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1. 发明申请

WO2005044793A2 NITROGEN-CONTAINING FUSED HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：含氮混合的杂环化合物
公开(公告)号：WO2005044793A2
公开(公告)日：2005-05-19
申请号：PCT/US2004/035648
申请日：2004-10-27
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , GYORKOS, Albert, Charles , CORRETTE, Christopher, Peter , CHO, Suk, Young , TURNER, Timothy, Mark , PRATT, Scott, Alan , ASO, Kazuyoshi , KORI, Masakuni , GYOTEN, Michiyo
发明人： GYORKOS, Albert, Charles , CORRETTE, Christopher, Peter , CHO, Suk, Young , TURNER, Timothy, Mark , PRATT, Scott, Alan , ASO, Kazuyoshi , KORI, Masakuni , GYOTEN, Michiyo
IPC分类号： C07D
CPC分类号： C07D235/30 , C07D471/04
摘要： There is provided a CRF receptor antagonist comprising a compound of the formula (I): wherein, ring A is a 5-membered ring represented by the formula (A'): wherein X is a carbon and X 1 is an oxygen, a sulfur or - NR 5 -, or formula (A"): wherein X is a nitrogen and R 6 is an optionally substituted hydrocarbyl, R 1 is an amino substituted by two optionally substituted hydrocarbyl groups, R 2 is an phenyl, Y 1 is CR 3a or a nitrogen, Y 2 is CR 3b or a nitrogen and Y 3 is CR 3C or a nitrogen, provided that one or less of Y 1 , Y 2 , and Y 3 is nitrogen, W is a bond, -(CH 2 )n-, and Z is a bond, -NR 4 -, etc.; or a salt thereof or a prodrug thereof.
摘要翻译：提供了包含式（I）化合物的CRF受体拮抗剂：其中环A是由式（A'）表示的5元环：其中X是碳，X 1是氧，硫或-NR 5 - ，>或式（A“）：其中X是氮，R 6是任选取代的烃基，R 1是被两个任选取代的烃基取代的氨基， R 2是苯基，Y 1是CR 3a或氮，Y 2是CR 3b或氮和Y 3是CR 3或氮，条件是一个或更少的Y 1，Y 2和Y 3是氮，W是键， - （CH 2）n - ，Z是键，-NR 4 - ， - 等。 ;或其盐或其前药。

2. 发明申请

WO2004017908A3 CALCIUM RECEPTOR MODULATING COMPOUND AND USE THEREOF 审中-公开
公开(公告)号：WO2004017908A3
公开(公告)日：2004-03-04
申请号：PCT/US2003/026317
申请日：2003-08-21
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , YASUMA, Tsuneo , MORI, Akira , KAWASE, Masahiro , KIMURA, Hiroyuki , YOSHIDA, Masato , GYORKOS, Albert, Charles , PRATT, Scott, Alan , CORRETTE, Christopher, Peter
发明人： YASUMA, Tsuneo , MORI, Akira , KAWASE, Masahiro , KIMURA, Hiroyuki , YOSHIDA, Masato , GYORKOS, Albert, Charles , PRATT, Scott, Alan , CORRETTE, Christopher, Peter
IPC分类号： C07D221/04
摘要： There is provided a calcium receptor modulator comprising a compound of the formula (I): wherein ring A is an optionally substituted 5- to 7- membered ring; ring B is an optionally substituted 5- to 7- membered heterocyclic ring; X 1 is CR 1 , CR 1 R 2 , N or NR 13 ; X 2 is N or NR 3 ; Y is C, CR 4 or N, Z is CR 5 , CR 5 R 6 , N or NR 7 ; Ar is an optionally substituted cyclic group; R is H, an optionally substituted hydrocarbon group, etc.; and --- is a single bond or a double bond; R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 and R 13 are independently H, an optionally substituted hydrocarbon group; or a salt thereof or a prodrug thereof. Compounds of the formula (II) and (III): wherein ring A is an optionally substituted 5- to 7- membered ring; Q is C, CR 5 or N; R 8 , R 9 ,R 10 , R 11 and R 12 are independently, H, an optionally substituted hydrocarbon group, etc., or a salt thereof are also provided. Also specify X 1 , R 3 , R 1 , Y and X 3 in formula (II) and (III) as before.

3. 发明申请

WO2008051533A2 BENZIMIDAZOLE COMPOUNDS 审中-公开
标题翻译：苯并咪唑化合物
公开(公告)号：WO2008051533A2
公开(公告)日：2008-05-02
申请号：PCT/US2007/022472
申请日：2007-10-24
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , ASO, Kazuyoshi , MOCHIZUKI, Michiyo , KOJIMA, Takuto , KOBAYASHI, Katsumi , PRATT, Scott, Alan , GYORKOS, Albert, Charles , CORRETTE, Christopher, Peter , CHO, Suk, Young
发明人： ASO, Kazuyoshi , MOCHIZUKI, Michiyo , KOJIMA, Takuto , KOBAYASHI, Katsumi , PRATT, Scott, Alan , GYORKOS, Albert, Charles , CORRETTE, Christopher, Peter , CHO, Suk, Young
IPC分类号： A61K31/4439
CPC分类号： C07D235/26 , C07D235/30 , C07D401/12 , C07D403/12
摘要： There is provided a compound of the formula (1) wherein R 1 is an optionally substituted C 1-10 alkyl; R 2 is H, or a C 1-6 alkyl which may be substituted with 1 to 3 substituents; R 3 is a 5- or 6-membered aromatic group which may be substituted with 1 to 5 substituents, wherein the 5- or 6-membered aromatic group may be fused with a 5- or 6- membered ring which may be substituted with 1 to 3 C 1-6 alkyls; R 4 is a hydrogen, a halogen, a hydroxy, a cyano, a C 1-6 alkyl or a C 1-6 alkoxy; Z is -O-, -S-, -SO-, -SO 2 -, or - NR 5 - wherein R 5 is a hydrogen or a C 1-6 alkyl; or a salt thereof or a prodrug thereof, which have CRF receptor antagonist activity and use thereof.
摘要翻译：本发明提供了式（1）的化合物，其中R 1是任选取代的C 1-10烷基; R 2是H或可以被1至3个取代基取代的C 1-6烷基; R 3是可以被1至5个取代基取代的5或6元芳族基团，其中5或6元芳族基团可以与5或6元环可以被1至3个C 1-6烷基取代的环; R 4是氢，卤素，羟基，氰基，C 1-6烷基或C 1-6烷氧基; Z是-O - ， - S - ， - SO - ， - SO 2 - 或-NR 5 - ，其中R 5是氢或C 1-6烷基; 或其盐或其前药，其具有CRF受体拮抗剂活性及其用途。

4. 发明申请

WO2005099688A2 CYCLIC COMPOUNDS 审中-公开
标题翻译：循环化合物
公开(公告)号：WO2005099688A2
公开(公告)日：2005-10-27
申请号：PCT/US2005/013583
申请日：2005-04-06
申请人： TAKEDA PHARMACEUTICAL COMPANY LIMITED , GYORKOS, Albert, Charles , CORRETTE, Christopher, Peter , CHO, Suk, Young , TURNER, Timothy, Mark , ASO, Kazuyoshi , KORI, Masakuni , GYOTEN, Michiyo , CONDROSKI, Kevin, Ronald , SIEDEM, Christopher, Stephen , BOYD, Steven, Armen
发明人： GYORKOS, Albert, Charles , CORRETTE, Christopher, Peter , CHO, Suk, Young , TURNER, Timothy, Mark , ASO, Kazuyoshi , KORI, Masakuni , GYOTEN, Michiyo , CONDROSKI, Kevin, Ronald , SIEDEM, Christopher, Stephen , BOYD, Steven, Armen
IPC分类号： A61K31/407
CPC分类号： C07D213/74 , C07C225/20 , C07C2602/08 , C07D215/233 , C07D215/56 , C07D231/56 , C07D237/28 , C07D239/46 , C07D239/47 , C07D239/56 , C07D239/94 , C07D239/95 , C07D239/96 , C07D265/36 , C07D455/02 , C07D471/04 , C07D487/04
摘要： There is provided a CRF receptor antagonist comprising a compound of the formula (I): A-W-Ar wherein, A is a group represented by the formula (A1) or (A2) (wherein, ring Aa is a 5-or 6-membered ring which may be further substituted; ring Ab is a 5-or 6-membered ring which may be further substituted; ring Ac is a 5- or 6-membered ring which may be substituted; R 1 is optionally substituted alkyl, substituted amino, substituted hydroxy, etc.; X is carbonyl, -O-, -S-, etc.; Y 1 , Y 2 and Q are independently optionally substituted carbon or nitrogen; … is a single or double bond); W is a bond, optionally substituted methylene, optionally substituted imino, -O-, -S-, etc.; Ar is optionally substituted aryl or optionally substituted heteroaryl; or a salt thereof or a prodrug thereof.
摘要翻译：提供了包含式（I）的化合物的CRF受体拮抗剂：AW-Ar，其中A是由式（A1）或（A2）表示的基团（其中，环Aa是5-或6-元环可以被进一步取代;环Ab是可以被进一步取代的5-或6-元环;环Ac是可被取代的5-或6-元环; R 1是任选取代的烷基，被取代的氨基，取代的羟基等; X是羰基，-O-，-S-等; Y 1，Y 2和Q独立地是任选取代的碳或氮; ...是单或双键）; W是一个键，任意取代的亚甲基，任选取代的亚氨基，-O - ， - S-等; Ar是任选取代的芳基或任选取代的杂芳基; 或其盐或其前药。

5. 发明公开

EP1677791A2 NITROGEN-CONTAINING FUSED HETEROCYCLIC COMPOUNDS 审中-公开
标题翻译：含氮缩合杂环化合物
公开(公告)号：EP1677791A2
公开(公告)日：2006-07-12
申请号：EP04810065.5
申请日：2004-10-27
申请人： Takeda Pharmaceutical Company Limited
发明人： GYORKOS, Albert, Charles , CORRETTE, Christopher, Peter , CHO, Suk, Young , TURNER, Timothy, Mark , PRATT, Scott, Alan , ASO, K. c/o Takeda Pharmaceutical Company Ltd. , KORI, M. c/o Takeda Pharmaceutical Company Ltd. , GYOTEN, M. c/o Takeda Pharmaceutical Company Ltd.
IPC分类号： A61K31/44 , A61K31/415 , C07D471/02 , C07D235/04
CPC分类号： C07D235/30 , C07D471/04
摘要： There is provided a CRF receptor antagonist comprising a compound of the formula (I): wherein, ring A is a 5-membered ring represented by the formula (A'): wherein X is a carbon and X1 is an oxygen, a sulfur or - NR 5-, or formula (A'): wherein X is a nitrogen and R6 is an optionally substituted hydrocarbyl, R1 is an amino substituted by two optionally substituted hydrocarbyl groups, R2 is an phenyl, Y1 is CR3a or a nitrogen, Y2 is CR3b or a nitrogen and Y3 is CR3C or a nitrogen, provided that one or less of Y1, Y2, and Y3 is nitrogen, W is a bond, -(CH2)n-, and Z is a bond, -NR 4-, etc.; or a salt thereof or a prodrug thereof.

6. 发明授权

EP1572113B1 CALCIUM RECEPTOR MODULATING COMPOUND AND USE THEREOF 有权转让
标题翻译：钙受体调节化合物及其用途
公开(公告)号：EP1572113B1
公开(公告)日：2017-05-17
申请号：EP03793273.8
申请日：2003-08-21
申请人： Takeda Pharmaceutical Company Limited
发明人： YASUMA, Tsuneo , MORI, Akira , KAWASE, Masahiro , KIMURA, Hiroyuki , YOSHIDA, Masato , GYORKOS, Albert, Charles , PRATT, Scott, Alan , CORRETTE, Christopher, Peter
IPC分类号： C07D487/04 , C07D221/04 , C07D471/04 , A61K31/519 , A61K31/473 , A61K31/551 , A61K31/53 , A61P19/10
CPC分类号： C07D487/04

7. 发明公开

EP1572113A2 CALCIUM RECEPTOR MODULATING COMPOUND AND USE THEREOF 有权转让
标题翻译： CALRIUM-REZEPTOR-MODULIERENDE VERBINDUNG UND IHRE VERWENDUNG
公开(公告)号：EP1572113A2
公开(公告)日：2005-09-14
申请号：EP03793273.8
申请日：2003-08-21
申请人： Takeda Pharmaceutical Company Limited
发明人： YASUMA, Tsuneo , MORI, Akira , KAWASE, Masahiro , KIMURA, Hiroyuki , YOSHIDA, Masato , GYORKOS, Albert, Charles , PRATT, Scott, Alan , CORRETTE, Christopher, Peter
IPC分类号： A61K6/00
CPC分类号： C07D487/04
摘要： There is provided a calcium receptor modulator comprising a compound of the formula (I): wherein ring A is an optionally substituted 5- to 7- membered ring; ring B is an optionally substituted 5- to 7- membered heterocyclic ring; X1 is CR1, CR1R2, N or NR13; X2 is N or NR3; Y is C, CR4 or N, Z is CR5, CR5R6, N or NR7; Ar is an optionally substituted cyclic group; R is H, an optionally substituted hydrocarbon group, etc.; and --- is a single bond or a double bond; R1, R2, R3, R4, R5, R6, R7 and R13 are independently H, an optionally substituted hydrocarbon group; or a salt thereof or a prodrug thereof. Compounds of the formula (II) and (III): wherein ring A is an optionally substituted 5- to 7- membered ring; Q is C, CR5 or N; R8, R9,R10, R11 and R12 are independently, H, an optionally substituted hydrocarbon group, etc., or a salt thereof are also provided. Also specify X1, R3, R1, Y and X3 in formula (II) and (III) as before.
摘要翻译：提供了包含式（I）化合物的钙受体调节剂：其中环A是任选取代的5-至7-元环; 环B是任选取代的5-至7-元杂环; X1是CR1，CR1R2，N或NR13; X2为N或NR3; Y为C，CR4或N，Z为CR5，CR5R6，N或NR7; Ar是任选取代的环状基团; R为H，任选取代的烃基等; ＆lt; img id =“CUSTOM-CHARACTER-00001”he =“3.13mm”wi =“8.47mm”file =“US20090215746A1-20090827-P00001.TIF”img-content =“character”img-format =“tif”/ >是单键或双键; R 1，R 2，R 3，R 4，R 5，R 6，R 7和R 13独立地为H，任选取代的烃基; 或其盐或其前药。式（II）和（III）的化合物：其中环A是任选取代的5-至7-元环; Q为C，CR5或N; R8，R9，R10，R11和R12独立地为H，任意取代的烃基等，或其盐。也如前所述，在式（II）和（III）中指定X1，R3，R1，Y和X3。

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