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1. 发明申请

WO2004017908A3 CALCIUM RECEPTOR MODULATING COMPOUND AND USE THEREOF 审中-公开
公开(公告)号：WO2004017908A3
公开(公告)日：2004-03-04
申请号：PCT/US2003/026317
申请日：2003-08-21
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , YASUMA, Tsuneo , MORI, Akira , KAWASE, Masahiro , KIMURA, Hiroyuki , YOSHIDA, Masato , GYORKOS, Albert, Charles , PRATT, Scott, Alan , CORRETTE, Christopher, Peter
发明人： YASUMA, Tsuneo , MORI, Akira , KAWASE, Masahiro , KIMURA, Hiroyuki , YOSHIDA, Masato , GYORKOS, Albert, Charles , PRATT, Scott, Alan , CORRETTE, Christopher, Peter
IPC分类号： C07D221/04
摘要： There is provided a calcium receptor modulator comprising a compound of the formula (I): wherein ring A is an optionally substituted 5- to 7- membered ring; ring B is an optionally substituted 5- to 7- membered heterocyclic ring; X 1 is CR 1 , CR 1 R 2 , N or NR 13 ; X 2 is N or NR 3 ; Y is C, CR 4 or N, Z is CR 5 , CR 5 R 6 , N or NR 7 ; Ar is an optionally substituted cyclic group; R is H, an optionally substituted hydrocarbon group, etc.; and --- is a single bond or a double bond; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 13 are independently H, an optionally substituted hydrocarbon group; or a salt thereof or a prodrug thereof. Compounds of the formula (II) and (III): wherein ring A is an optionally substituted 5- to 7- membered ring; Q is C, CR 5 or N; R 8 , R 9 ,R 10 , R 11 and R 12 are independently, H, an optionally substituted hydrocarbon group, etc., or a salt thereof are also provided. Also specify X 1 , R 3 , R 1 , Y and X 3 in formula (II) and (III) as before.

2. 发明授权

EP1572113B1 CALCIUM RECEPTOR MODULATING COMPOUND AND USE THEREOF 有权转让
标题翻译：钙受体调节化合物及其用途
公开(公告)号：EP1572113B1
公开(公告)日：2017-05-17
申请号：EP03793273.8
申请日：2003-08-21
申请人： Takeda Pharmaceutical Company Limited
发明人： YASUMA, Tsuneo , MORI, Akira , KAWASE, Masahiro , KIMURA, Hiroyuki , YOSHIDA, Masato , GYORKOS, Albert, Charles , PRATT, Scott, Alan , CORRETTE, Christopher, Peter
IPC分类号： C07D487/04 , C07D221/04 , C07D471/04 , A61K31/519 , A61K31/473 , A61K31/551 , A61K31/53 , A61P19/10
CPC分类号： C07D487/04

3. 发明公开

EP1572113A2 CALCIUM RECEPTOR MODULATING COMPOUND AND USE THEREOF 有权转让
标题翻译： CALRIUM-REZEPTOR-MODULIERENDE VERBINDUNG UND IHRE VERWENDUNG
公开(公告)号：EP1572113A2
公开(公告)日：2005-09-14
申请号：EP03793273.8
申请日：2003-08-21
申请人： Takeda Pharmaceutical Company Limited
发明人： YASUMA, Tsuneo , MORI, Akira , KAWASE, Masahiro , KIMURA, Hiroyuki , YOSHIDA, Masato , GYORKOS, Albert, Charles , PRATT, Scott, Alan , CORRETTE, Christopher, Peter
IPC分类号： A61K6/00
CPC分类号： C07D487/04
摘要： There is provided a calcium receptor modulator comprising a compound of the formula (I): wherein ring A is an optionally substituted 5- to 7- membered ring; ring B is an optionally substituted 5- to 7- membered heterocyclic ring; X1 is CR1, CR1R2, N or NR13; X2 is N or NR3; Y is C, CR4 or N, Z is CR5, CR5R6, N or NR7; Ar is an optionally substituted cyclic group; R is H, an optionally substituted hydrocarbon group, etc.; and --- is a single bond or a double bond; R1, R2, R3, R4, R5, R6, R7 and R13 are independently H, an optionally substituted hydrocarbon group; or a salt thereof or a prodrug thereof. Compounds of the formula (II) and (III): wherein ring A is an optionally substituted 5- to 7- membered ring; Q is C, CR5 or N; R8, R9,R10, R11 and R12 are independently, H, an optionally substituted hydrocarbon group, etc., or a salt thereof are also provided. Also specify X1, R3, R1, Y and X3 in formula (II) and (III) as before.
摘要翻译：提供了包含式（I）化合物的钙受体调节剂：其中环A是任选取代的5-至7-元环; 环B是任选取代的5-至7-元杂环; X1是CR1，CR1R2，N或NR13; X2为N或NR3; Y为C，CR4或N，Z为CR5，CR5R6，N或NR7; Ar是任选取代的环状基团; R为H，任选取代的烃基等; ＆lt; img id =“CUSTOM-CHARACTER-00001”he =“3.13mm”wi =“8.47mm”file =“US20090215746A1-20090827-P00001.TIF”img-content =“character”img-format =“tif”/ >是单键或双键; R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 13独立地为H，任选取代的烃基; 或其盐或其前药。式（II）和（III）的化合物：其中环A是任选取代的5-至7-元环; Q为C，CR5或N; R8，R9，R10，R11和R12独立地为H，任意取代的烃基等，或其盐。也如前所述，在式（II）和（III）中指定X1，R3，R1，Y和X3。

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