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    • 10. 发明授权
    • Dirofilaria and brugia thioredoxin peroxidase type-2 proteins and uses thereof
    • Dirofilaria和brugia硫氧还蛋白过氧化物酶2型蛋白及其用途
    • US06352836B1
    • 2002-03-05
    • US09633043
    • 2000-08-04
    • Ramaswamy ChandrashekarNaotoshi Tsuji
    • Ramaswamy ChandrashekarNaotoshi Tsuji
    • C12Q128
    • C12N9/0065A61K38/00C07K16/40Y02A50/421
    • The present invention relates to: Dirofilaria and Brugia thioredoxin peroxidase type-2 (TPx-2) proteins; Dirofilaria and Brugia TPx-2 nucleic acid molecules, including those that encode such TPx-2 proteins; antibodies raised against such TPx-2 proteins; and compounds that inhibit Dirofilaria and Brugia TPx-2 activity. The present invention also includes methods to obtain such proteins, nucleic acid molecules, antibodies, and inhibitory compounds. Also included in the present invention are therapeutic compositions comprising such proteins, nucleic acid molecules, antibodies and/or inhibitory compounds as well as the use of such therapeutic compositions to protect animals from diseases caused by parasitic helminths.
    • 本发明涉及:Dirofilaria和Brugia硫氧还蛋白过氧化物酶-2型(TPx-2)蛋白; Dirofilaria和Brugia TPx-2核酸分子,包括编码这种TPx-2蛋白的核酸分子; 针对这种TPx-2蛋白产生的抗体; 以及抑制Dirofilaria和Brugia TPx-2活性的化合物。 本发明还包括获得这些蛋白质,核酸分子,抗体和抑制性化合物的方法。 本发明还包括包含这些蛋白质,核酸分子,抗体和/或抑制化合物的治疗组合物,以及使用这些治疗组合物来保护动物免受寄生蠕虫引起的疾病。