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1. 发明授权

US08293190B2 Polymer compound for biomedical use and biochip substrate using such a polymer compound 有权
公开(公告)号：US08293190B2
公开(公告)日：2012-10-23
申请号：US13306240
申请日：2011-11-29
申请人： Mitsutaka Matsumoto , Sumio Shibahara , Takayuki Matsumoto , Kanehisa Yokoyama , Sohei Funaoka , Daisuke Masuda , Michael Patrick Coleman , Dominic Zichi
发明人： Mitsutaka Matsumoto , Sumio Shibahara , Takayuki Matsumoto , Kanehisa Yokoyama , Sohei Funaoka , Daisuke Masuda , Michael Patrick Coleman , Dominic Zichi
IPC分类号： G01N33/52
CPC分类号： C08J7/047 , C08F220/28 , C08F220/30 , C08F220/36 , C08F220/38 , C08F2220/286 , C08F2220/306 , C08J2365/00 , C08J2443/00 , G01N33/54393 , Y10T428/31504 , Y10T428/31938
摘要： A biochip substrate capable of realizing the high detection accuracy by restricting a nonspecific adsorption or bonding of a substance to be detected, when used for a detection or analysis of protein, nucleic acids and the like. The biochip substrate is for fixing a biologically active substance on a surface of a solid substrate, and characterized in that it has a layer comprising a polymer compound obtained by copolymerizing an ethylenically unsaturated polymerizable monomer having an alkylene glycol residue, an ethylenically unsaturated polymerizable monomer having a functional group for fixing a biologically active substance and an ethylenically unsaturated polymerizable monomer having a cross-linkable functional group, on the surface of the substrate.

2. 发明授权

US09046515B2 Polymer compound for medical material, and biochip substrate using the polymer compound 有权
标题翻译：用于医疗材料的高分子化合物和使用该高分子化合物的生物芯片基材
公开(公告)号：US09046515B2
公开(公告)日：2015-06-02
申请号：US11920560
申请日：2006-05-18
申请人： Takayuki Matsumoto , Sumio Shibahara , Sohei Funaoka , Daisuke Masuda
发明人： Takayuki Matsumoto , Sumio Shibahara , Sohei Funaoka , Daisuke Masuda
IPC分类号： B05D3/00 , C12M1/00 , G01N33/543 , C08F2/38 , C08F290/06 , C08G65/332 , C08G65/333 , C08G65/336 , C09D133/00 , C09D155/00 , C08F220/36 , G01N35/00
CPC分类号： G01N33/54393 , C08F2/38 , C08F220/36 , C08F290/06 , C08F290/062 , C08G65/3322 , C08G65/33379 , C08G65/33396 , C08G65/336 , C08L2203/02 , C09D133/00 , C09D155/005 , G01N2035/00158
摘要： A main object of the invention is to provide a polymer compound for medicine which has an excellent capability of fixing a biologically active substance and has such chemical/physical stability that the compound is less dissolved or deteriorated in a washing step, in particular, which can be suitably applied to a plastic substrate surface.The invention provides a polymer compound for medical material which is a polymer comprising repeating units derived from an ethylenically unsaturated polymerizable monomer (a) having a functional group for fixing a biologically active substance, wherein the polymer has a reactive functional group on at least one terminal side thereof, and a biochip substrate wherein a layer containing the polymer compound is formed on a substrate surface, thereby attaining the object.
摘要翻译：本发明的主要目的是提供一种具有优异的固定生物活性物质的能力的药物用高分子化合物，具有化学物质在洗涤工序中溶解性差或劣化的化学/物理稳定性，特别是可以适用于塑料基材表面。本发明提供一种医用材料用高分子化合物，其为含有具有固定生物活性物质的官能团的烯属不饱和可聚合单体（a）的重复单元的聚合物，其中，聚合物在至少一个末端具有反应性官能团以及在基材表面上形成含有高分子化合物的层的生物芯片基板，从而达到目的。

3. 发明申请

US20080175758A1 Polymer Compound For Biomedical Use and Biochip Substrate Using Such a Polymer Compound 有权
标题翻译：用于生物医学用途的聚合物化合物和使用这种聚合物化合物的生物芯片底物
公开(公告)号：US20080175758A1
公开(公告)日：2008-07-24
申请号：US11908170
申请日：2006-03-14
申请人： Mitsutaka Matsumoto , Sumio Shibahara , Takayuki Matsumoto , Kanehisa Yokoyama , Sohei Funaoka , Daisuke Masuda , Michael Patrick Coleman , Dominic Zichi
发明人： Mitsutaka Matsumoto , Sumio Shibahara , Takayuki Matsumoto , Kanehisa Yokoyama , Sohei Funaoka , Daisuke Masuda , Michael Patrick Coleman , Dominic Zichi
IPC分类号： B01J19/00 , C08F120/26 , C08F120/10 , C08F116/34 , C08F124/00 , B32B27/32 , B32B27/00 , B05D3/00 , C08F128/02 , C08F130/08 , C09D133/04
CPC分类号： C08J7/047 , C08F220/28 , C08F220/30 , C08F220/36 , C08F220/38 , C08F2220/286 , C08F2220/306 , C08J2365/00 , C08J2443/00 , G01N33/54393 , Y10T428/31504 , Y10T428/31938
摘要： A biochip substrate capable of realizing the high detection accuracy by restricting a nonspecific adsorption or bonding of a substance to be detected, when used for a detection or analysis of protein, nucleic acids and the like. The biochip substrate is for fixing a biologically active substance on a surface of a solid substrate, and characterized in that it has a layer comprising a polymer compound obtained by copolymerizing an ethylenically unsaturated polymerizable monomer having an alkylene glycol residue, an ethylenically unsaturated polymerizable monomer having a functional group for fixing a biologically active substance and an ethylenically unsaturated polymerizable monomer having a cross-linkable functional group, on the surface of the substrate.
摘要翻译：一种生物芯片基板，当用于检测或分析蛋白质，核酸等时，能够通过限制待检测物质的非特异性吸附或结合来实现高检测精度。生物芯片基板用于将生物活性物质固定在固体基材的表面上，其特征在于，其具有包含通过使具有亚烷基二醇残基的烯属不饱和可聚合单体和具有亚烷基二醇残基的烯键式不饱和可聚合单体共聚得到的聚合物，用于固定生物活性物质的官能团和具有可交联官能团的烯属不饱和可聚合单体。

4. 发明授权

US08088340B2 Polymer compound for biomedical use and biochip substrate using such a polymer compound 有权
标题翻译：用于生物医学用途的高分子化合物和使用这种高分子化合物的生物芯片底物
公开(公告)号：US08088340B2
公开(公告)日：2012-01-03
申请号：US11908170
申请日：2006-03-14
申请人： Mitsutaka Matsumoto , Sumio Shibahara , Takayuki Matsumoto , Kanehisa Yokoyama , Sohei Funaoka , Daisuke Masuda , Michael Patrick Coleman , Dominic Zichi
发明人： Mitsutaka Matsumoto , Sumio Shibahara , Takayuki Matsumoto , Kanehisa Yokoyama , Sohei Funaoka , Daisuke Masuda , Michael Patrick Coleman , Dominic Zichi
IPC分类号： G01N33/52
CPC分类号： C08J7/047 , C08F220/28 , C08F220/30 , C08F220/36 , C08F220/38 , C08F2220/286 , C08F2220/306 , C08J2365/00 , C08J2443/00 , G01N33/54393 , Y10T428/31504 , Y10T428/31938
摘要： A biochip substrate capable of realizing the high detection accuracy by restricting a nonspecific adsorption or bonding of a substance to be detected, when used for a detection or analysis of protein, nucleic acids and the like. The biochip substrate is for fixing a biologically active substance on a surface of a solid substrate, and characterized in that it has a layer comprising a polymer compound obtained by copolymerizing an ethylenically unsaturated polymerizable monomer having an alkylene glycol residue, an ethylenically unsaturated polymerizable monomer having a functional group for fixing a biologically active substance and an ethylenically unsaturated polymerizable monomer having a cross-linkable functional group, on the surface of the substrate.
摘要翻译：一种生物芯片基板，当用于检测或分析蛋白质，核酸等时，能够通过限制待检测物质的非特异性吸附或结合来实现高检测精度。生物芯片基板用于将生物活性物质固定在固体基材的表面上，其特征在于，其具有包含通过使具有亚烷基二醇残基的烯属不饱和可聚合单体和具有亚烷基二醇残基的烯键式不饱和可聚合单体共聚得到的聚合物，用于固定生物活性物质的官能团和具有可交联官能团的烯属不饱和可聚合单体。

5. 发明申请

US20090176298A1 Polymer Compound For Medical Material, And Biochip Substrate Using The Polymer Compound 有权
标题翻译：医用材料用高分子化合物及使用高分子化合物的生物芯片基板
公开(公告)号：US20090176298A1
公开(公告)日：2009-07-09
申请号：US11920560
申请日：2006-05-18
申请人： Takayuki Matsumoto , Sumio Shibahara , Sohei Funaoka , Daisuke Masuda
发明人： Takayuki Matsumoto , Sumio Shibahara , Sohei Funaoka , Daisuke Masuda
IPC分类号： C12M1/34 , C08F230/08 , C08L83/04
CPC分类号： G01N33/54393 , C08F2/38 , C08F220/36 , C08F290/06 , C08F290/062 , C08G65/3322 , C08G65/33379 , C08G65/33396 , C08G65/336 , C08L2203/02 , C09D133/00 , C09D155/005 , G01N2035/00158
摘要： A main object of the invention is to provide a polymer compound for medicine which has an excellent capability of fixing a biologically active substance and has such chemical/physical stability that the compound is less dissolved or deteriorated in a washing step, in particular, which can be suitably applied to a plastic substrate surface.The invention provides a polymer compound for medical material which is a polymer comprising repeating units derived from an ethylenically unsaturated polymerizable monomer (a) having a functional group for fixing a biologically active substance, wherein the polymer has a reactive functional group on at least one terminal side thereof, and a biochip substrate wherein a layer containing the polymer compound is formed on a substrate surface, thereby attaining the object.
摘要翻译：本发明的主要目的是提供一种具有优异的固定生物活性物质的能力的药物用高分子化合物，具有化学物质在洗涤工序中溶解性差或劣化的化学/物理稳定性，特别是可以适用于塑料基材表面。本发明提供一种医用材料用高分子化合物，其为含有具有固定生物活性物质的官能团的烯属不饱和可聚合单体（a）的重复单元的聚合物，其中，聚合物在至少一个末端具有反应性官能团以及在基材表面上形成含有高分子化合物的层的生物芯片基板，从而达到目的。

6. 发明申请

US20070219309A1 Transparent composite composition 审中-公开
标题翻译：透明复合组合物
公开(公告)号：US20070219309A1
公开(公告)日：2007-09-20
申请号：US11712328
申请日：2007-02-28
申请人： Sumio Shibahara , Wataru Oka , Yasuo Shimobe , Hiromitsu Kuramoto , Toshio Nakao
发明人： Sumio Shibahara , Wataru Oka , Yasuo Shimobe , Hiromitsu Kuramoto , Toshio Nakao
IPC分类号： C08L33/00
CPC分类号： C08J5/08 , C08J2333/06 , C08K3/40
摘要： The object of the invention is to provide an optical material serving as a glass substitute, showing high light transmissivity in a broad wavelength range and capable of being adequately used in producing transparent sheets, optical lenses, liquid crystal display element plastic substrates, color filter substrates, organic EL display element plastic substrates, solar cell substrates, touch panels, optical elements, optical waveguides and LED sealants, among others, by using ordinary glass fillers. The above optical material can be obtained from a transparent composite composition which comprises a transparent resin and a glass filler and in which the transparent resin has an Abbe number of not smaller than 45.
摘要翻译：本发明的目的是提供一种用作玻璃替代物的光学材料，其在宽波长范围内显示高透光率并且能够充分地用于制造透明片，光学透镜，液晶显示元件塑料基板，滤色器基板有机EL显示元件塑料基板，太阳能电池基板，触摸面板，光学元件，光波导和LED密封剂等。上述光学材料可以由包含透明树脂和玻璃填料的透明复合组合物获得，并且其中透明树脂的阿贝数不小于45。

7. 发明授权

US07132154B2 Transparent composite composition 有权
标题翻译：透明复合组合物
公开(公告)号：US07132154B2
公开(公告)日：2006-11-07
申请号：US10472517
申请日：2003-01-22
申请人： Sumio Shibahara , Wataru Oka
发明人： Sumio Shibahara , Wataru Oka
IPC分类号： B32B27/38 , B32B27/04
CPC分类号： G02B1/04 , C08K3/40 , C08L63/00 , G02F1/133305 , G02F2001/133302 , Y10T428/24994 , Y10T428/31511 , Y10T428/31525
摘要： A transparent composite composition is provided which comprises an epoxy resin (a) and a glass filler (b) and in which the epoxy resin (a) comprises at least one epoxy resin whose refractive index after curing is lower than the refractive index of the glass filler (b) and at least one epoxy resin whose refractive index after curing is higher than the refractive index of the glass filler (b). The transparent composite composition of the invention has a low coefficient of linear expansion and is excellent in transparency, heat resistance and solvent resistance, among others and, therefore, is judiciously used, for example, in the form of liquid crystal display device substrates and organic EL device substrates (in particular of the active matrix type) and, further, transparent sheets, optical lenses, color filter substrates, solar cell substrates, touch panels, optical devices, optical waveguides, LED sealing materials and so forth.
摘要翻译：提供一种透明复合组合物，其包含环氧树脂（a）和玻璃填料（b），其中环氧树脂（a）包含至少一种固化后的折射率低于玻璃的折射率的环氧树脂填料（b）和至少一种固化后的折射率高于玻璃填料（b）的折射率的环氧树脂。本发明的透明复合组合物的线膨胀系数低，透明性，耐热性和耐溶剂性优异，因此，例如以液晶显示装置用基板和有机物的形式被明智地使用 EL器件基板（特别是有源矩阵型），以及透明片，光学透镜，滤色器基板，太阳能电池基板，触摸面板，光学器件，光波导，LED密封材料等。

8. 发明授权

US07250209B2 Transparent composite composition 有权
标题翻译：透明复合组合物
公开(公告)号：US07250209B2
公开(公告)日：2007-07-31
申请号：US10472519
申请日：2003-01-22
申请人： Sumio Shibahara , Yasuo Shimobe , Hiromitsu Kuramoto
发明人： Sumio Shibahara , Yasuo Shimobe , Hiromitsu Kuramoto
IPC分类号： B32B17/10
CPC分类号： G02B1/04 , C08K3/40 , Y10T428/24994 , Y10T428/249948 , Y10T428/249994 , Y10T428/252 , Y10T428/31645 , Y10T428/31855 , C08L63/00
摘要： A transparent composite composition is provided which is low in coefficient of linear expansion and excellent in transparency, heat resistance and solvent resistance and can serve as an optical sheet for a liquid crystal display device or organic EL display device, for instance and can thus serve as a glass substitute. The transparent composite composition has a transparent resin (a) and a glass filler (b), and the transparent resin (a) is a copolymer obtained from at least one reactive monomer lower in refractive index than the glass filler (b) and at least one reactive monomer higher in refractive index than the glass filler (b).
摘要翻译：提供了一种透明的复合组合物，其线膨胀系数低，透明性，耐热性和耐溶剂性优异，并且可以用作例如液晶显示装置或有机EL显示装置的光学片，因此可以用作一个玻璃替代品。透明复合组合物具有透明树脂（a）和玻璃填料（b），透明树脂（a）是由至少一种折射率低于玻璃填料（b）的反应性单体得到的共聚物，至少一种反应性单体的折射率高于玻璃填料（b）。

9. 发明申请

US20050203239A1 Transparent composite composition 审中-公开
标题翻译：透明复合组合物
公开(公告)号：US20050203239A1
公开(公告)日：2005-09-15
申请号：US10497839
申请日：2003-06-19
申请人： Sumio Shibahara , Wataru Oka , Yasuo Shimobe , Hiromitsu Kuramoto , Toshio Nakao
发明人： Sumio Shibahara , Wataru Oka , Yasuo Shimobe , Hiromitsu Kuramoto , Toshio Nakao
IPC分类号： C08J5/08 , C08K3/40
CPC分类号： C08J5/08 , C08J2333/06 , C08K3/40
摘要： The object of the invention is to provide an optical material serving as a glass substitute, showing high light transmissivity in a broad wavelength range and capable of being adequately used in producing transparent sheets, optical lenses, liquid crystal display element plastic substrates, color filter substrates, organic EL display element plastic substrates, solar cell substrates, touch panels, optical elements, optical waveguides and LED sealants, among others, by using ordinary glass fillers. The above optical material can be obtained from a transparent composite composition which comprises a transparent resin and a glass filler and in which the transparent resin has an Abbe number of not smaller than 45.
摘要翻译：本发明的目的是提供一种用作玻璃替代物的光学材料，其在宽波长范围内显示高透光率并且能够充分地用于制造透明片，光学透镜，液晶显示元件塑料基板，滤色器基板有机EL显示元件塑料基板，太阳能电池基板，触摸面板，光学元件，光波导和LED密封剂等。上述光学材料可以由包含透明树脂和玻璃填料的透明复合组合物获得，其中透明树脂的阿贝数不小于45。

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