshi Endoh , Yasuhiko Fujii , Takuya Shintani , Ken'ichiroh Nakamura , Sae Jikihara , Tsuyoshi Hasegawa , Miho Oohara , Yukio Tada , Toshikatsu Maki , Akira Iida
IPC分类号： C07D251/46 , C07D417/12 , C07D413/12 , C07D405/06 , C07D401/14 , C07D251/52 , C07D405/14 , C07D401/12 , C07D403/12 , C07D403/04 , C07D413/14
CPC分类号： C07D251/46 , C07D251/52 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/12 , C07D417/14
摘要： The present invention provides novel compounds having a P2X3 and/or P2X2/3 receptor antagonistic effect.A pharmaceutical composition having an analgesic effect or an improving effect of urination disorder comprising a compound of the formula (I): wherein Rh and Rj are taken together to form a bond; Ra and Rb and/or Rd and Re are taken together to form oxo or the like; Rc is hydrogen, substituted or unsubstituted alkyl or the like; Rf is —(CR4aR4b)n—R2; R4a and R4b are hydrogen, substituted or unsubstituted alkyl or the like; R2 is substituted or unsubstituted cycloalkyl or the like; n is an integer of 1 to 4; —Rg is —X—R3; —X— is —O—, —S— or the like; R3 is substituted or unsubstituted cycloalkyl or the like, or its pharmaceutically acceptable salt or a solvate thereof.
摘要翻译：本发明提供具有P2X3和/或P2X2 / 3受体拮抗作用的新化合物。一种具有止痛作用或排尿障碍改善作用的药物组合物，其包含式（I）化合物：其中Rh和Rj一起形成键; Ra和Rb和/或Rd和Re一起形成氧代等; Rc是氢，取代或未取代的烷基等; Rf是 - （CR4aR4b）n-R2; R4a和R4b是氢，取代或未取代的烷基等; R2是取代或未取代的环烷基等; n为1〜4的整数， -Rg为-X-R3; -X-是-O-，-S-等; R3是取代或未取代的环烷基等，或其药学上可接受的盐或溶剂合物。

2. 发明申请

US20110319414A1 NOVEL TRIAZINE DERIVATIVE AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME 有权
标题翻译：新型TRIAZINE衍生物和药物组合物
公开(公告)号：US20110319414A1
公开(公告)日：2011-12-29
申请号：US13201209
申请日：2010-02-10
申请人： Hiroyuki Kai , Takayuki Kameyama , Tsuyoshi Hasegawa , MIho Oohara , Yukio Tada , Takeshi Endoh
发明人： Hiroyuki Kai , Takayuki Kameyama , Tsuyoshi Hasegawa , MIho Oohara , Yukio Tada , Takeshi Endoh
IPC分类号： A61K31/53 , C07D251/46 , C07D403/06 , A61P7/00 , C07D413/12 , A61K31/5377 , A61P29/00 , A61P25/00 , C07D251/38 , C07D251/52
CPC分类号： C07D251/46 , C07D251/16 , C07D251/44 , C07D251/52 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/12
摘要： The present invention provides a novel P2X3 and/or P2X2/3 receptor antagonist.A compound represented by the formula (I); wherein Ra, Rb and Rc are, (a) Ra and Rb are taken together ═Z; and Rc is a group represented by R1c; or (b) Rb and Rc are taken together to form a bond; and Ra is a group represented by —Y—R1a; R1a and R1c are each independently hydrogen, substituted or unsubstituted alkyl, etc.; R2 and R3 are each independently substituted or unsubstituted aryl, etc.; R4a and R4b are each independently hydrogen, substituted or unsubstituted alkyl, etc.; X is —N(R5)—, etc.; R5 is hydrogen, substituted or unsubstituted lower alkyl, etc.; —Y— is —O—, etc.; ═Z is ═O, etc.; and n is an integer of 0 to 4.
摘要翻译：本发明提供了一种新型的P2X3和/或P2X2 / 3受体拮抗剂。由式（I）表示的化合物; 其中Ra，Rb和Rc为（a）Ra和Rb一起为= Z; Rc为由R1c表示的基团; 或（b）Rb和Rc一起形成键; 并且R a是由-Y-R 1a表示的基团; R1a和R1c各自独立地为氢，取代或未取代的烷基等; R2和R3各自独立地是取代或未取代的芳基等; R4a和R4b各自独立地为氢，取代或未取代的烷基等; X是-N（R 5） - 等; R5是氢，取代或未取代的低级烷基等; -Y-是-O-等; ═Z是═O等; n为0〜4的整数。

3. 发明授权

US09150546B2 Triazine derivative and pharmaceutical composition comprising the same 有权
标题翻译：三嗪衍生物及其组合物
公开(公告)号：US09150546B2
公开(公告)日：2015-10-06
申请号：US13201209
申请日：2010-02-10
申请人： Hiroyuki Kai , Takayuki Kameyama , Tsuyoshi Hasegawa , Miho Oohara , Yukio Tada , Takeshi Endoh
发明人： Hiroyuki Kai , Takayuki Kameyama , Tsuyoshi Hasegawa , Miho Oohara , Yukio Tada , Takeshi Endoh
IPC分类号： A61K31/535 , A61K31/53 , C07D403/06 , C07D251/46 , C07D251/52 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/12
CPC分类号： C07D251/46 , C07D251/16 , C07D251/44 , C07D251/52 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D409/06 , C07D413/12
摘要： The present invention provides a novel P2X3 and/or P2X2/3 receptor antagonist.A compound represented by the formula (I): wherein Ra, Rb and Rc are, (a) Ra and Rb are taken together ═Z; and Rc is a group represented by R1c; or (b) Rb and Rc are taken together to form a bond; and Ra is a group represented by —Y—R1a; R1a and R1c are each independently hydrogen, substituted or unsubstituted alkyl, etc.; R2 and R3 are each independently substituted or unsubstituted aryl, etc.; R4a and R4b are each independently hydrogen, substituted or unsubstituted alkyl, etc.; X is —N(R5)—, etc.; R5 is hydrogen, substituted or unsubstituted lower alkyl, etc.; —Y— is —O—, etc.; ═Z is ═O, etc.; and n is an integer of 0 to 4.
摘要翻译：本发明提供了一种新型的P2X3和/或P2X2 / 3受体拮抗剂。由式（I）表示的化合物：其中Ra，Rb和Rc为（a）Ra和Rb一起为= Z; Rc为由R1c表示的基团; 或（b）Rb和Rc一起形成键; 并且R a是由-Y-R 1a表示的基团; R1a和R1c各自独立地为氢，取代或未取代的烷基等; R2和R3各自独立地是取代或未取代的芳基等; R4a和R4b各自独立地为氢，取代或未取代的烷基等; X是-N（R 5） - 等; R5是氢，取代或未取代的低级烷基等; -Y-是-O-等; ═Z是═O等; n为0〜4的整数。

4. 发明授权

US08630405B2 Echo removing apparatus 有权
标题翻译：回波消除装置
公开(公告)号：US08630405B2
公开(公告)日：2014-01-14
申请号：US12677200
申请日：2008-09-24
申请人： Yukio Tada
发明人： Yukio Tada
IPC分类号： H04M1/00 , H04M9/00 , H04M9/08
CPC分类号： H04M9/082 , H01L2924/14 , H01L2924/00
摘要： An echo removing apparatus that can remove an echo appropriately if the produced sound volume becomes large although the configuration is simple is provided. A control section 17 switches the operations of an echo suppressor 14 and an echo canceller 15 in response to the volume value input from a volume operation section 18. If the volume value is large, the echo suppressor 14 is operated and an echo is suppressed reliably. If the volume value is small, the echo canceller 15 is operated and double talk is enabled.
摘要翻译：如果产生的音量变大，则尽管配置简单，但是可以适当地去除回声的回波消除装置。控制部分17响应于从音量操作部分18输入的音量值来切换回波抑制器14和回波消除器15的操作。如果音量值大，则回波抑制器14被操作并且可靠地抑制回波。如果音量值较小，则回波消除器15被操作，并且启用双方通话。

5. 发明申请

US20060052411A1 Pyridone derivatives having a binding activity to the cannabinoid type 2 receptor 失效
标题翻译：对大麻素2型受体具有结合活性的吡啶酮衍生物
公开(公告)号：US20060052411A1
公开(公告)日：2006-03-09
申请号：US11168640
申请日：2005-06-29
申请人： Yukio Tada , Yasuyoshi Iso , Kohji Hanasaki
发明人： Yukio Tada , Yasuyoshi Iso , Kohji Hanasaki
IPC分类号： A61K31/4745 , A61K31/4741 , A61K31/4415 , C07D491/02 , C07D487/02
CPC分类号： C07D213/69 , C07D213/70 , C07D213/75 , C07D213/82 , C07D215/227 , C07D215/38 , C07D215/54 , C07D217/22 , C07D217/26 , C07D221/10 , C07D221/16 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D455/02 , C07D455/06 , C07D471/04 , C07D491/04
摘要： It was found that the compound having a binding activity to the cannabinoid type 2 receptor represented by the formula (I): wherein R1 is a group represented by the formula: —Y1—Y2—Y3—Ra wherein Y1 is single bond or the like; Y2 is —C(═O)—NH— or the like; Y3 is optionally substituted aryl or the like; R2 is hydrogen or the like; R3 is alkyl or the like; R4 is alkyl or the like; R5 is optionally substituted alkyl or the like; or R3 and R4 taken together with the adjacent atom form cyclic group or the like.
摘要翻译：发现对由式（I）表示的大麻素2型受体具有结合活性的化合物：

6. 发明申请

US20050120865A1 Music session support method, musical instrument for music session, and music session support program 有权
标题翻译：音乐会议支持方式，音乐会乐器和音乐会议支持节目
公开(公告)号：US20050120865A1
公开(公告)日：2005-06-09
申请号：US11002427
申请日：2004-12-02
申请人： Yukio Tada
发明人： Yukio Tada
IPC分类号： G06F15/00 , G10H1/00 , A63F9/24 , A63F13/00 , G06F17/00 , G06F19/00
CPC分类号： G10H1/0058
摘要： A music session support method which enables each of players in a music session which is performed via a network to immediately recognize whether or not the other players are in the state of being able to participate in the session. A session support apparatus 10 transmits sets of status information indicative of whether or not each of players is in a state of being able to participate in a session, and player identification information which identifies the players, to each of session terminals 20. Each of the session terminals 20 which have received the sets of status information and player identification information causes a touch display 24 thereof to display the status information for each of the players. The session support apparatus 10 acquires a set of status transition information indicating that a player of at least one of the session terminals 20 in which the detecting device has detected the performance preparatory operation has gone into the state of being able to participate in a session, and player identification information for a session terminal 20, from the session terminal 20. The session support apparatus 10 transmits the acquired set of status transition information and player identification information to the session terminals 20. Each of the session terminals 20 updates contents displayed on the touch display 24 thereof, based upon the status transition information and player identification information transmitted from the session support apparatus 10.
摘要翻译：一种音乐会话支持方法，其使得经由网络执行的音乐会话中的每个玩家能够立即识别其他玩家是否处于能够参与该会话的状态。会话支持装置10发送指示每个玩家是否处于能够参加会话的状态的状态信息集合以及识别玩家的玩家识别信息给每个会话终端20.每个已经接收到状态信息和玩家识别信息的会话终端20使其触摸显示器24显示每个玩家的状态信息。会话支持装置10获取指示检测装置已经检测到演奏预备操作的会话终端20中的至少一个已经进入能够参加会话的状态的一组状态转换信息，以及来自会话终端20的会话终端20的播放器识别信息。会话支持装置10将获取的一组状态转换信息和玩家识别信息发送到会话终端20.每个会话终端20更新显示在基于从会话支持装置10发送的状态转移信息和玩家识别信息，触摸显示器24。

7. 发明授权

US4946951A 2'-deoxy-5-fluorouridine derivatives 失效
标题翻译： 2'-脱氧-5-氟尿苷衍生物
公开(公告)号：US4946951A
公开(公告)日：1990-08-07
申请号：US225984
申请日：1988-07-29
申请人： Yukio Tada , Atsuhiko Uemura , Mitsugi Yasumoto , Setsuo Takeda , Hitoshi Saito , Norio Unemi
发明人： Yukio Tada , Atsuhiko Uemura , Mitsugi Yasumoto , Setsuo Takeda , Hitoshi Saito , Norio Unemi
IPC分类号： B09B3/00 , A61K31/70 , B02C18/00 , C07H19/06 , C07H19/073
CPC分类号： C07H19/06
摘要： Disclosed is a 2'-deoxy-5-fluorouridine derivative of the formula ##STR1## wherein one of R.sub.1 and R.sub.2 is a benzyl group which may optionally have substituent selected from the group consisting of C.sub.1 -C.sub.6 alkyl group, C.sub.1 -C.sub.6 alkoxy group, C.sub.1 -C.sub.3 halogenated alkyl group, halogen atom, hydroxyl group and nitro group on the phenyl ring, and the other constitutes an amino acid residue, or a salt thereof. The compounds are useful for treating cancer.
摘要翻译：公开了式（CHEM）2分钟的脱氧-5-氟尿苷衍生物，其中R 1和R 2之一是可以任选具有选自C 1 -C 6烷基，C 1 -C 6烷氧基的取代基的苄基苯基环上的C1-C3卤代烷基，卤原子，羟基和硝基，另一个构成氨基酸残基或其盐。该化合物可用于治疗癌症。

8. 发明授权

US4570587A Internal combustion engine 失效
标题翻译：内燃机
公开(公告)号：US4570587A
公开(公告)日：1986-02-18
申请号：US594162
申请日：1984-03-28
申请人： Yoshimi Watanabe , Yukio Tada , Takanori Suzuki , Hitoshi Suzuki
发明人： Yoshimi Watanabe , Yukio Tada , Takanori Suzuki , Hitoshi Suzuki
IPC分类号： F02B61/00 , F02B63/02 , F02B75/00 , F02B75/02 , F02B75/16 , F02F7/00 , F01B31/00
CPC分类号： F02B75/007 , F02B61/00 , F02B63/02 , F02B75/16 , F02F7/00 , F02B2075/027 , F02B2275/34 , Y10S123/06
摘要： An internal combustion engine includes a crank shaft having a crank web, a crank pin on one end of the crank web, and a weight on an opposite end of the crank web, a crank case supporting the crank shaft therein, a cylinder, a piston reciprocally fitted in the cylinder, a rod coupled to the piston by a piston pin and connecting the piston to the crank pin for reciprocally moving the piston in the cylinder, the crank case having an opening and extending obliquely to axes of the crank shaft and the cylinder. The cylinder has an end corresponding to a bottom dead center of the piston and having a first recess opening toward the opening, the first recess being of a size allowing the piston pin to pass therethrough when the piston is in the bottom dead center. The weight on the crank web has on one side a second recess of a shape defining with the end of the cylinder a space allowing the piston as disconnected from the rod to pass therethrough.
摘要翻译：一种内燃机，其特征在于，具备曲柄轴，曲柄腹板一端的曲柄销，曲柄腹板的另一端的曲柄轴，支承曲轴的曲轴箱，缸体，活塞往复安装在气缸中，杆通过活塞销连接到活塞，并将活塞连接到曲柄销，以使活塞在气缸中往复运动，曲轴箱具有开口并且倾斜地延伸到曲轴的轴线和圆筒。气缸具有对应于活塞的下死点的端部，并且具有朝向开口的第一凹部开口，当活塞处于下止点时，第一凹部具有允许活塞销穿过的尺寸。曲柄腹板上的重量在一侧具有形状为圆柱体端部的形状的第二凹槽，允许活塞与杆分离的空间通过。

9. 发明授权

US08168630B2 Aminodihydrothiazine derivatives substituted with a cyclic group 有权
标题翻译：用环状基团取代的氨基二氢噻嗪衍生物
公开(公告)号：US08168630B2
公开(公告)日：2012-05-01
申请号：US12596796
申请日：2008-04-23
申请人： Yuusuke Tamura , Shinji Suzuki , Yukio Tada , Shuji Yonezawa , Chiaki Fujikoshi , Sae Matsumoto , Yuuji Kooriyama , Tatsuhiko Ueno
发明人： Yuusuke Tamura , Shinji Suzuki , Yukio Tada , Shuji Yonezawa , Chiaki Fujikoshi , Sae Matsumoto , Yuuji Kooriyama , Tatsuhiko Ueno
IPC分类号： C07D417/12 , C07D417/14 , A61K31/497 , A61K31/54
CPC分类号： C07C215/20 , A61K9/0019 , A61K9/1623 , A61K9/2018 , C07D279/06 , C07D417/12 , C07D417/14 , C07D471/04 , C07D487/04 , C07D493/04 , C07D495/04 , C07D513/04
摘要： This invention provides a compound of the formula (I): wherein the ring A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group; R1 is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl; R2a and R2b are each independently hydrogen, optionally substituted lower alkyl or optionally substituted acyl; R3a, R3b, R3c and R3d are each independently hydrogen, halogen, hydroxy or optionally substituted lower alkyl etc.; a pharmaceutically acceptable salt or solvate thereof, which is useful for treating diseases induced by production, secretion and/or deposition of amyloid β protein.
摘要翻译：本发明提供式（I）的化合物：其中环A为任选取代的碳环基或任选取代的杂环基; R1是任选取代的低级烷基，任选取代的低级烯基，任选取代的低级炔基; R2a和R2b各自独立地为氢，任选取代的低级烷基或任选取代的酰基; R3a，R3b，R3c和R3d各自独立地为氢，卤素，羟基或任选取代的低级烷基等; 其药学上可接受的盐或溶剂合物，其可用于治疗由淀粉样蛋白的生产，分泌和/或沉积诱导的疾病; 蛋白。

10. 发明授权

US08088924B2 Pyridone derivatives having a binding activity to the cannabinoid type 2 receptor 有权
标题翻译：对大麻素2型受体具有结合活性的吡啶酮衍生物
公开(公告)号：US08088924B2
公开(公告)日：2012-01-03
申请号：US12585057
申请日：2009-09-02
申请人： Yukio Tada , Yasuyoshi Iso , Kohji Hanasaki
发明人： Yukio Tada , Yasuyoshi Iso , Kohji Hanasaki
IPC分类号： C07D215/38
CPC分类号： C07D213/69 , C07D213/70 , C07D213/75 , C07D213/82 , C07D215/227 , C07D215/38 , C07D215/54 , C07D217/22 , C07D217/26 , C07D221/10 , C07D221/16 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D403/12 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D455/02 , C07D455/06 , C07D471/04 , C07D491/04
摘要： It was found that the compound having a binding activity to the cannabinoid type 2 receptor represented by the formula (I): wherein R1 is a group represented by the formula: —Y1—Y2—Y3—Ra wherein Y1 is single bond or the like; Y2 is —C(═O)—NH— or the like; Y3 is optionally substituted aryl or the like; R2 is hydrogen or the like; R3 is alkyl or the like; R4 is alkyl or the like; R5 is optionally substituted alkyl or the like; or R3 and R4 taken together with the adjacent atom form cyclic group or the like.
摘要翻译：发现对由式（I）表示的大麻素2型受体具有结合活性的化合物：其中R1是下式表示的基团-Y1-Y2-Y3-Ra，其中Y1是单键等 ; Y2是-C（= O）-NH-等; Y 3是任选取代的芳基等; R2是氢等; R3是烷基等; R4是烷基等; R5是任选取代的烷基等; 或R 3和R 4与相邻原子一起形成环状基团等。

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