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1. 发明授权

US07531576B2 Biphenyl derivatives 失效
标题翻译：联苯衍生物
公开(公告)号：US07531576B2
公开(公告)日：2009-05-12
申请号：US10451408
申请日：2001-12-05
申请人： Takayuki Namiki , Kenichi Kishii , Masaki Mitani , Masashi Tamai , Naoki Hiyama , Makoto Kimura , Satoshi Ichinomiya
发明人： Takayuki Namiki , Kenichi Kishii , Masaki Mitani , Masashi Tamai , Naoki Hiyama , Makoto Kimura , Satoshi Ichinomiya
IPC分类号： A01N47/28 , A01N41/02 , A01N41/06 , A01N37/18 , C07C273/00 , C07C333/00 , C07C303/00 , C07C233/00
CPC分类号： C07D257/04 , C07C275/30 , C07C311/09 , C07C311/60
摘要： Biphenyl derivatives represented by the following formula (1): wherein R1 represents a C5-7 alkyl group, R2 represents a substituted or unsubstituted aromatic hydrocarbon, or cycloalkyl group, R3 represents a tetrazolyl group, —NHCOCF3, —NHSO2CF3 or —SO2NHCONHR4 in which R4 represents a substituted or unsubstituted aromatic hydrocarbon group, and Z represents a single bond, a C1-4 alkylene group or —SO2NH—, and salts thereof; and ACAT inhibitors and medicines containing them as active ingredients. The compounds according to the present invention possess excellent ACAT inhibitory activities, and are useful as preventives and/or therapeutics for diseases cased by the enhancement of ACAT activity, for example, hypercholesterolemia, atherosclerosis and the like.
摘要翻译：由下式（1）表示的联苯衍生物：其中R1表示C5-7烷基，R2表示取代或未取代的芳族烃或环烷基，R3表示四唑基，-NHCOCF3，-NHSO2CF3或-SO2NHCONHR4，其中 R4表示取代或未取代的芳族烃基，Z表示单键，C1-4亚烷基或-SO2NH-，及其盐; 和ACAT抑制剂和含有它们作为活性成分的药物。根据本发明的化合物具有优异的ACAT抑制活性，并且可用作通过增强ACAT活性（例如高胆固醇血症，动脉粥样硬化等）而引起的疾病的预防剂和/或治疗剂。

2. 发明授权

US5747493A Dopamine re-uptake inhibitor 失效
标题翻译：多巴胺再摄取抑制剂
公开(公告)号：US5747493A
公开(公告)日：1998-05-05
申请号：US557167
申请日：1995-12-21
申请人： Takayuki Namiki , Toshihiro Morimoto , Kenichi Kishii , Nobuyuki Kawakatsu , Makoto Kimura , Kyoko Yamasaki , Mariko Onoda , Yuji Yoshiko , Kazunori Harada , Masayuki Yanagi , Takeshi Yamamoto , Masato Inazu , Masaki Mitani
发明人： Takayuki Namiki , Toshihiro Morimoto , Kenichi Kishii , Nobuyuki Kawakatsu , Makoto Kimura , Kyoko Yamasaki , Mariko Onoda , Yuji Yoshiko , Kazunori Harada , Masayuki Yanagi , Takeshi Yamamoto , Masato Inazu , Masaki Mitani
IPC分类号： A61K31/495 , C07D213/74 , C07D295/13
CPC分类号： A61K31/495 , C07D213/74 , C07D295/13
摘要： A method for inhibiting dopamine re-uptake and treating Parkinson's disease is disclosed comprising administering a compound represented by formula (1) or a physiologically acceptable salt thereof as the active ingredient: ##STR1## wherein R.sup.1 and R.sup.2 represent each hydrogen or halogen, R.sup.3 represents hydrogen, alkyl or acyl, R.sup.4 represents hydrogen, alkyl, acyl, alkylsulfonyl or optionally esterified carboxyl, Ar represents optionally substituted phenyl or nitrogenous monocyclic heteroaromatic group, m represents a number of 1 to 5, and n represents a number of 0 to 5.
摘要翻译： PCT No.PCT / JP94 / 00728 Sec。 371 1995年12月21日第 102（e）日期1995年12月21日PCT 1994年4月28日PCT PCT。出版物WO95 / 00149 1995年1月5日公开了一种抑制多巴胺再摄取和治疗帕金森病的方法，包括给予式（1）表示的化合物或其生理学上可接受的盐作为活性成分：其中R1和R2 代表每个氢或卤素，R 3表示氢，烷基或酰基，R 4表示氢，烷基，酰基，烷基磺酰基或任意酯化的羧基，Ar表示任选取代的苯基或含氮单环杂芳基，m表示1至5的数，n表示代表0到5的数字。

3. 发明授权

US5391552A Diphenylpiperazine derivative and drug for circulatory organ containing the same 失效
标题翻译：二苯基哌嗪衍生物和含有其的循环器官的药物
公开(公告)号：US5391552A
公开(公告)日：1995-02-21
申请号：US988911
申请日：1993-05-10
申请人： Masato Inazu , Yoshiyuki Miyata , Toshihiro Morimoto , Takeshi Yamamoto , Yuji Yoshiko , Kazunori Harada , Yoshiharu Momota , Masayuki Yanagi , Ryoko Yokota , Tetsuo Katoh , Takayuki Namiki , Makoto Kimura , Nobuyuki Kawakatsu
发明人： Masato Inazu , Yoshiyuki Miyata , Toshihiro Morimoto , Takeshi Yamamoto , Yuji Yoshiko , Kazunori Harada , Yoshiharu Momota , Masayuki Yanagi , Ryoko Yokota , Tetsuo Katoh , Takayuki Namiki , Makoto Kimura , Nobuyuki Kawakatsu
IPC分类号： C07D295/088 , C07D295/092 , C07D295/13 , A61K31/495
CPC分类号： C07D295/088 , C07D295/13
摘要： A diphenylpiperazine derivative represented by general formula (1), salt thereof, and drug for the circulatory organs containing the same as the active ingredient: ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different from each other and each represents hydrogen, halogen, alkyl, alkoxy, nitro, amino, hydroxy, optionally esterified carboxyl or trifluoromethyl; R.sup.3 represents hydrogen, alkyl, aralkyl, acyl, nitro or optionally esterified carboxymethyl; Ar represents phenyl or naphthyl which may have one to three substituents such as halogen, alkyl, alkoxy, aryloxy, aralkyloxy, nitro, amino, cyano, acyl, hydroxy, optionally esterified carboxyl, substituted sulfonyl, aryl or trifluoromethyl; Z represents sulfur or -NR.sup.4 - wherein R.sup.4 represents hydrogen, alkyl, aralkyl, acyl, aryl, substituted sulfonyl or optionally esterified carboxyl; m represents a number of 1 to 5; and n represents a number of 0 to 5.
摘要翻译： PCT No.PCT / JP91 / 01227 Sec。 371日期：1993年5月10日 102（e）日期1993年5月10日PCT 1991年9月13日PCT PCT。出版物WO92 / 05165 1992年4月2日，由通式（1）表示的二苯基哌嗪衍生物及其盐，以及含有与活性成分相同的循环器官的药物：其中，R1和R2可以相同或各自表示氢，卤素，烷基，烷氧基，硝基，氨基，羟基，任意酯化的羧基或三氟甲基; R3表示氢，烷基，芳烷基，酰基，硝基或任意酯化的羧甲基; 卤素，烷基，烷氧基，芳氧基，芳烷氧基，硝基，氨基，氰基，酰基，羟基，任意酯化的羧基，取代的磺酰基，芳基或三氟甲基的苯基或萘基。 Z表示硫或-NR4-，其中R4表示氢，烷基，芳烷基，酰基，芳基，取代的磺酰基或任选酯化的羧基; m表示1〜5的数; n表示0〜5的数。

4. 发明授权

US08846012B2 Melanin production inhibitor 有权
标题翻译：黑色素生成抑制剂
公开(公告)号：US08846012B2
公开(公告)日：2014-09-30
申请号：US13131827
申请日：2009-12-22
申请人： Kouji Yokoyama , Makoto Kimura , Masashi Tamai , Yuko Saitoh , Tomomi Kato , Yu Ikeda
发明人： Kouji Yokoyama , Makoto Kimura , Masashi Tamai , Yuko Saitoh , Tomomi Kato , Yu Ikeda
IPC分类号： A61K8/49 , C07D233/58 , C07D401/06 , A61K8/44 , A61K8/41 , A61K8/34 , C07D207/404 , A61Q19/02 , C07D213/38 , C07D213/30 , C07D295/03 , C07D207/12 , C07D295/096
CPC分类号： A61K8/4946 , A61K8/31 , A61K8/34 , A61K8/41 , A61K8/411 , A61K8/418 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/4913 , A61K8/4926 , A61K8/494 , A61K2800/74 , A61Q19/02 , C07D207/12 , C07D207/404 , C07D213/30 , C07D213/38 , C07D233/58 , C07D295/03 , C07D295/096 , C07D401/06
摘要： Disclosed is a melanin production inhibitor which has an excellent inhibitory activity on the production of melanin and is highly safe. The melanin production inhibitor is represented by general formula (1) (excluding clotrimazole) and/or a pharmacologically acceptable salt thereof. In the formula, A1, A2 and A3 are independently selected from a hydrogen atom, an aryl group which may have a substituent, and an aromatic heterocyclic group which may have a substituent. At least one of A1, A2 and A3 is selected from the aryl group and the aromatic heterocyclic group, the total number of carbon atoms contained in A1, A2 and A3 is 6 to 50 and, when at least two of A1, A2 and A3 represent the aryl groups or the aromatic heterocyclic groups, the adjacent two aryl or aromatic heterocyclic groups may be bound to each other via an alkyl chain or an alkenyl chain to form a ring; m represents an integer of 0 to 2; X represents a hetero atom, a hydrogen atom, or a carbon atom; R1 and R2 are independently selected from a hydrogen atom and an oxo group. When one of R1 and R2 is an oxo group, the other is not present. R3 is selected from a hydrogen atom, and a C1-8 hydrocarbon group in which one or some of hydrogen atoms or carbon atoms may be substituted by a hetero atom or hetero atoms. The number of R3's present in the compound corresponds to X and, when two or more R3's are present, the R3's are independently present and the adjacent two R3's may be bound to each other to form, together with X, a ring, and the terminal of R3 may be bound to a carbon atom to which A1, A2 and A3 are bound, thereby forming a ring.
摘要翻译：公开了一种黑色素产生抑制剂，其对黑色素的生成具有优异的抑制活性，并且是高度安全的。黑色素产生抑制剂由通式（1）表示（不包括克霉唑）和/或其药理学上可接受的盐。在该式中，A1，A2和A3独立地选自氢原子，可以具有取代基的芳基和可以具有取代基的芳族杂环基。 A1，A2和A3中的至少一个选自芳基和芳族杂环基，A1，A2和A3中所含的碳原子总数为6〜50，A1，A2和A3中的至少2个表示芳基或芳族杂环基，相邻的两个芳基或芳族杂环基可以通过烷基链或烯基链彼此结合形成环; m表示0〜2的整数。 X表示杂原子，氢原子或碳原子; R 1和R 2独立地选自氢原子和氧代基。当R1和R2中的一个是氧代基时，另一个不存在。 R3选自氢原子和碳原子数为1〜8的烃基，其中一个或几个氢原子或碳原子可以被杂原子或杂原子取代。化合物中存在的R3的数目对应于X，并且当存在两个或更多个R 3时，R 3独立地存在，并且相邻的两个R 3可以彼此结合形成与X一起形成环，并且末端的R3可以结合到与A1，A2和A3结合的碳原子上，从而形成环。

5. 发明申请

US20110243865A1 MELANIN PRODUCTION INHIBITOR 有权
标题翻译： MELANIN生产抑制剂
公开(公告)号：US20110243865A1
公开(公告)日：2011-10-06
申请号：US13131827
申请日：2009-12-22
申请人： Kouji Yokoyama , Makoto Kimura , Masashi Tamai , Yuko Saitoh , Tomomi Kato , Yu Ikeda
发明人： Kouji Yokoyama , Makoto Kimura , Masashi Tamai , Yuko Saitoh , Tomomi Kato , Yu Ikeda
IPC分类号： A61K8/49 , C07D233/58 , C07D401/06 , A61K8/44 , C07C229/36 , A61K8/34 , C07C43/178 , A61K8/41 , C07C215/20 , C07C43/205 , C07C43/23 , C07C211/03 , C07D207/04 , C07D211/70 , C07D213/36 , C07D207/40 , C07D265/30 , C07D241/04 , A61Q19/02
CPC分类号： A61K8/4946 , A61K8/31 , A61K8/34 , A61K8/41 , A61K8/411 , A61K8/418 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/4913 , A61K8/4926 , A61K8/494 , A61K2800/74 , A61Q19/02 , C07D207/12 , C07D207/404 , C07D213/30 , C07D213/38 , C07D233/58 , C07D295/03 , C07D295/096 , C07D401/06
摘要： Disclosed is a melanin production inhibitor which has an excellent inhibitory activity on the production of melanin and is highly safe. The melanin production inhibitor comprises a compound represented by general formula (1) (excluding clotrimazole), and/or a pharmacologically acceptable salt thereof. In the formula, A1, A2 and A3 are independently selected from a hydrogen atom, an aryl group which may have a substituent, and an aromatic heterocyclic group which may have a substituent, wherein at least one of A1, A2 and A3 is selected from the aryl group and the aromatic heterocyclic group, the total number of carbon atoms contained in A1, A2 and A3 is 6 to 50 and, when at least two of A1, A2 and A3 represent the aryl groups or the aromatic heterocyclic groups, the adjacent two aryl or aromatic heterocyclic groups may be bound to each other via an alkyl chain or an alkenyl chain to form a ring; m represents an integer of 0 to 2; X represents a hetero atom, a hydrogen atom, or a carbon atom; R1 and R2 are independently selected from a hydrogen atom and an oxo group, wherein when one of R1 and R2 is an oxo group, the other is not present; and R3 is selected from a hydrogen atom, and a C1-8 hydrocarbon group in which one or some of hydrogen atoms or carbon atoms may be substituted by a hetero atom or hetero atoms, wherein the number of R3's present in the compound corresponds to the number of X's and, when two or more R3's are present, the R3's are independently present and the adjacent two R3's may be bound to each other to form, together with X, a ring, and the terminal of R3 may be bound to a carbon atom to which A1, A2 and A3 are bound, thereby forming a ring.
摘要翻译：公开了一种黑色素产生抑制剂，其对黑色素的生成具有优异的抑制活性，并且是高度安全的。黑色素生成抑制剂包含通式（1）表示的化合物（克霉唑除外）和/或其药理学上可接受的盐。在该式中，A1，A2和A3独立地选自氢原子，可以具有取代基的芳基和可以具有取代基的芳族杂环基，其中A1，A2和A3中的至少一个选自芳基和芳香族杂环基时，A1，A2，A3中含有的碳原子总数为6〜50，A1，A2，A3中的至少2个为芳基或芳香族杂环基时，两个芳基或芳族杂环基可以通过烷基链或烯基链彼此结合形成环; m表示0〜2的整数。 X表示杂原子，氢原子或碳原子; R 1和R 2独立地选自氢原子和氧代基，其中当R 1和R 2之一是氧代基时，另一个不存在; 和R3选自氢原子，其中一个或几个氢原子或碳原子可以被杂原子或杂原子取代的C1-8烃基，其中存在于化合物中的R3的数目对应于 X的数目，当存在两个或更多个R3时，R3独立地存在，并且相邻的两个R 3可以彼此结合形成与X一起形成环，并且R 3的末端可以与碳结合与A1，A2和A3结合的原子，从而形成环。

6. 发明授权

US08457428B2 Image coding apparatus, control method thereof, and storage medium 有权
标题翻译：图像编码装置，其控制方法和存储介质
公开(公告)号：US08457428B2
公开(公告)日：2013-06-04
申请号：US13085587
申请日：2011-04-13
申请人： Makoto Kimura
发明人： Makoto Kimura
IPC分类号： G06K9/36
CPC分类号： H04N19/436 , H04N19/176 , H04N19/60 , H04N19/91
摘要： Even in a case where there are a plurality of syntax elements, the invention reduces influence of the number of syntax elements and realizes high-speed encoding. An apparatus comprises N number of codes generation units arranged in parallel, which are configured to generate codes, including one or more codes, based on a transform coefficient; N number of first code concatenation units arranged in parallel, each of which is configured to concatenate the codes, respectively generated by the N number of codes generation units, for generating a code stream; N number of storage units arranged in parallel, each of which is configured to store the N number of code streams inputted from the N number of first code concatenation units; and a second code concatenation unit configured to read each of the code streams, which are stored in the N number of storage units, and concatenate the read code streams.
摘要翻译：即使在存在多个语法元素的情况下，本发明也减少了语法元素的数量的影响，实现了高速编码。一种装置，包括并行布置的N个代码生成单元，其被配置为基于变换系数生成包括一个或多个代码的代码; N个并行布置的第一代码级联单元，其中每个被配置为级联由N个代码生成单元生成的代码，用于生成代码流; N个并行布置的存储单元，每个存储单元被配置为存储从N个第一代码级联单元输入的N个代码流; 以及第二代码级联单元，被配置为读取存储在N个存储单元中的每个代码流，并且连接所读取的代码流。

7. 发明授权

US08228534B2 Communication system, image formation apparatus, controller, computer readable medium and data signal 有权
标题翻译：通信系统，图像形成装置，控制器，计算机可读介质和数据信号
公开(公告)号：US08228534B2
公开(公告)日：2012-07-24
申请号：US11907803
申请日：2007-10-17
申请人： Kouichi Azuma , Yukio Yamazaki , Makoto Kimura , Shinho Ikeda
发明人： Kouichi Azuma , Yukio Yamazaki , Makoto Kimura , Shinho Ikeda
IPC分类号： G06K15/00
CPC分类号： G03G15/80 , G03G15/5004
摘要： An image formation apparatus includes a reception section, a function section, an image formation section and a power output device. The reception section is configured to be connected to a communication line over which image information and power are transmitted. The reception section receives the image information and the power transmitted over the communication line. The function section receives supply of the power received by the reception section, to function. The image formation section forms an image on a medium based on the image information received by the reception section or the function section. The power output device receives power supply from a commercial power supply. The power output device outputs power of a predetermined voltage to the image formation section.
摘要翻译：图像形成装置包括接收部，功能部，图像形成部和电力输出装置。接收部被配置为连接到发送图像信息和电力的通信线路。接收部接收通过通信线路发送的图像信息和电力。功能部分接收由接收部分接收的功率的供应功能。图像形成部基于由接收部或功能部接收的图像信息，在介质上形成图像。电力输出装置从商用电源接收电源。功率输出装置向图像形成部输出预定电压的功率。

8. 发明申请

US20100322807A1 PUMP APPARATUS 有权
标题翻译：泵装置
公开(公告)号：US20100322807A1
公开(公告)日：2010-12-23
申请号：US12773426
申请日：2010-05-04
申请人： Makoto Kimura
发明人： Makoto Kimura
IPC分类号： F04C14/22
CPC分类号： B62D5/065 , B62D6/02
摘要： A pump apparatus includes a pump housing; a drive shaft; a pump element; a cam ring arranged to vary an inherent discharge amount based on the eccentric amount of the cam ring; a steering state sensing section configured to sense or estimate a steering angle, a steering angular speed or a steering angular acceleration, and to output the steering angle, the steering angular speed or the steering angular acceleration as a steering state sensing signal; and a solenoid configured to be controlled to suppress the eccentric amount of the cam ring so as to decrease the inherent discharge amount with respect to the steering state sensing signal when the vehicle speed is equal to or greater than a first predetermined vehicle speed, relative to the inherent discharge amount when the vehicle speed is smaller than the first predetermined vehicle speed.
摘要翻译：泵装置包括泵壳体; 驱动轴; 泵元件凸轮环，其布置成基于所述凸轮环的偏心量来改变固有排出量; 导向状态检测部，被配置为感测或估计转向角，转向角速度或转向角加速度，并输出转向角，转向角速度或转向角加速度作为转向状态感测信号; 以及螺线管，其构造成被控制为当车速等于或大于第一预定车速时相对于所述转向状态感测信号减小所述凸轮环的偏心量，从而相对于当车速小于第一预定车速时的固有排出量。

9. 发明授权

US07742872B2 On-vehicle navigation apparatus, turnoff road guiding method, driving lane specifying device, and driving lane specifying method 失效
标题翻译：车载导航装置，熄火道路导引方法，行驶车道指定装置以及行驶车道指定方法
公开(公告)号：US07742872B2
公开(公告)日：2010-06-22
申请号：US11146289
申请日：2005-06-07
申请人： Makoto Kimura , Kenjiro Nakano
发明人： Makoto Kimura , Kenjiro Nakano
IPC分类号： G01C21/00
CPC分类号： G08G1/096872 , G01C21/3655 , G01C21/3658 , G08G1/096827
摘要： An on-vehicle navigation apparatus 50 includes a current location calculator 21 calculating a current location of an own vehicle, a map information database 2 storing map information including road map data, a driving lane specifying section 23 detecting a lane change in response to an operation signal from a winker and specifying a driving lane of the own vehicle, and a guidance-timing controller 24 detecting a turnoff road ahead of the own vehicle in a traveling direction and conducting turnoff road guidance on a driver at a forward position distanced from the detected turnoff road depending on a location of the specified driving lane of the own vehicle.
摘要翻译：车载导航装置50包括计算本车辆的当前位置的当前位置计算器21，存储包括道路地图数据的地图信息的地图信息数据库2，响应于操作而检测车道变化的行驶车道指定部23 来自方向指示灯的指示信号和指定本车辆的行驶车道;以及引导定时控制器24，检测在行驶方向上的本车前方的交通道路，并且在远离所检测到的前方位置的驾驶员进行离场道路引导关闭道路取决于本车辆的指定行驶车道的位置。

10. 发明申请

US20100126794A1 MOTOR CONTROL APPARATUS, POWER STEERING APPARATUS AND BRAKE CONTROL APPARATUS 有权
标题翻译：电动机控制装置，动力转向装置和制动控制装置
公开(公告)号：US20100126794A1
公开(公告)日：2010-05-27
申请号：US12692890
申请日：2010-01-25
申请人： Kohtaro SHIINO , Makoto Kimura , Toshiro Yoda , Haruhiko Fujita , Yoshimori Kondo , Yoshiki Sakamoto
发明人： Kohtaro SHIINO , Makoto Kimura , Toshiro Yoda , Haruhiko Fujita , Yoshimori Kondo , Yoshiki Sakamoto
IPC分类号： B62D5/04
CPC分类号： B60T8/267 , B60T8/368 , B62D5/0406 , B62D5/064 , H02K7/06 , H02K7/075 , H02K7/081 , H02K7/1166 , H02K11/38 , H02K29/06
摘要： An electric power steering apparatus including: a power system board which is received in a housing, which supports a component of a power supply circuit to supply power to a motor; a control system board which is received in the housing, which supports a component of a control circuit to control the motor, and which extends radially with respect to an axis of the motor output shaft; a rotation sensor which is provided in the housing, which is located, in an axial direction of a motor output shaft, between the motor and the control system board, and which is arranged to sense a rotational position of the motor output shaft; and an output terminal which is provided with the rotation sensor, which is connected electrically with the control system board to supply a rotational position signal of the rotation sensor to the control circuit.
摘要翻译：一种电动助力转向装置，包括：电源系统板，其容纳在壳体中，其支撑供电电路的部件以向电动机供电; 控制系统板，其容纳在所述壳体中，所述控制系统板支撑控制电路的部件以控制所述电动机，并且所述控制系统板相对于所述电动机输出轴的轴线径向延伸; 旋转传感器，其设置在所述壳体中，所述旋转传感器沿所述电动机输出轴的轴向位于所述电动机和所述控制系统板之间，并且被布置成感测所述电动机输出轴的旋转位置; 以及设置有旋转传感器的输出端子，其与控制系统板电连接以将旋转传感器的旋转位置信号提供给控制电路。

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